Okay, let's tackle this math problem. We're starting with 88537 and subtracting 10501.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 7 in column 1 and get 6.
6 is the first digit of our result.

Step 2: We'll start by subtracting the digit 0 and the borrow 0 from 3 in column 2 and get 3.
3 is the next digit of our result.

Step 3: We'll start by subtracting the digit 5 and the borrow 0 from 5 in column 3 and get 0.
0 is the next digit of our result.

Step 4: We'll start by subtracting the digit 0 and the borrow 0 from 8 in column 4 and get 8.
8 is the next digit of our result.

Step 5: We'll start by subtracting the digit 1 and the borrow 0 from 8 in column 5 and get 7.
7 is the next digit of our result.

So, 88537 - 10501 = 78036.