D. Protein-protein interaction network of putative CDKL5 substrates from Table EV1. Confidence levels are based on the STRING database v11.0 combined score with following bins: 150-400: low confidence (blue), 400-700: medium confidence (gold), 700-900: high confidence (not encountered in this dataset), >900: very high confidence (black). P-value was calculated as 0.00068. 