B. Schematics depicting the rationale for designing a BRCT-Sgs1 chimera. The BRCT3/4-Sgs1 fusion protein is expected to engage at DNA lesions via the 9-1-1 clamp. For simplicity, the ssDNA-binding heterotrimer RPA and the obligatory Mec1 cofactor Ddc2 have been omitted from the diagram. 