Principal component analysis (PCA) of brain samples based on proteome profiles obtained by Data Independent Acquisition (DIA) quantification treated with Bortezomib or vehicle control (DMSO). n=10 per sample group. The smaller dots represent individual samples and the larger dots the centroids of each age-matched group. Ellipses represent 95% confidence intervals. The percentage of variance explained by the first two PC axes is reported in the axis titles. 