Let's dive into this subtraction. We'll start with 250435 and subtract 9459 from it.

Step 1: We'll start by subtracting the digit 9 and the borrow 0 from 5 in column 1 and get -4.
We add -4 to 10 and get 6 as the first digit of the result.

Step 2: We'll start by subtracting the digit 5 and the borrow 1 from 3 in column 2 and get -3.
We add -3 to 10 and get 7 as the next digit of the result.

Step 3: We'll start by subtracting the digit 4 and the borrow 1 from 4 in column 3 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 4: We'll start by subtracting the digit 9 and the borrow 1 from 0 in column 4 and get -10.
We add -10 to 10 and get 0 as the next digit of the result.

Step 5: We'll start by subtracting the digit 0 and the borrow 1 from 5 in column 5 and get 4.
4 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 2 in column 6 and get 2.
2 is the next digit of our result.

So, 250435 - 9459 = 240976.