<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Sulfasalazine exes its primary action in ulcerative colitis by :
Options:
A. Folic acid synthesis
B. Formation of prostaglandins (PG)
C. Inhibition of NF-KB Activation
D. Formation of interleukins
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is C: Inhibition of NF-KB Activation. Explanation: MOA* Inhibition of NF-KB Activation* Inhibition of PG synthesis* Scavenging of Free radicals 5-ASA compounds exe its local anti-inflammatory effect by inhibiting leukotriene production (PG synthesis) by inhibition of 5-lipooxygenase activity; also inhibits the production of IL-1 and TNF. Commonly Used 5-ASA Formulations in IBD Sulfasalazine Oral mesalamine agents Azo compounds: Balsalazide, Olsalazine<|im_end|>
