m) (left) tSNE plots comparing the distribution of young and old intrahepatic leukocytes. Red indicates high frequency categorization of cells to a cluster while blue indicates low frequency; (right) tSNE plots comparing p16Ink4a expression in young and old intrahepatic leukocytes. Red indicates high p16Ink4a expression while blue indicates low expression. Data are from n=5 mice per group; n) % of p16Ink4a positive cells (detected by CyTOF) in different intrahepatic leukocyte populations isolated from young and old mice. Data are mean±s.e.m of n=5 mice per group; 