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All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology Gastroenterology Immunology Infectious Diseases Mental Health Neurology Obstetrics Orthopedics Public Health Respiratory Rheumatology Urology Track topics on Twitter Track topics that are important to you In this study, serum adiponectin and resistin levels were determined in 46 patients with polycystic ovarian syndrome (PCOS), and their correlation with serum sexual hormones and insulin resistance (IR) were examined. The subjects included 26 obese patients with body mass index (BMI)>25 and 20 non-obese patients with BMI[Symbol: see text]25, with 25 obese and 25 non-obese healthy volunteers without PCOS serving as controls. Serum adiponectin and resistin levels in all subjects were measured, and endocrinal and metabolic indices were also analysed. Our results showed that the serum adiponectin levels in both obese and non-obese PCOS groups were significantly lower than their controls, while the serum resistin levels in obese and non-obese PCOS group were significantly higher than in their controls (P<0.001). The serum adiponectin level was significantly lower and serum resistin level significantly higher in the non-obese PCOS group as compared with the obese control group (P<0.05). Serum adiponectin level was negatively correlated with FIN, HOMA-IR, LH and LH/FSH (P<0.05), but serum resistin level was positively correlated with FIN, HOMA-IR, LH and LH/FSH (P<0.05). We are led to conclude that PCOS patients have obvious IR, low serum adiponectin and high serum resistin, and adiponectin and resistin might play important roles in the pathogenesis of IR in PCOS patients. Department of Obstetrics and Gynecology, the First Clinical College of Ji'nan University, Guangzhou, 510630, China, sunneywang@126.com. This article was published in the following journal. Name: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia. Alterations in serum adipokines in preeclampsia remain vague. We investigated the roles of leptin, adiponectin and resistin and their relationships with clinical characteristics in normotensive and pr... Blood ghrelin, adiponectin and resistin levels during controlled ovarian stimulation in IVF cycles. The aim of the present study was to investigate changes of blood ghrelin, adiponectin and resistin levels in IVF/ICSI-ET cycles. Twenty women were stimulated with recombinant FSH in a GnRH agonist sho... Hormonal Changes After Laparoscopic Ovarian Diathermy in Patients with Polycystic Ovarian Syndrome. To assess the changes in hormonal profile (serum FSH, LH, prolactin and total testosterone) following laparoscopic ovarian drilling (LOD) in patients with polycystic ovarian syndrome. Serum anti-Mullerian hormone levels after ovarian drilling for the second-line treatment of polycystic ovary syndrome: a pilot-randomized study comparing laparoscopy and transvaginal hydrolaparoscopy. Aim of the study was to asses and compare serum anti-Mullerian harmone (AMH) levels after laparoscopic ovarian drilling (LOD) and transvaginal hydrolaparoscopy (THL) ovarian drilling in clomifene citr... Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome. This study was designed to evaluate insulin resistance and plasma levels of visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome (PCOS). A total of 37 premenopausal PCO... Evaluation of Adipokines in Obese and Non-obese Egyptian Women With Polycystic Ovary Syndrome To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS). Normal Serum Adiponectin Levels in Females The purpose of the study is to establish the normal levels of the hormone adiponectin in women. Adiponectin is a newly discovered hormone, which is said to be associated with many changes ... Effect of an Anti-Oxidant Treatment on Resistin Serum Levels. A Randomized Study The aim of the present study was to evaluate whether an in vivo treatment with an antioxidant vitamin (vitamin C) might substantially affect serum levels of resistin, a recently described ... Effect of Metformin Therapy on Serum Under-carboxylated Osteocalcin Levels in Hyperandrogenic Lean Polycystic Ovarian Syndrome Women High ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity. Meformin is an insulin sensitizing agent will be given for these women try... Comparison of Bone Morphogenetic Protein-4 (BMP-4) and 7 Levels Between Control and Polycystic Ovarian Syndrome (PCOS) Patients. The investigators aim to compare the levels of bone morphogenetic protein-4 and -7 (BMP-4 and 7) in blood, follicular fluid and ovarian organ culture supernatant obtained from healthy sub... Adiponectin A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS. Receptors, Adiponectin Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin. Hyperthyroxinemia, Familial Dysalbuminemic An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4. Resistin A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake. Adipokines Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions. Quick Links Advanced Search | Login | Subscribe | RSS Search PubMed Journal Article Database
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Zlopaša, Gordan (2011) Adipokini u bolesnica sa sindromom policističnih jajnika [Adipokines in patients with polycystic ovary syndrome]. PhD thesis, Sveučilište u Zagrebu. Croatian abstract Sindrom policističnih jajnika (PCOS) je multisistemski, endokrinološki, reprodukcijski i metabolički poremećaj, karakteriziran oligo/anovulacijama, hiperandrogenizmom i policističnim izgledom jajnika. Često je udružen s debljinom i inzulinskom rezistencijom. Žene s PCOS imaju povišen rizik za šećernu bolest tipa 2, dislipidemiju i kardiovaskularne bolesti. Sve je više studija koje govore u prilog da je lučenje hormona masnog tkiva – adipokina (leptina, adiponektina, grelina i rezistina) promijenjeno u bolesnica s PCOS te da bi promjene u lučenju adipokina kod žena s PCOS mogle biti važan pretskazatelj kliničkog tijeka bolesti uključujući nastanak dijabetesa i kardiovaskularnih bolesti. ----- ISPITANICE I METODE: U istraživanje smo uključili 151 ženu s dijagnozom PCOS postavljenu prema Rotterdamskim kriterijima i 95 zdravih žena usklađenih prema dobi i tjelesnoj težini. Usporedili smo razine leptina, rezistina, grelina i adiponektina te biokemijskih pokazatelja inzulinske rezistencije (inzulin i HOMA indeks) i kardiovaskularnog rizika (kolesterol, LDL, hsCRP) između ispitivanih skupina s ciljem utvrđivanja razlika u njihovim vrijednostima. Potom smo usporedili vrijednosti ovih adipokina između različitih fenotipa PCOS i pokušali utvrditi koji od ispitivanih čimbenika ima najveći utjecaj na njihove serumske razine. ----- REZULTATI: Utvrdili smo statistički značajne razlike u serumskim razinama svih adipokina između ispitivanih skupina ( p<0,001). Vrijednosti inzulina i HOMA indeks te kolesterol, LDL i hsCRP bili su značajno viši u PCOS skupini (p<0,001). Značajna razlika nađena je u razinama svih adipokina unutar PCOS skupine kada smo usporedili bolesnice normalne težine s onima prekomjerne težine (p<0,001). Utvrdili smo značajnu pozitivnu povezanost koncentracija leptina i rezistina i značajnu negativnu povezanost koncentracija adiponektina i grelina s porastom težine PCOS fenotipa koji se razlikovao obzirom na nazočnost ili izočnost hiperandrogenemije, inzulinske rezistencije i debljine. Metodom standardne linearne regresije ustanovili smo najveći utjecaj same dijagnoze PCOS na razine adiponektina (B= -0,743, p<0,001) i grelina (B= -0,660, p<0,001), u serumu ispitanica, dok je na razinu leptina najveći utjecaj imao ITM (B= 0,540, P<0,001). Na razinu rezistina utjecaj dijagnoze (B= 491, p<0,001) i ITM (B= 491, p<0,001) bio je gotovo identičan. Unutar skupine PCOS ispitanica na razine svih adipokina u cirkulaciji najviše je utjecala debljina, odnosno ITM. ----- ZAKLJUČAK: Bolesnice s PCOS imaju značajno povišene razine leptina i rezistina i značajno snižene razine adiponektina i grelina u serumu u odnosu na zdrave žene, a njihove koncentracije mijenjaju se s težinom fenotipa. Identifikacijom bolesnica s promjenama u lučenju adipokina, kao putativnih markera kasnijih metaboličkih komplikacija, na vrijeme bi se moglo započeti s preventivnim strategijama u smislu promjena životnih navika i/ili korištenja lijekova koji smanjuju osjetljivost na inzulin. English abstract Polycystic ovary syndrome (PCOS) is a multisystem endocrinological reproductive-metabolic disorder, characterised with oligo/anovulation, hyperandrogenism and polycystic ovaries. PCOS is often connected with obesity and insulin resistance. Patients with PCOS have increased risk for infertility, diabetes mellitus type 2, hypetension and cardiovascular diseases. ----- STUDY SUBJECTS AND METHODS: The study included 151 women diagnosed with PCOS set by the Rotterdam criteria and 95 healthy women matched by age and weight. We compared the levels of leptin, resistin, ghrelin, and adiponectin, and biochemical parameters of insulin resistance (insulin and HOMA index) and cardiovascular risk factors (cholesterol, LDL, hsCRP) between the two groups to determine differences in their values. Furthermore, we compared the values of these adipokines among different PCOS phenotypes and tried to determine which of the examined factors have the greatest impact on their serum levels. ----- RESULTS: We found statistically significant differences in all adipokines serum levels between PCOS patients and healthy controls (p <0.001). The values of insulin and HOMA index, and cholesterol, LDL, and hsCRP were significantly higher in PCOS group (p <0.001). There were a significant differences in adipokines serum levels between normal weight (BMI ≤25) and overweight (BMI ≥25) PCOS patients (p <0.001). A significant positive correlation for the leptin and resistin concentrations, and significant negative correlation for the adiponectin and ghrelin concentrations with increasing severity of PCOS phenotype was observed (the more risk factors, such as higher BMI, hyperandrogenemia, and greater insulin resistance patient had, the lower concentration of adiponectin and ghrelin, and the higher concentration of leptin and resistin were found). By the method of standard linear regression, we found the greatest impact of the diagnosis of PCOS on adiponectin levels (B = -0.743, p <0.001) and ghrelin levels (B = -0.660, p <0.001) in the serum of patients, whereas on the leptin levels BMI had the greatest impact (B = 0.540, P <0.001). The impact of PCOS diagnosis (B = 491, p <0.001) and BMI (B = 491, p <0.001) on serum resistin levels was nearly identical. Among the PCOS patients, the greatest impact of ITM on the circulating adipokine levels was found. ----- CONCLUSIONS: Women with PCOS have significantly elevated leptin and resistin serum levels, and significantly lower adiponectin and ghrelin serum levels than healthy women, and their concentrations change with the severity of the phenotype. Identification of women with altrued adipokine expression as putative markers of possible metabolic and cardiovascular complications, would be usefull for settingup preventive strategies by life-style changes and/or use of insulin-sensitising agens. Actions (login required)