D. Cartoon illustration of the modes of WT or NN binding to MT lattice, based on cryo-EM results. WT decorates the GTP/GDP.Pi lattice predominantly via CDC ('C') or via both DC domains ('N-C') and the GDP lattice predominantly via NDC ('N') or via both DC domains ('N-C'). NN can decorate the GDP lattice via its N-terminal NDC ('N'), C-terminal NDC ('C') or both ('N-C'). Modes 'N' and 'C' are compatible with MT cross-linking (bundling) by NN. 