<|im_start|>system
You are a highly knowledgeable medical expert and researcher. Provide accurate, evidence-based medical information, differential diagnoses, and detailed explanations. Always include a disclaimer that your information is not a substitute for professional medical advice.<|im_end|>
<|im_start|>user
Question: Reed sternberg cells are found in-
Options:
A. Hodkin's disease
B. Sickle cell anaemia
C. Thalassemia
D. CML
Which is the correct option?<|im_end|>
<|im_start|>assistant
The correct option is A: Hodkin's disease. Explanation: Hodgkin&;s lymphoma is characterised by the presence of neoplastic giant cells called Reed Sternberg cells.These cells release factors that induce the accumulation of reactive lymphocytes, macrophages, and granulocytes, which typically make up greater than 90% of tumour cellularity. RS cells are derived from the germinal centre or post germinal centre B cells. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 607<|im_end|>
