<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Pyrogens act on which site of brain ?
Options:
A. Basal ganglia
B. Limbic system
C. Thalamus
D. Hypothalamus
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is D: Hypothalamus. Explanation: Ans. is 'd' i.e., Hypothalamus PyrogenesPyrogenes are substances that cause fever.Pyrogens may be exogenous or endogenousExogenous - Bacterial toxinsEndogenous - IL-1, TNF-a, IL-6, Interferons, Ciliory's neurotropic factorThese pyrogenes increase the level of PGE, in the hypothalamus that elevates the thermoregulatory set point and causes fever.<|im_end|>
