http___hr.adaptogens.com_c-1527.aspx_1.xml
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(This page does not work yet, I hope it will be different in the future and will be used to calculate the required ginseng dosage due to the effects described.) It is slowly becoming the standard that quantitative data are being reported on the effects of various forms of ginseng and individual panaxosides. This gives the opportunity to calculate the appropriate dosing. The problem of panaxoside variability and interactions The situation is plagued by the fact that many physiological parameters have different panaxosides in opposition , so the overall effect of ginseng can not be easily estimated. Different forms of ginseng (fresh, white , red ...) are again significant differences in the quantities and proportions of the content substances. Another source of variability is absorption, which modulates the efficacy of the patient's gut tract and the activity of the bacteria living there and the modified panaxosides partially modified by the cleavage of the sugar residues. MUDr. physicians in Asia are aware of this, and therefore require treatment for some of the purified panaxosides, or their prescribed mixtures, which are sometimes given by injection (such as infarctions). In addition to the rate of absorption, excretion and transduction across the cell membrane, the CNS effects also include the rate of transfer across the blood-brain barrier. At the current stage of the pharmacodynamic question I ignore and try to calculate for some effects the required single dose, assuming an immediate even distribution of the active substances in the soft tissues of the whole organism. Content of ginsenoside in red ginseng (Analysis of red ginseng ( gineng radix rubra ) provided by the faculty of TCM in Taipei.) A single dose corresponding to a concentration of 10 ug / ml Assuming that the human body contains 40 liters of water and provided the panaxosides are distributed evenly (due to their amphiphilic nature, the situation is close to reality), a single dose of red ginseng will correspond to the concentration of ginsenoside 1 ug / ml as follows: Interpretation with respect to individual effects - effect pxsd. Rb 1 for the normalization of immune vascular parameters occurred at a dose of 10 ug / ml, corresponding to 268 g of red ginseng ( he2007peg ) - effect pxsd. Rb 1 against aggression occurred at 2.5 mg / kg, corresponding to a dose of more than 53.6 g of red ginseng ( yoshimura1988ace ) - the effect of P. notoginseng panaxoside extract on endothelial proliferation and vascular repair occurred at a dose of 0.1 ug / ml ( hong2009aes ), which would probably correspond to less than 0.3-1g of P. notoginseng (estimated). - ( kwon2003ekr ) [ other ] Increase in liver regeneration rate by 20% (experimental resection in a dog) at a dose of 250mg / kg ginseng radix rubra for 9 days (-1 to 7 due to surgery). At 80kg, it would be 20g ginseng radix rubra a day. - ( morisaki1995mae ) [ cardiovascular ] 100% increase in "capillary" growth rate was achieved with ginseng radix rubra 10ug / ml saponin, i.e. 60L soft tissues, 600mg ginseng radix rubra . An increase in growth rate of 300% was achieved by 100ug / ml, ie under the same assumptions as 6g ginseng radix rubra . Further to processing Rg 1 ( against hypertension : extends blood vessels kang1995gpg ) (supports vascular growth of sengupta2004may ) (protects neurons liao2002neg ) (microglia relaxation wu2007deg ) (anti-stress kim2003iii ) (immunomodulation in favor of type 2 yu2005pgd ) Rg 2 (protects the memory by antiapoptotic action ( zhang2008pgg ), protects the brain against glutamate neurotoxicity ( li2007peg )) (microglia calming wu2007deg ) (possible immunomodulation for type 1 cho2002gfp ) Rb 1 (normalizes the he2007peg immunity) (a relaxing effect of yoshimura1988ace ) (possibly immunomodulation for type 2 cho2002gfp ) (expands blood vessels and protects them from arteriosclerosis he2007peg ) (suppresses leung2007gri vascular growth ) Rb 2 (anti-stress kim2003iii ) (microglia calming wu2007deg ) (anti-inflammatory, TNF-a inhibition in macrophages ( cho2001vie ) (possible immunomodulation for type 1 cho2002gfp ) Rc (normalizes stress (increases / decreases as needed) kim2003egs ) Rd (anti-stress kim2003iii ) (microglia calming wu2007deg , lin2007gra ) Re (fertility zhang2006gif , zhang2007grp ) (calming microglia wu2007deg )
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Ovdje su opisani učinci koji se montira izravno literatura crveni ginseng (ginseng radix rubra), ili njen ekstrakt. Takva izvješća ima više od tisuću, ova stranica sadrži samo vrlo mali postotak njih. - Poboljšanje regeneraciju jetre poslije 40% resekcije eksperimentalnih (psi pomiješa utrka). Uspoređenih kontrolu i dozu crvenog ginsenga 250 mg / kg, respektivno. 500 mg / kg na dan oralno na dane -1 do 7, zbog operacije. Primjena crvenog ginsenga se kaže da se poveća brzina regeneracije jetre u usporedbi s kontrolom, oko 25%, koja je, s obzirom na ukupan broj 15 životinja za statistički značajne na razini od p = 0,05. Među doze 250 mg / kg i 500 mg / kg ne pokazuje razlike. Red Ginseng je također rekao da su citozaštitnog učinak na regeneraciju jetre histološke promatranje. ( Kwon2003ekr ) [citozaštitno, drugi] - U kliničkoj studiji, crveni ginseng značajno poboljšati liječenje inače neizlječivih čireva na dijabetes i progerija (Werner sindrom). ( Morisaki1995mae ) [dijabetes, drugi] - Red Ginseng, respektivno. ukupni ekstrakt saponin značajno ubrzao oporavak kapilare (cijevi u gel u uvjetima in vitro) iz humane vene endotela. U usporedbi s kontrolom, ukupna koncentracija saponina ekstrakta crvenog ginseng 1 ppm / ml kapilarnom rasta ubrzana oko 20% koncentracije 10 ug / ml, oko 100%, a koncentracija 100 ug / ml, više od 300%. Ukupno, saponini crvenog ginsenga, a povećava izlučivanje plazminogena (tPA, aktivatora tkivnog plazminogena) i smanjeni hladinuinhibitoru aktivator plazminogena (PAI inhibitor aktivatora plazminogena). Ukupno saponin crveni ginseng neznatno povećava proliferaciju endotelnih stanica, ali već povećala njihova migracija brzinu u odnosu na dozu, u dozi od 100 | ig / ml do 3-struko, u ovom pogledu nalikovati učinak faktor rasta fibroblasta (FGF, faktor rasta fibroblasta). Ukupno saponin Red Ginseng je također značajno poboljšana zacjeljivanje kože rana u dijabetičara štakora - povećana mehanička čvrstoću i učestalost novonastalih kapilara u ozdravljenja tkiva. ( Morisaki1995mae ) [kardiovaskularnih, dijabetes, drugi]