F. Docked pose of TP-16 with critical residues in the putative binding pocket of human EP4 protein. EP4 is shown as a color cartoon, the residues important for the interaction are depicted in magenta sticks, and TP-16 is shown as a cyan stick figure. G. The LIGPLOT diagram summarizes key interactions between TP-16 (purple lines) and residues that originate from EP4. T69, T76, T168 and R316 establishes hydrogen bonds with TP-16. Semicircles with radiating lines indicate non-polar interactions. 