http___hr.265health.com__p_22_1.xml
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Red Wine, Chocolate, Grapes Not Associated With Improved Health Bottom Line: The antioxidant resveratrol found in red wine, chocolate and grapes was not associated with longevity or the incidence of cardiovascular disease, cancer and inflammation. Author: Richard D. Semba, M.D., M.P.H., of the Johns Hopkins University School of Medicine, Baltimore, Md., and colleagues. Background: The “French Paradox” of a low incidence of coronary heart disease despite a diet high in cholesterol and saturated fat in France has been attributed to the regular intake of red wine, in particular, to resveratrol and other polyphenols contained in wine. Some preliminary evidence also suggests that resveratrol may have anti-inflammatory effects, prevent cancer, and decrease blood vessel stiffness. How the Study Was Conducted: The participants (a sample of 783 men and women 65 years or older) were part of the Aging in the Chianti Region study from 1998 to 2009 in two Italian villages. The authors sought to determine if resveratrol levels achieved through diet were associated with inflammation, cancer, cardiovascular disease, and death. Levels were measured using 24 hour urine collections to look for breakdown products of resveratrol. Results: During nine years of follow-up, 268 participants (34.3 percent) died; of the 639 participants free of cardiovascular disease at enrollment, 174 (27.2 percent) developed cardiovascular disease during the follow-up; and of the 734 participants who were free of cancer at enrollment, 34 (4.6 percent) developed cancer during the follow-up. Urine resveratrol metabolite levels were not associated with death, inflammation, cardiovascular disease or cancer. Discussion: “In conclusion, this prospective study of nearly 800 older community-dwelling adults shows no association between urinary resveratrol metabolites and longevity. This study suggests that dietary resveratrol from Western diets in community-dwelling older adults does not have a substantial influence on inflammation, cardiovascular disease, cancer, or longevity.”
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Prema nedavno objavljenom istraživanju, prehrana bogata tim spojem ne pokazuje značajan učinak u smanjenju bolesti srca, raka ili smrti. Kako bi ispitali dugoročni učinak resveratrola, znanstvenici su proučavali uzorke urina kod 783 zdravih žena i muškaraca, starih 65 godina ili više, iz dva talijanska sela u regiji Chianti, gdje je uobičajena konzumacija crnog vina. Znanstvenici su uspoređivali pristunost resveratrol u njihovom urinu s njihovom vjerojatnošću od smrti, razvoja srčanih bolesti ili raka tijekom 11-godišnjeg razdoblja studije, do 1989. do 2009. godine. U tom razdoblju, 27.2 posto sudionika oboljelo je od srčanih bolesti, dok ih je gotovo 5 posto oboljelo od nekog oblika raka. Više od trećine – 34.3 posto – umrlo je tijekom studije. Nakon što su se u obzir uzeli dob, spol i drugi faktori, znanstvenici su otkrili da osobe s visokim koncentracijama resveratrola u urinu, nisu imale manju vjerojatnost od smrti, razvoja srčanih bolesti, raka ili upalnih markera od osoba bez resveratrol. ‘Ova studija sugerira da resveratrol iz zapadnih dijeta kod starijih osoba nema značajan utjecaj na upale, kardiovaskularne bolesti, rak ili dugovječnost’, napisali su autori studije. ‘Ispada da je priča o resveratrolu još jedan slučaj dizanja u nebo zdravstvenih koristi koje nisu izdržale test vremena’, kaže vodeći autor studije, dr. Richard D. Semba, profesor oftalmologije na Medicinskom fakultetu Sveučilišta Johns Hopkins. ‘Smatralo se da su neke namirnice dobre za vas jer sadrže resveratrol. To uopće nismo pronašli.’ Prethodna istraživanja imala su mješovite rezultate. Jedna je studija pokazala da resveratrol produžava dugovječnost debelih miševa, ali ne i onih koji su mršavi. Druga je izrazila sumnju da je resveratrol aktivan u tijelu nakon probave te postavila pitanje koliko crnog vina treba popiti da bi od njega imali zdravstvene koristi. ‘To ne znači da su koristi od čokolade ili crnog vina potpuno beznačajne. Vjerojatno dolaze od drugog spoja koji tek treba identificirati’, kaže dr. Semba. ‘To je kompleksna hrana, a iz naše studije smo došlo do saznanja da korist vjerojatno ne dolazi iz resveratrola.’