Sure thing! We've got 65840 and 11221, and we're going to subtract the second number from the first.

Step 1: We'll start by subtracting the digit 1 and the borrow 0 from 0 in column 1 and get -1.
We add -1 to 10 and get 9 as the first digit of the result.

Step 2: We'll start by subtracting the digit 2 and the borrow 1 from 4 in column 2 and get 1.
1 is the next digit of our result.

Step 3: We'll start by subtracting the digit 2 and the borrow 0 from 8 in column 3 and get 6.
6 is the next digit of our result.

Step 4: We'll start by subtracting the digit 1 and the borrow 0 from 5 in column 4 and get 4.
4 is the next digit of our result.

Step 5: We'll start by subtracting the digit 1 and the borrow 0 from 6 in column 5 and get 5.
5 is the next digit of our result.

So, 65840 - 11221 = 54619.