A Representation of METTL5's role in 18S rRNA. Large ribosomal subunit (LSU) and small ribosomal subunit (SSU) of the ribosome are shown in light pink and antique pink, respectively (left). The secondary structure of 18S rRNA in the SSU (middle) was adapted from (http://apollo.chemistry.gatech.edu/RibosomeGallery/).METTL5 (shown in brown) catalyzes A1832 methylation on 18S rRNA in the SSU of the ribosome. 