hnRNPA2 interacts with transport granule components hnRNPF and ch-TOG in the phase separated state. Disease mutations (X) D290V and P298L induce aggregation of hnRNPA2 in vitro, while D290V induces tdp-1-dependent neurodegeneration in a C. elegans model. hnRNPA2 LC tyrosine phosphorylation alters hnRNPA2 LC LLPS in vitro, prevents interaction with hnRNPF and ch-TOG, reduces aggregation in vitro, and expression of an activated tyrosine kinase reduces D290V-associated neurodegeneration in the C. elegans model. 