D. Traces showing average changes (mean) in intracellular Ca2+ (Fura2 ratio) over time in response to perfusion of TG as indicated in the upper bar in SH-SY5Y S1-/- cells transfected with STIM1,STIMA or STIM1A_D503A IRES mCherry and measured with and without incubation with 1 µM PF-04957325 (n=82-134). 