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Kids with high uric acid at higher risk of BP at age seven: Study Washington D.C. [USA], Mar. 16 (ANI): A recent study reveals, babies, especially preterm ones, with high levels of serum uric acid during early years of life, may be associated with high blood pressure at the age of seven, further leading to hypertension in adulthood. The study further says, this high level of serum uric acid at very early years in tots, is a result of the in-utero environment. The findings, published in the American Journal of Hypertension, suggest that baseline serum uric acid levels measured at three years of age, significantly affected subsequent blood pressure in the sex and body mass index adjusted longitudinal data analysis. The participants with high uric acid levels at both three and five years of age had the highest systolic blood pressure at seven years of age. "Many studies have shown that early-life health can affect adulthood," said the study's lead author Hyesook Park from from Oxford University Press USA. "We think that along with childhood health monitoring, early intervention in childhood is the most effective way to prevent future disease," Park added. Foods and beverages, with high purine contents include liver, anchovies, mackerel, dried beans, beer and wine and high levels of uric acid have the potential to lead to gout, diabetes and chronic kidney disease. The researchers measured the uric acid levels of 449 children in Seoul, South Korea, and performed at least two follow-up examinations between 2001 and 2006. The cohort was composed of mothers who visited hospitals for prenatal care between 24 and 28 weeks of gestation. Serum uric acid levels, blood pressure and anthropometric characteristics were assessed at three, five, and seven years of age. The findings suggest the importance of maintaining appropriate levels of serum uric acids from the early life. Appropriate monitoring and intervention of uric acid levels in a high-risk group can potentially reduce the risk of a future increased blood pressure.
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Matijević, Vesna (2011) Povezanost koncentracije urične kiseline u serumu i ishoda sustavnog trombolitičkog liječenja akutnog infarkta mozga alteplazom [Correlation of serum uric acid level and the efficacy of systemic thrombolyses with alteplase in acute ischemic stroke]. PhD thesis, Sveučilište u Zagrebu. Abstract A large number of epidemiological studies reported controverse association between elevated serum levels of uric acid and stroke outcome. Results of some studies show link between increasing serum urate level and worse outcome and risk of early clinical deterioration after acute stroke. Others report a protective, antioxidant role of uric acid that inffluence positively on recanalization succes and reduce infarct volume size, and thus better clinical recovery. Following clinical outcome of our thrombolised patients with defined levels of serum uric acid in 24 hours after stroke onset period, we didn't find worse outcome in those with elevated serum uric acid. Patients with higher uric acid levels had higher sistolic an dyastolic blood pressure at admission, and lower NIHSS score. Significant lower proportion of intracerebral bleeding occured in patients with higher uric acid levels, and we defined cut off value as 256 umol/L. Patients with higher uric acid level had atrial flutter more frequently than others. Our results are consistent with the results of possible neuroprotective role of uric acid in patients with stroke treated with thrombolytic therapy. Abstract in Croatian Objavljen je niz epidemioloških studija s kontroverznim rezultatima o povezanosti povišene razine urične kiseline u serumu i ishoda cerebrovaskularnih bolesti. Neke studije ukazuju na povezanost hiperuricemije s češćom pojavom i lošijim ishodom liječenja akutnog infarkta mozga, dok rezultati ostalih ukazuju na moguću protektivnu ulogu urata, koja se temelji na njihovom antioksidativnom potencijalu. Prateći rezultate ishoda sustavnog trombolitičkog liječenja naše grupe bolesnika s utvrđenim vrijednostima serumske urične kiseline unutar 24 sata od nastanka infarkta mozga nismo utvrdili povezanost viših razina urata i lošijeg ishoda liječenja. Bolesnici s višim razinama urične kiseline imali su više sistoličke i dijastoličke tlakove, te niži NIHSS bodovni zbroj kod prijama. Isti bolesnici imali su rjeđe komplikaciju intracerebralnog krvarenja od onih s nižim vrijednostima urične kiseline, a kao graničnu vrijednost utvrdili smo serumsku razinu od 256 umol/L. Bolesnici s višim vrijednostima urične kiseline imali su češće fibrilaciju atrija kao čimbenik rizika. Naši su rezultati stoga sukladni rezultatima ispitivanja koja upućuju na moguću protektivnu ulogu urata kod bolesnika s akutnim ishemijskim moždanim udarom, liječenima trombolitičkom terapijom. Actions (login required) Downloads Downloads per month over past year