A) Capture-C from hypoxicMCF-7 cells (top) and ChIP-seq tracks for subunits of HIF, H3K4me1, H3K27ac, CTCF and RNAseq in normoxic and hypoxicMCF-7 cells as indicated at the ARRDC3 (arrestin domain containing 3) and LUCAT1 (lung cancer associated transcript 1 - non-protein coding) gene loci. RNA-seq tracks are shown in both low-scale and high-scale to represent regulation of transcripts with differing transcript levels. Capture-C was performed using oligonucleotides to a 'viewpoint' region at the HIF-binding site (highlighted in red). Interaction with the TSS of both LUCAT1 and ARRDC3 is highlighted in blue. Association with regions including additional enhancers, are highlighted in green.B) Regions associated with HIF-binding sites were classified according to the presence of a UCSC annotated TSS, or coincidence with H3K4me1 or H3K4me3 ChIP-seq signal. The bar chart shows the average number of each type of site that interacted per HIF-binding site.C) Histogram showing the frequency distribution of elements interacting with HIF-binding sites according to absolute distance from the 'viewpoint' site on the horizontal axis. 