F-J Many Age-TFs function in a synergetic manner. Synergetic interactions networks were generated from top 30 Age-TFs by synergy analysis, filtered by P<0.001. The hub genes selected from the synergetic network using the MCC algorithm of CytoHubba plugin in Cytoscape. The Age-TFs are ranked by the P-values from MARINa. The Age-TFs in the synergetic network are coloured by their MCC values. proAge-TFs are defined as those promoting the transcriptomic changes (up- and down-regulation) during ageing, whereas antiAge-TFs are those inhibiting these changes. proAge-TFs promote whereas antiAge-TFs suppress the ageing-induced transcriptomic changes. Please note that these two classes of TFs are not necessarily pro- or anti-aging by their names. The transcriptomic changes triggered by a proAge-TF could be adaptive for ageing and induce longevity. 