(N) The SMAD3 inhibitor decreased melanoma cell density. Cell lines have been exposed to SMAD3i (0, 3, 10, 15 or 20 µM, 84h). The cell lines defined as S and R to BRAFi in the item 5M are indicated in blue and red. Normal human melanocytes (NEHM) have been used to evaluate the effect of SMAD3i on normal cells (n=3 independent donors). The SMAD3i effect on NHEMs is weak and manageable for these normal cells (NHEM). 