A. The total observed and predicted metabolome of uRBC and iRBC. The total number of metabolites and those with a unique KEGG identification number are reported. Numbers in parenthesis refer to unmatched metabolites that were predicted from the genomic reconstruction but not observed, or observed metabolites that were not predicted. The total number of metabolites common to both predicted and observed lists (percentage in parenthesis) are referred to as 'matched'. An UpSet plot summarising the overlap of metabolites present in the predicted and observable metabolomes across uRBCs and iRBCs, with the inset depicting the metabolite size of each cell type. 