<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Most common cause of death in primary amyloidosis is?
Options:
A. Respiratory failure
B. Cardiac failure
C. Renal failure
D. Septicemia
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is B: Cardiac failure. Explanation: ANSWER: (B) Cardiac failureREF: Harrison's Internal Medicine 17th edition chapter 324. AmyloidosisThe kidneys are the most frequently affected organ (80%), Renal amyloidosis is usually manifested by proteinuria, which is often in the nephrotic range and associated with significant hypoalbuminemia and edema or anasarca; rarely, tubular rather than glomerular deposition of amyloid can produce azotemia without significant proteinuria. Cardiac symptoms are the second most common presentation (40%), but cardiac dysfunction is associated with death in 75% of patients.<|im_end|>
