They develop exposure profiles for each SEG and update them when controls are modified, including changes in engineering controls or personal protective equipment; 3) the agent hazard profile is updated; 4) there is a change in an agent’s acceptable exposure limit (the internal DuPont occupational exposure limit), a published Occupational Exposure Limit (OEL), or the applicable regulatory OEL or; 5) quantitative data (e.g., personal monitoring results) have been collected.