No problem, let's work through this together. We're starting with 643046 and are subtracting 38652 from it.

Step 1: We'll start by subtracting the digit 2 and the borrow 0 from 6 in column 1 and get 4.
4 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 4 in column 2 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 3: We'll start by subtracting the digit 6 and the borrow 1 from 0 in column 3 and get -7.
We add -7 to 10 and get 3 as the next digit of the result.

Step 4: We'll start by subtracting the digit 8 and the borrow 1 from 3 in column 4 and get -6.
We add -6 to 10 and get 4 as the next digit of the result.

Step 5: We'll start by subtracting the digit 3 and the borrow 1 from 4 in column 5 and get 0.
0 is the next digit of our result.

Step 6: We'll start by subtracting the digit 0 and the borrow 0 from 6 in column 6 and get 6.
6 is the next digit of our result.

So, 643046 - 38652 = 604394.