<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: The difference between leukemia and leukemoid reaction is done by -
Options:
A. Leukocyte alkaline phosphatase
B. Immature cells
C. Total leukocyte count
D. E.S.R.
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is A: Leukocyte alkaline phosphatase. Explanation: Leukemoid reaction is defined as a reactive excessive leukocytosis in peripheral blood resembling that of leukemia in a subject who doesnot have leukemia. Leucocyte alkaline phosphatase (LAP) score in the cytoplasm of mature neutrophils is high in leukaemoid reaction whereas reduced in CML .It is very useful to distinguish between the two. Reference; Harsh Mohan textbook of pathology, 7th edition.Pg no.332<|im_end|>
