D. Comparison of the fraction of kinases that result a growth phenotype over all conditions-strain pairs. Kinases are grouped into 179 (67%) with a yeast ortholog and 87 (33%) human protein kinases without orthologous yeast kinases. The latter group includes 41 tyrosine kinases and 46 S/T kinases which were separated in the analysis. The former group contains both one-to-many and many-to-many orthologous kinases. Tyrosine kinases strongly inhibited yeast growth and human kinases that are orthologous to yeast kinases were more likely to perturb yeast growth than human kinases without a yeast orthologData are from a single large-scale growth measurement. The boxes extend from 1st to 3rd quartile with the central band representing the median. The whiskers extend to the furthest point up to 1.5 times the interquartile range away from the nearest quartile, with any further points marked as outliers. P-values are calculated using the Mann-Whitney test. 