Number of up- and down-regulated protein-coding genes (PCG) defined as differentially expressed in Epi-HOT, -HOTΗP and -HOTΗP cells compared to Epi-CTR by RNA-seq and DESeq analysis (fold change > 2 and adj. P-value < 0.05), including those associated with EMT (Gröger set, Dataset EV2) and already identified as HOTAIR/PRC2 targets (Gupta set, Dataset EV2); nd stands for non-determined. 