Correlation of the Maximum-likelihood tree with genetic and phenotypic classification/clustering. Maximum-likelihood tree was constructed using genome-wide SNPs of 1634 S. suis isolates. Tip nodes are colored based on the host source (human in red; diseased pig in yellow; healthy pig in green). From inside to outside: the first ring represents BAPS clustering; the second ring represents the country source. Human-associated Clade (HAC) are colored in red, with Diseased-pig Clade (DPC) in yellow and Healthy-pig Clade (HPC) in green. Phylogenetic relationship is consistent with BAPS clustering and correlates with host source. Most isolates in BAPS2, BAPS5, BAPS6 were obtained from healthy pigs. The majority of isolates in BAPS7 and BAPS8 were obtained from patients and diseased pigs, respectively. 