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Red yeast rice Precautions It's not clear whether it is safe to use red yeast rice for longer than 12 weeks. People with liver disease and those at risk for liver disease should not take red yeast rice. Red yeast rice may affect liver function in the same way prescription cholesterol lowering medications can. The following people should not take red yeast rice: people with kidney disease, people with thyroid disorders, those at higher risk of cancer, and those with musculoskeletal disorders. People who drink more than two alcoholic beverages a day, have a serious infection or physical disorder, or have undergone an organ transplant should also avoid using red yeast rice. Side Effects Side effects of red yeast rice are rare but can include: - Headache - Stomach ache or bloating - Gas - Dizziness - Heartburn - Muscle aches and weakness -- this can lead to a serious condition called rhabdomyolysis, and you should stop taking red yeast rice immediately and call your doctor Pregnancy and Breastfeeding Pregnant and breastfeeding women should not take red yeast rice. Pediatric Use People under 20 should not take red yeast rice until more research is done. Geriatric Use No studies have specifically looked at the safety of red yeast rice in older adults. However, elderly people who took 1,200 mg per day of red yeast rice in an 8 week study had no significant side effects. Interactions and Depletions Cholesterol-lowering medications -- Red yeast rice should not be taken with cholesterol-lowering medications unless supervised by your doctor. Red yeast rice may make the effect of these drugs stronger, increasing the risk of liver damage. If you are already taking a statin or other drug to lower cholesterol, talk to your doctor before adding red yeast rice to your regimen. Anticoagulants (blood-thinners) -- Red yeast rice may increase the risk of bleeding. Grapefruit juice -- If you take a statin, grapefruit and grapefruit juice can increase the amount of the drug in your blood. That can increase your risk of side effects and liver damage. Because red yeast rice may act like statins in the body, you should avoid drinking grapefruit juice or eating grapefruit while taking red yeast rice. Coenzyme Q10 -- Statins can lower the amount of Coenzyme Q10 in the body. CoQ10 is very important in heart and muscle health and in energy production. Side effects of CoQ10 depletion include fatigue, muscle aches and pains, and muscle damage. Red yeast rice also may lower amounts of CoQ10 in the body. Ask your doctor about taking 150 - 200 mg CoQ10 at night while you are taking red yeast rice products, and for 4 weeks after you stop taking red yeast rice. Supporting Research Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med. Becker DJ, Gordon RY, Morris PB, Yorko J, Gordon YJ, Li M, Iqbal N. Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial. Mayo Clin Proc. Bonovich, K, Colfer H, Davidson M, Dujovne C, Greenspan M, Karlberg R, et al. A Multi-Center, Self-Controlled Study of Cholestin In Subjects With Elevated Cholesterol. American Hear Association. 39th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, Orlando, Fl. Havel R. Dietary supplement or drug? The case of cholestin. Heber D, Yip I, Ashley JM, Elashoff DA, Go VLW. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr. Huang CF, Li TC, Lin CC, Liu CS, Shih HC, Lai MM. Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients. Eur J Cardiovasc Prev Rehabil. Li C, Li Y, Hou Z. Toxicity study for Monascus purpureus (red yeast) extract. Information of the Chinese Pharmacology Society. Li C, Zhu Y, Wang Y, Zhu J, Chang J, Kritchevsky D. Monascus Purpureus-Fermented Rice (Red Yeast Rice): A natural food product that lowers blood cholesterol in animal models of hypercholesterolemia. Nutrition Research. Liu J, Zhang J, Shi Y, Grimsgaard S, Alraek T, Fønnebø V. Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chin Med. Ma J, Li Y, Ye Q, Li J, Hua Y, Ju D, et al. Constituents of red yeast rice, a traditional Chinese food and medicine. J Agric Food Chem. Mark D. All red yeast rice products are not created equal. The Am J of Cardiol. Mueller PS. Symptomatic myopathy due to red yeast rice. Ann Intern Med. Ong HT, Cheah JS. Statin alternatives or just placebo: an objective review of omega-3, red yeast rice and garlic in cardiovascular therapeutics. Chin Med J (Engl). Qin S, Zhang W, Qi P, Zhao M, Dong Z, Li Y , et al. Elderly patients with primary hyperlipidemia benefited from treatment with a Monacus purpureus rice preparation: A placebo-controlled, double-blind clinical trial. American Heart Association. 39th Annual conference on Cardiovascular Disease Epidemiology and Prevention, Orlando, Fl. Wang J, Lu Z, Chi J, Wang W, Su M, Kou W, et al. Multicenter clinical trial of serum lipid-lowering effects of a Monascus purpureus (red yeast) rice preparation from traditional Chinese medicine. Curr Ther Res. Venero C, Venero J, Wortham D, Thompson P. Lipid-lowering efficacy of red yeast rice in a population intolerant to statins. The Am J Cardiol. Vercelli L, Mongini T, Olivero N, Rodolico C, Musumeci O, Palmucci L. Chinese red rice depletes muscle coenzyme Q10 and maintains muscle damage after discontinuation of statin treatment. J Am Geriatr Soc. Alternative NamesAngkak; Beni-koji; Hong qu; Hung-chu; Monascus; Red koji; Red leaven; Red rice; Xue zhi kang; Zhitai Therapeutic Uses Prevention Red yeast rice has been shown in several studies to lower "bad" LDL cholesterol levels. High cholesterol levels increase the risk of heart disease. Research has shown that red yeast (Monascus purpureus) stops the action of an enzyme in the body called HMG-CoA reductase, which helps make cholesterol. Red yeast rice contains substances known as monacolins. One of these, monacolin K, has the same chemical makeup as lovastatin, a prescription drug that lowers cholesterol. Some researchers think that this substance is responsible for red yeast rice's cholesterol lowering properties. But others note that the amount of lovastatin in red yeast rice is below what you would find in the prescription drug, and think there may be other substances in red yeast rice that help lower cholesterol. More research is needed. Treatment Several studies suggest that red yeast rice significantly reduces high cholesterol. However, most of the studies have used a formulation of red yeast rice -- Cholestin -- that is no longer available in the U.S. Although a product called Cholestin is available, it no longer contains red yeast rice. The Food and Drug Administration requires any red yeast product discovered to contain monacolin to be taken off the market. It may be hard for American consumers to know what the red yeast rice product they buy contains. These studies support the ability of red yeast rice to lower cholesterol: - A 2008 study compared a group of people with high cholesterol who took fish oil and red yeast rice with a group who took a standard dose of simvastatin. The red yeast rice was purchased directly from the manufacturer and contained lovastatin, but at a lower dose than what you would find in the prescription drug. Both groups saw a similar reduction in cholesterol levels. - One study by UCLA School of Medicine involved 83 people with high cholesterol levels. Those who received red yeast rice over a 12 week period experienced significantly lower levels of total cholesterol, "bad" LDL cholesterol, and triglycerides (fats in the blood) compared to those taking placebo. "Good" HDL cholesterol levels did not change in either study group. - A study presented before the American Heart Association also showed that red yeast rice lowered LDL cholesterol. In the first study, 187 people had mild-to-moderate elevations in total cholesterol and LDL cholesterol. The study showed that treatment with red yeast rice reduced total cholesterol by more than 16%, LDL cholesterol by 21%, and triglycerides by 24%. HDL cholesterol also increased by 14%. - In another 8-week study of 446 people with high cholesterol, those receiving red yeast rice had a significant drop in cholesterol levels compared to those who took placebo. Total cholesterol fell by 22.7%, LDL by 31%, and triglycerides by 34% in the red yeast rice group. HDL cholesterol increased by 20% in the red yeast rice group as well. Dietary Sources Asia and Chinese communities in North America use red yeast rice in powdered form as a food coloring for fish, alcoholic beverages, and cheese. Dosage and Administration Red yeast rice is an ingredient in several commercially available combination supplement products that are marketed to promote heart health. Red yeast rice is also available in commercial preparations. One of the proprietary products most often studied was Cholestin, which contained monacolin. However, the Food and Drug Administration required the manufacturer to remove that product from the market. The current formulation of Cholestin does not contain red yeast rice. Pediatric People younger than 20 years should not use red yeast rice supplements. Adult In Traditional Chinese Medicine, the dosage of dietary or supplemental red yeast rice is as high as 6,000 - 9,000 mg per day. But the appropriate dosage for adults may vary, depending on the form of the supplement. Most studies have used standardized extract: use 600 mg (oral doses), 2 - 4 times daily. Introduction Overview Red yeast rice has been used for centuries in China as both a food and a medicinal product. It is made by fermenting a type of yeast called Monascus purpureus over red rice. In Chinese medicine, red yeast rice is used to lower cholesterol, promote blood circulation, and aid digestive problems. Research has shown that red yeast rice contains substances that are similar to prescription statin medications. One of these substances, called monacolin K, has the same makeup as the drug lovastatin. Statins are prescribed to lower "bad" LDL cholesterol levels and help reduce the risk of heart disease. Researchers aren't sure if the cholesterol lowering effect of red yeast rice was due to the presence of monacolin or other compounds, such as unsaturated fatty acids, isoflavones, and phytosterols, in red yeast rice. But because many red yeast rice supplements did contain monacolin, the Food and Drug Administration considered them to be drugs, not supplements, and required that manufacturers remove any red yeast rice products that contained monacolin from the market. As a result, many of the red yeast rice products now on the U.S. market may not contain monacolin. Consumers cannot distinguish between red yeast products that contain monacolin from those that don't because manufacturers make no label claims for monacolin content. A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process, and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation ( www.HONcode.ch.) The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. ©1997-2012 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited. 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Tá rís giosta dearg a bhí an-tóir ar feadh na gcéadta bliain sa tSín. Tá sé freisin ar tóir orthu i measc na hÁise. Tá an giosta dearg a úsáidtear mar dhatháin bia, leasaitheach bia, spíosra, agus mar chomhábhar i fíon ríse. Tá giosta dearg a úsáid mar bhia. Is giosta dearg úsáideach freisin le haghaidh a dhéanamh táirge míochaine. Tá an forlíonadh nádúrtha a úsáid mar tháirge íocshláinte go háirithe le haghaidh gach indigestion a mhaolú agus chun feabhas a chur i gcúrsaíocht fola. An rís giosta dearg ar fáil freisin i bhfoirm púdair. Is é seo an púdar fhoirm dearg giosta an-tóir san Áise agus pobail na Síne i Meiriceá Thuaidh. Tá púdar giosta Dearg a úsáidtear go coitianta mar dath bia nádúrtha. Tá an giosta dearg coitianta a úsáidtear le haghaidh dathú an deochanna alcólacha, cáis, agus iasc. Lig dúinn plé faoi na húsáidí a giosta dearg. Chun an méid galar tá sé úsáideach? Is giosta dearg ar cheann de na leigheasanna tábhachtach a chabhróidh i ísliú colaistéaról. Deir an taighde eolaíoch go bhfuil an giosta dearg ar fhorlíonadh nádúrtha monacolin K. an giosta dearg bhfuil na substaintí sin is é sin 'monacolin K' atá cosúil leis na cógais ar oideas statin. Tá an substaint a thógáil céanna le drugaí lovastain. Monacolin K Tá an-tábhachtach chun níos ísle ar an cholesterol LDL. Imríonn sé ról ríthábhachtach le haghaidh a ísliú tríghlicrídí. Méaduithe colaistéaról ard leibhéal an baol galar croí. An seans taom croí a mhéadú nuair a théann an leibhéal cholesterol i gcorp suas. Cuidíonn an gníomh ar einsím a dtugtar HMG-CoA i gcorp an duine colaistéaról a dhéanamh. An purpureus Monascus (dearg giosta) stopann an ghníomhaíocht ar einsím. Is é an rís giosta dearg dath maith le haghaidh rialú na leibhéil cholesterol i gcorp. Ceann de na substainte tábhachtach dearg giosta ríse eadhon monacolin K Tá makeup cosúil cosúil le drugaí ar oideas lovastatin. Is é an tsubstaint lovastatin cabhrach freisin i leibhéil cholesterol ísliú agus a chothabháil le cothromaíocht chuí sa chomhlacht. Is é an tsubstaint lovastatin atá freagrach as an ísliú cholesterol i gcorp an duine. Is é an giosta dearg is fearr a bhaint amach an chothromaíocht cheart na cholesterol i gcorp an duine. Laghdaíonn chothromaíocht cheart de colaistéaról LDL an seans taom croí. Is féidir leis an fhorlíonta giosta dearg cóireáil draíochta d'othair croí. An bhfuil Tá forlíonadh giosta dearg níos fearr ná cinn eile? An bhfuil aon fo-iarsmaí a ba chúis leis mar gheall ar fhorlíontaí giosta dearg? Cad iad na héifeachtaí diúltacha a bhíonn ag giosta dearg? Rhabdomyolysis Is é an éifeacht is mó olc ba chúis leis mar gheall ar giosta dearg. Ciallaíonn sé an briseadh síos na fíocháin muscle. Is féidir le dosage Ard na forlíonta giosta dearg ar feadh tréimhsí fada damáiste a dhéanamh don fíocháin muscle. Tá myopathy Shiomptóim bharr gheall ar giosta dearg. Bhí na leibhéil hepatic agus cairdiach a fháil a laghdú. Is giosta dearg riachtanach chun laghdú ar an leibhéal colaistéaróil ar fáil tá sé a glacadh i gcainníochtaí cruinn eile a bheidh ann éifeachtaí os coinne. Tá tinneas cinn, gás, pian comhpháirteach, indigestion, boilg gach, bloating, sruthán croí, meadhrán, laige, pianta matáin, etc roinnt gearáin coitianta mar gheall ar iontógáil giosta ríse dearg. TÁBHACHTACH Gréasáin:. Féach ar an Dochtúra Cur i láthair saor in aisce ar Conas ndóigh agus droim ar ais go Sábháilte Galar Croí agus Cholesterol Íochtarach Cliceáil Anseo nó http://HealthTipsThatWork.com/CholesLo Tabhair cuairt .