B-The relative level of Atg5 RNA in the brain of Canton S male flies, held in LD 12:12 or in DD and in per01 mutants in LD 12:12 (mean RQ +/- SE). The Atg5 RNA cycles in the brains of Canton S in LD 12:12, reaching the highest level 4 h after the beginning of the day (ZT4) and 4 h before the end of the night (ZT20) [Kruskal-Wallis test: H (5, N = 35) = 23,34957 p =, 0003, post hoc multiple comparison test: * < 0.05]. 