(A) Euc1 domain structure is reminiscent of transcription factors. Top: Schematic representation of Euc1, with a predicted coiled-coil domain (CC) and GCR1-domain indicated. Predicted DNA binding of the C-terminal part was confirmed in Y1H experiments (Appendix Fig. S3A-C). Bottom: Euc1-like protein sequences from closely related Saccharomyces species were aligned and a phylogenetic tree was generated using Clustal Omega. Jalview was used to graphically display the degree of sequence conservation (see also Appendix Fig. S4A). 