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Description What Amitriptyline tablets are and what they are used for Amitriptyline belongs to a group of medicines called tricyclic antidepressant drugs. These medicines alter the levels of chemicals in the brain to relieve the symptoms of depression. Amitriptyline is used: • to treat the symptoms of depression. • for the relief of bed-wetting at night by children. Before you take Do not take Amitriptyline tablets and tell your doctor if you or your child (if they are the patient): • are allergic (hypersensitive) to amitriptyline, other tricyclic antidepressants or any of the other ingredients. The 25mg tablets contain sunset yellow (E110), which may cause allergic-type reactions including asthma. Allergy is more common in those people who are allergic to aspirin. • have heart disease such as irregular heart beats, heart block or failure, coronary artery disease or have recently had a heart attack • suffer from periods of increased and exaggerated behaviour (mania) • have severe liver disease • are taking monoamine oxidase inhibitors (MAOI) or you have taken MAOIs within the previous 14 days for depression • are breast-feeding • if the child is under 7 years old. Thoughts of suicide and worsening of your depression or anxiety disorder If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this: • If you have previously had thoughts about killing or harming yourself. • If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in young adults (less than 25 years old) with psychiatric conditions who were treated with an antidepressant. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour. Check with your doctor or pharmacist before taking Amitriptyline tablets if you or your child (if they are the patient): • have any blood disorders (you may bruise easily, frequently suffer from infections or be anaemic) • have any psychiatric disorder (eg schizophrenia or manic depression) • have liver or cardiovascular disease • are not able to pass water or have an enlarged prostate gland • have an overactive thyroid gland and are taking medicines to treat a thyroid disorder • have a history of epilepsy • are being given electroconvulsive therapy (ECT) • have increased pressure in the eye (glaucoma) • are due to have any surgery, including dental, that involves an anaesthetic. Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Especially: • altretamine (to treat some types of cancer) • apraclonidine and brimonidine (to treat glaucoma) • baclofen (a muscle relaxant) • disulfiram (to treat alcohol addiction) • painkillers such as nefopam, tramadol, codeine, dihydrocodeine • medicines to treat some heart conditions such as amiodarone, diltiazem, disopyramide, procainamide, propafenone, quinidine, sotalol, verapamil • medicines to treat angina that you spray or dissolve under your tongue (eg glyceryl trinitrate “GTN”, isosorbide dinitrate) • rifampicin or linezolid (to treat infections) • carbamazepine or phenobarbital (to treat epilepsy) • terfenadine (to treat allergies or hayfever) • methylphenidate (to treat attention deficit/hyperactivity disorder (ADHD)) • any medicines to treat high blood pressure such as guanethidine, debrisoquine, bethanidine or clonidine or diuretics (“water” tablets) • medicines to treat some mental illnesses such as clozapine, pimozide, thioridazine chlorpromazine, haloperidol, prochlorperazine, sulpiride • cimetidine (to treat ulcers) • ethchlorvynol (to help you sleep) • entacapone or selegiline (to treat Parkinson’s disease) • oral contraceptives (“the pill”) • sibutramine (to suppress appetite) • sympathomimetic medicines such as adrenaline (epinephrine), ephedrine, isoprenaline, noradrenaline (norepinephrine), phenylephrine and phenylpropanolamine (these may be present in many cough and cold remedies) • ritonavir (to treat HIV) • fluconazole (to treat fungal infections) Pregnancy and breast-feeding Amitriptyline tablets should not be taken in the first 3 months and last 3 months of pregnancy. If taken in the last three months, the newborn may have withdrawal symptoms. Do not take Amitriptyline tablets if you are breast-feeding. Driving and using machines Amitriptyline may impair your alertness. Make sure you are not affected before you drive or operate machinery. Important information about some of the ingredients If you have been told you have an intolerance to some sugars, contact your doctor before taking this medicine, as it contains a type of sugar called lactose. The 25mg tablets also contain a colour called ‘sunset yellow’ which may cause allergic reactions. How to take Always take Amitriptyline tablets exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist. Swallow the tablets with a glass of water. You are advised not to drink alcohol with this medicine. You may not notice any improvement in your symptoms for up to 4 weeks after starting treatment. If you take more than you should If you or the patient (or someone else) swallow a lot of tablets at the same time, or you think a child may have swallowed any, contact your nearest hospital casualty department or tell your doctor immediately. Symptoms of an overdose include fast regular heart beat, dilated pupils, drowsiness, coma, difficulty breathing, jerky movements, hot dry skin, dry mouth and tongue, difficulty passing water, intestinal blockage, uncontrolled eye movement. If you forget to take the tablets Do not take a double dose to make up for a forgotten dose. If you forget to take a dose, take another as soon as you remember and then your next dose at the usual time. If you stop taking the tablets Talk to your doctor before you stop taking the tablets and follow their advice as you may experience withdrawal symptoms. Possible side effects Like all medicines, Amitriptyline tablets can cause side effects, although not everybody gets them. Stop taking Amitriptyline tablets and contact your doctor at once if you experience the following: allergic reaction, a skin rash, which may be itchy, sensitivity to the sun or sun lamps, puffy, swollen face or tongue, which may be severe causing shortness of breath, swelling, shock and collapse. Tell your doctor if you notice any of the following side effects or notice any other effects not listed: Blood: bone marrow depression or reduction in some blood cells (you may experience a sore throat, mouth ulcers and recurring infections, bleeding or bruising easily) Endocrine system and metabolism: disturbances in sexual function or sex drive, breast swelling in men and women, swelling of the testicles, production or over-production of breast milk, changes in blood sugar levels, increased appetite and weight gain. Inappropriate secretion of the hormone ADH (antidiuretic hormone), which may make you urinate more frequently Brain and central nervous system: dizziness, tiredness or sleepiness, weakness, headache, difficulty concentrating, confusion, difficulty sleeping, nightmares, slight hyperactivity, exaggerated behaviour, delusions, seeing things that are not there, anxiety, excitement, disorientation (not knowing where you are), restlessness, pins and needles, lack of co-ordination, shaky movements, tremor, fits. Anticholinergic effects (dry mouth, fever, constipation, blurred or double vision, difficulty passing water (urine), dilation of the pupil of the eye, glaucoma and blockage of the small intestine) Heart: feeling faint when getting up (postural hypotension), increased blood pressure, fast/racing heart, palpitations, heart attack, stroke, irregular or slow heart-beats and very low blood pressure Stomach and intestines: feeling or being sick, diarrhoea, loss of appetite, inflammation of the mucus membranes in the mouth, swollen saliva glands, abdominal pains, black tongue, impairment of taste Liver: hepatitis, including changes in liver function (as seen in blood tests), jaundice (yellowing of the skin and/or whites of the eyes) Other: increased sweating, hair loss, ringing in the ears, increased need to urinate. An increased risk of bone factures has been observed in patients taking this type of medicine. Withdrawal symptoms: feeling sick, malaise and headache, dream and sleep disturbances, irritability and restlessness. Mania or hypomania (exaggerated mood and/or elation) may occur 2-7 days after stopping the tablets. If taken to treat bed-wetting: drowsiness, mild sweating, itching, changes in behaviour and “Anticholinergic effects” (as described above). Tell your doctor if you notice any of the above side effects or any other effects not listed: How to store Keep out of the reach and sight of children. Store below 25°C in a dry place, protected from light. Do not use Amitriptyline tablets after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month. Return any unused medicines to your pharmacist for safe disposal. Amitriptilina is also known as Amitriptyline, which is its generic name. This is a medication that is meant to help people battling clinical depression. It is so strong that it is not generally given to patients who are experiencing a milder form of depression. There are other treatment uses for it also, including the treatment of chronic pain. Amitriptilina has been an approved medication since 1961 when the FDA declared it to be safe to prescribe to people who need it. This medication has been tested when it comes to treating patients with conditions such as insomnia, eating disorders, chronic coughing, incontinence, interstitial cystitis and Attention Deficit Disorder. It has been used as either a substitute for other common types of ADD medication or in addition to other ADD medications. Many people avoid taking Amitriptilina because of the number of adverse effects it has on those who take it. These effects include dizziness, weight gain, headache, impotence, libido suppression, tremor, sweating, agitation, insomnia, confusion and anxiety. There are some less common side effects of taking this medication as well, including nausea, arrhythmias, mania and hypomania, skin allergy reactions, and breast enlargement in both men and women. Side effects that patients can, but rarely see as a result of taking Amitriptilina include hypertension, failure of the liver, hepatitis, hypotension, heart palpitations, stroke, heart attack, heart block and fainting. There are also some side effects to taking this medication where it is unknown how often they might occur, such as seizures, delusions, tingling, numbness, weakness, swelling of testicles, incoordination, frequent urination, a black tongue, coma, tinnitus, ataxia and an increase in perspiration. Some people are not able to take this medication safely. This includes anyone under the age of seven, those who are breast feeding, suffering from liver disease and patients with a history of heart blockage, myocardial infarction and a hypersensitivity to any similar types of antidepressant medication. This is a carefully controlled substance due to the fact that an overdose of it could cause minor as well as major health problems. The more minor problems than can arise from overdosing on Amitriptilina include drowsiness and vomiting. Some of the more major problems that can arise include coma, convulsions, severely low blood pressure, hypothermia, a dangerously high heart rate and electrocardiogram changes. Anyone who finds thy have overdosed on Amitriptilina can try ingesting charcoal within an hour or two after the overdose occurs. In more serious cases, for example, if the person who overdosed has lost consciousness, charcoal can be ingested by inserting a nasograstic tube to send the charcoal into their stomach. Amitriptilina is always sold under many different brand names and must be prescribed by a licensed doctor.
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Amora tablete za tlak. Podijelite članak Sadržaj pakiranja i druge informacije 1. AMORA sadrži dvije djelatne tvari: ramipril i amlodipin. Ramipril pripada skupini lijekova koju nazivamo ACE inhibitori inhibitori angiotenzin konvertirajućeg enzimadok amlodipin pripada skupini lijekova koju nazivamo blokatori kalcijevih kanala. Erekcijska disfunkcija Ramipril smanjuje stvaranje tvari koje mogu povisiti Vaš krvni tlak, opušta i širi krvne žile te na taj način olakšava Vašem srcu pumpati krv u sve dijelove tijela. Amlodipin opušta i širi krvne žile. AMORA se koristi za liječenje hipertenzije povišenog krvnog tlaka za bolesnike kod kojih amora tablete za tlak postignuta kontrola krvnog tlaka primjenom pojedinih djelatnih tvari u dozama istovjetnim dozama u kombinaciji, ali u odvojenim lijekovima. Nemojte uzimati AMORA kapsule: ako ste alergični na ramipril, amlodipin ili neki drugi sastojak ovog lijeka naveden u dijelu 6. Vaš liječnik će donijeti odluku možete li uzimati ovaj lijek ili ne. Upozorenja i mjere opreza Obratite se Vašem liječniku ili ljekarniku prije nego uzmete AMORA kapsule: ako ste starija osoba ako imate problema sa srcem, jetrom ili bubrezima ako imate ozbiljno i naglo povećanje krvnog tlaka u kratkom vremenu hipertenzivna kriza ako ste izgubili dosta soli i tekućine zbog povraćanja, proljeva, pojačanog znojenja, prehrane s malim unosom soli, dulje primjene diuretika lijekova koji potiču mokrenje ili dijalize pročišćavanje krvi kod nedovoljne bubrežne funkcije ako idete na liječenje kako bi smanjili učinke alergije na ubod pčele ili ose desenzibilizacija ako trebate primiti anesteziju zbog operacije ili zahvata na zubima pri čemu će možda trebati prekinuti liječenje AMORA kapsulama. Prije operacije ili zahvata na zubima svakako se posavjetujte s Vašim liječnikom. Uputa o lijeku – AMORA 2,5 mg/5 mg tvrde kapsule Vaš liječnik može provoditi redovite krvne pretrage, osobito za provjeru razine natrija u krvi, posebno ako ste starija osoba. AMORA se ne preporučuje u prva 3 mjeseca trudnoće, a ako se koristi nakon trećeg mjeseca trudnoće može ozbiljno štetiti Vašem djetetu pogledajte dio Trudnoća i dojenje. Liječnik Vam može provjeravati bubrežnu funkciju, krvni tlak, krvnu sliku i količinu elektrolita npr. To bi mogao biti znak teške alergijske reakcije koja se može dogoditi u bilo koje vrijeme tijekom liječenja. Osobe crne boje kože mogu imati veći rizik pojave ovog stanja. NAJJAČI LIJEK ZA MOZAK!!! BOLJE OD SVAKE TABLETE! Ako se razviju takvi simptomi, morate odmah obavijestiti svog liječnika. Ako se nešto od gore navedenog odnosi na Vas ili, pak, niste sigurni, javite se svom liječniku. Djeca i adolescenti Primjena AMORA kapsula ne preporučuje se u djece i adolescenata mlaĎih od 18 godina zbog nedostatka podataka o sigurnosti i djelotvornosti primjene za ove dobne skupine. Drugi lijekovi i AMORA Obavijestite Vašeg liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove. Zujanje u ušima uz druge tegobe Obavijestite liječnika ako uzimate sljedeće lijekove jer oni mogu umanjiti učinak AMORA kapsula: lijekove za ublažavanje boli i upale nesteroidni protuupalni lijekovi, npr. Liječnik će Vam provjeravati vrijednosti krvnog tlaka. Obavijestite liječnika ako istodobno s AMORA kapsulama uzimate sljedeće lijekove jer oni mogu povećati mogućnost razvoja nuspojava: lijekove za ublažavanje boli i upale nesteroidni protuupalni lijekovi, npr. Potrebno je pažljivo pratiti razinu kalija u krvi kod istovremene primjene ovih lijekova. Obavijestite liječnika ako uzimate sljedeće lijekove jer AMORA kapsule mogu utjecati na njihov učinak: lijekovi za liječenje dijabetesa šećerne bolesti kao što su lijekovi za snižavanje razine šećera u krvi koji se uzimaju na usta i inzulin. AMORA kapsule mogu povisiti razinu amora tablete za tlak u krvi, pa je potrebno da Vam Vaš liječnik pažljivo prati razinu litija u krvi simvastatin lijek za snižavanje razine kolesterola. Ako niste sigurni koliko alkohola smijete popiti dok uzimate AMORA kapsule, posavjetujte se s Vašim liječnikom s obzirom da lijekovi za snižavanje krvnog tlaka i alkohol mogu imati združeni učinak. Također bi tijekom uzimanja AMORA kapsula trebalo izbjegavati istodobnu konzumaciju grejpa ili soka od grejpa. Grejp i sok od grejpa mogu povisiti razinu djelatne tvari amlodipina u krvi, što može dovesti do amora tablete za tlak sniženja krvnog tlaka. Trudnoća i dojenje Ako ste trudni ili dojite, mislite da biste amora tablete za tlak biti trudni ili planirate krvni pritisak visok simptomi, obratite se Vašem liječniku ili ljekarniku za savjet prije nego uzmete ovaj lijek. Liječenje hipertenzije AMORA se ne smije uzimati za vrijeme trudnoće. AMORA se izlučuje u majčino mlijeko i ne smije se uzimati za vrijeme dojenja. Najčešće se na početku liječenja mogu javiti mučnina, vrtoglavica ili umor te glavobolja i omaglica. Uvijek uzmite ovaj lijek točno onako kako Vam je rekao Vaš liječnik ili ljekarnik. Provjerite s Vašim liječnikom ili ljekarnikom ako niste sigurni. AMORA kapsule se uzimaju cijele, s tekućinom, svaki dan u isto vrijeme neovisno o obroku. Kapsulu ne smijete lomiti ili žvakati. Odrasli Uobičajena doza je 1 kapsula amora tablete za tlak u dozi koju Vam je preporučio Vaš liječnik. Ovisno o učinku lijeka Vaš liječnik može izmijeniti dnevnu dozu. Djeca i adolescenti Ne preporučuje se primjena AMORA kapsula u djece i adolescenata mlađih od 18 godina zbog nedostatnih podataka o sigurnosti primjene i djelotvornosti. Stariji bolesnici iznad 65 godina Vaš liječnik će Vam odrediti nižu početnu dozu i postupno će prilagođvati daljnje doziranje. Bolesti jetre i bubrega U slučaju bolesti jetre i bubrega moguće je da će dozu lijeka trebati prilagoditi. Znate li kad je najbolje vrijeme da popijete lijek? Obratite se Vašem liječniku ukoliko imate dojam kako je djelovanje lijeka prejako ili preslabo. Ako uzmete više AMORA kapsula nego što ste trebali Ako ste uzeli previše kapsula, to može rezultirati sniženjem krvnog tlaka, pa čak i značajnim padom krvnog tlaka. Može se javiti vrtoglavica, slabost ili nesvjestica. Ako se krvni tlak jako snizi, može nastati i šok. Vaša koža može biti hladna i znojna i mogli biste izgubiti svijest. Nemojte sami voziti u bolnicu, neka Vas odveze netko drugi ili pozovite hitnu pomoć. Uzmite sa sobom pakiranje lijeka kako bi liječnik mogao točno znati koji amora tablete za tlak lijek uzeli. Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljenu dozu. Ako prestanete sa uzimanjem lijeka ranije no što Vam je savjetovano možete očekivati pogoršanje Vaše bolesti. Ako imate bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se Vašem liječniku ili ljekarniku. Moguće nuspojave Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave iako se one neće razviti kod svakoga. Prestanite uzimati AMORA kapsule i odmah se obratite liječniku ako primijetite neku od amora tablete za tlak nuspojava, s obzirom da će Vam možda biti potrebna hitna medicinska skrb: oticanje lica, usana ili grla može otežati gutanje ili disanjekao i svrbež i osip. Lijekovi za tlak povučeni iz Hrvatske i još 20 zemalja, mogu izazvati rak Odmah se javite liječniku ako primijetite sljedeće: ubrzane, nepravilne i snažne otkucaje srca aritmijabol u prsima, stezanje u prsima ili ozbiljnije probleme, uključujući srčani i moždani udar nedostatak zraka ili kašalj, jer to mogu biti znaci problema s plućima ako primijetite da Vam se češće pojavljuju modrice, krvarenje koje traje dulje od uobičajenog ili bilo kakvi znakovi krvarenja npr. Ostale nuspojave: Obavijestite Vašeg liječnika ako neke od sljedećih nuspojava postanu ozbiljne ili traju dulje od nekoliko dana. Vrlo često mogu se javiti u više od 1 amora tablete za tlak 10 osoba : edem oticanje. Amora tablete za tlak mogu se javiti u manje od 1 na 10 osoba : palpitacije lupanje srcacrvenilo lica uz osjećaj vrućine — edem gležnjeva oticanje glavobolja, omaglica, pospanost, umor češće na početku liječenja ili kod povećanja doze hipotenzija nizak krvni tlakposebice kod naglog sjedanja ili ustajanja, nesvjestica, naleti crvenila suh, nadražujući kašalj, sinuitis upala sinusa ili bronhitis upala bronhazaduha dispneja bol ili nelagoda u trbuhu, proljev, probavne smetnje, mučnina ili povraćanje osip s ili bez uzdignuća na koži bol u prsima grčevi ili bol u mišićima povišene razine kalija u krvi vidljive krvnim pretragama opća slabost, gubitak snage astenija. Ako imate te amora tablete za tlak, obratite se Vašem liječniku što je prije moguće. Prijavljivanje nuspojava Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti Vašeg liječnika ili ljekarnika. To uključuje i svaku moguću nuspojavu koja nije navedena u ovoj uputi. Nuspojave možete prijaviti izravno putem nacionalnog sustava za prijavu nuspojava: navedenog u Dodatku V. Prijavljivanjem nuspojava možete pridonijeti u procjeni sigurnosti ovog lijeka. Ovaj lijek čuvajte izvan pogleda i dohvata djece. Pripravci za intravenozno hipertenzije, Čuvati u originalnom pakiranju radi zaštite od svjetlosti. Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji. Je li normalno uzimati dva ili tri lijeka za povišeni tlak? Aktivni pristup Ako ste dugogodišnji hipertoničar osoba koja boluje od visokoga krvnog tlakauz sve navedene savjete redovito uzimajte propisane lijekove. Učenjem o rizičnim čimbenicima, promjenom prehrane, redovitom kontrolom krvnoga tlaka, izbjegavanjem stresnih situacija te redovitim boravkom u prirodi i vježbanjem koliko vam to dozvoljavaju godine i zdravstveno stanjepoboljšat ćete svoje zdravstveno stanje. Ako ste dugogodišnji hipertoničar osoba koja boluje od visokoga krvnog tlakauz sve navedene savjete redovito uzimajte propisane lijekove. Rok valjanosti odnosi se na zadnji dan navedenog mjeseca. Nikada nemojte nikakve lijekove bacati u otpadne vode ili kućni otpad. Svjetlo lijek za hipertenziju, KoMMeHTapии: 4 koMMeHTapиeB Pitajte Vašeg ljekarnika kako baciti lijekove koje više ne koristite. Ove će mjere pomoći u očuvanju okoliša. Sadržaj pakiranja i druge informacije Što Amora kapsule sadrže? Djelatne tvari su ramipril i amlodipin. Pomoćne tvari su: Sadržaj kapsule: celuloza, mikrokristalična tip LMkalcijev hidrogenfosfat, bezvodni, škrob, prethodno geliran, natrijev škroboglikolat, vrsta A, natrijev stearilfumarat. Tijelo želatinske kapsule: titanijev dioksid Eželatina.