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The feedback from low uric acid it is rare and usually not of concern. The main causes of reduced uric acid are increased renal elimination, often due to concomitant drug therapy, or reduced urate production due to rare genetic disorders, particular drugs or a diet low in protein. In most cases there are no specific symptoms associated with hypouricemia. Uric acid What is Uric Acid? What does it mean uricemia? L'uric acid it is the final product of the degradation of purines, which are a fundamental component for the construction of our DNA. L'uricemia it is nothing more than a term used to indicate the levels of uric acid in the blood. Uric acid is produced mainly in the liver in the small intestine, that is, in the two systems that contain an enzyme called xanthine oxidase, which is essential for the breakdown of purines and the production of urates. The uric acid thus produced is eliminated mainly by the kidney about three quarters of the total, while the residual amount is eliminated by the intestine. Low uric acid The finding of a reduction in uric acid values is neither frequent nor usually worrying. The main reasons for the drop in uricemia levels (called hypouricemia) are above all the increased renal elimination, often due to concomitant drug therapy, and / or the reduced production of uric acids. But let's see when it comes to low uric acid. Low uric acid levels The concentration of uric acid in plasma varies with age and sex, but for the reference range, low uric acid values are practically the same for women and men, young or old. We talk about low uric acid when its levels are below 4 mg / dl (milligrams per deciliter) or 238 µmol / l (micromoles per liter) in men and below 2.5 mg / dl (milligrams per deciliter) ie 149 µmol / l (micromoles per liter) ) in women (source Healtline). Causes of low uric acid The main causes of low uric acid are essentially two - Reduced production of uric acids - Increased renal or intestinal elimination of urates In reality, these two mechanisms often coexist. Hypouricemia is a rare finding, as it is thought to be present in less than 0.2% in blood tests performed by the general population, and less than 0.8% in blood tests performed by hospitalized patients. In most cases, low uric acid is secondary to increased renal excretion. Often the culprit is a drug with uricosuric properties, that is, it accentuates the elimination of uric acid in the urine. Below we report the medications that more frequently can give this problem: - Furosemide and other diuretic drugs - Ascorbic acid, or vitamin C - Citrate, - Dicumarols such as warfarin (coumadin), - iodized contrast medium used in radiology, - Estrogen hormones such as the pill, - Glucocorticoids (cortisone drugs), - Acetylsalicylic acid (aspirin) in doses greater than 2 g per day - Tetracyclines (a particular antibiotic drug) when used after the expiration date. Total parenteral nutrition, i.e. intravenous nutrition, can also cause hypoglycaemia probably due to the high glycine content in the infusion bags. Other diseases that can increase renal clearance of urates are: - cirrhosis of the liver - diabetes mellitus - inappropriate secretion of ADH (vasopressin) such as in SIADH - some types of neoplasms - a storage disease called cystinosis - multiple myeloma - heavy metal intoxication - congenital kidney problems with congenital defects of uric acid transport, such as renal tubule defects (Fanconi syndrome or Wilson disease) There are also very rare hereditary causes which involves a reduced production of urates. All of these causes are characterized by the finding of normal or elevated uricosuria (concentration of uric acid in normal or elevated urine). This data allows to differentiate the low uric acid picture from reduced production, which instead is characterized by a reduced or absent quantity of uric acid in the urine. The main causes of reduced uric acid production are all diseases that involve a deficiency in purine production, and all those therapies that inhibit DNA production such as anticancer therapies (chemotherapies). Furthermore, patients treated with allopurinol (trade name Zyloric) used to reduce blood levels of uric acid, may have a low uricaemiaa or deleted. Finally, uricemia and diet they can also be connected in a negative sense: a low-protein diet can contribute, in part, to the reduction of urate values in the blood. Low Uric Acid Symptoms What are the main symptoms of hypouricemia? Uric acid: symptoms specific? Most cases of uric acids reduced is not associated with any type of particular symptom. The only symptoms that may be present are not directly related to low uric acid levels, but rather to the concomitant pathology that may be present, such as - Skin jaundice, weight loss, fatigue, fluid accumulation in case of liver cirrhosis - Tiredness, weight loss, skin pallor, widespread pain in case of neoplasms - Confusion, very high blood sugar, abundant and frequent urination in inadequately treated diabetes mellitus - Accumulation of fluids various parts of the body reduction of the amount of urine in the SIADH Give your +1! [sz-gplus-one size = "tail" align = "center" annotation = "inline" /] Tags: Storage diseases Laboratory medicine
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काठमाडौँ । युरिक एसिड रगतमा नभई नहुने महत्वपूर्ण तत्व हो। यसले शरीरमा ‘एन्टी अक्सिडेन्ट’को काम गर्छ। तर, युरिक एसिडको मात्रा चाहिनेभन्दा बढी भएमा यसले जोर्नीहरुमा समस्या ल्याउँछ र ‘गाउट’ भन्ने रोग लाग्छ। युरिक एसिडलाई एक प्रकारको बाथरोगका रुपमा बुझ्न सकिन्छ। यसले जोर्नीहरुमा अत्याधिक दुखाइ गराउँछ। रगतमा युरिक एसिड बन्ने र युरिक एसिड पिसाबबाट बाहिर निस्किने प्रक्रियामा गडबडी भयो भने रगतमा पर्याप्त मात्रामा युरिक एसिड घुल्न पाउँदैन र विस्तारै गाउटको रुप लिन्छ। एउटा स्वस्थ मानिसमा युरिक एसिडको मात्रा ६ दशमलब ८ एमजीरडिएल हुनुपर्छ। जसलाई गाउट वा युरिक एसिडको समस्या छ त्यस्ता व्यक्तिमा युरिक एसिडको मात्रा ५ एमजीरडिएलभन्दा कम राख्नुपर्ने हुन्छ। कुनै व्यक्तिमा युरिक एसिड बढी देखिए पनि जोर्नीको दुखाइ नहुन सक्छ। यस्ता व्यक्तिलाई गाउट नभएर ‘हाइपरयुरेसिमिया’ भएको हुन सक्छ। त्यसले जोर्नीमा असर गर्दैन। जसलाई युरिक एसिड भएकै कारण जोर्नी (खुट्टाको बुढी औँला र आसपास) मा दुख्छ, त्यो गाउट हो भनेर बुझ्नुपर्छ। युरिक एसिडबाट हुने बाथरोग नै गाउट हो। यो वंशाणुगत समस्या पनि हुन्छ। यसलाई दुई तरिकाले हेर्न सकिन्छ। कसरी हुन्छ ? शरीरमा प्रोटिनको मेटाबोलिज्म भएर निस्कने तत्वलाई युरिक एसिड भनिन्छ । न्युक्लिक एसिड र प्युरिन ग्रुपको प्रोटिनबाट युरिक एसिड बन्छ । यो सामान्यतः पिसाबबाट बाहिर निस्कन्छ । जब मिर्गौलाको छान्ने क्षमता कम हुन्छ र युरिक एसिड रहन्छ, तब त्यो हड्डीको जोर्नीमा गएर जम्मा हुन्छ । मिर्गौलाले युरिक एसिड कम उत्सर्जन गर्दा पनि त्यो रगतमा जम्मा हुन पुग्छ । उपवास वा अत्याधिक रूपमा तौल घटाउने प्रयास गर्दा पनि अस्थायी रूपमा युरिक एसिडको स्तर बढ्न सक्छ । साथै युरिक एसिड बढाउन मधुमेहको औषधिले पनि उत्तिकै भूमिका खेल्ने गर्छ । असर शरीरका सानासाना जोर्नीमा दुख्ने समस्या उत्पन्न हुन्छ । यदि २५ वर्ष बढीे उमेरका युवाहरू छन् र धेरै खाना खाने गर्छन् भने यो रोगको जोखिममा पर्न सक्ने सम्भावना अत्यधिक रहन सक्छ। राति सुतेको बेला हातको औंला र खुट्टाको औंलाका जोर्नीमा दुखाइ महसुस हुन्छ भने त्यो युरिक एसिडको लक्षण हुन सक्छ। युरिक एसिड खासगरी हड्डीको जोर्नीमा गएर जम्मा हुन्छ र जोर्नीमा पीडा महसुस हुन्छ। युुरिक एसिड एक्कासी बढ्न पनि सक्छ । यदि यो अचानक बढेमा खुट्टाको पिडौला, जोर्नी, मिर्गौला तथा शरीरका अन्य भागमा जमेर बस्न सक्छ र यसले भविष्यमा जोर्नीको दुखाइ बाथरोग लाग्न सक्छ। यो रोग लागेका १० देखि २५ प्रतिशत व्यक्तिलाई मिर्गौलाको पत्थरी, मुत्रनलीको संक्रमण, अनिद्रा, चिन्ता तनाव र नैराश्यताजस्ता मनोरोग पनि लाग्न सक्छन्।