D Ratio of toxicity and viability of U87 spheroids (3D) treated as indicated (NEN 1.2 µM, Domperidone (Domp), Imipramine (Imi), Amitriptyline (Ami), Desipramine (Desi), each 30 µM, Clomipramine (Clomi 20 µM, Cyclodextrin (CD) 0.75%). Data information: , data are presented as mean (SD) (N=3) and were analyzed by a one-way ANOVA with Tukey post-hoc test or a two-way ANOVA with Tukey post-hoc test * p< 0.05; ** p< 0.01;*** p< 0.001; **** p < 0.0001. 