4'-phosphorylated phosphoinositides (4'-PIPs) generated by PfPI4K interact with the PH domain of PfCDPK7 (Kumar et al., 2014) and regulate the localization and thereby the function of PfCDPK7 (Fig. 5A), which in turn promotes the synthesis of phosphatidylcholine (PC) (Fig. 2A,D) by regulating enzymes (indicated in red) like ethanolamine kinase (PfEK) and phosphoethanolaminemethyltransferase (PfPMT) (Fig. 3,4) that are involved in PL metabolism (Fig. 2C). In addition, phosphoproteomics suggest that PfCDPK7 may contribute to vesicular trafficking via effectors (indicated in green) like PfRab11b but this pathway needs further investigation (Fig. 1A,C). Collectively, these events regulate intraerythrocytic development of the parasite. 