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Patients with neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) tend to have more severe visual field damage and irregularity than those with idiopathic optic neuritis. They also tend to have a worse prognosis than patients with idiopathic optic neuritis. For both types of optic neuritis, the 2 most common types of abnormalities were diffuse abnormalities and nerve fiber bundle abnormalities. Neurologic abnormalities, on the other hand, were more common in patients with NMOSD-ON, while central scotoma was more common in those with idiopathic optic neuritis. Finally, the visual function of patients with NMOSD-ON at 1 month was related to the prognosis of the disease, while that at 3 months was related to prognosis in patients with idiopathic optic neuritis. Continue Reading These are the findings of a study published in BMC Ophthalmology, the aim of which was to compare visual field defect evolvement in these 2 conditions. Read more about the prognosis of NMOSD The prospective study recruited 33 patients with NMOSD-ON and 71 patients with idiopathic optic neuritis who were followed for at least 6 months. The researchers compared the pattern and recovery pattern of visual field defects, mean defect and pattern standard deviation of the visual field, and best corrected visual acuity at disease onset and at 1, 3, and 6 months after onset. The results showed that the percentage of visual field defects was higher in patients with NMOSD-ON than in those with idiopathic optic neuritis. Moreover, the mean defect and pattern standard deviation of patients with NMOSD-ON were significantly worse at 1, 3, and 6 months than those of patients with idiopathic optic neuritis. There was a positive correlation in mean defect and pattern standard deviation between 1 and 6 months in patients with both conditions. There was a positive correlation in best corrected visual acuity between 1 and 6 months only in patients with NMOSD-ON. The most common pattern was the quadrant recovery pattern in both groups of patients. Reference Liang J, Zhang Y, Liu K, et al. Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study. BMC Ophthalmol.
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Vidović, Tomislav (2011) Vizualno senzorni deficiti u ranoj dijagnostici multiple skleroze [Visual sensory impairment in early stage of multiple sclerosis]. PhD thesis, Sveučilište u Zagrebu. Abstract AIM: to investigate the pattern of visual impairement in MS patients and to evaluate the effectiveness of various visual function tests in detecting visual function impairment. PATIENTS AND METHODS: 105 MS patients were examined and divided into three groups with 35 patients each: patients with acute unilateral optic neuritis (AON); patients with subjective feeling of blurred vision, normal visual acuity (KON); and patients free from subjective signs of visual impairment (SON). Study patients underwent standard ophthalmologic examination, Octopus perimetry, Pelli Robson contrast sensitivity testing, and color vision testing with Ishihara plates. RESULTS: visual field defects were found in all patients in group AON, in 75% of patients in group KON and 71% of patients in group SON. Mean scores for Pelli Robson test are 1.43 for affected eye and 1.50 for fellow eye in group KON, 1.48 in group KON, and 1.64 in group SON. No patients read all Ishihara plates during acute optic neuritis in group AON. CONCLUSION: The presence of subclinical form of optic nerve involvement could be demonstrated in early stage of multiple sclerosis by the introduction of visual function tests in the standard examination protocol. Abstract in Croatian UVOD: Multipla skleroza (MS) najčešća je kronična bolest središnjega živčanog sustava i pripada širokoj i važnoj skupini bolesti koje obilježuje razaranje mijelinskih ovojnica živčanih vlakana u mozgu, kralježničnoj moždini i vidnim putovima. Smatra se da je akutni optički neuritis najčešći oftalmološki znak te bolesti, no postoje i drugi oblici oštećenja vida. CILJ ISTRAŽIVANJA: Uporabom funkcionalnih metoda oftalmološke dijagnostike dokazati oštećenja vidne funkcije u bolesnika s multiplom sklerozom, te utvrditi vrstu, oblik i opseg oštećenja, potom oblik i opseg oštećenja vida u bolesnika s MS koji nisu imali akutni optički neuritis usporediti s onim bolesnicima u kojih je optički neuritis vodeći ili prvi simptom i evaluirati uporabu funkcionalnih pretraga – testiranje vidnog polja, kontrastne osjetljivosti i raspoznavanja boja u ranoj dijagnostici i praćenju bolesnika s MS. UZORAK I METODE: Istraživanje je uključilo tri skupine ispitanika s multiplom sklerozom, te kontrolnu skupinu zdravih ispitanika. Prvu skupinu „AON“ čine ispitanici s akutnim optičkim neuritisom, u drugoj skupini KON nalaze se ispitanici koji su se zbog subjektivnih smetnji zamućenja vida javili na oftalmološki pregled, ali im je vidna oštrina uredna. Treću skupinu SON čine ispitanici koji nikada nisu imali optički neuritis, niti subjektivne smetnje vida. Istraživanje je obuhvaćalo standardni oftalmološki pregled (vidna oštrina, biomikroskopija i oftalmoskopija), testiranje vidnog polja automatskim perimetrom Octopus 101, testiranje kontrastne osjetljivosti Pelli Robson tablicama, te ispitivanje kolornog vida pseudoizokromnim tablicama prema Ishihari. REZULTATI: Ovim istraživanjem je u sve tri skupine ispitanika nađeno oštećenje vidnog polja. Najčešći oblici oštećenja su depresija mrežnične osjetljivosti u perifernoj zoni i defekt snopića živčanih vlakana. Reducirana kontrastna osjetljivost nađena je u svim trima skupinama ispitanika, dok je raspoznavanje boja poremećeno na zahvaćenom oku u svih ispitanika skupine s akutnim optičkim neuritisom. ZAKLJUČAK: Ovo istraživanje je dokazalo da oštećenje vidne funkcije postoji i u onih bolesnika s multiplom sklerozom koji nisu imali akutni optički neuritis, niti subjektivne znakove zamućenja vida. U velikog broja ispitanika nađeno je oštećenje vidnog polja i redukcija kontrastne osjetljivosti što upućuje na znatno veću učestalost kroničnog i supkliničkog oblika optičkog neuritisa kao važnog simptoma u dijagnostici i praćenju 89 bolesnika s MS. Test raspoznavanja boja Ishihara tablicama pokazao se važnim u dijagnostici i evaluaciji akutnog optičkog neuritisa i kao pokazatelj oporavka vidne funkcije nakon provedene terapije. U dijagnostički algoritam bolesnika s multiplom sklerozom treba uključiti testiranje vidnog polja automatskim perimetrom, test kontrastne osjetlljivosti i Ishihara test raspoznavanja boja u cilju rane dijagnostike MS i procjene zahvaćanja vidnog sustava. Actions (login required) Downloads Downloads per month over past year