Let's break this down. We're going to add 4221 and 8543 together.

Step 1: We'll start by adding the digits 1 & 3 in column 1 and get 4.

Step 2: We'll start by adding the digits 2 & 4 in column 2 and get 6.

Step 3: We'll start by adding the digits 2 & 5 in column 3 and get 7.

Step 4: We'll start by adding the digits 4 & 8 in column 4 and get 12.
We'll write down the last digit 2 and carry the 1 to the next column.

So, 4221 + 8543 = 12764.

