(B) Schematics of the cst-1 and cst-2 gene models and DNA sequences of the cst-1 and/or cst-2 mutants that were generated via CRISPR-Cas9. Purple bar, Serine/Threonine kinase domain; blue bar, SARAH (Salvador-Rassf-Hippo homolog) domain. Arrow, sgRNA target site; green, target sequence; red, PAM sequence; blue, inserted nucleotide; dashed lines, deleted nucleotides. 