I-K p53+/+ and p53-/- HCT116 cells transfected with control or SQLE siRNA for 48 hours were injected into nude mice separately. (I) Tumor volume were recorded after inoculation (top). Western blot was performed using lysates of xenograft tumors (bottom). (J) Average tumor weights (top) and images (bottom) of xenograft tumors (3weeks, means ± SD, n=7) are shown. (K) Cholesterol concentrations of xenograft tumors were examined. 