•	All	first	and	second	line	managers	and	 employees	extensively	dealing	with	third	 parties	(i.e.	front-end	manufacturing,	back-end	 manufacturing,	R&D,	purchasing	and	site	 management)	shall	be	regularly	reminded	of	the	 contents	of	this	SOP	and	requested	to	complete	 and	sign	a	yearly	compliance	statement.