Superposition of the IAPV-IRES in complex with 80S (class 1) with tRNAs in different configurations indicated at the bottom. Alignments of the models were computed with the 40S body, excluding from the computation the ligands (IRES/tRNAs) and the 40S head. IAPV-IRES PKI components SL-III/ASL-like domain populates a space of the intersubunit space similar to a A/P-tRNA. IAPV-IRES PKIII (red) mimics the elbow region of a hybrid P/E-tRNA. 