A. Comparative phosphoproteomic and proteomic analyses were performed on late ring / early trophozoite stage wild type (3D7) or PfCDPK7-KO parasites. The phosphorylation fold-change ratio of identified phosphopeptides was normalized to total protein abundance fold-change. The fold-change ratios for all phosphopeptides from various replicates are provided The S-curve for the normalized data is provided for some of the significantly altered hyper-(blue) and hypo-(red) phosphorylated sites belonging to key proteins are indicated. Phosphorylation sites of key enzymes involved in PL biosynthesis that exhibited reduced phosphorylation in PfCDPK7-KO parasites are indicated in green. 