The 2 mature miRNAs generated from this cluster, miR-143-3p and miR-145-5p collaborate to mediate phenotypic transition towards a drug resistant undifferentiated mesenchymal-like state by targeting Fascin actin-bundling protein 1 (FSCN1), increasing focal adhesion signaling (FAs), cytoskeleton remodeling, YAP/MRTFA mechanotransduction pathways activation and ECM production. This mechanism leading to an undifferentiated fibrotic-like drug resistant phenotype can be targeted by the anti-fibrotic dru nintedanib. 