(K) Volcano plot showing protein changes induced by TMEM33 OE (p value <0.05) and PKM2 KO (p value <0.05) in MDA-MB-231 cells. TMEM33 labeled in red dot was upregulated in both TMEM33 OE and PKM2 KO cells and PKM2 labeled in purple had no change in TMEM33 OE cells. ANOVA was used to calculate the p-value. 