D.- E. Network representation of enriched Gene Ontology (GO) Biological Process (BP) terms of top 50 genes most strongly negatively correlated with STAT3 (GS ≤ - 0.6, adj. p-value ≤ 0.01) in cluster 2 (D, blue) and cluster 3 (E, pink) (MM ≥ 0.8, adj. p-value ≤ 0.01). Node size indicates the percentage of associated genes. Similar colors indicate terms of the same GO group. GS = Gene significance, MM = module membership. 