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All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery Endocrinology Gastroenterology Immunology Infectious Diseases Mental Health Neurology Obstetrics Orthopedics Public Health Respiratory Rheumatology Urology Track topics on Twitter Track topics that are important to you Regulatory T (Treg) cells are a subpopulation of T cells with the ability to control the responses of both CD4+ and CD8+ T cells. A case-control study was conducted in order to determine the functional attributes of Treg cells within the breast cancer milieu. Triple-color flow cytometry was utilized to study the phenotype expression of CD4+CD25+ Treg cells and CD8+ T cells in autologous tumor-infiltrating lymphocytes (TILs) and peripheral blood lymphocytes (PBLs) derived from 33 patients with stage I-III breast cancer. The prevalence of CD4+CD25+ T cells was significantly higher in TILs than in PBLs. The expressions of FOXP3 and GITR in CD4+CD25+ Treg cells were lower in PBLs than in TILs. Functional studies showed that both granzyme B and perforin were barely expressed in peripheral Treg cells but were highly expressed in Treg cells in the tumor microenvironment. On the contrary, down-regulation of both granzyme B and perforin expressed in the CD8+ cytotoxic T lymphocytes was significantly lower in TILs than in PBLs. Further functional assays demonstrated that Th1 cytokines and cytotoxic molecules were synchronously up-regulated in CD8+ cytotoxic T cells. The in vitro kinetic study showed that adequate activation of TILs derived from breast cancer tissue could restore the appropriate antitumor immune response. Department of Surgery, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan. This article was published in the following journal. Name: Immunologic research Pages: Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation. To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulato... Spatial distribution of FoxP3+ and CD8+ tumour infiltrating T cells reflects their functional activity. Regulatory and cytotoxic T cells are key players in the host's anticancer immune response. We studied the spatial distribution of FoxP+ and CD8+ cells to identify potential interactions. Subpopulations of T regulatory cells in blood stem cell harvests influence development of acute graft vs. host disease in allogeneic transplant recipients. CD4(+) FoxP3(+) regulatory T cells (Tregs) are potent suppressors of activation and proliferation of conventional T cells. Tregs subdivided by their expression of FoxP3 and CD45RA identify clinically ... Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-B during Murine Colitis. Myeloid-derived suppressor cells (MDSCs) are well known regulators of regulatory T cells (Treg cells); however, the direct regulation of MDSCs by Treg cells has not been well characterized. We find t... Overrepresentation of IL-10-Expressing B Cells Suppresses Cytotoxic CD4+ T Cell Activity in HBV-Induced Hepatocellular Carcinoma. Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis and low five-year survival rate. A strong and effective CD4+ T cell-mediated cytotoxicity was associated with better survival and ... Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients New therapeutic approaches of MS are emerging, targeting different actors of the immune system. Some of them target a specific population of white blood cells: B lymphocytes composed of di... Rapamycin and Regulatory T Cells in Kidney Transplantation The immune system response is mediated by the interaction between the antigen presenting cell (APC), CD4+ T helper cells (Th) and CD4+ CD25+ regulatory T cells, a subgroup of CD4+ T cell w... Training of Neural Responding in BPD Emotion-related brain activation is made visible for patients via neurofeedback with the aim to improve discriminability of emotional arousal and emotion regulation. With functional magnet... Importance of CD4+CD25+ly in UC1. Investigation of Difference Between Blood Concentration IL 17, IL 33, Regulatory T ly in Patients With UC and Control Group Mucosal inflammation in patients with UC is the result of immunosuppression disturbance because decreasing number of regulatory T ly and activation IL 17 Lymphoid follicles, consisting of T-and B cells, are involved in the chronic inflammatory response in COPD. Foxp3 positive regulatory T cells (Tregs) are present in these follicles and may... Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Cathepsin W A cysteine endopeptidase found in NATURAL KILLER CELLS and CYTOTOXIC T-LYMPHOCYTES. It may have a specific function in the mechanism or regulation of cytolytic activity of immune cells. Down-regulation A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. Up-regulation A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. Cd8-positive T-lymphocytes A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes. Quick Links Advanced Search | Login | Subscribe | RSS Blood Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo... Breast Cancer Track and monitor developments in breast cancer research and commercial development. Follow the tabs above to read the latest global news, research, clinical trials on breast cancer and follow companies active in the development of breast cancer tr... Search PubMed Journal Article Database
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Boras, Zagorka (2004) Citokinski profil limfocita T iz krvi i bronhoalveolarnog ispirka u bolesnika s plućnom tuberkulozom [ Cytokine profile of T-lymphocytes from peripheral blood and bronchoalveolar lavage fluid in patients with active pulmonary tuberculosis ]. PhD thesis, Sveučilište u Zagrebu. Abstract Cell-mediated immunity, especially from CD4+ T-lymphocyte function, plays an important role in eliminatig mycobacteria in tuberculosis. Reports on Th1-type and Th2-type cytokines in human tuberculosis are conflicting, and little is known about their role in tissue damage. We examined the cytokine responses of CD4+ and CD8+ T-lymphocytes in peripheral blood and bronchoalveolar lavage fluid (BAL) from 20 purified protein derivative skin-positive (PPD+) and from nine PPD skin-negative patients with active pulmonary tuberculosis. Parallel blood and BAL fluid samples from each subject were shortly incubated with or without PMA and ionomycin, and the proportions of CD4+ and CD8+ T-lymphocytes producing interferon- (IFN-) or interleukin-4 (IL-4) were measured by flow cytometry. There was no age or BMI difference of examiness between PPD+ and PPD- group. PPD- patients, in relation to PPD+ patients, had a significant higher percent of CD4+ T-lymphocytes in the BAL. No significant difference was found between groups in percent CD4+ T-lymphocytes in peripheral blood and CD8+ T-lyphocytes peripheral blood and BAL. At the same time, PPD- patients have shown a significant higher percent of CD4+ T-lymphocytes which produced IFN- in relation to the entire number activated CD4+ T-lymphocytes in a peripheral blood. No significant difference was found in the production IFN- of CD8+ T-lymphocytes peripheral blood and BAL and CD4+ T-lymphocytes in the BAL. CD4+ T-lymphocytes of peripheral blood in two PPD-patients produced IL-4 while the rest of the T-lymphocytes peripheral blood and BAL suppressed the production of this cytokine. Among PPD+ patients group we have found a higher percent of CD4+ as well as CD8+ T-lymphocytes which produce IFN- in BAL in relation to the peripheral blood, while the BAL in PPD- group was more active only in CD4+ production IFN-. These results suggest a higher immune activity in the blood of PPD- patients while the BAL is more active in both groups of examinees in relation to the peripheral blood. It suggests that the separation of T-lymphocytes, specially those producing IFN- from peripheral blood to the lungs, occurs in tuberculosis. Abstract in Croatian Stanicama je posredovana imunost, naročito CD4+ T-limfocitima, ključna u eliminaciji mikobakterija u tuberkulozi. Dosadašnja saznanja o Th1 i Th2 tipu citokinske proizvodnje u ljudskoj tuberkulozi konfliktna su i malo se zna o njihovoj ulozi u tkivnom oštećenju. Mi smo istraživali citokinski odgovor CD4+ i CD8+ T-limfocita periferne krvi i BAL-a u 20 PPD+ i devet PPD- bolesnika s aktivnom plućnom tuberkulozom. Uzorci periferne krvi i BAL-a svakog bolesnika bili su kratkotrajno inkubirani s PMA i ionomicinom ili bez njih, nakon čega smo na protočnom citometru određivali CD4+ i CD8+ T-limfocite koji su proizvodili IFN- ili IL-4. Između PPD+ i PPD- skupine nije bilo razlike u dobi ispitanika i BMI. PPD- bolesnici su, u odnosu na PPD +, imali značajno veći postotak CD4+ T-limfocita u BAL-u. Nije bilo značajnije razlike među grupama u postotku CD4 T-limfocita u perifernoj krvi i CD8+ u perifernoj krvi i BAL-u. Istovremeno, PPD- bolesnici iskazali su značajno veći postotak CD4+ T-limfocita u perifernoj krvi koji su proizvodili IFN-, a u odnosu na sveukupni broj tih aktiviranih CD4+ T-limfocita. Nije bilo razlike između skupina u proizvodnji IFN- od CD8+ T-limfocita krvi i BAL-a i CD4+ T-limfocita BAL-a. CD4+ T-limfociti periferne krvi dva PPD- bolesnika su proizvodili IL-4, a ostali su T-limfociti periferne krvi i BAL-a zakazali u proizvodnji navedenog citokina. Unutar PPD+ skupine bolesnika našli smo značajno veći postotak i CD4+ i CD8+ T-limfocita koji proizvode IFN- u BAL-u u odnosu na perifernu krv, dok je u PPD- skupine BAL bio aktivniji samo u CD4+ proizvodnji IFN-. Ovakvi rezultati sugeriraju veću imunološku aktivnost u PPD- bolesnika u krvi, a BAL je obje skupine ispitanika aktivniji u odnosu na perifernu krv. Sve to sugerira da u tuberkulozi dolazi do odjeljivanja T-limfocita, naročito onih koji proizvode IFN-, iz periferne krvi u pluća. Actions (login required) Downloads Downloads per month over past year