A: IGSF10 domains and N-terminal mutations identified in the study. Region I contains leucine-rich repeats (LRR) 1-7 flanked by a LRR N-terminal (LRR Nt) and C-terminal (LRR Ct) cap. Region II is structurally disordered. Region III contains two Ig-like domains (Ig). Region IV is structurally disordered. Region V contains 10 Ig-like domains (Ig). 