http___medlib.mef.hr_1007__2.xml
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Polašek, Ozren and Jerončić, Iris and Mulić, Rosanda and Klišmanić, Zorana and Pehlić, Marina and Zemunik, Tatijana and Kolčić, Ivana (2010) Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series. Croatian Medical Journal, 51 (1). English abstract Aim. To investigate whether intra-personal variation in serum uric acid concentration is influenced by genes that were described to be associated with serum uric acid levels in cross-sectional studies. ----- Methods. The study included 92 participants from the isolated community of the Croatian island of Vis. For each participant, two uric acid concentration measurements were available, one from 2002 and one from 2003. Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12. ----- Results. Thirteen participants (14%) had uric acid concentration change greater than 130 mumol/L. Greater variability of uric acid concentration was recorded in women (coefficient of variation 49% vs 12% in men). Two SNPs belonging to SLC17A3 gene (rs9393672 and rs942379) yielded significant association with serum uric acid concentration changes in women. These two single-nucleotide polymorphisms (SNP) explained 0.2%-1.3% of variance for 2002 or 2003 uric acid measurement and 1.1%-1.8% of variance for the average value of these two measurements. ----- Conclusions. Repeated measurements offer a possibility to enrich the percent of explained variance and contribute to the understanding of the "missing heritability" concept. Although a number of genes have been shown to affect serum uric acid concentration, SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. Actions (login required)
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Matijević, Vesna (2011) Povezanost koncentracije urične kiseline u serumu i ishoda sustavnog trombolitičkog liječenja akutnog infarkta mozga alteplazom [Correlation of serum uric acid level and the efficacy of systemic thrombolyses with alteplase in acute ischemic stroke]. PhD thesis, Sveučilište u Zagrebu. Abstract A large number of epidemiological studies reported controverse association between elevated serum levels of uric acid and stroke outcome. Results of some studies show link between increasing serum urate level and worse outcome and risk of early clinical deterioration after acute stroke. Others report a protective, antioxidant role of uric acid that inffluence positively on recanalization succes and reduce infarct volume size, and thus better clinical recovery. Following clinical outcome of our thrombolised patients with defined levels of serum uric acid in 24 hours after stroke onset period, we didn't find worse outcome in those with elevated serum uric acid. Patients with higher uric acid levels had higher sistolic an dyastolic blood pressure at admission, and lower NIHSS score. Significant lower proportion of intracerebral bleeding occured in patients with higher uric acid levels, and we defined cut off value as 256 umol/L. Patients with higher uric acid level had atrial flutter more frequently than others. Our results are consistent with the results of possible neuroprotective role of uric acid in patients with stroke treated with thrombolytic therapy. Abstract in Croatian Objavljen je niz epidemioloških studija s kontroverznim rezultatima o povezanosti povišene razine urične kiseline u serumu i ishoda cerebrovaskularnih bolesti. Neke studije ukazuju na povezanost hiperuricemije s češćom pojavom i lošijim ishodom liječenja akutnog infarkta mozga, dok rezultati ostalih ukazuju na moguću protektivnu ulogu urata, koja se temelji na njihovom antioksidativnom potencijalu. Prateći rezultate ishoda sustavnog trombolitičkog liječenja naše grupe bolesnika s utvrđenim vrijednostima serumske urične kiseline unutar 24 sata od nastanka infarkta mozga nismo utvrdili povezanost viših razina urata i lošijeg ishoda liječenja. Bolesnici s višim razinama urične kiseline imali su više sistoličke i dijastoličke tlakove, te niži NIHSS bodovni zbroj kod prijama. Isti bolesnici imali su rjeđe komplikaciju intracerebralnog krvarenja od onih s nižim vrijednostima urične kiseline, a kao graničnu vrijednost utvrdili smo serumsku razinu od 256 umol/L. Bolesnici s višim vrijednostima urične kiseline imali su češće fibrilaciju atrija kao čimbenik rizika. Naši su rezultati stoga sukladni rezultatima ispitivanja koja upućuju na moguću protektivnu ulogu urata kod bolesnika s akutnim ishemijskim moždanim udarom, liječenima trombolitičkom terapijom. Actions (login required) Downloads Downloads per month over past year