http___metro-portal.hr_dokazano-postojanje-maticnih-stanica-raka_85082_1.xml
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Top Notch cancer stem cells by paracrine NF-kB signaling in breast cancer 1 Department of Pathology, University of Iowa/Carver College of Medicine, 100 Medical Laboratories, Iowa City, IA 52241, USA 2 Fox Chase Cancer Center, Cancer Prevention and Control Program, 333 Cottman Ave., Philadelphia, PA 19111, USA Breast Cancer Research 2013, 15:316 doi:10.1186/bcr3565Published: 30 October 2013 Abstract Cancer stem cells are likely to play critical roles in metastasis, therapy resistance, and recurrence of hematological and solid malignancies. It is well known that the stem cell niche plays a key role for asymmetric division and homeostasis of normal stem cells, whereas cancer stem cells seem to use these niches. Among many pathways involved in self-renewal of cancer stem cells, nuclear factor-kappa B (NF-kB) signaling has been documented to promote their expansion in a cell-autonomous fashion. A recent study, however, suggests that paracrine NF-kB activation promotes the expansion of cancer stem cells through the activation of Notch in basal-type breast cancer cells.
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Dokazano postojanje matičnih stanica raka I rak ima svoje matične stanice koje su korijen raka, a uz to podržavaju rast tumora i napredak bolesti u tijelu Matične stanice ima i karcinom, a one ne samo da su korijen raka, već su odgovorne za podršku rastu tumora i napredak ove zloćudne bolesti u tijelu, tvrde znanstvenici s eminentnih institucija - Sveučilišta Oxford i Karolinska Instituta. Što je najgore, ove matične stanice mogu proizvoditi i druge vrste stanica raka, baš kao što i zdrave matične stanice proizvode nove, normalne stanice. Ovo bi otkriće moglo predstavljati revoluciju u liječenju karcinoma, jer bi uništenjem matičnih stanica raka bolest potpuno i nepovratno nestala iz tijela. Nadamo se da od otkrića do primjene neće proteći previše vremena.