<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Multiple myeloma most common part involved is-
Options:
A. Bone marrow
B. Cortex of bone
C. Metaphyses
D. Epiphyses
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is A: Bone marrow. Explanation: Ans. is 'a' i.e., Bone marrow Multiple mveiomao Multiple myeloma is a plasma cell neoplasm characterized by involvement of the skeleton at multiple sites,o Plasma cells proliferate abnormally and the proliferated plasma cells infiltrate various organs, particularly bone marrow, but can also spread to lymph nodes and extranodal sites like skin,o The proliferation and survival of myeloma cells are dependent on several cytokines, IL-h Is particularly important.o The neoplastic plasma cells secrete abnormally large amounts of immunoglobulin.o The immunoglobulin secreted by neoplastic plasma cells are quiet different form the immunoglobulin normally present in the blood.o The normal immunoglobulin consists of two heavy and two lights chains molecules and the production of both chain is tightly balanced.o The immunoglobulin secreted in this condition may be : -Isolated light chain or heasy chain.May be an intact antibody molecule of any heavy chain subclass.May be an altered antibody or fragment.<|im_end|>
