Proteins enriched in aggregates show a predicted higher molecular chaperone requirement for folding (top vs. bottom 20% p=0.0055, Kolmogorov-Smirnov test), and are richer in intrinsically disordered regions (s2D-derived scores, top vs. bottom 20% p=0.0019, Kolmogorov-Smirnov test). Violin plots: the solid line shows the median, the dotted lines the interquartile ranges. The same result was obtained with cleverSuite-derived scores (top vs. bottom 20% p=0.0201, Kolmogorov-Smirnov test) (Figure EV4C). ** p < 0.01, Kolmogorov-Smirnov test. 