Jarid2 is present as a full-length protein in multi-potent and undifferentiated cells. Full-length JARID2 with the help of N-terminal PRC2 interacting domain can recruit PRC2 and suppress differentiation genes. Upon differentiation N-terminal of JARID2 is cleaved (ΔN-JARID2) which leads to reduction in PRC2 recruitment and possibly H3K27me3 levels at differentiation genes. However, PRC2 removal is not sufficient for activation of differentiation genes and, in addition, ΔN-JARID2 is required for their up-regulation likely through, directly or indirectly, facilitating transcription factors such as AP-1. 