(C) The incubation of lysosomal preparation with Htt-552 was described as above. The incubation of lysosomal preparation with Htt-552 was described as above. The effects of Hsc70 neutralizing antibody on degradation of Htt-552 by isolated lysosomes. Values are the mean±SE of three independent experiments. **P<0.01 (compared with Htt-552-18Q without lysosomes); ##P<0.01, #P<0.05 (compared with Htt-552-100Q without lysosomes); $$P<0.01 (compared with Htt-552-18Q without Hsc70 antibody); P0.05 (compared with Htt-552-100Q without Hsc70 antibody). 