<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: A 24 yr-old female has flaccid bullae over the skin and oral erosions. Histopathology shows intraepidermal blister with acantholytic cells. Diagnosis is:
Options:
A. Pemphigoid
B. Erythema multiforme
C. Pemphigus vulgaris
D. Dermatitis herpetiformis
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is C: Pemphigus vulgaris. Explanation: The features of intaepidermal acantholytic blisters coupled with flacid bullae over skin and oral erosions points towards P. vulgaris. The other 3 diseases do now show intraepidermal blistering. They are devoid of mucosal involement. Erythema Multiforme: Target lesion seen on distal extremeties. If mucosa involved it is called as Epidermal Multiforme Major Dermatitis herpetiformis: Extremely pruritic vesicopapules over extensors Pemphigoid: Tense bullae<|im_end|>
