E Percentage of apoptotic cells, determined by measuring Annexin-V and PI positive HCT116 or U87 cells by FACS. The effects were assessed after a 24h or 48h treatment respectively (NEN (N) 1.2 µM; Domperidone (Domp, D) 30 µM, zVAD-FMK (zVAD) 100 µM, Staurosporine 100 µM. Cells were pre-treated for 1h with the zVAD-FMK inhibitor prior to adding the drugs. Data information: Data are presented as mean (SD) (N=3) and were analyzed by one-way ANOVA with Tukey post-hoc test (for (E, upper graph) HCT116 cells) or by Kruskal-Wallis with Dunn´s post-hoc tests (for (E, lower graph) U87 cells). Significance is indicated for multiple comparisons as indicated. * p< 0.05; ** p< 0.01;*** p< 0.001; **** p < 0.0001. 