C. Hierarchical clustering of the results of the yeast growth phenotype screen. In each strain, the 266 kinases were binned (0-4) according to the number of conditions in which the kinase caused a growth phenotype. Hierarchical clustering revealed sets of topmost (52), highly (98) and moderately active (116) kinases. Top 30 active kinases causing many growth phenotypes over all conditions-strain pairs are listed. 