http___en.wikipedia.org_wiki_Spanish_influenza_2.xml
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Испански грип Испански грип е названието на световната пандемия от грип (инфлуенца), обхванала целия свят през 1918 година. Пандемията продължава от януари 1918 година до декември 1920 година,[1] достигайки разпространение дори до Арктика и отдалечените островни групи в Тихия океан. Данните за смъртността варират в доста широки граници, от 50 до 130 милиона жертви, но дори отчитайки по-малкото число, Испанският грип се явява едно от най-смъртоносните природни бедствия в човешката история.[2][3][4][5][6] При тогавашното население на Земята от 1,86 милиарда души, между 3% и 5% загиват, 500 милиона (27%) са заразените. В историческите и епидемиологичните данни няма яснота относно географския произход на пандемията.[2] За разлика от повечето грипни епидемии, които засягат предимно малолетни и по-възрастни хора в недобро здравословно състояние, при испанския грип голяма част от заразените са млади зрели хора в отлично здраве. Бедствието оказва влияние на значителното покачване на случаите на Летаргичен енцефалит през 1920-те години.[7] След изследване на тъкан взета от замразени жертви се стига до заключение, че вирусът е убивал посредством предизвикване на т.нар. цитокинна буря (свръх-реакция на имунната система). Това обяснява как реакцията на силните имунни системи фактически е опустошавала тялото на заразения. Съдържание Етимология[редактиране | редактиране на кода] Първите случаи на болестта са регистрирани в континенталната част на Съединените щати и Европа, преди достигането ѝ до Испания. По време на първата световна война, Испания е неутрална държава и поради това няма наложена цензура в новините относно пораженията от разпростиращата се епидемия. В същото време, наложената цензура в Германия, Великобритания, Франция и САЩ прикрива нивото на пораженията, нанесени от грипа в тези страни с цел запазване на високия дух на населението в трудните военни времена.[8] Всичко това поражда грешното впечатление, че разпространението на грипната вълна в Испания е многократно по-силно, поради което се налага названието „Испански грип“.[9] История[редактиране | редактиране на кода] Първата световна война не е причина за възникването на пандемията, въпреки че масираното придвижване на големи военни части, както и разполагането на казарми в населените места, спомагат за разпространението на вируса. Основен фактор при тази пандемия е неимоверно нарасналите пътувания на хората в световен мащаб. В началото на 20-и век, масовото навлизане на модерни транспортни системи улесняват придвижването на близки и далечни разстояния, както на войници и моряци, така и на цивилни пътници, довеждайки до масовото разпространение на болестта в рамките на кратък период от време. В Съединените щати, първото регистриране на болестта става през януари 1918 година в окръг Хаскъл, Канзас, подтиквайки местния лекар Лоринг Майнер да алармира американската обществена здравна служба. На 4 март 1918 година, се съобщава за заболели във военната база Форт Райли, Канзас. До обяд на 11 март, вече над 100 войника от базата са постъпили в болница. В рамките на няколко дни е докладвано за заболяването на 522 души в същата база. Към датата 11 март, болестта е достигнала Куинс, Ню Йорк. През август 1918 година, още по-вирулентен щам се появява едновременно в Брест (Франция), Фрийтаун (Сиера Леоне) и Бостън, (САЩ). През ноември 1918 година, болестта навлиза от Франция в Испания, където поради неутралността на държавата, получава по-голямо медийно внимание. Тогава съюзническите сили започват да наричат бедствието „Испански грип“. Фермери от Албърта, Канада носят маски за защита от болестта. Полицаи носят маски в Сиатъл, САЩ (1918). Изгаряне на жертви на болестта в град Норт Ривър, Нюфаундленд и Лабрадор, Канада (1918). Смъртност[редактиране | редактиране на кода] Няма точни данни за глобалното количество на жертвите от пандемията през 1918-1919 година, но ориентировъчно се приема, че между 10% и 20% от заболелите умират. Имайки предвид, че близо една трета от тогавашното население на Земята се заразява с болестта, което означава, че между 3% и 6% от хората са загинали вследствие на Испанския грип.[10] Предполага се, че само за първите 25 седмици от пандемията, жертвите са около 25 милиона. Съвременните изчисления варират в диапазона от 50 до 100 милиона жертви за целия период в световен мащаб. Бедствието е сравнявано дори с чумната пандемия от средновековието известна като Черната смърт. Изследванията сочат, че Испанският грип за 24 седмици убива повече хора отколкото Синдромът на придобитата имунна недостатъчност (СПИН) за 24 години. По държави отражението на пандемията е: Симптомите на инфлуенцата от 1918 година били толкова необичайни, че в началото заболяването е било погрешно диагностицирано като Денга, Холера и Коремен тиф. Друго необичайно при тази пандемия е поразяването предимно на зрели млади хора в добро здравословно състояние. Близо 99 % от смъртните случаи са на хора на възраст под 65 години, като половината от тях са на хора на възраст между 20 и 40 години.[11] Известни личности жертви на пандемията[редактиране | редактиране на кода] - Франсиско де Паула Родригес Алвес, президент на Бразилия (†16 януари, 1919)[12] - Гийом Аполинер, френски поет (†9 ноември, 1918) - Феликс Арндт, американски пианист и композитор (†16 октомври, 1918) - Луис Бота, първи министър-председател на южноафриканския съюз, (†27 август, 1919)[13] - Амадео де Соуза Кардосо, португалски художник (†25 октомври, 1918) - Лари Чапел, американски бейзболист, (†8 ноември, 1918) - Роуз Кливланд, сестра на президента на САЩ Гроувър Кливланд (†22 ноември, 1918) - Gaby Deslys, френска актриса и танцьорка (†11 февруари, 1920) - Anton Dilger, немски лекар - Джеймс Кагни – старши, баща на холивудската звезда Джеймс Кагни - Джон Франсис Додж, основател на автомобилната компания „Додж Брадърс Къмпани“ (†14 януари, 1920) - Хорас Елгин Додж, основател на автомобилната компания „Додж Брадърс Къмпани“ (†10 декември, 1920) - Ангъс Дъглъс, шотландски футболист, (†14 декември, 1918) - Харолд Гилман, британски художник (†12 февруари, 1919) - Мърдъл Гонзалес, американска филмова актриса (†22 октомври, 1918) - Едуард Кидър Греам, президент на университета в Северна Каролина (†26 октомври, 1918) - Софи Халберщат-Фройд, дъщеря на Зигмунд Фройд, (†1920) - Фиби Хърст, майка на американския медиен магнат Уилям Рандолф Хърст, прототип на Гражданинът Кейн (†13 април, 1919) - Лаймън Кинън, американски бригаден генерал (†9 септември, 1918) - Вера Холодная, руска актриса (†16 февруари, 1919) - Густав Климт, австрийски художник (†6 февруари, 1918)[14] - Бохомил Кубица, чешки художник, (†27 ноември, 1918) - Руби Линдзи, австралийски илюстратор и художник (†12 март 1919) - Харолд Локууд, звезда на нямото кино (†19 октомври, 1918) - Дан Макмичъл, треньор на шотландския футболен отбор Хибърниън (†1919) - Сър Хъбърт Пери, британски композитор (†7 октомври, 1918) - Едмон Ростан, френски драматург и поет (†2 декември, 1918) - Франц Карл Салвадор (1893–1918), внук на Елизабет Баварска (Сиси) и император Франц Йосиф. - Мортон Шамберг, американски художник модернист (†13 октомври, 1918). - Егон Шиле, австрийски художник (†31 октомври, 1918).[15] - Яков Свердлов, болшевишки лидер (†16 март, 1919) - Марк Сайкс, британски политик и дипломат (†16 февруари, 1919) - Джордж Тупоу ІІ, крал на Тонга и съпругата му Anaseini Takipō, умират и двамата съответно на 5 април, 1918 и 26 ноември, 1918. - Фредерик Тръмп, дядо на магната Доналд Тръмп, (†30 март, 1918) - Принц Умберто, граф на Салеми, член на италианската кралска фамилия (†19 октомври, 1918) - Принц Ерик, дюк на Вестманланд (Erik Gustav Ludvig Albert Bernadotte), шведски принц (†20 септември, 1918) - Макс Вебер, немски социолог (†14 юни, 1920) Бележки и Източници[редактиране | редактиране на кода] - ↑ Institut Pasteur. La Grippe Espagnole de 1918 (Powerpoint presentation in French). - ↑ а б 1918 Influenza: the Mother of All Pandemics. // Centers for Disease Control and Prevention, January, 2006. Архив на оригинала от 1 October 2009. Посетен на 9 May 2009. - ↑ Patterson, KD и др. The geography and mortality of the 1918 influenza pandemic. // Bull Hist Med. 65 (1). - ↑ Tindall 2007 - ↑ Billings, Molly. The 1918 Influenza Pandemic. // Virology at Stanford University. Архив на оригинала от 4 May 2009. Посетен на 1 May 2009. - ↑ Johnson NP, Mueller J. Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic. // Bull Hist Med 76 (1). 2002. - ↑ Vilensky JA, Foley P, Gilman S. Children and encephalitis lethargica: a historical. // Pediatr. August 2007. - ↑ Valentine, Vikki. Origins of the 1918 Pandemic: The Case for France. // NPR, 20 February 2006. Посетен на 2 October 2011. - ↑ Galvin, John. Spanish Flu Pandemic: 1918. // Popular Mechanics, 31 July 2007. Посетен на 2 October 2011. - ↑ Taubenberger, J., Morens, M.. 1918 Influenza Pandemic. Архив на оригинала от 1 October 2009. Посетен на 14 May 2009. - ↑ Simonsen, L и др. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. // J Infect Dis 178 (1). - ↑ Frank D. McCann. Soldiers of the Pátria: a history of the Brazilian Army, 1889-1937. Stanford University Press, 2004. - ↑ Duncan 2003, с. 16 - ↑ see time line and life history Retrieved December 12, 2010 - ↑ Frank Whitford, Expressionist Portraits, Abbeville Press, 1987, p. 46. Външни препратки[редактиране | редактиране на кода] - Nature "Web Focus" on 1918 flu, including new research - Influenza Pandemic on stanford.edu - The Great Pandemic: The U.S. in 1918–1919. US Dept. of HHS
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1918 flu pandemic The 1918 flu pandemic (January 1918 – December 1920) was an unusually deadly influenza pandemic, the first of the two pandemics involving H1N1 influenza virus.[1] It infected 500 million[2] people across the world, including remote Pacific islands and the Arctic, and killed 50 to 100 million of them—three to five percent of the world's population[3]—making it one of the deadliest natural disasters in human history.[2][4][5][6] Most influenza outbreaks disproportionately kill juvenile, elderly, or already weakened patients; in contrast the 1918 pandemic predominantly killed previously healthy young adults. Modern research, using virus taken from the bodies of frozen victims, has concluded that the virus kills through a cytokine storm (overreaction of the body's immune system). The strong immune reactions of young adults ravaged the body, whereas the weaker immune systems of children and middle-aged adults resulted in fewer deaths among those groups.[7] Historical and epidemiological data are inadequate to identify the pandemic's geographic origin.[2] It was implicated in the outbreak of encephalitis lethargica in the 1920s.[8] To maintain morale, wartime censors minimized early reports of illness and mortality in Germany, Britain, France, and the United States;[9][10] but papers were free to report the epidemic's effects in neutral Spain (such as the grave illness of King Alfonso XIII), creating a false impression of Spain as especially hard hit[11]—thus the pandemic's nickname Spanish flu.[12] Contents - 1 History - 2 Mortality - 3 Legacy - 4 Spanish flu research - 5 In popular culture - 6 Gallery - 7 References - 8 External links History Hypotheses about source Investigative work by a British team led by virologist John Oxford[13] of St Bartholomew's Hospital and the Royal London Hospital, identified a major troop staging and hospital camp in Étaples, France as almost certainly being the center of the 1918 flu pandemic. A significant precursor virus was harbored in birds, and mutated to pigs that were kept near the front.[14] Earlier hypotheses of the epidemic's origin have varied. Some hypothesized the flu originated in the Far East.[15] Dr. C. Hannoun, leading expert of the 1918 flu for the Institut Pasteur, asserted the former virus was likely to have come from China, mutated in the United States near Boston, and spread to Brest, France, Europe's battlefields, Europe, and the world using Allied soldiers and sailors as main spreaders.[16] Hannoun considered several other hypotheses of origin, such as Spain, Kansas, and Brest, as being possible, but not likely. Historian Alfred W. Crosby speculated the flu originated in Kansas.[17] Popular writer John Barry echoed Crosby in describing Haskell County, Kansas, as the likely point of origin.[18] Political scientist Andrew Price-Smith published data from the Austrian archives suggesting the influenza had earlier origins, beginning in Austria in the spring of 1917.[19] Historian Mark Humphries of Canada's Memorial University of Newfoundland states that newly unearthed records confirm that one of the side stories of the war, the mobilization of 96,000 Chinese laborers to work behind the British and French lines on World War 1's Western Front, may have been the source of the pandemic. In the new report, Humphries finds archival evidence that a respiratory illness that struck northern China in November 1917 was identified a year later by Chinese health officials as identical to the Spanish flu.[20][21] Spread The close quarters and massive troop movements of World War I hastened the pandemic and probably both increased transmission and augmented mutation; the war may also have increased the lethality of the virus. Some speculate the soldiers' immune systems were weakened by malnourishment, as well as the stresses of combat and chemical attacks, increasing their susceptibility.[22] A large factor in the worldwide occurrence of this flu was increased travel. Modern transportation systems made it easier for soldiers, sailors, and civilian travelers to spread the disease.[23] In the United States, the disease was first observed in Haskell County, Kansas, in January 1918, prompting local doctor Loring Miner to warn the U.S. Public Health Service's academic journal. On 4 March 1918, company cook Albert Gitchell reported sick at Fort Riley, Kansas. By noon on 11 March 1918, over 100 soldiers were in the hospital.[24] Within days, 522 men at the camp had reported sick.[25] By 11 March 1918 the virus had reached Queens, New York.[26] Failure to take preventative measures in March/April was later criticised. In August 1918, a more virulent strain appeared simultaneously in Brest, France, in Freetown, Sierra Leone, and in the U.S. in Boston, Massachusetts. The Allies of World War I came to call it the Spanish flu, primarily because the pandemic received greater press attention after it moved from France to Spain in November 1918. Spain was not involved in the war and had not imposed wartime censorship.[28] Mortality Around the globe The global mortality rate from the 1918/1919 pandemic is not known, but an estimated 10% to 20% of those who were infected died. With about a third of the world population infected, this case-fatality ratio means 3% to 6% of the entire global population died.[31] Influenza may have killed as many as 25 million people in its first 25 weeks. Older estimates say it killed 40–50 million people,[4] while current estimates say 50–100 million people worldwide were killed.[32] This pandemic has been described as "the greatest medical holocaust in history" and may have killed more people than the Black Death.[33] It is said that this flu killed more people in 24 weeks than AIDS has killed in 24 years, more in a year than the Black Death killed in a century.[34] The disease killed in every corner of the globe. As many as 17 million died in India, about 5% of the population.[35] The death toll in India's British-ruled districts alone was 13.88 million.[36] In Japan, 23 million people were affected, and 390,000 died.[37] In the Dutch East Indies (now Indonesia), 1.5 million were assumed to have died among 30 million inhabitants.[38] In Tahiti, 13% of the population died during only a month. Similarly, in Samoa in November 1918, 22% of the population of 38,000 died within two months.[39] In the U.S., about 28% of the population suffered, and 500,000 to 675,000 died.[40] Native American tribes were particularly hard hit. In the Four Corners area alone, 3,293 deaths were registered among Native Americans.[41] Entire villages perished in Alaska.[42] In Canada 50,000 died.[43] In Brazil 300,000 died, including president Rodrigues Alves.[44] In Britain, as many as 250,000 died; in France, more than 400,000.[45] In West Africa, an influenza epidemic killed at least 100,000 people in Ghana.[46] Tafari Makonnen (the future Haile Selassie, Emperor of Ethiopia) was one of the first Ethiopians who contracted influenza but survived,[47] although many of his subjects did not; estimates for the fatalities in the capital city, Addis Ababa, range from 5,000 to 10,000, or higher.[48] In British Somaliland one official estimated that 7% of the native population died.[49] This huge death toll was caused by an extremely high infection rate of up to 50% and the extreme severity of the symptoms, suspected to be caused by cytokine storms.[4] Symptoms in 1918 were so unusual that initially influenza was misdiagnosed as dengue, cholera, or typhoid. One observer wrote, "One of the most striking of the complications was hemorrhage from mucous membranes, especially from the nose, stomach, and intestine. Bleeding from the ears and petechial hemorrhages in the skin also occurred."[32] The majority of deaths were from bacterial pneumonia, a secondary infection caused by influenza, but the virus also killed people directly, causing massive hemorrhages and edema in the lung.[29] The unusually severe disease killed up to 20% of those infected, as opposed to the usual flu epidemic mortality rate of 0.1%.[29][32] Patterns of fatality An unusual feature of this pandemic was that it mostly killed young adults. In 1918-1919, 99% of pandemic influenza deaths in the US occurred in people under 65, and nearly half in young adults 20 to 40 years old. In 1920 the mortality rate among people under 65 had decreased six-fold to half the mortality rate of people over 65, but still 92% of deaths occurred in people under 65. [50] This is noteworthy, since influenza is normally most deadly to weak individuals, such as infants (under age two), the very old (over age 70), and the immunocompromised. In 1918, older adults may have had partial protection caused by exposure to the 1889–1890 flu pandemic, known as the Russian flu.[51] According to historian John M. Barry, the most vulnerable of all – "those most likely, of the most likely", to die – were pregnant women. He reported that in thirteen studies of hospitalized women in the pandemic, the death rate ranged from 23% to 71%. Of the pregnant women who survived childbirth, over one-quarter (26%) lost the child.[52] Another oddity was that the outbreak was widespread in the summer and autumn (in the Northern Hemisphere); influenza is usually worse in winter.[53] Modern analysis has shown the virus to be particularly deadly because it triggers a cytokine storm, which ravages the stronger immune system of young adults.[7] In fast-progressing cases, mortality was primarily from pneumonia, by virus-induced pulmonary consolidation. Slower-progressing cases featured secondary bacterial pneumonias, and there may have been neural involvement that led to mental disorders in some cases. Some deaths resulted from malnourishment. Deadly second wave The second wave of the 1918 pandemic was much deadlier than the first. The first wave had resembled typical flu epidemics; those most at risk were the sick and elderly, while younger, healthier people recovered easily. But in August, when the second wave began in France, Sierra Leone and the United States,[54] the virus had mutated to a much deadlier form. This has been attributed to the circumstances of the First World War.[55] In civilian life, natural selection favours a mild strain. Those who get very ill stay home, and those mildly ill continue with their lives, preferentially spreading the mild strain. In the trenches, natural selection was reversed. Soldiers with a mild strain stayed where they were, while the severely ill were sent on crowded trains to crowded field hospitals, spreading the deadlier virus. The second wave began and the flu quickly spread around the world again. Consequently, during modern pandemics health officials pay attention when the virus reaches places with social upheaval (looking for deadlier strains of the virus).[56] The fact that most of those who recovered from first-wave infections were now immune showed that it must have been the same strain of flu. This was most dramatically illustrated in Copenhagen, which escaped with a combined mortality rate of just 0.29% (0.02% in the first wave and 0.27% in the second wave) because of exposure to the less-lethal first wave.[57] On the rest of the population it was far more deadly now; the most vulnerable people were those like the soldiers in the trenches – young healthy adults.[58] Devastated communities Even in areas where mortality was low, so many were incapacitated that much of everyday life was hampered. Some communities closed all stores or required customers to leave orders outside. There were reports that the health-care workers could not tend the sick nor the gravediggers bury the dead because they too were ill. Mass graves were dug by steam shovel and bodies buried without coffins in many places.[59] Several Pacific island territories were particularly hard-hit. The pandemic reached them from New Zealand, which was too slow to implement measures to prevent ships carrying the flu from leaving its ports. From New Zealand, the flu reached Tonga (killing 8% of the population), Nauru (16%) and Fiji (5%, 9,000 people).[60] Worst affected was Western Samoa, a territory then under New Zealand military administration. A crippling 90% of the population was infected; 30% of adult men, 22% of adult women and 10% of children died. By contrast, the flu was kept away from American Samoa when Governor John Martin Poyer imposed a blockade.[60] In New Zealand itself, 8,573 deaths were attributed to the 1918 pandemic influenza, resulting in a total population fatality rate of 0.74%.[61] Less-affected areas In Japan, 257,363 deaths were attributed to influenza by July 1919, giving an estimated 0.425% mortality rate, much lower than nearly all other Asian countries for which data are available. The Japanese government severely restricted maritime travel to and from the home islands when the pandemic struck. In the Pacific, American Samoa[62] and the French colony of New Caledonia[63] also succeeded in preventing even a single death from influenza through effective quarantines. In Australia, nearly 12,000 perished.[64] By the end of the pandemic, only one major region on the entire planet had not reported an outbreak: an isolated island called Marajó, located in Brazil's Amazon River Delta.[65] Aspirin poisoning In a 2009 paper published in the journal Clinical Infectious Diseases, Karen Starko proposed that aspirin poisoning had contributed substantially to the fatalities. She based this on the reported symptoms in those dying from the flu, as reported in the post mortem reports still available, and also the timing of the big "death spike" in October 1918 which happened right after the Surgeon General of the United States Army, and the Journal of the American Medical Association both recommended very large (by today's standards) dosages of aspirin.[66] Further, Starko suggests that the wave of aspirin poisonings was due to a "perfect storm" of events: Bayer's patent on aspirin expired, so that many companies rushed in to make a profit and greatly increased the supply; this coincided with the flu pandemic; and the symptoms of aspirin poisoning were not known at the time.[66] This hypothesis, insofar as it sought to provide an explanation to the universally high mortality rate, was questioned in a letter to the journal published in April 2010. In it, Andrew Noymer and Daisy Carreon of the University of California, Irvine, and Niall Johnson of the Australian Commission on Safety and Quality in Health Care, questioned this universal applicability given the high mortality rate in countries such as India, where there was little or no access to aspirin at the time.[67] But they overlooked the fact that inexpensive aspirin became available in India and other places after October 1918, when the Bayer patent expired. On this basis, they concluded that "the salicylate [aspirin] poisoning hypothesis [was] difficult to sustain as the primary explanation for the unusual virulence of the 1918–1919 influenza pandemic."[67] In responding, Starko pointed to anecdotal evidence of aspirin over-prescription in India and argued that even if aspirin over-prescription had not contributed to the high Indian mortality rate, it could still have been a major factor for other high rates in areas where other exacerbating factors present in India played less of a role.[68] End of the pandemic After the lethal second wave struck in late 1918, new cases dropped abruptly – almost to nothing after the peak in the second wave.[7] In Philadelphia, for example, 4,597 people died in the week ending 16 October, but by 11 November, influenza had almost disappeared from the city. One explanation for the rapid decline of the lethality of the disease is that doctors simply got better at preventing and treating the pneumonia that developed after the victims had contracted the virus, although John Barry stated in his book that researchers have found no evidence to support this.[7] Another theory holds that the 1918 virus mutated extremely rapidly to a less lethal strain. This is a common occurrence with influenza viruses: there is a tendency for pathogenic viruses to become less lethal with time, as the hosts of more dangerous strains tend to die out.[7] Legacy Academic Andrew Price-Smith has made the argument that the virus helped tip the balance of power in the later days of the war towards the Allied cause. He provides data that the viral waves hit the Central Powers before they hit the Allied powers, and that both morbidity and mortality in Germany and Austria were considerably higher than in Britain and France.[69] In the United States, Britain and other countries, despite the relatively high morbidity and mortality rates that resulted from the epidemic in 1918–1919, the Spanish flu began to fade from public awareness over the decades until the arrival of news about bird flu and other pandemics in the 1990s and 2000s.[70] This has led some historians to label the Spanish flu a "forgotten pandemic".[17] Various theories of why the Spanish flu was "forgotten" include the rapid pace of the pandemic, which killed most of its victims in the United States, for example, within a period of less than nine months, resulting in limited media coverage. The general population was familiar with patterns of pandemic disease in the late 19th and early 20th centuries: typhoid, yellow fever, diphtheria, and cholera all occurred near the same time. These outbreaks probably lessened the significance of the influenza pandemic for the public.[71] In some areas, the flu was not reported on, the only mention being that of advertisements for medicines claiming to cure it.[72] In addition, the outbreak coincided with the deaths and media focus on the First World War.[73] Another explanation involves the age group affected by the disease. The majority of fatalities, from both the war and the epidemic, were among young adults. The deaths caused by the flu may have been overlooked due to the large numbers of deaths of young men in the war or as a result of injuries. When people read the obituaries, they saw the war or postwar deaths and the deaths from the influenza side by side. Particularly in Europe, where the war's toll was extremely high, the flu may not have had a great, separate, psychological impact, or may have seemed a mere extension of the war's tragedies.[74] The duration of the pandemic and the war could have also played a role. The disease would usually only affect a certain area for a month before leaving, while the war, which most had initially expected to end quickly, had lasted for four years by the time the pandemic struck. This left little time for the disease to have a significant impact on the economy. One final issue that the 1918 Spanish flu outbreak had on the world was the effects on the global economy. Many businesses in the entertainment and service industries suffered losses in revenue, but the health care industry reported profit gains.[75] Historian Nancy Bristow has argued that there was a gendered response of health caregivers to the pandemic in the United States. Male doctors were unable to cure the patients, and they felt like failures. Women nurses also saw their patients die, but they took pride in their success in fulfilling their professional role of caring for, ministering, comforting, and easing the last hours of their patients, and helping the families of the patients cope as well. Spanish flu research The origin of the Spanish flu pandemic, and the relationship between the near-simultaneous outbreaks in humans and swine, have been controversial. One hypothesis is that the virus strain originated at Fort Riley, Kansas, in viruses in poultry and swine which the fort bred for food; the soldiers were then sent from Fort Riley around the world, where they spread the disease.[77] Similarities between a reconstruction of the virus and avian viruses, combined with the human pandemic preceding the first reports of influenza in swine, led researchers to conclude the influenza virus jumped directly from birds to humans, and swine caught the disease from humans.[78][79] Others have disagreed,[80] and more recent research has suggested the strain may have originated in a nonhuman, mammalian species.[81] An estimated date for its appearance in mammalian hosts has been put at the period 1882–1913.[82] This ancestor virus diverged about 1913–1915 into two clades (or biological groups), which gave rise to the classical swine and human H1N1 influenza lineages. The last common ancestor of human strains dates to between February 1917 and April 1918. Because pigs are more readily infected with avian influenza viruses than are humans, they were suggested as the original recipients of the virus, passing the virus to humans sometime between 1913 and 1918. An effort to recreate the 1918 flu strain (a subtype of avian strain H1N1) was a collaboration among the Armed Forces Institute of Pathology, Southeast Poultry Research Laboratory and Mount Sinai School of Medicine in New York City. The effort resulted in the announcement (on 5 October 2005) that the group had successfully determined the virus's genetic sequence, using historic tissue samples recovered by pathologist Johan Hultin from a female flu victim buried in the Alaskan permafrost and samples preserved from American soldiers.[83] On 18 January 2007, Kobasa et al. reported that monkeys (Macaca fascicularis) infected with the recreated strain exhibited classic symptoms of the 1918 pandemic, and died from a cytokine storm[84]—an overreaction of the immune system. This may explain why the 1918 flu had its surprising effect on younger, healthier people, as a person with a stronger immune system would potentially have a stronger overreaction.[85] On 16 September 2008, the body of British politician and diplomat Sir Mark Sykes was exhumed to study the RNA of the flu virus in efforts to understand the genetic structure of modern H5N1 bird flu. Sykes had been buried in 1919 in a lead coffin which scientists hoped to have helped preserve the virus.[86] However, the coffin was found to be split because of the weight of soil over it, and the cadaver was badly decomposed. Nonetheless, samples of lung and brain tissue were taken through the split, with the coffin remaining in situ in the grave during this process.[87] In December 2008, research by Yoshihiro Kawaoka of the University of Wisconsin linked the presence of three specific genes (termed PA, PB1, and PB2) and a nucleoprotein derived from 1918 flu samples to the ability of the flu virus to invade the lungs and cause pneumonia. The combination triggered similar symptoms in animal testing.[88] In June 2010, a team at the Mount Sinai School of Medicine reported the 2009 flu pandemic vaccine provided some cross-protection against the 1918 flu pandemic strain.[89] One of the few things known for certain about the influenza in 1918 and for some years after was that it was, out of the laboratory, exclusively a disease of human beings.[90] In 2013, AIR’s Research and Modeling Group "characterizes the historic 1918 pandemic and estimates the effects of a similar pandemic occurring today using the AIR Pandemic Flu Model". In the model, "a modern day “Spanish flu” event would result in additional life insurance losses of between USD 15.3– 27.8 billion in the United States alone" with 188,000–337,000 deaths in the United States.[91] In popular culture The 2013 film World War Z makes reference to the pandemic.[92] The TV Show, Resurrection, uses the pandemic, in the episode "Afflictions" that aired on November 2, 2014, as the reason why many of the Returned, were getting sick and disappearing. In season four of British drama Upstairs, Downstairs, Hazel Bellamy dies of Spanish Flu in 1918 or 1919, after her husband James Bellamy survives injuries in the Great War (WWI). In season two of British Downton Abbey, Lavinia Swire dies of the Spanish Flu in April 1919, after her fiancé Matthew Crawley recovers from injuries and temporary paralysis from the Great War (WWI). Twentieth century fiction includes at least three novels with the flu pandemic as a major theme: Katherine Anne Porter's Pale Horse, Pale Rider, Thomas Mullen's The Last Town on Earth, and Thomas Wolfe's Look Homeward Angel. Gallery Two American Red Cross nurses demonstrated treatment practices during the influenza pandemic of 1918. Albertan farmers wore masks to protect themselves from the flu. Policemen wearing masks provided by the American Red Cross in Seattle, 1918 A street car conductor in Seattle in 1918 refusing to allow passengers aboard who are not wearing masks Red Cross workers remove a flu victim in St. Louis, Missouri (1918) Influenza ward at Walter Reed Hospital during the Spanish flu pandemic of 1918–1919 Burying flu victims, North River, Canada (1918) Cavalry memorial on the hill Lueg, memory of the Bernese cavalrymen victims of the 1918 flu pandemic; Emmental, Bern, Switzerland References Notes - ^ Institut Pasteur. La Grippe Espagnole de 1918 (Powerpoint presentation in French). - ^ a b c Taubenberger, Jeffery K.; Morens, David M. (January 2006). "1918 Influenza: the Mother of All Pandemics". Centers for Disease Control and Prevention. Archived from the original on 1 October 2009. Retrieved 9 May 2009. - ^ "Historical Estimates of World Population". Retrieved 29 March 2013. - ^ a b c Patterson, KD; Pyle GF (Spring 1991). "The geography and mortality of the 1918 influenza pandemic". Bull Hist Med. - ^ Billings, Molly. "The 1918 Influenza Pandemic". Virology at Stanford University. Archived from the original on 4 May 2009. Retrieved 1 May 2009. - ^ Johnson NP, Mueller J (2002). "Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic". Bull Hist Med 76 (1): 105–15. - ^ a b c d e Barry 2004[page needed] - ^ Vilensky JA, Foley P, Gilman S (August 2007). "Children and encephalitis lethargica: a historical". Pediatr. Neurol. - ^ Valentine, Vikki (20 February 2006). "Origins of the 1918 Pandemic: The Case for France". NPR. Retrieved 2 October 2011. - ^ Anderson, Susan (29 August 2006). "Analysis of Spanish flu cases in 1918–1920 suggests transfusions might help in bird flu pandemic". American College of Physicians. Retrieved 2 October 2011. - ^ Barry, John M. (2004). The Great Influenza: The Epic Story of the Greatest Plague in History. Viking Penguin. - ^ Galvin, John (31 July 2007). "Spanish Flu Pandemic: 1918". Popular Mechanics. Retrieved 2 October 2011. - ^ "EU Research Profile on Dr. John Oxford". Archived from the original on 11 May 2009. Retrieved 9 May 2009. - ^ Connor, Steve, "Flu epidemic traced to Great War transit camp", The Guardian (UK), Saturday, 8 January 2000. Archived 11 May 2009. - ^ 1918 killer flu secrets revealed. BBC News. 5 February 2004. HANNOUN : La Grippe, Ed Techniques EMC (Encyclopédie Médico-Chirurgicale), Maladies infectieuses, 8-069-A-10, 1993. Documents de la Conférence de l'Institut Pasteur : La Grippe Espagnole de 1918. - ^ a b Crosby 2003 - ^ Barry, John. The site of origin of the 1918 influenza pandemic and its public health implications, Journal of Translational Medicine, 2:3. Archived 4 May 2009. - ^ Andrew Price-Smith, Contagion and Chaos, Cambridge, MA: MIT Press, 2009. - ^ Paths of Infection: The First World War and the Origins of the 1918 Influenza Pandemic: http://wih.sagepub.com/content/21/1/55.abstract?patientinform-links=yes&legid=spwih;21/1/55 - ^ 1918 Flu Pandemic That Killed 50 Million Originated in China, Historians Say: http://news.nationalgeographic.com/news/2014/01/140123-spanish-flu-1918-china-origins-pandemic-science-health/ - ^ Film: We Heard the Bells: The Influenza of 1918 (2010). U.S. Department of Health and Human Services, Center for Medicare and Medicaid Services. Retrieved 20 February 2012. - ^ "Influenza 1918". American Experience. Retrieved 17 January 2012. - ^ Avian Bird Flu. 1918 Flu (Spanish flu epidemic). - ^ Spanish flu strikes during World War I, Timelines of great Epidemics, xtimeline.com. - ^ The Influenza Pandemic of 1918 - ^ Channel 4 – News – Spanish flu facts. - ^ a b c Taubenberger, J; Morens D (2006). "1918 Influenza: the mother of all pandemics". Emerg Infect Dis 12 (1): 15–22. Archived from the original on 1 October 2009. Retrieved 28 September 2009. - ^ "1918 Influenza: the Mother of All Pandemics". Cdc.gov. Archived from the original on 1 October 2009. Retrieved 2 September 2009. - ^ Taubenberger, J., Morens, M. (2006). "1918 Influenza Pandemic". CDC EID. Archived from the original on 1 October 2009. Retrieved 14 May 2009. - ^ a b c Knobler 2005, pp. 60–61. - ^ Potter, CW (October 2006). "A History of Influenza". J Appl Microbiol. - ^ Barry, John. “The Great Influenza: The Epic Story of the Deadliest Plague in History.” London: Penguin Books, 2004. - ^ Flu experts warn of need for pandemic plansBritish Medical Journal. - ^ Chandra, S; Kuljanin G; Wray J (2012). "Mortality From the Influenza Pandemic of 1918–1919: The Case of India". Demography 49 (3): 857–65. - ^ "Spanish Influenza in Japanese Armed Forces, 1918–1920". Centers for Disease Control and Prevention (CDC). - ^ Historical research report from University of Indonesia, School of History, as reported in Emmy Fitri. Looking Through Indonesia's History For Answers to Swine Flu. The Jakarta Globe. 28 October 2009 edition. - ^ Kohn, George C. (2008). Encyclopedia of plague and pestilence: from ancient times to the present. Infobase Publishing. - ^ The Great Pandemic: The United States in 1918–1919, U.S. Department of Health & Human Services. - ^ "Flu Epidemic Hit Utah Hard in 1918, 1919". Retrieved 7 July 2012. - ^ "The Great Pandemic of 1918: State by State". Archived from the original on 6 May 2009. Retrieved 4 May 2009. - ^ "A deadly virus rages throughout Canada at the end of the First World War". CBC History. - ^ "A gripe espanhola no Brasil – Elísio Augusto de Medeiros e Silva, empresário, escritor e membro da AEILIJ" (in Portuguese). Jornal de Hoje. Retrieved 22 January 2014. - ^ The "bird flu" that killed 40 million. BBC News. 19 October 2005. "The burdens of disease: epidemics and human response in western history.". - ^ Harold Marcus, Haile Sellassie I: The formative years, 1892–1936 (Trenton: Red Sea Press, 1996), pp. 36f; Pankhurst 1990, p. 48f. - ^ Pankhurst 1990, p. 63. - ^ Pankhurst 1990, p. 51f. - ^ Simonsen, L; Clarke M; Schonberger L; Arden N; Cox N; Fukuda K (July 1998). "Pandemic versus epidemic influenza mortality: a pattern of changing age distribution". J Infect Dis 178 (1): 53–60. - ^ O Hansen, 1923, Undersøkelser om influenzaens opptræden specielt i Bergen 1918–1922 Skrifter utgit ved Klaus Hanssens Fond. Bergen: Medicinsk avdeling, Haukeland Sykehus, 1923: 3. - ^ Barry, John M. 2004. The Great Influenza. Penguin Books. - ^ Key Facts about Swine Influenza [1] accessed 22:45 GMT-6 30 April 2009. Archived 4 May 2009. - ^ UK Parliament – http://www.parliament.the-stationery-office.com/pa/ld200506/ldselect/ldsctech/88/88.pdf. Archived 8 May 2009. - ^ Gladwell, Malcolm. "The Dead Zone". The New Yorker (29 September 1997): 55. - ^ Gladwell, Malcolm. "The Dead Zone". The New Yorker (29 September 1997): 63. - ^ Fogarty International Center. "Summer Flu Outbreak of 1918 May Have Provided Partial Protection Against Lethal Fall Pandemic". Fic.nih.gov. - ^ Gladwell, Malcolm. "The Dead Zone". The New Yorker (29 September 1997): 56. - ^ Fortune article " Viruses of Mass Destruction" written 1 November 2004. accessed 01:12 GMT+1 30 April 2009 - ^ a b DENOON, Donald, “New Economic Orders: Land, Labour and Dependency”, in DENOON, Donald (éd.), The Cambridge History of the Pacific Islanders, Cambridge University Press, 2004, ISBN 0-521-00354-7, p. 247. - ^ Rice, Geoffrey W. (2005). Black November; the 1918 Influenza Pandemic in New Zealand. University of Canterbury Press. - ^ World Health Organization Writing Group (2006). "Nonpharmaceutical interventions for pandemic influenza, international measures". Centers for Disease Control and Prevention (CDC) Emerging Infectious Diseases (EID) Journal 12 (1): 189. - ^ Anne Grant, History House, Portland. Influenza Pandemic 1919. Portland Victoria. - ^ Ryan, Jeffrey, ed. Pandemic influenza: emergency planning and community preparedness. Boca Raton : CRC Press, 2009. - ^ a b Karen M. Starko (2009). "Salicylates and Pandemic Influenza Mortality, 1918–1919, Pharmacology, Pathology, and Historic Evidence". Clinical Infectious Diseases 49 (9): 1405–1410. - ^ a b Noymer et al.; Carreon, Daisy; Johnson, Niall (2010). "Questioning the salicylates and influenza pandemic mortality hypothesis in 1918–1919". Clinical infectious diseases 50 (8): 1203. - ^ Karen Starko (2010). "Reply to Noymer et al". Clinical infectious diseases 50 (8): 1203. - ^ Andrew Price-Smith, Contagion and Chaos, MIT Press, 2009. - ^ Honigsbaum - ^ Morrisey, Carla R. "The Influenza Epidemic of 1918." Navy Medicine 77, no. 3 (May–June 1986): 11–17. - ^ Benedict, Michael Les; Braithwaite, Max (2000). "The Year of the Killer Flu". In the face of disaster: true stories of Canadian heroes from the archives of Maclean's. New York, N. Y: Viking. - ^ Simonsen, L; Clarke M, Schonberger L, Arden N, Cox N, Fukuda K (Jul 1998). "Pandemic versus epidemic influenza mortality: a pattern of changing age distribution." - ^ Garrett 2007 - ^ Nancy K. Bristow, American Pandemic: The Lost Worlds of the 1918 Influenza Epidemic (Oxford University Press, 2012) p 13, ch 4 - ^ Spanish Influenza in North America, 1918–1919 Harvard Open Collections - ^ Sometimes a virus contains both avian-adapted genes and human-adapted genes. Both the H2N2 and H3N2 pandemic strains contained avian flu virus RNA segments. "While the pandemic human influenza viruses of 1957 (H2N2) and 1968 (H3N2) clearly arose through reassortment between human and avian viruses, the influenza virus causing the 'Spanish flu' in 1918 appears to be entirely derived from an avian source (Belshe 2005)." (from Chapter Two: Avian Influenza by Timm C. Harder and Ortrud Werner, an excellent free on-line book called Influenza Report 2006 which is a medical textbook that provides a comprehensive overview of epidemic and pandemic influenza.) - ^ Taubenberger JK, Reid AH, Lourens RM, Wang R, Jin G, Fanning TG (October 2005). "Characterization of the 1918 influenza virus polymerase genes". - ^ Antonovics J, Hood ME, Baker CH (April 2006). "Molecular virology: was the 1918 flu avian in origin?". Nature 440 (7088): E9; discussion E9–10. - ^ Vana G, Westover KM (June 2008). "Origin of the 1918 Spanish influenza virus: a comparative genomic analysis". Molecular Phylogenetics and Evolution 47 (3): 1100–10. - ^ Dos Reis M, Hay AJ, Goldstein RA.(2009) Using Non-Homogeneous Models of Nucleotide Substitution to Identify Host Shift Events: Application to the Origin of the 1918 'Spanish' Influenza Pandemic Virus. J Mol Evol - ^ Center for Disease Control: Researchers Reconstruct 1918 Pandemic Influenza Virus; Effort Designed to Advance Preparedness Retrieved on 2 September 2009 - ^ Kobasa, Darwyn; et al. (2007). "Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus". - ^ USA Today: Research on monkeys finds resurrected 1918 flu killed by turning the body against itself Retrieved on 14 August 2008. - ^ BBC News: Body exhumed in fight against flu Retrieved on 16 September 2008. - ^ BBC Four documentary. In Search of Spanish Flu - ^ Fox, Maggie (29 December 2008). "Reuters. December 29, 2008. Researchers unlock secrets of 1918 flu pandemic.". Reuters. Retrieved 2 September 2009. - ^ Fox, Maggie (16 June 2010). "Swine flu shot protects against 1918 flu: study". Reuters. - ^ Crosby, Alfred. “America’s Forgotten Pandemic: The Influenza of 1918.” New York: Cambridge University Press, 1989. - ^ By Nita Madhav, M.S.P.H.; Edited by Molly J. Markey, Ph.D. (February 21, 2013). "Modeling a Modern-Day Spanish Flu Pandemic". AIR’s Research and Modeling Group. Retrieved 5 August 2014. - ^ http://www.moviequotesandmore.com/world-war-z-quotes.html Bibliography - Barry, John M. (2004). The Great Influenza: The Epic Story of the Greatest Plague in History. Viking Penguin. - Bristow, Nancy K. American Pandemic: The Lost Worlds of the 1918 Influenza Epidemic (Oxford University Press, 2012) - Collier, Richard (1974). The Plague of the Spanish Lady – The Influenza Pandemic of 1918–19. USA: Atheneum. - Crosby, Alfred W. (1976). Epidemic and Peace, 1918. Westport, Ct: Greenwood Press. - Crosby, Alfred W. (2003). America's Forgotten Pandemic: The Influenza of 1918 (2 ed.). Cambridge: Cambridge University Press. - Duncan, Kirsty (2003). Hunting the 1918 flu: one scientist's search for a killer virus (illustrated ed.). University of Toronto Press. - Ewald, Paul. Evolution of infectious disease, New York, Oxford University Press, 1994. - Garrett TA (2007), Economic Effects of the 1918 Influenza Pandemic: Implications for a Modern-day Pandemic, Retrieved from http://www.stlouisfed.org/community_development/assets/pdf/pandemic_flu_report.pdf on 11/4/2010 - Honigsbaum, Mark. Living with Enza: The Forgotten Story of Britain and the Great Flu Pandemic of 1918, ISBN 978-0-230-21774-4. - Knobler S, Mack A, Mahmoud A, Lemon S (ed.). "1: The Story of Influenza". The Threat of Pandemic Influenza: Are We Ready? Workshop Summary (2005). Washington, D.C.: The National Academies Press. - Pankhurst, Richard. An Introduction to the Medical History of Ethiopia. Trenton: Red Sea Press, 1990 - Phillips, Howard. "The re-appearing shadow of 1918: trends in the historiography of the 1918-19 influenza pandemic." Canadian Bulletin of Medical History/Bulletin canadien d'histoire de la médecine (2010) 21#1: 121-134. Further reading - Barry, John M. (2004). The Great Influenza: The Epic Story of the Deadliest Plague in History. Viking Press. - Beiner, Guy (2006). "Out in the Cold and Back: New-Found Interest in the Great Flu". Cultural and Social History 3 (4): 496–505. - Humphries, Mark Osborne. The Last Plague: Spanish Influenza and the Politics of Public Health in Canada (University of Toronto Press; 29013) examines the public-policy impact of the 1918 epidemic, which killed 50,000 Canadians. - Johnson, Niall (2006). Britain and the 1918–19 Influenza Pandemic: A Dark Epilogue. London and New York: Routledge. - Johnson, Niall (2003). "Measuring a pandemic: Mortality, demography and geography". Popolazione e Storia: 31–52. - Johnson, Niall (2003). "Scottish 'flu – The Scottish mortality experience of the "Spanish flu". Scottish Historical Review 83 (2): 216–226. - Johnson, Niall; Juergen Mueller (2002). "Updating the accounts: global mortality of the 1918–1920 'Spanish' influenza pandemic". Bulletin of the History of Medicine 76 (1): 105–15. - Kolata, Gina (1999). Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It. New York: Farrar, Straus and Giroux. - Little, Jean (2007). If I Die Before I Wake: The Flu Epidemic Diary of Fiona Macgregor, Toronto, Ontario, 1918. Dear Canada. Markham, Ont.: Scholastic Canada. - Noymer, Andrew; Michel Garenne (2000). "The 1918 Influenza Epidemic's Effects on Sex Differentials in Mortality in the United States". Population and Development Review 26 (3): 565–581. - Oxford JS, Sefton A, Jackson R, Innes W, Daniels RS, Johnson NP (2002). "World War I may have allowed the emergence of "Spanish" influenza". The Lancet infectious diseases 2 (2): 111–4. - Oxford JS, Sefton A, Jackson R, Johnson NP, Daniels RS (1999). "Who's that lady?". Nat. Med. - Pettit, Dorothy; Janice Bailie (2008). A Cruel Wind: Pandemic Flu in America, 1918–1920. Murfreesboro, TN: Timberlane Books. - Phillips, Howard; David Killingray (eds) (2003). The Spanish Flu Pandemic of 1918: New Perspectives. London and New York: Routledge. - Rice, Geoffrey W.; Edwina Palmer (1993). "Pandemic Influenza in Japan, 1918–1919: Mortality Patterns and Official Responses". Journal of Japanese Studies 19 (2): 389–420. - Rice, Geoffrey W. (2005). Black November: the 1918 Influenza Pandemic in New Zealand. Canterbury University Press: Canterbury Univ. Press. - Tumpey TM, García-Sastre A, Mikulasova A, et al. (2002). "Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus". Proc. Natl. Acad. Sci. External links - Nature "Web Focus" on 1918 flu, including new research - Influenza Pandemic on stanford.edu - The Great Pandemic: The U.S. in 1918–1919. US Dept. of HHS - The American Influenza Epidemic of 1918–1919: A Digital Encyclopedia Largest digital collection of newspapers, archival manuscripts and interpretive essays exploring the impact of the epidemic on 50 U.S. cities (Univ. of Michigan). - Little evidence for New York City quarantine in 1918 pandemic. 27 Nov 2007 (CIDRAP News) - Flu by Eileen A. Lynch. The devastating effect of the Spanish flu in the city of Philadelphia, PA, USA - Dialog: An Interview with Dr. Jeffery Taubenberger on Reconstructing the Spanish Flu - The Deadly Virus – The Influenza Epidemic of 1918 US National Archives and Records Administration – pictures and records of the time - The 1918 Influenza Pandemic in New Zealand – includes recorded recollections of people who lived through it - PBS – recovery of flu samples from Alaskan flu victims - An Avian Connection as a Catalyst to the 1918–1919 Influenza Pandemic - Fluwiki.com Annotated links to articles, books and scientific research on the 1918 influenza pandemic - Alaska Science Forum – Permafrost Preserves Clues to Deadly 1918 Flu - Pathology of Influenza in France, 1920 Report - Yesterday's News blog 1918 newspaper account on impact of flu on Minneapolis - "Study uncovers a lethal secret of 1918 influenza virus" University of Wisconsin – Madison, 17 January 2007 - Spanish Influenza in North America, 1918–1919 - 1918 Influenza Virus and memory B-cells – Exposure to virus generates lifelong immune response. - Influenza Research Database – Database of influenza genomic sequences and related information. - Spanish Flu with rare pictures from Otis Historical Archives - "No Ordinary Flu" a comic book of the 1918 flu pandemic published by Seattle & King County Public Health - "Influenza 1918" The American Experience (PBS) - "Closing in on a Killer: Scientists Unlock Clues to the Spanish Influenza Virus" An online exhibit from the National Museum of Health and Medicine. - Sources for the study of the 1918 influenza pandemic in Sheffield, UK Produced by Sheffield City Council's Libraries and Archives - Booknotes interview with Gina Kolata on Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It, 27 February 2000.