<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Causes of diffuse hyperpigmentation include all of the following except?
Options:
A. Busulfan administration
B. Nelsons syndrome
C. Addison disease
D. Hermansky-Pudlak Syndrome
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is D: Hermansky-Pudlak Syndrome. Explanation: Busulfan administration Busulfan, cyclophosphamide, 5-fluorouracil, and inorganic arsenic induce pigment production and cause diffuse hyperpigmentation Nelson's syndrome Increased ACTH (Which has paial MSH activity) due to bilateral adrenalectomy Addison's disease Increased ACTH (Which has paial MSH activity) due to destruction of adrenal coex and low coisol Hermanksy- Pudlak syndrome Autosomal recessive disorder which results in oculo-cutaneous albinism (decreased pigmentation), and bleeding problems due to a platelet abnormality (platelet storage pool defect)<|im_end|>
