Let's dive into this subtraction. We'll start with 361044 and subtract 66450 from it.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 4 in column 1 and get 4.
4 is the first digit of our result.

Step 2: We'll start by subtracting the digit 5 and the borrow 0 from 4 in column 2 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 3: We'll start by subtracting the digit 4 and the borrow 1 from 0 in column 3 and get -5.
We add -5 to 10 and get 5 as the next digit of the result.

Step 4: We'll start by subtracting the digit 6 and the borrow 1 from 1 in column 4 and get -6.
We add -6 to 10 and get 4 as the next digit of the result.

Step 5: We'll start by subtracting the digit 6 and the borrow 1 from 6 in column 5 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 6: We'll start by subtracting the digit 0 and the borrow 1 from 3 in column 6 and get 2.
2 is the next digit of our result.

So, 361044 - 66450 = 294594.