http___hr.265health.com_conditions-treatments_deafness_1016016384.html_1.xml
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treatment General: Aminoglycoside-induced deafness (AID) is not a curable condition. Instead, treatment focuses on managing hearing loss. AID is bilateral and severe to profound, occurring within a few days to weeks after administration of any amount (even a single dose) of an aminoglycoside antibiotic. About 40% of individuals with a mutation in the MTRN1 gene who have not received aminoglycoside antibiotics develop hearing loss by age 30. By age 65, this proportion increases to 80%. Hearing aids: People with AID who experience hearing loss may benefit from hearing aids. These battery-operated devices allow people to hear a greater range of sounds by amplifying sounds and are available in three basic styles: behind the ear, in the ear, and inside the ear canal. Patients should talk to their healthcare provider to determine the type of hearing aid that is best for them. A behind-the-ear device is used for mild-to-profound hearing loss. The device is worn behind the ear and is attached to a plastic ear mold inside the outer ear. In-the-ear hearing aids are worn inside the outer ear and are used for mild-to-severe hearing loss. Canal hearing aids are smaller hearing aids that fit inside the patient's ear canal. They are used for mild-to-moderately severe hearing loss. If hearing loss is severe, patients may benefit from cochlear implants. These electronic devices are surgically implanted inside the ears. Unlike a hearing aid, which amplifies sound, a cochlear implant compensates for damaged parts of the inner ear. integrative therapies Currently, scientific evidence on the use of integrative therapies for the treatment or prevention of aminoglycoside-induced deafness (AID) is lacking. prevention General: Aminoglycoside-induced deafness (AID) may be prevented by obtaining a rigorous family history and undergoing molecular testing. Once people who have the defective MTRN1 gene are identified, they can be educated to avoid exposure to aminoglycoside antibiotics, including streptomycin, gentamicin, kanamycin, tobramycin, and neomycin. However, some individuals with the genetic mutation can develop hearing loss even without exposure to aminoglycoside antibiotics. Genetic testing and counseling: Individuals who have AID may meet with a genetic counselor to discuss the risks of having children with the disease. Individuals with family histories of AID, but who have not been diagnosed with the syndrome themselves, may meet with a genetic counselor to determine whether they carry the defective MTRN1 gene. If an individual who has not yet been diagnosed with AID is found to have inherited one of the defective genes, he or she may undergo genetic counseling before conceiving a child. Genetic counselors can explain the options and the associated risks of various tests, including preimplantation genetic diagnosis (PGD), amniocentesis, and CVS. PGD may be used with in vitro (artificial) fertilization. In PGD, embryos are tested for the defective MTRN1 gene, and only the embryos that are not affected may be selected for implantation. Because AID can be detected in a fetus, parents may choose whether to continue the pregnancy. Genetic counselors may assist parents with these difficult decisions.
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