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Brief Summary : There are significant differences in their definition and therapeutic use among adaptogens and Paracelsus drugs . Adaptogens in the treatment of diseases Health is (in a simplified way) the sum of many physiological parameters that our organism maintains in balance. A related term is homeostasis . Disease is (simply) a deviation of these parameters from normal. In each environment, the stresses act on the body to resist (adapt to them). A set of stress factors is called stress in the broader sense of the word. The range of environmental stressors that the body still tolerates is called adaptive range . If physiological deviations occur from normal, the physician may intervene by treatment (for example by administering the drug) to return physiological parameters to normal. The administration of a suitable adaptogen leads (as defined) to an extension of the adaptation range. Therefore, it is said that adaptogens consolidate health (science of health consolidation is called valeology ). But they can also serve health, ie to treat illnesses. Note: This is an absolutely basic nursery statement from the field of theoretical medicine , which, of course, is sufficient for the purposes of the discussion of the concept of adaptogen. Paracelsus drugs - liberal definition, demanding use According to the Paracelsus paradigm , each drug, including poisons, can be a drug. More precisely, Paracelsus's view of poisons and drugs does not distinguish at all. (Even more precisely, poisons prefer, but it does not matter to say.) If there is a therapeutic index of the active substance (ratio LD 50 / ED 50 ) greater than 1 in any particular indication (main effect), it can be used for treatment and not just for chemical struggle. In other words, it is a Paracelsian type drug. Paracelsus himself has historically used mercury, arsenic and other heavy elements to treat. The easiest to understand is that for Paracelsus medicines, we pay for the necessity of their definition by necessity: - precise, milligrams of standardized dosage forms - careful prescribing and accurate dose compliance For Paracelsus drugs, it is assumed that the physician knows in what parameters and in what direction the patient's state is deviated from normal. Example: Antacid or another hydrochloric acid-lowering drug may be used in a patient with stomach acid reflux. However, administering the same medication to a healthy person leads to a deviation of the physiological parameter of acidity of the stomach below normal. So the doctor can not give it up when the patient says he suffers from "heartburn". He has to perform a differential diagnosis: an examination that confirms that there really is an increased concentration of gastric acid and not any other disease causing heartburn. Another example: Insulin. For a diabetic with excess blood sugar, this hormone can be given to resolve the physiological deviation from normal. But administration of insulin to a normal individual or a person suffering from hypoglycaemia can lead to death. That is why diabetics carry a pocket glycemia meter and pharmaceutical companies win prizes for smart delivery systems of insulin. On the other hand, a patient who knows his ancestry about diabetes and carefully supplements his diet with high doses of antidiabetic adaptogens will receive the disease five years later (or not at all). Unlike insulin, this patient, when consuming antidiabetic adaptogens, does not have to deal with what is currently his blood composition and what he has just about glycemia. The advantage of Paracelsus drugs is that the precise pharmaceutical form and the precise diagnosis of the physiological condition allows us to therapeutically use a huge amount of poisons that ordinary herbalists would be afraid to take and hand. The Paracelsus approach is most famous for the invention of effective antibiotics , because common herbal antibiotics have been microbes with their cursed rapid evolution have long been adapted. The disadvantages of Paracelsus drugs are, however, their so-called side effects (for the Paracelsus paradigm is the word poisoning of taboo) and also the need for precise diagnosis and pharmaceutical forms (while adaptogens can be eaten only). Adaptogens - demanding definition, smarter action Unlike Paracelsus drugs, the definition of adaptogen is more demanding. It does not allow poisonous or unilateral effects. It requires an adaptogen to the physiological parameter that always works in the normalization direction (return to health) regardless of the direction in which the parameter is deflected. It requires that people who are completely healthy should not have any side effects in addition to fixing the adaptogen. These are very strict requirements, and it is strange that some herbs and chemicals actually meet these requirements without their nanocomposite nanocomposite molecules having artificial nanointelligence. They usually do so by relying on the natural intelligence of our immune system, and doing their calculations on a chemical microcomputer running through signal cascades and genetic networks in the cytoplasm of each cell. The functioning of natural adaptogenes in human patients is also built on millions of years of coevolution of mammals with plants where we as a monkey have already learned to tolerate most of the secondary metabolites and plant defense substances in the jungle, while the plants have in turn learned to provide us with very valuable molecules with minimal energy investment. And because there were no drugstore drugstores on the tertiary forests, the plants were taught to make more money when they sell adaptogens than if they were selling Paracelsus drugs. The extreme case is ginseng right, a plant growing in completely shadowy deep forests, in a complete energy shortage, a plant that can not afford to add to its berries a pinch of precious sugar. Under this evolutionary pressure, ginseng made the berries, beyond the strikingly reddish color, attractive to quality adaptogens - steroid saponins called panaxosides. Due to panaxosides, animals and birds find this plant intensely, even if it is rare, and its collection is much more demanding than graze on common forest fruit. (The Chinese made an evolutionary decision to make spit and ginseng in its quaternary beds because of its healing properties in their forests, but of course, the ginseng could not know it in advance.) Physicians should know the adaptogens and be able to recommend their patients, although their use does not require milligram accuracy. Additionally, smoking, lifestyle and obesity recommendations do not require accurate weights. (For a weight that obese need to use a precision of 50 grams per day for a massive weight reduction, the half-kilogram precision of most cheap weights is not enough!) Adaptogens are typically prescribed with grams. Physicians familiar with TČM have in addition a treasure trove of standard herbal mixtures, which are generally closer to adaptogens than Paracelsus drugs. The TCM clearly shows that the excuses that adaptogens make doctors and pharmacists unnecessary do not apply. Example: A practitioner of the TCM accepts a patient with a stroke. He does not know exactly what he is, he does not have a tomograph, centrifuge or HPLC, but according to the ancestral tradition, he has ginseng right and a lot of other herbs, as he learned from his masters over a ten-year-long TCE study. Ginseng protects the tissue from further damage, stabilizes blood pressure ( Chen2012krg , Ping2011eas , Liang2005pns ), relieves the risk of thrombosis without worsening bleeding and inducing faster repair and regeneration. On the other hand, our doctor with MUDr. the diploma will place a high dose of aspirin and a lot of other medications according to its curriculum at the heart stroke. Aspirin protects the patient from further thrombosis and prevents ongoing damage to ischemic tissue. Ginseng will strengthen his effect. If he had just aspirin without a ginseng, he would barely have half the effect. And because it is not yesterday, with both eyes overwhelmed by a stack of articles and pamphlets warning Western practitioners before ginseng is administered to cardiac patients. The advantage of adaptogens is that we can prescribe and take them with much less concerns about dosage, differential diagnosis of the patient and adverse effects. There are at least dozens of considerably beneficial herbs , whose consumption for the reasons given above benefits in specific disease states, without imposing therapeutic limitations on the conventional treatment of these conditions by other current methods of medicine. Disadvantage of adaptogens : They are not miraculous drugs. It can even be said to be better served as a long-term prevention than dealing with acute emergency health conditions, where our (western) surgery and Paracelsus pharmacotherapy excel. Adaptogens, however, serve as an inspiration for physicians, pharmacists, American bio-engineers to lessen the physical functions that a healthy human body naturally provides (such as smart delivery delivery systems for insulin), and to place more emphasis on expanding human horizons and developing new generation artificial implants , as preached by the gloomy tomorrow, to which the Czech society of real capitalism is inevitably going.
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Među adaptogena i paracelsovskými droga su značajne razlike u definiranju i njihovu terapijsku upotrebu. Liječenje bolesti Jednostavno rečeno, zdravlje je zbroj mnogih fizioloških parametara nalaze se u ravnoteži. Srodan pojam je homeostaze. U svakom okruženju na organizam djeluje čimbenike koji odstupaju od ravnoteže. Sažetak ovih faktora se zove stres u širem smislu, jednostavno učitati češki. Ovaj teret organizam u svojim prilagodbe rasponu odupire - prilagođava na njega. Ako je teret prelazi opseg adaptacije organizma nastaje pojam značajno odstupanje od fiziološke ravnoteže - bolest ili smrt. Napomena: U smislu teoretske medicine , definicija zdravlja pojednostavljenom, ali dovoljno ovdje. Paracelsian lijekovi - lako definicija, teško koristiti Prema paracelsovského paradigma može biti bilo ljekovite supstance, uključujući aktivne otrova. Konkretnije, Paracelsian pogled između otrova i lijekova ne razlikuju uopće. Ako postoji određeni pokazatelj (glavni učinak), terapeutski indeks tvari (omjer LD50 / ED50) veći od 1, može se smatrati Paracelsian lijek. Povijesno sama Paracelsusa koristiti za liječenje spojevi žive, arsena i drugih anorganskih i organskih toksina. Na najlakše shvatiti da pod definiciju skromnosti plaća za lijekove paracelsovských nužnost - precizni, standardizirani miligrama po obliku doziranja, - Pametan propisivanje i točne usklađenosti prednosti Za paracelsovských droga nije štetna jednostrana akcija na fizioloških parametara. Kao rezultat toga, oni se mogu koristiti samo kada je odstupanje od fiziološke ravnoteže - bolest. Kada se primjenjuje na zdravog pojedinca Paracelsian lijeka uzrokuje odstupanje u suprotnom smjeru suprotnom bolesti. Primjer: Atropin se može primijeniti kao antidot za muskarinski trovanja. Kada se primjenjuje na zdravim ispitanicima atropin vlastiti otrov. Drugi primjer: Inzulin je lijek za dijabetes s povišenim razinama glukoze u krvi (hiperglikemija). Ako inzulin se primjenjuje na osobe s normalnim šećera u krvi, što rezultira hipoglikemijom, gubitak svijesti i može biti smrtonosna. Paracelsovských lijekovi prednost je da nam lako definicija daje izbor velikog broja kemikalija, među kojima se nalaze učinkovite antibiotike i druge lijekove. Nedostatak je da „sporedni učinci” (Paracelsian paradigma toksičnost se ne koristi), koji zahtijevaju precizno doziranje i farmaceutski oblik. Liječnik mora „nuspojave” lijekova za liječenje paracelsovskými znanje i uzeti u obzir. Adaptogens - restriktivna definicija, jednostavan za korištenje Za razliku od paracelsovských droga je definicija adaptogen teže. Ova restriktivna definicija, međutim, omogućuje relativno jednostavno korištenje i doziranje. Adaptogens ne bi trebalo biti jednostrano djelovanje na fizioloških parametara. Kada abnormalnost može adaptogen vraćanje fiziološke parametre natrag prema zdravlju, ali zdrav ne može doći do devijacija suprotno. Primjer: ginseng pomiješa smanjenja krvnog tlaka kod nekih vrsta eksperimentalnog hipertenzije ( Lee2016aek , Zhao2015epn , Lee2014rmp ). U bolesnika s normalnom ili sniženom tlaku, ali ne uzrokuje hipotenziju ( Chen2012krg , Ping2011eas , Liang2005pns ). Adaptogens prednost je da možemo koristiti kao da je hrana. Naime, u ovoj kategoriji imamo trenutno dostupan za stotine ljekovitih biljaka čiji je potrošnja za nas zbog naše evolucijske prošlosti potpuno bez opasnosti. Nedostatak: Adaptogens su definicija „pametnih lijekova”, a danas su u velikoj mjeri oslanjaju na unutarnje inteligencije našeg tijela. Razvoj umjetnih adaptogena nova generacija će biti zbog ovog zahtjeva je znatno teže nego na razvoj novih lijekova paracelsovských.