Average growth rate per day (k) of ecto-Ronin (Ronin del/del TET-ON Ronin-FLAG) ESC cultured continuously in the presence of Dox (+ Dox); without Dox for 5 passages (-Dox) or grown without Dox for 3 passages and then switched to Dox-containing medium for another 2 passages (-Dox -> +Dox). Ordinary one-way Anova, error bars represent median with interquartile range, technical replicates (+ Dox, n = 13), (- Dox n = 13), (-Dox -> +Dox, n = 7) of three independent experiments. 