 Figure 7. Model for the regulation of Notch target genes by L3MBTL3. A NOTCH ICD binds to RBPJ-bound Notch-responsive elements where it builds up a coactivator complex composed of Mastermind-like 1 (MAML1) and additional co-activators to induce expression of Notch target genes. B In the absence of Notch signaling, L3MBTL3 interacts with RBPJ at Notch-responsive elements where it recruits KDM1A to repress Notch target genes. C Loss-of-function of L3MBTL3 leads to de-repression of Notch target genes. 