E, Apoptotic assay of BEAS-2B and BEAS-2B-KRAS cells treated with vehicle (DMSO), AZD4547 (2.5 µM) and BI2536 (5 nM), alone or in combination for 72h. Data are presented as mean ± SD (n=3). *p<0.05 and ***P<0.001 by two-way ANOVA with Tukey's multiple comparisons test. 