http___medlib.mef.hr_1537__1.xml
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Fišter, Kristina and Polašek, Ozren and Vuletić, Silvije and Kern, Josipa (2009) Single nucleotide polymorphisms and health behaviours related to obesity - trawling the evidence in the prospect of personalised prevention. Studies in health technology and informatics, 150. English abstract Efforts aimed at primary and secondary prevention of cardiovascular diseases, the major killer of contemporary adult populations, largely rely on modification of risk behaviours related to smoking, physical activity, dietary intake, and alcohol consumption, and also control of obesity and hypertension, the interim risk states between health and disease. We propose that the extent to which the gene x ‘'obesogenic' environment interaction depends on associations between particular single nucleotide polymorphisms (SNPs) and behavioural risk factors for overweight or obesity determines opportunities for novel, personalised preventive interventions. We systematically searched for SNPs that might be of interest for this postulate and we present various SNPs that have been shown to be associated with overweight or obesity and behavioural risk factors for developing these traits, and thus hold promise for future design of personalised preventive interventions. Actions (login required)
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Fišter, Kristina and Vuletić, Sivije and Kern, Josipa (2012) Paving the way for personalised behaviourally based prevention of obesity: systematic search of the literature. Collegium Antropologicum, 36 (S1). pp. 201-10. Croatian abstract UTIRANJE PUTA ZA PERSONALIZIRANU PONAŠAJNU PREVENCIJU PRETILOSTI: SUSTAVNA PRETRAGA LITERATURE ----- Cilj ovog rada bio je identificirati polimorfizme jednog nukleotida (SNP, od engl. single nucleotide polymorphism) koji bi mogli odrediti interindividualne razlike u odgovoru, u smislu promjene tjelesne težine, na pojedine ponašajne čimbenike rizika za prekomjernu debljinu ili pretilost, stoga otvarajući mogućnosti za personalizirane ponašajne preventivne intervencije. U bibliografskim bazama, bez jezičnih restrikcija, identificirali smo radove koji su izvještavali o povezanosti pojedinih SNP-ova s prekomjernom debljinom ili pretilošću kao i s ponašajnim rizičnim čimbenicima za razvoj ovih značajki. Identificirali smo 64 genske varijante koje bi mogle biti uključene u interakcije gen-pretilost- -ponašanje. Temeljem ovih rezultata moguće je zamisliti razvoj personaliziranog savjetovanja o promjeni životnih navika, s ciljem smanjena tjelesne težine, međutim genomika pretilosti još je u ranoj translacijskoj fazi; potrebna je replikacija rezultata u brojnim budućim istraživanjima prije no što ovi u velikoj mjeri pionirski rezultati unaprijede kliničku i javnozdravstvenu praksu. U kvaliteti istraživanja kao i izvještavanja o njima ima mnogo prostora za poboljšanja. Zaključ ujemo da je personalizacija ponašajnih preventivnih intervencija protiv pretilosti izvediva no automatizacija pretraž ivačkih algoritama i razvoj učinkovitijih metoda sinteze znanja generiranih u genomskim istraživanjima mogli bi ubrzati translaciju prema širokoj dostupnosti personaliziranih preventivnih pristupa. Naša će buduća nastojanja stoga uključivati razvoj takvih metoda i oruđa, kao i razvoj repozitorija istraživanja posvećenog uporabi javnozdravstvene genomike u kontroli pretilosti. English abstract We have identified in the literature variants in 64 genes that may be involved in gene-obesity-behaviour interactions. Personalisation of behaviourally based preventive approaches against obesity seems feasible, however obesity genomics is still in the discovery phase of translational research and abundant replication studies are needed before these largely pioneering findings can be extended to practice and population impact. Automation of search algorithms and development of more efficient tools for knowledge synthesis of genomic research into gene-obesity-behaviour interactions might facilitate the advent of widely available personalised prevention approaches. Our future efforts shall therefore concentrate on developing such tools, as well as a research repository dedicated to the use of public health genomics for obesity control. Actions (login required)