B) Burial analysis on a set of E. coli structures of cytoplasmic, monomeric proteins. Violin- and boxplots indicate distribution of the degree of mainchain burial for each of the charged amino acids, grouped by their usage as GK. The upper whiskers indicate the largest value no further than 1.5 times the Inter-Quartile Range (IQR) from the upper hinge, the lower whiskers show the smallest value at least 1.5 * IQR from the lower hinge. Notches extend 1.58 * IQR / sqrt(n) from either side of the median and represent a 95% confidence interval for the median value. Statistical differences between charged residues flanking APRs versus charged residues elsewhere in the protein were determined through Wilcoxon test. P-values are indicated. 