Carbon data from natural gas sources are calculated using regional specific emission factors from US EPA Rule Part 110819 Guidelines for Amgen’s facilities in the United Kingdom (Uxbridge, Abingdon, and Cambridge); from the NL Agency standard CO2 emission factors for Amgen’s facility in the Netherlands (Breda); and from the Methodology for Reporting 2013 /Ministry of Environment Victoria, BC, 2013, for Amgen’s facility in Burnaby, Canada.