D, F. Fat oxidation (F) recorded for 45h during light and dark period (grey area) after acute icv injection of saline (black curve), LPS (red curve) or LPS+INCB3344 (blue curve) in WT mice (n=5-8).E, G. Fat oxidation (G) average over 4 periods of 12 hours after acute icv injection of saline (black bars), LPS (red bars) or LPS+INCB3344 (blue bars) in WT mice (n=5-8). 