A. Schematic diagram of the establishment of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal cancer model and drug therapy regimen. AOM/DSS-induced colorectal tumor mice were treated with vehicle, TP-16 (75 mg/kg, po, daily), PD-1 antibody (50 μg, ip, twice weekly), or TP-16 and anti-PD-1 combined. The endpoint was day 37 from treatment initiation. 