A. Schematic of phospho-dependent interaction of the estrogen receptor ERα with 14‑3‑3β. Phosphorylation of ERα promotes its interaction with 14‑3‑3 proteins. This interaction removes ERα from the E2-stimulated ERα dimerization and consequently inhibits ERα-DNA interactions and gene expression. A protein kinase that can modulate the binding of ERα to 14‑3‑3 proteins is unknown. 