B) PLAAC analysis (Lancaster et al., 2014) of hnRNPA2 (black), changing all tyrosine residues in hnRNPA2 LC to glutamate (17 YE, red), 5 serine to glutamate phosphomimic mutations (5 SE, blue), all serine (12 SE, purple), and all tyrosine to glutamine (17 YQ) shows that hnRNPA2 LC prion-like character reduces slightly with serine phosphomimic mutations, but decreases drastically with tyrosine phosphomimic mutations. 