 Figure 2 - Simulation of primary response gene dynamics upon different signalling durations. A: Different activation patterns of signalling molecules (input functions, left) can elicit multiple different response profiles (right) with different response times (r) depending on mRNA half-lives (t1/2) and transcriptional delays (∆t). Rapid induction requires short half-lives (red lines). Late induction can be caused by transcriptional delays (blue lines), long half-lives (yellow lines), or combinations thereof. Decoding of signal duration depends on mRNA half-life. Short-lived mRNAs relay signal duration to response duration, whereas long-lived mRNAs decode signal duration to response amplitude (yellow lines). 