B. Superposition of the yeast Aar2 (orange, PDB entry 3SBT; (Weber et al, 2011)) 3D structure and a homology model of human AAR2 derived from HHpred (marine), based on the yeast Aar2p structure (Santos et al, 2015). The inset on the right shows a close-up view of the C-terminal domain, where serines 253 (yeast) and 284 (human) are displayed as sticks. Residues 154-170 and 318-356 of yeast Aar2 as well as residues 1-18, 170-201 and 359-384 of human AAR2 are not shown for clarity. 