Mouse YUMM1.7 melanoma cells were subcutaneously inoculated into C57BL/6 mice and when tumors reached 100 mm3 mice were treated with vehicle (Ctrl), Nintedanib/BIBF1120 (BIBF), MAPKi (BRAFi, Vemurafenib and MEKi, Trametinib) or BRAFi/MEKi plus BIBF (n=6). Tumor sections were stained with picrosirius red and imaged under polarized light. (E) Representative image of collagen fibers network in tumors from mice under the different treatments. Scale bar 200 μm. 