(A) FBW7 mutations across medulloblastoma molecular subgroup as identified by exome sequencing. In the SHH medulloblastoma subgroup, FBW7 mutations occurred approximately 11 % in a cohort containing 133 SHH medcases (Kool et al., 2014) and can be categorized as stop-gain (n=3), non-synonymous (n=7). One case of splicing error mutation is detected in the Group 3 medulloblastoma. 