A schematic diagram showing functional domains of JARID2: UIM, ubiquitin interaction motif; transcription repressive domain consisting of sub-domains 1-3; JmjN, JumonjiN; ARID, AT-rich DNA binding domain; GSGFP which is a SUZ12 binding domain; JmjC, JumonjiC; and ZF, zinc finger domain. Domains 1-3 constitute PRC2 associated domains. Domain 1 is required for PRC2 stimulation, domain 2 is needed for binding to EZH2 and domain 3 is needed for nucleosomal binding. The RNA binding domain has been indicated with dashed box. 