B-E. After 5 days of treatment TEWL was measured on the back skin (B), epidermal thickness was analyzed on H&E stained sections (C), epidermal Ki-67+ cells (D) and the ratio of Ratio of K5 to K10 positive areas (E) were analyzed by immunofluorescence as described in Fig EV3 (B,C). (n = 4-15; 5 independent experiments). Data information: Data are shown as mean ± SEM. P‐values were calculated by one-way ANOVA with Tukey Statistical significance: ns > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, **** P < 0.0001. See Appendix Table S3 for exact P‐values. 