F, Growth curve of a KRAS-mutant patient-derived xenograft (BE564T) treated with vehicle, AZD4547 (10 mg/kg/per day), BI6727 (5 mg/kg/per day), alone or in combination. *P<0.05 by one-way ANOVA with Tukey's multiple comparisons test. Data are the mean of tumor volume of each group (5 mice/group); error bar: SD 