(B) The effects of LAMP-2A neutralizing antibody on degradation of Htt-552 by isolated lysosomes. The incubation of lysosomal preparation with Htt-552 was described as above. Values are the mean±SE of three independent experiments **P<0.01 (compared with Htt-552-18Q without lysosomes); #P<0.05, ##P<0.01 (compared with Htt-552-100Q without lysosomes); $$P<0.01 (compared with Htt-552-18Q without LAMP-2A antibody); P0.01 (compared with Htt-552-100Q without LAMP-2A antibody). 