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Категории: Билкови екстракти, Мастни киселини Марка: Nature's Bounty Разфасовка: 60 гелкапсули Вечерната иглика е диво цвете, което расте в Северна Америка, Европа и някои части на Азия. Семената на това растение (Oenothera biennis) съдържат масло, което е богато на гама-линоленова киселина (GLA), която е от съществено значение за омега-6 мастната киселина (ЕСА). Тялото GLA се преобразува в простагландини вещества, които функционират като хормони и помагат за регулиране на телесните процеси. Маслото от Вечерна иглика често се препоръчва като алтернативно лечение на пременструален синдром, симптомите на менопаузата, болки в гърдите (mastalgia) и възпалителни заболявания като екзема, атопичен дерматит, ревматоиден артрит и диабетна невропатия. Теоретично, тя е полезна: GLA се превръща в съставна част, известна като дихомо-гама-линоленова киселина (DGLA), която се използва от организма да произвежда простагландини с противовъзпалително действие. В действителност, обаче, клиничните изпитания върху хора са имали различни резултати. Това може да се дължи на границите на дозите, използвани в различните проучвания. Например, последните изследвания стигат до заключението, че от GLA в допълнение, касис или вечерна иглика има облекчаващо действие върху ревматичните оплаквания, но само в дози, равни на/над 1400mg GLA на ден. По-ниските дози (т.е. 500мг/ден) не са ефективни. Да вземем друг пример, едно скорошно изследване показа, че Вечерната иглика може да помогне за намаляването на някои (но не всички) на симптомите на атопичния дерматит - вид на екзема, която води до сърбеж, зачервяване, възпалена кожа. Отрицателни проучвания на Вечерната иглика (или други източници на GLA), не съществуват. GLA допълнението изглежда е относително безопасна намеса, дори и за малки деца. Има също така и някои предварителни данни от опити с животни, които показват, че приема на вечерна иглика може да подобри диабетната невропатия, както и микроваскуларните усложнения. В допълнение, Вечерната иглика може да инхибира резорбцията на костите и да предпази от остеопороза. Същото нещо може да се каже и за използването на маслото от Вечерна иглика за лечение на рак или сърдечно-съдово заболяване. Ин витро проучвания показват, че GLA има цитотоксични ефекти срещу някои видове ракови клетки, както и че може да разширя дейността на противоракови лекарства, но това изследване е все още предварително. Също така, опитите върху животни показват Вечерната иглика има антикоагулантни ефекти и може да забави развитието на атеросклеротичните лезии. Маслото от Вечерна иглика често се разглежда като добавка за жените, поради известността си за облекчаване на менструални / менопауза оплаквания. За съжаление, има малко твърди доказателства, че Вечерната иглика е полезно за лечение на цикличен mastalgia, пременструален синдром (PMS) или съпътстващите менопаузата горещи вълни. Маслото от Вечерна иглика се предлага, като капсули и в течна форма. Страничните ефекти не са чести, но може да включват подуване на корема и абдоминален дискомфорт в малък процент от хората. За минимизиране на неприятни странични ефекти от използването на капсулите вечер е най-добре да ги приемате с храна. Добавка масло от Вечерна иглика не се препоръчва за бременни жени и хора с конвулсивни нарушения. Купи Цена: 15 лв. Посочените цени са крайни с включено ДДС.
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Gammalinolenic acid + rheumatoid arthritis by Nathan Wei, MD, FACP, FACR Nathan Wei is a nationally known board-certified rheumatologist and author of the Second Opinion Arthritis Treatment Kit. It's available exclusively at this website... not available in stores. Click here: Second Opinion Arthritis Treatment Kit Gamma-linolenic acid (GLA) is an essential fatty acid (EFA) in the omega-6 family that is found primarily in plant-based oils. EFAs are essential to human health but cannot be made in the body. For this reason, they must be obtained from food. EFAs are needed for normal brain function, growth and development, bone health, stimulation of skin and hair growth, regulation of metabolism, and maintenance of reproductive processes. Linoleic acid (LA), another omega-6 fatty acid, is found in cooking oils and processed foods and converted to GLA in the body. GLA is then broken down to arachidonic acid (AA) and/or another substance called dihomogamma-liolenic acid (DGLA). AA can also be consumed directly from meat, and GLA is available directly from evening primrose oil (EPO), black currant seed oil, and borage oil. Most of these oils also contain some linoleic acid. The average North American diet provides more than 10 times the necessary amount of linoleic acid and tends to have too much omega-6 fatty acids compared to omega-3 fatty acids, another important class of EFAs. In fact, for optimum health, the ratio of omega-6 to omega-3 fatty acids should be between 1:1 and 4:1. The typical North American and Israeli diets are usually in the range of 11:1 to 30:1. This imbalance contributes to the development of long-term diseases such as heart disease, cancer, asthma, arthritis, and depression as well as, possibly, increased risk of infection. Interestingly, not all omega-6 fatty acids behave the same. Linoleic acid (not to be confused with alpha-linolenic acid, which is in the omega-3 family) and arachidonic acid (AA) tend to be unhealthy because they promote inflammation, thereby increasing the risk of the diseases mentioned when consumed in excess. In contrast, GLA may actually reduce inflammation. Much of the GLA taken from the oils mentioned or as a supplement is not converted to AA, but rather to DGLA. DGLA competes with AA and prevents the negative inflammatory effects that AA would otherwise cause in the body. Having adequate amounts of certain nutrients in the body (including magnesium, zinc, and vitamins C, B3, and B6) helps to promote the conversion of GLA to DGLA rather than AA. It is important to know that many experts feel that the science supporting the use of omega-3 fatty acids to reduce inflammation and prevent diseases is much stronger than the information regarding use of GLA for these purposes. Two important, and most studied, omega-3 fatty acids include eicosopentaenoic acid (EPA) and docosahexaenoic acid (DHA), both found in fish and fish oils. Some preliminary information indicates that GLA, from EPO, borage oil, or black currant seed oil, may diminish joint pain, swelling, and morning stiffness. GLA may also allow for reduction in the amount of pain medication used by those with rheumatoid arthritis. The studies to date, however, have been small in size. Additional research would be helpful, including testing a proposed theory that using GLA and EPA (an omega-3 fatty acid from fish and fish oil) together would be helpful for rheumatoid arthritis. In the meantime, talk to your doctor about whether using GLA is safe for you and then pay attention, over 1 to 3 months of use, to whether your symptoms get better or not. In terms of borage oil, some researchers theorize that it may not be safe to use with non-steroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, which are commonly used for arthritis). This theory needs to be tested. GLA is found in the plant seed oils of evening primrose, black currant, borage, and fungal oils. Spirulina (often called blue-green algae) also contains GLA. GLA supplements are derived from evening primrose oil (EPO) as well as black currant seed and borage seed oils. The GLA supplements are often packaged in oil containing capsules. EPO has been the most researched source of GLA. Generally, high-quality oil will be certified as organic by a reputable third party, packaged in light-resistant containers, refrigerated, and marked with a freshness date. For general health, there should be a balance between omega-6 and omega-3 fatty acids; the ratio should be in the range of 1:1 to 4:1; the typical North American diet, however, normally provides ratios from 11:1 to 30:1. • The recommended dosage for rheumatoid arthritis is 1,400 mg per day of GLA or 3,000 mg of EPO. • Studies have suggested that up to 2,800 mg of GLA per day is well tolerated. Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable healthcare provider. Omega-6 supplements, including GLA and EPO, should not be used if you have a seizure disorder because there have been reports of these supplements inducing seizures. Borage seed oil, and possibly other sources of GLA, should not be used during pregnancy because they may be harmful to the fetus and induce early labor. Doses of GLA greater than 3,000 mg per day should be avoided because, at that point, production of AA (rather than DGLA) may increase. If you are currently being treated with any of the following medications, you should not use GLA without first talking to your healthcare provider. GLA may increase the effectiveness of ceftazidime, an antibiotic in a class known as cephalosporins, against a variety of bacterial infections. GLA may increase the effects of anti-cancer treatments, such as doxorubicin, cisplatin, carboplatin, idarubicin, mitoxantrone, tamoxifen, vincristine, and vinblastine. Taking omega-6 fatty acids, such as GLA, during therapy with cyclosporine, a medication used to suppress the immune system after an organ transplant, for example, may increase the immunosuppressive effects of this medication and may protect against kidney damage (a possible side effect from this medication). Theoretically, use of NSAIDs, such as ibuprofen, together with borage oil or other GLA containing supplements may counteract the effects of the supplement. Research in this area is needed to know if this theory is accurate. Individuals taking a class of medications called phenothiazines (such as chlorpromazine, fluphenazine, perphenazine, promazine, and thioridazine) to treat schizophrenia should not take EPO because it may interact with these medications and increase the risk of seizures. The same may be true for other GLA containing supplements. Arthritis Rheum. gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M. University of Massachusetts Medical Center, Worcester 01655-0335, USA. OBJECTIVE: To assess the clinical efficacy and adverse effects of gamma-linolenic acid (GLA), a plant seed oil-derived unsaturated fatty acid that suppresses inflammation and joint tissue injury in animal models, in the treatment of active rheumatoid arthritis (RA). METHODS: Fifty-six patients with active RA were randomized to treatment groups in a 6-month, double-blind trial of GLA versus placebo. This was followed by a 6-month, single-blind trial during which all patients received GLA. Patients were treated with 2.8 gm/day of GLA as the free fatty acid or with sunflower seed oil (placebo) administered in identical capsules. RESULTS: Treatment with GLA for 6 months resulted in statistically significant and clinically relevant reductions in the signs and symptoms of disease activity in patients with RA. Overall meaningful responses (at least 25% improvement in 4 measures) were also better in the GLA treatment group (14 of 22 patients versus 4 of 19 in the placebo group; P = 0.015). During the second 6 months, both groups exhibited improvement in disease activity. Thus, patients taking GLA during the entire study showed progressive improvement during the second 6 months. In this group, 16 of 21 patients showed meaningful improvement at 12 months compared with study entry. CONCLUSION: GLA at doses used in this study is a well-tolerated and effective treatment for active RA. GLA is available as a component of several plant seed oils and is usually taken in far lower doses than were used in this trial. It is not approved in the United States for the treatment of any condition, and should not be viewed as therapy for any disease. Further controlled studies of its in RA are warranted. Return to arthritis home page.