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Aspirin (acetylsalicylic acid) is an anti-inflammatory drug of natural origin. It is an acetic ester of salicylic acid isolated from willow bark, which was once traditionally used against inflammation. Aspirin is an example of how medication can improve the quality of some natural medicines. The bark is full of tannins and other defensive substances that prevent the herbivores from barking in the wild. By cleaning the active substance, these defenses are removed and dosing is facilitated. Standardization (ie availability of tablets with the same dose of aspirin) removes the uncertainty about the active substance content in the used bark of a piece. Modification of salicylic acid to aspirin in turn reduces its irritability. Moreover, aspirin is easily manufactured purely synthetically, making it cheaper than its natural equivalents. (I would like to point out that other natural medicines - such as red ginseng - do not require processing into a tablet form.) Aspirin works by irreversible inactivation of cycloxygenase - a key enzyme that produces an immune signaling molecule called prostaglandins. Prostaglandins are many kinds, and the immune system uses them to mark the sites where the tissue has inflammation. Prostaglandins in these places increase blood flow, sensitivity (pain), and attract white blood cells that fight against the cause of inflammation and soothe after the fight. Aspirin disables this alarm, which is effective when it comes to a false alarm - for example, in civilization or autoimmune diseases. At each drop, aspirin removes fever and pain in the short term, which in turn has earned its great popularity. Aspirin also has an inhibitory effect on blood platelets - it prevents the formation of blood clots, or "thin blood". Because of this, aspirin is recommended for continued use as a prevention of thrombosis and heart attack. In summary, aspirin has 2 main effects: Aspirin is not an adaptogen (it acts unilaterally) , but it is relatively harmless for most people even with long-term administration. With its anti-inflammatory action, it also reduces cell damage in stroke and ischemia, so both of its main effects are in the prevention of thrombosis and stroke. It seems to have some preventative effect on tumors at moderate doses, which is probably related to its anti-inflammatory effect. At high doses, aspirin is not recommended. Aspirin (acetylsalicylic acid), which is available without prescription, was introduced in the Guinness Book of Records as the best-selling medicine in the world in the 1950s. Comparison of aspirin and ginseng Aspirin can be combined with anti-inflammatory adaptogens ( ginseng , ginger , bajkal , and vitamin C ). The use of adaptogens, which are more balanced than the one-sided, allosteric aspirin, will make it possible to achieve a therapeutic effect even at lower doses of aspirin. This avoids its undesirable effects and gains the other positive health effects that these adaptogens have. Ginseng is a model adaptogen that protects and aids many diseases. On the other hand, the ginseng suffers from the "all-pervading" attribute, which is now just an overflow. This attribute was once meant seriously and positively - and even the generic name Panax means literally everything. However, today the inadequate "specialization" of the drug (which is the rule of adaptogens) is suspicious. Additionally, the definition of the adaptogen (especially those who do not want to understand it) is suspected of being nothing more than an attempt to wrap the notion of panacea into scientific gown. In an era of molecular pharmacology, an explanation of a specific mechanism of action is needed to refute the suspicion of fraud, exaggeration, and panacea. It turns out that in this situation it is very appropriate to compare ginseng with a substantially simpler "pancreas" - aspirin. As for aspirin, there is no doubt about its effectiveness and mechanism of action. Aspirin has only two main effects (it reduces inflammation + fever and dilutes blood), but it is used in a large number of inflammatory and fever illnesses and is used on a mass scale. Aspirin belongs to those cheap medicines that people use very often and some even constantly. Under another name (like Stacyl ), it is also used to treat blood thinning in the fight against thrombosis , ie people use it virtually constantly. In the Czech Republic, more than 100 tonnes of aspirin are consumed per year, while ginseng consumption is scarce. The quantitative comparison of ginseng and other common drugs is similar.
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Aspirin (acetilsalicilna kiselina) je protuupalni lijek prirodnog podrijetla. To je octeni ester salicilne kiseline izoliran od kore vrba, koji je nekoć bio tradicionalno korišten protiv upale. Aspirin je primjer kako lijek može poboljšati kvalitetu nekih prirodnih lijekova. Kora je puna tanina i drugih obrambenih tvari koje sprječavaju da biljojedi lave u divljini. Čišćenjem aktivne tvari uklanjaju se oblici i doziranje se olakšava. Standardizacija (tj. Dostupnost tableta s istom dozom aspirina) uklanja nesigurnost o sadržaju aktivne tvari korištenog kore elementa. Modifikacija salicilne kiseline prema aspirinu pak smanjuje njenu razdražljivost. Štoviše, aspirin se lako proizvodi sintetski, što ga čini jeftinijim od njegovih prirodnih ekvivalenata. (Želio bih istaknuti da drugi prirodni lijekovi - poput crvenog ginsenga - ne zahtijevaju obradu u obliku tableta.) Aspirin djeluje nepovratnom inaktivacijom ciklooksigenaze - ključnim enzimom koji proizvodi imunosna signalna molekula nazvanog prostaglandini. Prostaglandini su mnoge vrste, a imunološki sustav ih koristi kako bi obilježio mjesta na kojima tkivo ima upalu. Prostaglandini na tim mjestima povećavaju protok krvi, osjetljivost (bol) i privlače bijele krvne stanice koje se bore protiv uzroka upale i smiruju nakon borbe. Aspirin onemogućuje ovaj alarm, koji je učinkovit kada se radi o lažnom alarmu - na primjer, u civilizaciji ili autoimunim bolestima. Kod svake kapi, aspirin uklanja povišenu temperaturu i bol u kratkom roku, što zauzvrat zaslužuje veliku popularnost. Aspirin također ima inhibitorski učinak na krvne pločice - sprečava stvaranje krvnih ugrušaka ili "tanke krvi". Zbog toga se aspirin preporuča za daljnje korištenje kao prevencija tromboze i srčanog udara. Ukratko, aspirin ima 2 glavna učinka: Aspirin nije adaptogen (djeluje jednostrano) , ali za većinu ljudi to je relativno bezopasno čak i za dugotrajnu uporabu. Zbog protuupalnog djelovanja, ona također ograničava oštećenja stanica u moždanom udaru i ishemiji, pa su oba njegova glavna učinka u prevenciji tromboze i moždanog udara. Čini se da ima neki preventivni učinak na tumore kod umjerenih doza, što je vjerojatno povezano s njegovim protuupalnim učinkom. Kod visokih doza aspirin se ne preporučuje. Aspirin (acetilsalicilna kiselina), dostupan bez recepta, uveden je u Guinnessovu knjigu rekorda kao najprodavaniju medicinu na svijetu 1950-ih godina. Usporedba aspirina i ginsenga Aspirin se može kombinirati s protuupalnim adaptogensima ( ginseng , đumbir , bajkal i vitamin C ). Korištenje adaptogena, koje su uravnoteženije od jednostranog, alosteričnog aspirina, omogućit će postizanje terapeutskog učinka čak i pri nižim dozama aspirina. Time se izbjegavaju nepoželjni učinci i dobivaju druge pozitivne učinke na zdravlje koje ti adaptogeni imaju. Ginseng je model adaptogena koji štiti i pomaže mnogim bolestima. S druge strane, ginseng pati od "panache", koji je sada samo prepun. Taj je atribut jednom bio ozbiljno i pozitivno - pa čak i općeniti naziv Panax znači doslovno sve. Međutim, danas je neadekvatna "specijalizacija" lijeka (koja je pravilo adaptogena) sumnjiva. Dodatno, definicija adaptogena (pogotovo onih koji ga ne žele razumjeti) sumnja se da nije ništa drugo nego pokušaj da se pojam panacea pretvori u znanstvene ožiljke. U doba molekularne farmakologije potrebna je objašnjenja specifičnog mehanizma djelovanja za pobijanje sumnje na prijevaru, pretjerivanje i panacej. Ispada da je u ovoj situaciji vrlo prikladno usporediti ginseng sa znatno jednostavnijom "gušteračom" - aspirinom. Što se tiče aspirina, nema sumnje o njegovoj učinkovitosti i mehanizmu djelovanja. Aspirin ima samo dva glavna učinka (smanjuje upalu + groznicu i razrjeđuje krv), ali se koristi u velikom broju upalnih i groznica bolesti i koristi se na masovnoj skali. Aspirin pripada onim jeftinim lijekovima koje ljudi koriste vrlo često, a neki čak stalno. Pod drugim imenom (kao što je Stacyl ), također se koristi za liječenje razrjeđivanja krvi u borbi protiv tromboze , tj. Ljudi ga koriste gotovo stalno. U Češkoj se godišnje konzumira više od 100 tona aspirina, dok potrošnja ginsenga nema. Kvantitativna usporedba ginseng i drugih uobičajenih lijekova je slična.