D. Gene ontology enrichment analysis of up- and down-regulated genes, analyzed separately using Metascape (http://metascape.org). The top 10 significant GO terms (biological pathways and processes) associated with up- and down-regulated genes are shown. The y-axis represents the GO category (ribosomal biogenesis pathways/processes are highlighted in bold), and the x-axis represents the -Log10 (P-value) of GO terms. 