<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Premalignant bone lesion among the following is -
Options:
A. Pagets disease
B. Osteoid osteoma
C. Osteochondroma
D. Enchondroma
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is A: Pagets disease. Explanation: Ans. is 'a' i.e., Pagets disease Paget's disease o Paget s disease is characterized by increased bone turnover and enlargement and thickening of the bone the internal architecture is abnormal and the bone is usually brittle, o Primary defect is in osteolastic. o It is marked by regions of furious osteolastic bone resorption which is followed by a period of hectis bone formation. The net effect is gain in bone mass. o It has the following three stages Initial osteocytic stage Mixed osteoclast osteoblastic stage Burned out quiescent osteosclerotic stage o Following complications can occur in Paget's Increased risk of development of sarcomas (osteosarcoma chondrosarcoma) Fractures in weight bearing bones Osteoarthritis High output cardiac failure Cranial nerve compression Otoscleosis<|im_end|>
