Carbon data from natural gas sources are calculated using regional specific emission factors from US EPA Rule Part sites; from the Ireland UFCCC for Amgen’s facility in Dun Laoghaire, Ireland; from U.K. Defra/DECC’s 110819 Guidelines for Amgen’s facilities in the United Kingdom (Uxbridge, Abingdon, and Cambridge); from the NL Agency standard CO 2 emission factors for Amgen’s facility in the Netherlands (Breda); and from the Methodology for Reporting 2011 Version 2.0/Ministry of Environment Victoria, BC, December 2011, for Amgen’s facility in Burnaby, Canada.