Small-molecule kinase inhibitor screen. Data are shown as an XY plot of normalized mean staining intensity of AlexaFluor555-HcT versus α-p75NTR. The α-p75NTR was detected using an AlexaFluor 647-conjugated donkey anti-rabbit secondary antibody [12]. Compounds that increased the accumulation of HcT or α-p75NTR by at least three standard deviations (yellow box) were classified as active compounds (A1-light blue, C3-purple, E4-dark blue). The negative control (EHNA) is shown in red (≥ 25 cell bodies were imaged per condition, N= 3 independent experiments). 