(a) Vps34 overall structure with its helical domain (blue, residues 286-532) and catalytic domain (green, residues 533-873). Regions are colored as follows: gatekeeper (red), P-loop (cyan), hinge (blue), DFG (orange), activation loop (magenta) and catalytic loop (gray). (b) Surface representation of the ATP binding site of Vps34, showing the shape complementarity between SAR405 (in sticks) and the site. (c) Description of the binding mode of SAR405, showing the main nonbonding interactions as black dashes (numbers represent distances in Å). 