B Relative UPP1 mRNA expression levels in HCT116 cells treated as indicated (NEN (N) 1.2 µM, Domperidone (Domp, D) 30 µM, Imipramine (Imi), Desipramine (Desi), Amitriptyline (Ami) each 30 µM, Clomipramine (Clomi) 20 µM), determined by qPCR. Data information: data (N=3) are presented as mean (SD) and were analyzed by one-way ANOVA with Tukey post-hoc test In (B), right panel, significance is indicated for the comparison of combinatorial treatments (NEN+TCAs) to controls. ** p< 0.01;*** p< 0.001; **** p < 0.0001. 