Okay, let's tackle this math problem. We're starting with 78288 and subtracting 25449.

Step 1: We'll start by subtracting the digit 9 and the borrow 0 from 8 in column 1 and get -1.
We add -1 to 10 and get 9 as the first digit of the result.

Step 2: We'll start by subtracting the digit 4 and the borrow 1 from 8 in column 2 and get 3.
3 is the next digit of our result.

Step 3: We'll start by subtracting the digit 4 and the borrow 0 from 2 in column 3 and get -2.
We add -2 to 10 and get 8 as the next digit of the result.

Step 4: We'll start by subtracting the digit 5 and the borrow 1 from 8 in column 4 and get 2.
2 is the next digit of our result.

Step 5: We'll start by subtracting the digit 2 and the borrow 0 from 7 in column 5 and get 5.
5 is the next digit of our result.

So, 78288 - 25449 = 52839.