A) Schematic depicting wild type NBs (left panel) which express Mira (red), undergoing asymmetric division to generate a GMC, which divides only once to give rise to two postmitotic neurons. The cell fate determinant Pros (blue) is inherited by the GMC, where it translocates to the nucleus to promote differentiation. Postmitotic neurons express Pros (blue) and Nerfin-1 (green). Upon the loss of Nerfin-1 (nerfin-1-, middle panel), neurons undergo step-wise reversion, by increasing cellular growth, and switching on stem cell genes while maintaining the expression of neuronal specific markers such as Pros, before their complete reversion to NBs, giving rise to clones consisting a mixture of NBs and neurons. In pros- clones, GMCs fail to differentiate, and revert to NBs, giving rise to clones consisting mostly of Mira+ NBs. Schematic depicting type II wild type NB lineages (left) and dedifferentiation of INP to NBs upon Notch over-activation, which gives rise to clones consisting of mostly NBs (right). 