Gene expression profile of P240 PR-SET7ΔHepA livers and comparison with transcriptomes of ductal progenitor cellsA Overexpression of stem cell-specific, oncofetal hepatic and proliferation-dependent genes in P240 PR-SET7ΔHepA livers. Volcano plot of normalized RNAseq data obtained with P240 wild-type and PR-SET7ΔHepA livers. Significance cutoff value was set at P = 0.05 in -log10 scale (horizontal dashed line) and fold change cutoffs at −0.6 and 1 in log2 scale (vertical dashed lines).B Volcano plots showing dots corresponding to representative stem cell marker genes (red), oncofetal hepatic genes (blue) and proliferation-dependent genes (black) are indicated.C, D Comparison of differentially expressed genes in P240 PR-SET7ΔHepA livers with those reported in Lgr5-LacZ+ sorted cells or MIC1-1C3+ sorted ductal cells (Huch et al, 2013). 