http___medlib.mef.hr_968__1.xml
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Kovačić, Zrnka and Henigsberg, Neven and Pivac, Nela and Nedić, Gordana and Borovečki, Andrea (2008) Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32 (2). English abstract Posttraumatic stress disorder (PTSD) is a serious and global problem, a psychiatric disorder that frequently occurs with different comorbidities, and is associated with a high suicide rate. Pathophysiologically, both PTSD and suicidal behavior are related to disturbances in the central serotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) controls emotional behavior, anxiety, impulsivity and aggression, and nearly all known antidepressants and antianxiety drugs affect 5-HT transmission. Platelet 5-HT can be used as a limited peripheral marker of the central serotonergic synaptosomes, since it is related to particular basic psychopathological characteristics of several psychiatric disorders. Platelet 5-HT concentration has been reported to be similar in PTSD subjects and healthy controls, but suicidal patients across different psychiatric diagnoses have reduced platelet 5-HT concentration. This study examined platelet 5-HT concentration by the spectrofluorimetric method in male subjects: 73 suicidal and 47 non-suicidal veterans with current and chronic combat related PTSD, 45 suicidal and 30 non-suicidal comparative non-PTSD subjects and 147 healthy men. The presence of suicidal behavior (score=0, non-suicidal; scores >/=1, suicidal) was assessed with the Hamilton Depression Rating Scale-17 (HDRS). Platelet 5-HT concentration was significantly lower in suicidal PTSD and non-PTSD patients compared to non-suicidal patients or healthy controls. Since the majority of patients scored very low on item 3 of HDRS, no significant correlation between suicidal scores and platelet 5-HT concentration was found. These results show that reduced platelet 5-HT concentration is related to suicidal behavior in PTSD, and suggest that platelet 5-HT concentration might be used as a peripheral marker to predict suicidal behavior across psychiatric diagnoses. Actions (login required)
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Marčinko, Darko and Bilić, Vedran and Pivac, Nela and Tentor, Berislav and Franić, Tomislav and Lončar, Mladen and Medjedović Marčinko, Vesna and Jakovljević, Miro (2011) Serum cholesterol concentration and structured individual psychoanalytic psychotherapy in suicidal and non-suicidal male patients suffering from borderline personality disorder. Collegium Antropologicum, 35 (Suppl.). pp. 219-23. Croatian abstract KONCENTRACIJA KOLESTEROLA I STRUKTURIRANA INDIVIDUALNA PSIHOANALITIČKA PSIHOTERAPIJA KOD SUICIDALNIH I NESUICIDALNIH MUŠKIH BOLESNIKA OBOLJELIH OD GRANIČNOG POREMEĆAJA OSOBNOSTI ----- Rezultati istraživanja brojnih studija upućuju na povezanost niske razine kolesterola i suicidalnog ponašanja kod bolesnika iz različitih dijagnostičkih kategorija. Cilj ovog istraživanja bio je ustanoviti jesu li vrijednosti serumskog kolesterola kod suicidalnih muških bolesnika s graničnim poremećajem osobnosti (N=20) niže u odnosu na nesuicidalne muške bolesnike s graničnim poremećajem osobnosti (N=20) i kontrolnu skupinu zdravih muških ispitanika (N=20) i provjeriti utječe li strukturirana individualna psihoanalitička psihoterapija na suicidalno ponašanje. Skupine su bile usklađene s obzirom na dob i indeks tjelesne mase (BMI). Rezultati istraživanja pokazuju da nema značajnih razlika u vrijednosti serumskog kolesterola između suicidalnih i nesuicidalnih muških bolesnika s graničnim poremećajem osobnosti i kontrolnih zdravih muških ispitanika. Razina psihopatologije (mjerena skalama Brief Psychiatric Rating Scale i Hamilton Depression Rating Scale) bila je značajno naglašenija kod suicidalnih bolesnika u odnosu na nesuicidalne bolesnike, što upućuje da je u praksi bitno prepoznati određene kliničke simptome kod bolesnika s graničnim poremećajem osobnosti s ciljem da se prevenira suicidalno ponašanje. Nesuicidalni bolesnici značajno su češće primili strukturiranu individualnu psihoanalitičku psihoterapiju prije hospitalizacije nego suicidalni bolesnici. Ti rezultati naglašavaju ulogu ovog oblika psihoterapije u preveniranju suicidalnog ponašanja u bolesnika sa graničnim poremećajem osobnosti. English abstract Findings from numerous studies suggest an association between low cholesterol levels and suicidal behavior in patients with different psychiatric diagnoses. The aims of this case-control study were to test whether cholesterol levels in male suicidal patients (N=20) with borderline personality disorder (BPD) are lower than in male non-suicidal patients (N=20) with BPD and male healthy control group (N=20), and to evaluate the influence of structured individual psychoanalytic psychotherapy on suicidal behavior. The groups were matched for age and body mass index (BMI). Results showed that serum cholesterol levels did not differ significantly between suicidal and non-suicidal BPD patients and healthy controls. The level of psychopathology (measured by Brief Psychiatric Rating Scale and Hamilton Depression Rating Scale) was significantly higher in the group of suicidal patients, which indicates the importance of evaluating particular clinical symptoms in BPD, in order to prevent suicidal behavior. Non-suicidal male patients suffering from BPD received more frequently structured individual psychoanalytic psychotherapy prior to the hospitalization than suicidal group. These results emphasized the role of this type of psychotherapy in preventing suicidal behavior in BPD patients. Actions (login required)