B, KRAS-mutant (n=17) and wild-type (n=14) cancer cell lines treated for 72h with AZD4547 (5 µM) and BI2536 (5 nM), alone or in combination. with the combination index (CI) of AZD4547/BI2536 across the cell lines with different driver mutations shown in (B). CI < 0.8 indicates strong synergistic effect. 