E. Odds of predicted deleterious Cys>Trp (red) missense at detected (n=6,057) versus undetected (n=34,049) residues in 3840 detected proteins. Deleterious missense defined by CADD38, FATHMM, and DANN score thresholds (y axis). CADD38 OR = 0.76, p = 3.40e-22; FATHMM OR = 0.92 , p = 0.02; DANN OR = 0.690 , p = 6.69e-26. Odds of predicted deleterious Lys>Ile (blue) missense at detected (n=3,581) versus undetected (n=63,385) residues in 3840 detected proteins. CADD38 OR = 1.80, p = 1.03e-53; FATHMM OR = 1.55, p = 3.47e-33; DANN OR = 1.75, p = 9.21e-14. *p < 0.0042 Bonferroni adjusted (two-tailed Fisher's Exact test) Data information: 95% confidence intervals (line segments) and odds ratios (squares). 