J Working model. The molecular mechanisms of m6A-dependent sorafenib-resistance in liver cancer. The expression of METTL3 was down-regulated in sorafenib-resistant liver cancer, and caused decrease of FOXO3 by the m6A modification in an YTHDF1-dependent manner. Degradation of FOXO3 thus promoted autophagy-associated sorafenib-resistance in liver cancer. 