Visualization of age-related changes of proteins and transcripts projected on the 80S ribosome complex structure. Ribosomal RNAs are depicted in ribbon form: 28S rRNA, 5S rRNA, 5.8S rRNA of large subunit are depicted in light gray and 18S rRNA of small subunit is depicted in black. Ribosomal proteins are depicted as molecular surfaces and shown only if significant changes in the level of corresponding mRNA or protein were detected. Affected proteins of large and small subunits are visualized in 2 different shades of red (up regulated), or blue (down regulated). For clarity, down regulated components are displayed as transparent molecular surfaces. Visualization was performed with USCF Chimera program (version 1.12), according to Protein Data Bank archive - human 80S ribosome 3D model: 4UG0. 