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Стволовите клетки и тяхното съхранение Какво представляват стволовите клетки ? Стволовите клетки са изграждащите елементи на нашия организъм. Те имат потенциала да се трансформират в друг тип клетки на тялото ни – клетки от кръвта, сърцето, костите, кожата, мускулите, мозъка, както и всички тъкани, които ни правят това, което сме. Стволовите клетки са клетки, откривани в повечето, ако не във всички многоклетъчни организми. Те се характеризират със способността да се самовъзстановяват чрез митотично клетъчно делене и да се диференцират до различни класове от специализирани клетъчни типове. Изследователи в областта на медицината вярват, че изследването на стволовите клетки има потенциал да промени борбата с болестите при човека, като се използва за поправка на определени тъкани или за отглеждане на органи. При бозайниците стволовите клетки са два основни типа: ембрионални стволови клетки, които се откриват в бластоцистите и възрастни стволови клетки, откривани в зрелите тъкани. В развиващият се ембрион, стволовите клетки могат да се диференцират във всички от специализираните ембрионални тъкани. При възрастните организми, стволовите клетки и клетките от първоизточника действат като система за възстановяване на тялото, заменяща специализираните клетки, но също така и поддържа нормалната реорганизация на регенерираните органи, като кръв, кожа или интестинални тъкани. Новата техника може да доведе до производство на сърдечна тъкан от клетъчен материал на пациента, което ще премахне нуждата от намиране на подходящ донор и ще намали вероятността от имунна реакция. Важно! В случай, че имате нужда от професионални SEO услуги и платени публикации в силни сайтове, без значение от тематиката, то можете да ни пишете на e-mail: office@w-seo.com или да се свържете с нас на GSM: 088 999 62 62 Future Health Technologies е първата семейна банка в Европа притежаваща пълна акредитация ,която има право да извършва поръчки, тестове, изследвания, обработка, съхранение, внос и износ на човешки тъкани и клетки. Кръвта от пъпната връв се транспортира, чрез одобрени медицински куриери, в специална кутия за временно съхраняване, която поддържа пробата на стайна температура – (IАТА UN3373). На всяка проба от кръв и пъпна връв се правят подробни изследвания, гарантиращи качеството, виталността и стерилността й. Обработка се осъществява в специално построените стерилни стаи в лабораториите, собственост на Future Health Technologies (клас В чистота на помещенията, клас А въздушен поток в работните зони). По официални данни на Изпълнителна Агенция по Трансплантация, Future Health е банката с най-много съхранени проби от кръв и тъкан от пъпна връв в България за 2014 год. Осигурете си спокойно бъдеще! Здравето е наша отговорност! Съвременната медицина прилага използването на хемопоетични стволови клетки /от кръв от пъпната връв / в лечението на над 85 вида заболявания на имунната система ,а над 400 заболявания се третират с този вид стволови клетки. Кръвта от пъпна връв е богата на хемопоетични стволови клетки, чието приложение е рутинна практика в медицинските среди за заболявания като левкемия , анемия, лимфоми, болест на Ходжкинс и много др.Хемопоетичните стволови клетки имат редица предимства пред тези от извлечени от костен мозък. 1.Кръвта от пъпна връв е много по-наситена с хемопоетични стволови клетки на обемна основа; 2.Стволовите клетки от кръв от пъпна връв са с пълна или висока съвместимост при трансплантация; 3.Извличането на кръв от пъпна връв е абсолютно безопасно , бързо и не причинява дискомфорт; 4. Имат по-малка имунологична зрялост, в резултат на което трансформацията им в друг тип клетка е много по-лесна. Някои наследствени заболявания успешно се лекуват посредством използването на хемопоетични клетки. Заболяванията, лекувани с помощта на стволови клетки, могат да се разделят на три групи: -Стандартни терапии -Терапии на етап клинично проучване -Експериментални лечения Стандартни терапии Това са заболявания, при които трансплантацията на стволови клетки (трансплантация на хематопоетични стволови клетки, HSCT) е стандартно лечение. За някои от тези заболявания това е единствената терапия, в други случаи се прилагат само след изчерпване на обичайните възможности за лечение или заболяването е изключително агресивно. Повечето от заболяванията, за които HSCT е стандартно лечение са разстройства, свързани с кръвните клетки – от стволови клетки в костния мозък до специфични видове клетки в кръвта. В САЩ, повечето застрахователи заплащат трансплантациите на стволови клетки ако диагнозата на пациента е в групата на “стандартните терапии”. Почти всички стандартни терапии са алогенни, при които пациентът трябва да има подходящ донор. Единственото изключение са пациентите, при които се прави трансплантация поради големи тумори или придобити анемии. Терапии на етап клинично проучване Това са заболявания, при които леченията със стволови клетки са показали добри резултати, но не са одобрени като стандартни терапии. При някои от тези заболявания, трансплантацията на стволови клетки само забавя развитието на болестта, но не предлага лечение. При други болести стволовите клетки могат да помогнат за излекуване, но са необходими допълнителни проучвания за определяне на типа пациенти, подходящи за подобно лечение, оптималната доза стволови клетки, оптималния метод за доставяне на клетките и т.н.Етапите на клиничното проучване са следните: Етап 1: Проучване на безопасността – показва дали процедурата или лекарството се приема добре от организма. Етап 2: По-широко проучване за измерване на ефективността на новото лечение в сравнение с контролна група. Етап 3: Още по-широко проучване за сравнение на ефектите на различни параметри като дозировка, метод на приложение, както и за наблюдаване на странични ефекти преди пускане на пазара. Етап 4: Проучване след пускане на пазара за наблюдение на рискове, ползи, оптимална употреба. Леченията със стволови клетки на заболявания на етап клинично проучване са както алогенни, така и автоложни. Експериментални лечения Това са разстройства, при които не е доказано, че лечението със стволови клетки е ефективно при хора. Проучванията се извършват или в лабораторни условия върху клетъчни култури, или с животни. При експерименталните проучвания често не се знае дали една евентуална бъдеща терапия ще бъде автоложна или алогенна. Чрез съхранението на стволови клетки на Вашето дете, Вие гарантирате, че при нужда от трансплантация на стволови клетки – детето или генетично свързан член на семейството винаги ще има уникален достъп до пробата. Стволовите клетки ще бъдат криосъхранени и съхранени само за вашето семейство и никой друг няма право да получи пробата без Ваше позволение. Попитайте вашия гинеколог – той най-компетентно може да Ви запознае с ползите от съхранението на стволови клетки. Future Health осигурява финансова подкрепа в случай на трансплантация на стволовите клетки.
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Stem cells are considered the “master cells” of the body. These immature cells have the remarkable potential to develop into many different types of cells that make up our blood, tissue, organs, and immune system.1 Stem cells also act as an internal repair system by repeatedly dividing to replenish other cells as they die or are damaged.1 Where can you obtain stem cells come from? Stem cells may be found in many places, including the bone marrow, cord blood and tissue, and placental blood and tissue.2 These stem cells are known as multipotent stem cells, which means they can give rise to multiple types of cells.3 The controversy around stem cell research was sparked by a different kind of stem cell, known as an embryonic stem cell.4 The stem cells collected from the cord and placenta are not embryonic and are non-controversial. What are the different types of stem cells? The two main types of stem cells are hematopoetic stem cells and mesenchymal stem cells. Hematopoietic stem cells (HSCs):5 - Differentiate into any type of blood cell, including white and red blood cells and platelets - Are found in umbilical cord blood, placental blood, bone marrow, and peripheral blood - Have been used as medical treatment for over 25 years and for up to 80 different diseases, particularly for cancers of the blood6 Mesenchymal stem cells (MSCs):7 - Can differentiate into nerve cells as well as bone, cartilage, muscle, and fat - Are found in placental tissue, where they are genetically unique to the mother - Are found in umbilical cord tissue, where they are a genetic match to the baby - Are currently being researched for the treatment of diseases such as diabetes, heart disease, liver disease, stroke damage, and spinal cord injury8 A stem cell transplant is a type of medical treatment that offers the possibility of replacing diseased blood-forming cells (called hematopoietic stem cells) with healthy ones.9 Stem cell transplants can use stem cells that have been collected from cord blood, bone marrow, or peripheral (circulating) blood. But there are many advantages for certain people to have cord blood stem cell transplants. Stem cells for transplantation can come from: - The person having the procedure (“autologous transplants”) - An unrelated matched donor (“unrelated allogeneic transplant”) - A related matched donor (“related allogeneic transplant”) Stem cell treatment for cancer For people with leukemia, lymphoma, myeloma, myelodysplastic syndromes (MDS), and other blood cancers, a stem cell transplant will typically follow chemotherapy or radiation treatment.10 The procedure can also be beneficial for people with other inherited or acquired bone marrow or immune system disorders. Stem cell transplant procedure The stem cell transplant procedure itself has 4 key steps:9 - Stem cell collection, from either banked cord or placental blood, bone marrow, or PBSC - Patient Preparation, including chemotherapy with or without radiation - Transplantation, whereby the stem cells are put into the patient’s body through the veins - Recovery, which can last weeks to months Every 2 minutes a child is diagnosed with cancer.11 Many families have no prior history of the disease, which may require treatment with stem cell transplants. In addition, stem cells are actively being studied in an emerging medical field called regenerative medicine. So your family could potentially benefit from future stem cell-related treatments. Cord blood banking enables parents to save stem cells from the umbilical cord blood of their child immediately after birth. Families preserve these cells so that they are available for use in existing and future medical treatments. When expectant parents are considering the pros and cons of cord blood banking, the cost of private banking is often a source of concern. With enrollment, collection, processing, and storage fees, it’s understandable to wonder, “Is cord blood banking worth it?”—especially at a time when the regular costs of having and taking care of a new baby are looming. Cord blood banking can be thought of as “biological insurance” for your child and your family’s future health. Your child or a family member has a 1 in 200 chance of needing a stem cell transplant during their lifetime.12 Paying $123 to $150 a year for cord blood banking with LifebankUSA (in addition to a collection fee) is a lot less than the cost of other insurance policies we don’t hesitate to buy, such as life, health, property, or car insurance. Consider your family history The case for whether cord blood banking is worth it becomes even stronger if there's already a family history of one of the diseases currently treatable with cord blood, including leukemia, lymphomas, sickle cell anemia, and immune deficiency diseases, among others. With a family history of one of these diseases, your family's chances of needing a stem cell transplant at some point in the future are higher than the general population's. Planning for more than one child? You may find the idea of cord blood banking particularly reassuring if you have or plan to have more than one child. Your baby’s cord blood stem cells can be used for siblings and other family members. Your baby’s stem cells have a 25% chance of being a perfect genetic match and a 50% chance of being a partial genetic match for your baby’s brother or sister. So you’re not just banking for your baby’s benefit, but truly for your whole family. Plan for the future Like other insurance, cord blood banking provides security, in this case against a number of life-threatening diseases – and that can be considered priceless. By adding placental blood, placental tissue, and cord tissue to your cord blood collection, you’re increasing the odds of your family being able to take advantage of future medical advancements as they become available, including regenerative medicine. Public cord blood banking is free. The cost of cord blood banking with a private bank varies from company to company. LifebankUSA has a range of pricing options across our banking services to meet your family’s individual needs. The cost of cord blood banking with LifebankUSA starts at $1,750 for enrollment, collection and processing, and the first year of storage. Thereafter, storage fees start at $125 a year (when prepaid for 25 years). Our comprehensive banking options allow your family to take advantage of more of the benefits of both today’s and tomorrow’s stem‑cell‑based medical treatments. Adding placental blood, placental tissue, or cord blood tissue to your cord blood collection will be reflected in the associated costs. Learn more about our comprehensive banking services and their associated prices. Ways to help manage the cost To help your family manage the cost of cord blood banking and our other banking services, LifebankUSA offers several cost-saving programs, including: - LifebankUSA Gift Registry: Receive contributions from friends and family members toward the cost of banking - Refer a Friend, Get a Gift: For every person you refer who signs up and banks stem cells with LifebankUSA, you’ll receive a $150 Amazon gift card - Bank Again at a Discount: Call for a discount on enrollment when you bank with us a second (or third!) time How are stem cells processed? When considering the cost of cord blood banking, it can be helpful to understand just where your money will go. LifebankUSA uses state-of-the-art collection, processing, and storage methods to help ensure that your baby’s stem cells are preserved for the long term, giving you immediate access if you should need them. LifebankUSA’s heparin-free collection process uses an FDA-recommended cell-protecting solution called citrate phosphate dextrose (CPD), which allows cells to maintain their integrity in the time between collection and processing. LifebankUSA removes red blood cells, which have no therapeutic benefit and can lead to transplant complications13, from cord blood through a customized process called “red blood cell depletion”. Our process ensures that the cord blood units are 99% pure* on average.14 Our trained technicians manually separate red blood cells from stem cells, giving your collection the personalized attention it deserves. Other cord blood banks use an automated process and may have purity levels as low as 71%.15,16 *Purity is defined as the absence of red blood cells in cord blood. With LifebankUSA, you can bank more stem cells—and more life-saving opportunities—by collecting from three stem-cell-rich sources: placental blood, cord blood, and placental tissue. Placental blood banking preserves potent stem cells from the blood of the placenta, and provides a greater number of stem cells for your family. Transplanting more stem cells has been shown to increase the probability of transplant success and survival.17,18,19 In the near future, having more cells available may also prove beneficial for new treatments in an emerging medical field called regenerative medicine.20,21,22 Placental blood banking gives you and your family the opportunity to take advantage of today's medical treatments, should you need them, and tomorrow's emerging medical advancements as they become reality. When you bank with LifebankUSA, we give you the option to add placental tissue banking. Placental tissue contains mesenchymal-like stem cells, which may one day be useful for regenerative medicine therapies.20,21,22 At birth, a baby is still attached to its mother by the umbilical cord, which is part of the placenta.23 Clamping the umbilical cord is the procedure typically used to separate the newborn baby from the placenta. For many years, it has been common practice to clamp the umbilical cord shortly after the baby is born (within 15 to 30 seconds) in order to help reduce the risk of maternal bleeding.1,23,24 Recently, however, the timing of cord clamping has been revisited. Delayed cord clamping (at least 30 to 60 seconds after birth) allows continued blood flow between the placenta, the umbilical cord, and the baby.23,25 Recent research has found that this can offer benefits to the baby. For instance, delayed cord clamping can improve iron stores in the first few months of life, possibly benefiting the baby’s later development.24 The benefits are even more pronounced in pre-term babies.26 In light of the mounting research in favor of delayed cord clamping, the American College of Obstetricians and Gynecologists now recommends a delay in umbilical cord clamping for at least 30 to 60 seconds after birth.27 Of course, the decision of whether or not to delay cord clamping should ultimately be made by the parents after discussing all the possible pros and cons with their doctor. There’s a lot of recent discussion about delayed cord clamping vs. cord blood banking. The concern is that a delay in clamping the umbilical cord leaves less blood in the cord and placenta, resulting in fewer stem cells in your collection. The point of delayed cord clamping is to allow some of the stem-cell-rich blood from the umbilical cord to flow into the newborn baby. This is most likely to happen within the first 30 to 60 seconds after birth.23 Research has found that delaying cord clamping by 20 seconds or more leads to a significant decrease (several hundred million cells fewer) in the recovered cell count.28 However, even though there is less cord blood, and therefore fewer stem cells, with delayed cord clamping, you can still collect a meaningful, albeit smaller, number of stem cells. If you decide on delayed cord clamping with advice from your doctor, then there’s even more reason to consider placental blood banking in addition to your cord blood collection. Banking placental blood increases the total number of stem cells collected. LifebankUSA is the only stem cell bank that offers expectant parents the opportunity to collect stem cells from the placental blood. Ultimately, the decision of whether or not to delay cord clamping should be made by the parents after discussing all the possible pros and cons with their doctor. Absolutely! The entire process is performed by your own healthcare provider, is non-invasive, and only takes about 5 minutes. Once your baby is born and the umbilical cord has been cut, your healthcare provider will collect blood from the portion of the cord still attached to the placenta. If you are banking placental stem cells, the entire placenta will be collected separately and placed into a special bag. The collection kit will then be transported by medical courier to the LifebankUSA laboratories for processing and preservation. The stem cells will be cryopreserved in a vapor-phase liquid nitrogen storage tank that is continuously monitored 24 hours a day, 7 days a week until the time when your family may need them. Learn more about the collection process. Once a family makes a donation, assuming it meets collection standards, the stem cells become available for any potential matching patient or for research. There's no way to guarantee access to your child’s stem cells (a perfect genetic match) at a later date. It's possible, but public banks rely on donations and cannot guarantee that a good genetic match will be available. Unfortunately, many patients who need stem cell transplants don't receive them because they are unable to find a suitable match from a public bank.29 Private stem cell banking ensures that you have immediate access to an adequate number of stem cells that are a perfect genetic match for your child.* In addition, your baby's stem cells have a much greater likelihood of providing a good match for other close blood relatives. *For some diseases and genetic conditions, children will not be able to use their own stem cells and would require a stem cell transplant from a sibling or unrelated donor. A close family member is a first-degree (parent, sibling, or child) or second-degree relative (half-sibling, aunt, uncle, niece or nephew, grandparent, or grandchild). Cousins, great-grandparents, and great-grandchildren do not fall into this category. The sooner, the better! As soon as you enroll to take advantage of this once-in-a-lifetime opportunity, we will mail you your collection kit so you have it well in advance of your baby’s birth.