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Serum visfatin levels in women with polycystic ovary syndrome. Summary of "Serum visfatin levels in women with polycystic ovary syndrome." The aim of this study is to determine the serum levels of visfatin in patients with polycystic ovary syndrome (PCOS) and to understand its correlations with other metabolic and hormonal parameters. Thirty-seven patients with PCOS and 30 women without concomitant disease were included in this study. Serum visfatin levels were similar in patients with PCOS and control group. Visfatin levels were higher in normal weight PCOS when compared with obese PCOS, but it did not reach statistical significance. Visfatin levels correlated negatively with fasting blood glucose, total cholesterol (TC), low-density lipoprotein (LDL) and lipoprotein-a levels in PCOS patients. CRP levels increased both in obese PCOS and in obese controls. Plasma visfatin levels had no correlation with homeostasis model assessment-insulin resistance and fasting insulin levels, but the negative correlation between plasma visfatin levels and lipoprotein-a, fasting plasma glucose, TC and LDL levels may indicate a role for visfatin in cardiovascular disease independent of insulin resistance. Affiliation Department of Obstetrics and Gynecology , Istanbul , Turkey. Journal Details This article was published in the following journal. Name: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Pages: Links - PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22313145 PubMed Articles Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome. Polycystic ovary syndrome (PCOS) is a common disorder. PCOS women are at a high risk for insulin resistance and metabolic syndrome (MS). Adiponectin is positively related to insulin sensitivity. It ha... Polycystic ovary syndrome influences the level of serum amyloid A and activity of phospholipid transfer protein in HDL2 and HDL3. Is polycystic ovary syndrome (PCOS) associated with altered levels of pro-inflammatory high-density lipoproteins (HDL) and activity of HDL-associated enzymes? Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome. Polycystic ovary syndrome (PCOS) is a common reproductive endocrinology disease, however, an explicit etiology is not known. Insulin resistance (IR) appears to be central to the pathogenesis of PCOS a... Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome. The aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls. Are insulin resistance and serum resistin levels increased in women with idiopathic hirsutism? To investigate the insulin resistance and serum resistin levels in women with idiopathic hirsutism compared to controls and women with polycystic ovary syndrome (PCOS). Clinical Trials Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome OBJECTIVES: I. Determine whether reduction of serum insulin levels by metformin increases ovulatory response to clomiphene citrate in women with polycystic ovary syndrome. Evaluation of Serum Prostatic Specific Antigen (PSA) After Cyproterone Compound Treatment Compared With Oral Contraceptives Pill in Hirsute Polycystic Ovary Syndrome Patients The purpose of this study is to evaluate the effect of oral contraceptive on the serum free prostatic specific antigen (PSA)in women with polycystic ovary syndrome(PCOD)compared with cypro... Cortisol Regulation in Polycystic Ovary Syndrome (PCOS) The purpose of this study is to determine if insulin resistance (how well the body uses insulin and clears sugar) can affect cortisol levels in normal healthy women and women with polycyst... Simvastatin Therapy in Women With Polycystic Ovary Syndrome. The purpose of this study is to determine whether statins (simvastatin) improve clinical (excessive hair, skin problems), endocrine (androgens) and metabolic (lipids, markers of systemic i... Insulin and the Polycystic Ovary Syndrome--Weight Reduction Study The polycystic ovary syndrome is the leading cause of female infertility in the United States. The disorder affects approximately 6-10% of women of reproductive age. It is widely accepte... Medical and Biotech [MESH] Definitions Polycystic Ovary Syndrome A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading. Hyperandrogenism A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION. Hyperthyroxinemia, Familial Dysalbuminemic An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4. Thyroid Hormone Resistance Syndrome An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels. Hyper-igm Immunodeficiency Syndrome A rare inherited immunodeficiency syndrome characterized by normal or elevated serum IMMUNOGLOBULIN M levels with absence of IMMUNOGLOBULIN G; IMMUNOGLOBULIN A; and IMMUNOGLOBULIN E. It results in a profound susceptibility to BACTERIAL INFECTIONS and an increased susceptibility to OPPORTUNISTIC INFECTIONS. Several subtypes of hyper-IgM immunodeficiency syndrome exist depending upon the location of genetic mutation.
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Zlopaša, Gordan (2011) Adipokini u bolesnica sa sindromom policističnih jajnika [Adipokines in patients with polycystic ovary syndrome]. PhD thesis, Sveučilište u Zagrebu. Abstract Polycystic ovary syndrome (PCOS) is a multisystem endocrinological reproductive-metabolic disorder, characterised with oligo/anovulation, hyperandrogenism and polycystic ovaries. PCOS is often connected with obesity and insulin resistance. Patients with PCOS have increased risk for infertility, diabetes mellitus type 2, hypetension and cardiovascular diseases. ----- STUDY SUBJECTS AND METHODS: The study included 151 women diagnosed with PCOS set by the Rotterdam criteria and 95 healthy women matched by age and weight. We compared the levels of leptin, resistin, ghrelin, and adiponectin, and biochemical parameters of insulin resistance (insulin and HOMA index) and cardiovascular risk factors (cholesterol, LDL, hsCRP) between the two groups to determine differences in their values. Furthermore, we compared the values of these adipokines among different PCOS phenotypes and tried to determine which of the examined factors have the greatest impact on their serum levels. ----- RESULTS: We found statistically significant differences in all adipokines serum levels between PCOS patients and healthy controls (p <0.001). The values of insulin and HOMA index, and cholesterol, LDL, and hsCRP were significantly higher in PCOS group (p <0.001). There were a significant differences in adipokines serum levels between normal weight (BMI ≤25) and overweight (BMI ≥25) PCOS patients (p <0.001). A significant positive correlation for the leptin and resistin concentrations, and significant negative correlation for the adiponectin and ghrelin concentrations with increasing severity of PCOS phenotype was observed (the more risk factors, such as higher BMI, hyperandrogenemia, and greater insulin resistance patient had, the lower concentration of adiponectin and ghrelin, and the higher concentration of leptin and resistin were found). By the method of standard linear regression, we found the greatest impact of the diagnosis of PCOS on adiponectin levels (B = -0.743, p <0.001) and ghrelin levels (B = -0.660, p <0.001) in the serum of patients, whereas on the leptin levels BMI had the greatest impact (B = 0.540, P <0.001). The impact of PCOS diagnosis (B = 491, p <0.001) and BMI (B = 491, p <0.001) on serum resistin levels was nearly identical. Among the PCOS patients, the greatest impact of ITM on the circulating adipokine levels was found. ----- CONCLUSIONS: Women with PCOS have significantly elevated leptin and resistin serum levels, and significantly lower adiponectin and ghrelin serum levels than healthy women, and their concentrations change with the severity of the phenotype. Identification of women with altrued adipokine expression as putative markers of possible metabolic and cardiovascular complications, would be usefull for settingup preventive strategies by life-style changes and/or use of insulin-sensitising agens. Abstract in Croatian Sindrom policističnih jajnika (PCOS) je multisistemski, endokrinološki, reprodukcijski i metabolički poremećaj, karakteriziran oligo/anovulacijama, hiperandrogenizmom i policističnim izgledom jajnika. Često je udružen s debljinom i inzulinskom rezistencijom. Žene s PCOS imaju povišen rizik za šećernu bolest tipa 2, dislipidemiju i kardiovaskularne bolesti. Sve je više studija koje govore u prilog da je lučenje hormona masnog tkiva – adipokina (leptina, adiponektina, grelina i rezistina) promijenjeno u bolesnica s PCOS te da bi promjene u lučenju adipokina kod žena s PCOS mogle biti važan pretskazatelj kliničkog tijeka bolesti uključujući nastanak dijabetesa i kardiovaskularnih bolesti. ----- ISPITANICE I METODE: U istraživanje smo uključili 151 ženu s dijagnozom PCOS postavljenu prema Rotterdamskim kriterijima i 95 zdravih žena usklađenih prema dobi i tjelesnoj težini. Usporedili smo razine leptina, rezistina, grelina i adiponektina te biokemijskih pokazatelja inzulinske rezistencije (inzulin i HOMA indeks) i kardiovaskularnog rizika (kolesterol, LDL, hsCRP) između ispitivanih skupina s ciljem utvrđivanja razlika u njihovim vrijednostima. Potom smo usporedili vrijednosti ovih adipokina između različitih fenotipa PCOS i pokušali utvrditi koji od ispitivanih čimbenika ima najveći utjecaj na njihove serumske razine. ----- REZULTATI: Utvrdili smo statistički značajne razlike u serumskim razinama svih adipokina između ispitivanih skupina ( p<0,001). Vrijednosti inzulina i HOMA indeks te kolesterol, LDL i hsCRP bili su značajno viši u PCOS skupini (p<0,001). Značajna razlika nađena je u razinama svih adipokina unutar PCOS skupine kada smo usporedili bolesnice normalne težine s onima prekomjerne težine (p<0,001). Utvrdili smo značajnu pozitivnu povezanost koncentracija leptina i rezistina i značajnu negativnu povezanost koncentracija adiponektina i grelina s porastom težine PCOS fenotipa koji se razlikovao obzirom na nazočnost ili izočnost hiperandrogenemije, inzulinske rezistencije i debljine. Metodom standardne linearne regresije ustanovili smo najveći utjecaj same dijagnoze PCOS na razine adiponektina (B= -0,743, p<0,001) i grelina (B= -0,660, p<0,001), u serumu ispitanica, dok je na razinu leptina najveći utjecaj imao ITM (B= 0,540, P<0,001). Na razinu rezistina utjecaj dijagnoze (B= 491, p<0,001) i ITM (B= 491, p<0,001) bio je gotovo identičan. Unutar skupine PCOS ispitanica na razine svih adipokina u cirkulaciji najviše je utjecala debljina, odnosno ITM. ----- ZAKLJUČAK: Bolesnice s PCOS imaju značajno povišene razine leptina i rezistina i značajno snižene razine adiponektina i grelina u serumu u odnosu na zdrave žene, a njihove koncentracije mijenjaju se s težinom fenotipa. Identifikacijom bolesnica s promjenama u lučenju adipokina, kao putativnih markera kasnijih metaboličkih komplikacija, na vrijeme bi se moglo započeti s preventivnim strategijama u smislu promjena životnih navika i/ili korištenja lijekova koji smanjuju osjetljivost na inzulin. 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