F. Odds of ClinVar pathogenic variant overlapping detected (6,057 Cys; 8,868 Lys) versus undetected (34,050 Cys; 140,652 Lys) residues in 3,840 detected proteins. Cys detected in ClinVar pathogenic site (red, OR = 1.17, p = 0.457) and Lys detected at ClinVar Pathogenic site (light blue, OR = 2.76, p = 1.03e-04). Combined Cys and Lys (dark blue, OR = 2.26, p = 9.99e-07) *p < 0.0167 Bonferroni adjusted (two-tailed Fisher's Exact test). Data information: 95% confidence intervals (line segments) and odds ratios (squares). 