A) Capture-C tracks (averaged across the two replicates) from normoxic (red) and hypoxic (inverted in blue) MCF-7 cells are shown for each HIF-binding site captured.B) The interaction frequency (normalized to the number of informative reads in each dataset and to the expected distribution of counts at a given distance from the capture site) in hypoxia (vertical axis) was plotted against that in normoxia (horizontal axis) for each site that interacted significantly with a HIF-binding site in either normoxia or hypoxia or both. Highlighted in red are sites that had a significantly different interaction frequency in either condition.C) CTCFChIP-seq peaks immediately flanking the captured HIF-binding sites were identified and the average normalized CTCFChIP-seq signal (RPKM) was plotted for normoxic (red) and hypoxic (blue) MCF-7 cells. 