F. Effect on MCH-R1 antagonist on LPS- and CCL2-induced weight loss. Data are expressed in mean % of weight variation compared to initial body weight at different times (from 2 to 48h) after acute icv injection of saline (black bar), H6408 (dark blue bar), LPS (red bar), or LPS+H6408 (light red bar), CCL2 (orange bar), CCL2+H6408 (yellow bar) in WT mice (n=3 to 12). Data are expressed as means ± SEM. *p<0.05, **p<0.01, ***p<0.001, color-coded asterisks indicate a significant difference from the experimental condition assigned to the respective color-coded bar. 