(A) A cartoon and corresponding immunofluorescence image depicting the Drosophila germarium. Terminal filament cells (TFC) and cap cells (CapC) create a niche for female germline stem cells (GSC), which divide asymmetrically to self-renew and produce a cystoblast (CB). The CB undergoes four mitotic divisions to create differentiating cystocytes (CC). The germline (gray) is supported by somatic (green) escort cells (EC) and follicle stem cells (FSC) that produce follicle cells that surround developing egg chambers. The spectrosome (Spec, red) is a specialized organelle in the early-stage germline, such as GSCs and CBs. The spectrosome structure is round while fusome is branched, which branches over the mitotic divisions in further differentiated germ cells, connecting the CCs within a cyst. 