Layers of epidermis (left) and Trans-epidermal water loss (TEWL) (right) were analyzed in the back skin of indicated mice. (Left: n = 8-14, right: n = 6-14; ≥ 2independent experiments). Data information: Data are shown as mean ± SEM. P‐values were calculated by one-way ANOVA with Tukey Statistical significance: ns > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, **** P < 0.0001. See Appendix Table S3 for exact P‐values. 