B) Scheme of Sen1 protein. Globular domains are denoted by solid bars whereas intrinsically disordered regions are shown by a line. The disorder prediction was obtained using IUPred (Dosztányi et al., 2005). The sequence of the RNAPII S5P-CTD and Trf4 and Sen1 NIMs is shown on the top. Structural elements that are important for the interaction with Nrd1 CID are indicated. Conserved positions are underlined. 