Let's get this math done. We have 302653 and 80252, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 2 and the borrow 0 from 3 in column 1 and get 1.
1 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 5 in column 2 and get 0.
0 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 6 in column 3 and get 4.
4 is the next digit of our result.

Step 4: We'll start by subtracting the digit 0 and the borrow 0 from 2 in column 4 and get 2.
2 is the next digit of our result.

Step 5: We'll start by subtracting the digit 8 and the borrow 0 from 0 in column 5 and get -8.
We add -8 to 10 and get 2 as the next digit of the result.

Step 6: We'll start by subtracting the digit 0 and the borrow 1 from 3 in column 6 and get 2.
2 is the next digit of our result.

So, 302653 - 80252 = 222401.