Repsox (1 μM) was used on day 2-7 to inhibit early EMT during reprogramming with 5C medium. TGFβ (TGFβ1/2/3, 1ng/ml each) on day 2-7, LSD1i (SP2509, 10 nM), and sequential introduction of Yamanaka factors (OK+M+S) were used to induce early EMT during reprogramming with mES medium (D). 