The graph shows that the ratio between Xpb1(spliced) / Xpb1(unspliced) is lower (i.e., lower levels of UPR) in LSK which have Cct-3 down-regulated compared to controls only when cultured under low glucose conditions. Error bars are s.d. from the mean. P < 0.001 (three asterisks) and n.s. indicates not significant using two-tailed Student's test with equal sample variance. n = 3 mice. 