A) Boxplots showing all-atom analysis of GK energetic contributions to a set of native folds from the E. coli cytoplasmic proteome. The upper whiskers indicate the largest value no further than 1.5 times the Inter-Quartile Range (IQR) from the upper hinge, the lower whiskers show the smallest value at least 1.5 * IQR from the lower hinge. Notches extend 1.58 * IQR / sqrt(n) from either side of the median and represent a 95% confidence interval for the median value. Grey shaded area indicates total energy associated with the placement of GKs in the native fold, the remainder of the plot shows the breakdown of this total energy into constituent energy terms. The number of observations per GK is indicated above the boxes depicting the distribution of the total energy for each of the GKs. 