We are presented with 643 and 5490. Let's work out the sum.

Step 1: We'll start by adding the digits 3 & 0 in column 1 and get 3.

Step 2: We'll start by adding the digits 4 & 9 in column 2 and get 13.
We'll write down the last digit 3 and carry the 1 to the next column.

Step 3: We'll start by adding the digits 6 & 4 in column 3 and get 11.
We'll write down the last digit 1 and carry the 1 to the next column.

Step 4: We'll start by adding the digits 0 & 5 in column 4 and get 6.

So, 643 + 5490 = 6133.

