(B) SCAP-GFP stability in parental and PKM2 KO MDA-MB-231 cells (n=5). Cells stably expressing SCAP-GFP were treated with cycloheximide (CHX). GFP signal was measured at the indicated time. Data information: Data are displayed as means ± SD. Statistical significance was assessed using two-tailed Student's t-test, ∗p < 0.05, ∗∗p < 0.01 and ∗∗∗p < 0.001. 