Sure thing! We've got 451421 and 17579, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 9 and the borrow 0 from 1 in column 1 and get -8.
We add -8 to 10 and get 2 as the first digit of the result.

Step 2: We'll start by subtracting the digit 7 and the borrow 1 from 2 in column 2 and get -6.
We add -6 to 10 and get 4 as the next digit of the result.

Step 3: We'll start by subtracting the digit 5 and the borrow 1 from 4 in column 3 and get -2.
We add -2 to 10 and get 8 as the next digit of the result.

Step 4: We'll start by subtracting the digit 7 and the borrow 1 from 1 in column 4 and get -7.
We add -7 to 10 and get 3 as the next digit of the result.

Step 5: We'll start by subtracting the digit 1 and the borrow 1 from 5 in column 5 and get 3.
3 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 4 in column 6 and get 4.
4 is the next digit of our result.

So, 451421 - 17579 = 433842.