(I) TEPP-46 treatment attenuates accumulation of polyubiquitinated proteins by NMS-873 detected with anti-Ub western blot. MCF7 cells were treated with DMSO, NMS873 (5μM), TEPP-46 (10μM), or NMS873 (5μM) plus TEPP-46 (10μM) for 7 hours followed by co-treatment with cycloheximide (CHX, 50 μg/ ml) for one hour. 