7] (C) Venn-diagram shows 2622 SOX9 bound sites in GPCs, which are not co-targeted by SOX3, and their overlap with SOX10 bound sites in mature oligodendrocytes. Bar graph shows that mostly oligodendrocyte-specific genes are sequentially bound by SOX9 in GPCs and by SOX10 in oligodendrocytes. However, SOX9 and SOX10 also bind genes that are selectively expressed in astrocytes. (D) ChIP-seq peak graphics around the oligodendrocyte gene Plekhb1. ChIP-seq peaks are derived from four different experiments; SOX3 ChIP-seq in NPCs, SOX3 ChIP-seq in GPCs, SOX9 ChIP-seq in GPCs and SOX10 ChIP-seq in oligodendrocytes. Both ChIP-seq reads and called peak regions (underlying black lines) are shown for all data sets except for SOX10, for which only called peak regions are shown (black line). Triangle in the SOX10 data set indicate called peak. SOX10 ChIP raw reads could not be transferred from rn5 to mm9 assembly and therefore only SOX10 peak regions are shown in the figure. Scale bar: 5kb 