A Relative ATF4 and CHOP mRNA expression levels in HCT116 cells upon the indicated treatments determined by qPCR (NEN (N) 1.2 µM; Domperidone (Domp, D), Imipramine (Imi), Desipramine (Desi) and Amitriptyline (Ami), each 30 µM; Clomipramine (Clomi) 20 µM). Data information: Data are presented as mean (SD) and were analyzed by one-way ANOVA with Tukey post-hoc test (A, upper left and lower left graphs, (N=3), (D (N=3)), Kruskal-Wallis with Dunn´s post-hoc tests (A, upper right and lower right graphs, (N=5, besides NEN+Clomi (N=4) and NEN+Desi (N=4)) In (A), right graphs, significance is indicated for the comparison of combinatorial treatments (NEN+TCAs) to controls. * p< 0.05; ** p< 0.01;*** p< 0.001; **** p < 0.0001. 