Picornavirus RNA has an internal ribosome entry site (IRES) in the 5′ untranslated region and a 3′ poly(A) tail. Viral protease (2A or leader) digests eIF-4G. The truncated eIF-4G shows higher efficiency in the IRES-driven translation than the cap-dependent translation (Ohlmann et al, 1995; Ali et al, 2001). 