The corporate governance “therapeutics” include establishment and enhancement of Board committees responsible for safety oversight; regular public disclosure of API status; enhanced commitment to shareholder involvement through regular dialogue regarding corporate governance; updating the Codes of Conduct to reflect best practice as well as to more fully promote and ensure safety culture and reporting; stating the respective responsibilities of the Chief Safety Officer (CSO), the Chief Ethics and Compliance Officer (CECO), and the Boards and their committees regarding instillation of safety culture; additional clarity and accountability regarding communication and information access and exchange between employees, management, key compliance and safety officers, Board Committees, and the Boards of Directors; clarification regarding the incorporation of safety, compliance, and ethics into officer compensation; enhancement of a speak-up culture for employees and Board members; and enhancement of safety training for employees and Board members.