http___www.in-portal.hr_in-portal-news_moderna-vremena_2664_znanstvenici-genska-terapija-kljuc-je-borbe-protiv-pretilosti_1.xml
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Categories - Allergy - Alzheimer's Disease - Arthritis - Asthma - Breast Cancer - Cardio Health - Cold and Flu - Colon Cancer - Diabetes - Dieting - Epilepsy - General - Hair Loss - Headache - Heartburn - HIV & AIDS - Kidney Health - Leukemia - Lung Cancer - Lymphoma - Men's Health - Mental Health - Multiple Sclerosis - Nutrition - Oral Health - Osteoporosis - Parkinson's Disease - Prostate Health - Respiratory Diseases - Skin Health - Sleep Disorders - Women's Health Study of Severely Obese Family Leads to Gene Discovery -- Robert Preidt Body's ability to control appetite, burn calories may be linked to gene mutation, researchers say THURSDAY, Nov. 21, 2013 (HealthDay News) -- Researchers report that they have identified a gene that is tied to severe obesity. They say their findings could lead to new treatments for obesity. The team studied an Israeli Arab family whose members were severely obese. They found that the family members had a mutation in a gene that produces a protein called CEP19. When the researchers deleted this gene in mice, the rodents became obese and developed diabetes. They also had increased appetites and burned less energy. Scientists note, however, that research done in animals often fails to produce similar results in humans. The study was published online Nov. 21 in the American Journal of Human Genetics. "Starting with gene discovery in a single family with morbid obesity, these studies led to the identification of a gene that seems to be fundamental to regulating nutritional status [body weight]," study co-senior author Dr. John Martignetti, of the Icahn School of Medicine at Mount Sinai, in New York City, said in a journal news release. "This gene is shown to be present not only in humans and mice, but also in the simplest known single-cell animal," he said. "Nature considers this gene so important that it has preserved its structure for more than 700 million years." The specific role of the CEP19 protein in maintaining a balance between leanness and obesity remains unknown. Further research is needed to determine how the protein affects appetite control, the amount of calories the body burns and insulin sensitivity, the study authors said. Previous research has indicated that genes play a role in 40 percent to 90 percent of cases of obesity, according to the news release. More information The U.S. National Heart, Lung, and Blood Institute has more about overweight and obesity. BigHealthTree.com Disclaimer Bighealthtree.com Does Not Provide Medical Advice. This site, including the above information, is for informational purposes only and is not a substitute for professional medical or health advice. Always seek the advice of your physician or a qualified health or medical professional before starting any new treatment, changing existing treatment, or altering your current exercise and/or diet program. If you think you are having a medical emergency, call 911 (or the emergency services in your area) or your doctor immediately.
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Genetičar John Martignetti kazao je kako je istraživanje koje je počelo s otkrićem gena kod jedne obitelji koja pati od ekstremne pretilosti dovelo do identifikacije gena za koji se čini da je ključan u reguliranju procesa hranjenja. Taj gen prisutan je ne samo kod ljudi i miševa nego i kod najjednostavnijih jednostaničnih organizama, kaže Martignetti i ističe da priroda smatra taj gen toliko važnim da je očuvala njegovu strukturu više od 700 milijuna godina Američko-izraelski znanstveni tim utvrdio je da 90 posto pretilih osoba može imati mutaciju istog gena koja znači da su programirani da jedu više i kreću se manje i smatra da bi upravo genska terapija mogla sadržati ključ borbe protiv epidemije pretilosti u svijetu, prenosi britanski list Daily Mail. Proučavajući samo jednu obitelj znanstvenici su uspjeli utvrditi da defektni gen CEP19 izaziva pretilost. U okviru istraživanja analizirana je DNK iz krvnih uzoraka 13 ekstremno pretilih, čiji je prosječni indeks tjelesne mase bio je 48,7, i 31 vitkih članova iste izraelske obitelji koja živi u jednom selu na sjeveru Izraela. Analiza je otkrila mutaciju gena koja osim u pretilost može voditi i u bolesti bubrega, jetara, gušterače i kostiju. Istraživanje na miševima nakon toga pokazalo je da je mutacija gena CEP19 toliko snažna da izaziva kod miševa udvostručenje težine a oni su i skloni razvoju tipa 2 dijabetesa. Taj gen kontrolira apetit i razinu energije a njegovo isključivanje kod miševa izazvalo je morbidnu pretilost. Genetičar John Martignetti kazao je kako je istraživanje koje je počelo s otkrićem gena kod jedne obitelji koja pati od ekstremne pretilosti dovelo do identifikacije gena za koji se čini da je ključan u reguliranju procesa hranjenja. Taj gen prisutan je ne samo kod ljudi i miševa nego i kod najjednostavnijih jednostaničnih organizama, kaže Martignetti i ističe da priroda smatra taj gen toliko važnim da je očuvala njegovu strukturu više od 700 milijuna godina. Američko-izraelski tim utvrdio je da isključivanje gena kod miševa izaziva kod njih morbidnu pretilost jer ih potiče da jedu više i manje se kreću a time i troše manje energije. Kad su znanstvenici uništili verziju CEP19 gena kod laboratorijskih miševa oni su osim što su postali pretili razvili i dijabetes. Uz jačanje apetita kod njih je uočena smanjena potrošnja energije kao i smanjena sposobnost da razgrađuju mast. Znanstvenici vjeruju da liječenje čiji je cilj oživjeti taj gen kod osoba koje su izložene riziku pretilost može pomoći u borbi protiv globalne pretilosti i tipa 2 dijabetesa. Hina