<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Cholangiocarcinoma ?
Options:
A. Obesity
B. Opistorchissinensis infection
C. Salmonella carrier state
D. HBV infection
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is B: Opistorchissinensis infection. Explanation: Ans. is 'b' i.e., Opistorchissinensis infectionCholangiocarcinomaCholangiocarcinoma is malignancy of the biliary tree, arising from bile ducts within or outside the liver.Risk factors : -Primary sclerosing cholangitisCongenital fibropolycystic disease of the biliary system (caroli disease, choledochal cyst).Exposure to thorotrast.Opisthorchis sinensis infection.PathologyCholangiocarcinoma are adenocarcinoma arising from bile ducts epithelium.Most are well to moderately differentiated.Markdly desmoplastic, with dens collegenous stroma separating the glandular elements.Cells are not bile stained, because bile is synthesized by hepatocytes and not by bile duct epithelium.<|im_end|>
