E. Dot plot of top lineage-specific expression changes upon HAstV1 infection for mock, 4hpi and 16hpi organoids. F. Same as in E but for ISG. The dot size represents the percentage of cells expressing the gene; the color represents the average expression across the lineage. Triangle and stars represent significantly changing genes (FDR < 0.05) in mock-infected samples vs. 4 hpi as well as and mock-infected samples vs 16 hpi, respectively. G 