A-H. (A) Experimental design for the mouse model in Fig. 7A-H. p53+/+ and p53-/- C57BL/6N male mice (p53+/+ mice n=8;p53-/- mice n=6) were fed with HFD diet for 10 weeks and were administered PBS or terbinafine (80mg/kg) every day for 8 weeks. (B) Mice body weight of p53 +/+ (left) and p53-/- (right) mice. (C) Representative liver photos of mice (left), changes in liver weight (right), H＆E staining (D) and Oil-Red staining (E) of liver tissues are shown respectively. Total liver cholesterol concentrations (F) and triglyceride levels (G) of each group were examined. (H) SQLE mRNA expression of mice liver tissues by qRT-PCR. 