B, Flow cytometry-based measure of ROS in H358, A549 and MIA PaCa-2 cells treated for 24 h with AZD4547 (5 µM) and BI2536 (5 nM) in the presence or absence of NAC (5mM). Quantification of relative ROS levels was shown in the right. Data are presented as the mean ± SD (n=3). ****P<0.0001 by two-way ANOVA with Tukey's multiple comparisons test. 