http___www.irb.hr_Istrazivanja_Zavodi-i-centri_Zavod-za-organsku-kemiju-i-biokemiju_2.xml
1.1 2.1 3.1 4.1 5.1 6.1 7.1 8.1 9.1 10.1 11.1 11.2 12.1 12.2 13.1 13.2 13.3 14.1 14.2 15.1 16.1 16.2 16.3 17.1 18.1 18.2 18.3 18.4 19.1 19.2 19.3 20.1 20.2 20.3 21.1 22.1 23.1 24.1 25.1 26.1 27.1 29.1 30.1 31.1 32.1 33.1 34.1 35.1 36.1 37.1 38.1 39.1 41.1 42.1 43.1 44.1 45.1 46.1 47.1 48.1 49.1 50.1 51.1 52.1 54.1 55.1 56.1 58.1 59.1 60.1 61.1 62.1 63.1 64.1 65.1 67.1 69.1 71.1 73.1 75.1 76.1 77.1 78.1 79.1 80.1 81.1 82.1 84.1 85.1 86.1 87.1 88.1 90.1 91.1 92.1 93.1 94.1 95.1 96.1 98.1 99.1 101.1 102.1 103.1 104.1 105.1 106.1 108.1 109.1 110.1 112.1 114.1 116.1 118.1 120.1 121.1 122.1 123.1 124.1 125.1 126.1 127.1 127.2 127.3 127.4 128.1 129.1 129.2 129.3 130.1 130.2 131.1 132.1 133.1 134.1 135.1 136.1 137.1 138.1 139.1 140.1 141.1 142.1 143.1 144.1 145.1 146.1 147.1 148.1 149.1 150.1 150.2 150.3 151.1 152.1 153.1 153.2 154.1 155.1 156.1 157.1 157.2 157.3 158.1 159.1 160.1 161.1 162.1 163.1 164.1 165.1 166.1 167.1 168.1 169.1 170.1 171.1 172.1 173.1
Division of Organic Chemistry and Biochemistry The mission of the Division of Organic Chemistry and Biochemistry (DOCB) is to sustain excellence in fundamental scientific research covering selected experimental and theoretical topics of organic chemistry and biochemistry, to promote and intensify international collaboration in these fields and actively participate at the undergraduate and postgraduate levels of education in organic chemistry and biochemistry at Croatian universities by providing specific expertise and facilities. Acting head of Division Davor Margetić Administration Barica Baborsky tel. fax. e-mail: baborsky@irb.hr Research in the DOCB covers broad topics in modern experimental and theoretical organic chemistry and biochemistry: the development of new synthetic methods and their application in the preparation of new organic molecules and materials, experimental and theoretical studies of molecular properties and reaction mechanisms, as well as research in the field of medicinal chemistry. In the last few years, we have considerably increased our contribution to higher education in Croatia. DOCB scientists are teaching over 30 undergraduate and graduate courses at the Universities of Zagreb, Rijeka, Osijek, Split and Dubrovnik. DOCB scientists are members of many scientific EU-committees, such as ESF, the COSTESOR-Standing Committee, as well as members of national committees, boards and councils. Some were members of the organizational committees of international symposiums (ESOC, ESOR), as well as COST and FP6-workshops. In 2005, on the basis of EU patent “Potential anticancer drugs” from the Laboratory for Supramolecular and Nucleoside Chemistry, a spin-off company, BioZyne, was established. Also in 2006, from the Laboratory for Stereoselective Catalysis and Biocatalysis, another spin-off company, CHIRALLICA, was established. For work on chiral stationary phases, chiral separation and production of chiral HPLC-columns, ISO 9001 certification was obtained. The Group for Quantum Organic Chemistry (GQOC) is concerned with the application of state-of-the-art theoretical approaches to important problems in organic chemistry and biochemistry. Particular focus is devoted to understanding of the structure and function of proteins and the properties and design of functional molecules such as (super) acids and bases.more » The research carried out in the laboratory is centered on molecular enzymology of metallopeptidases – structure-activity relationship, mechanism of catalysis and protein interactions.more » We are engaged in fundamental studies related to the omnipresent and everlasting problem of reactivity of organic and organometallic compounds. In conducting these studies, an integrated approach is employed involving synthesis, product analysis, determination of reaction mechanisms and structural interrogation via spectroscopic and computational methods. In synthetic work, extensive use of high pressure techniques and microwave assisted synthetic methods is made.more » Laboratory for Carbohydrate, Peptide and Glycopeptide Research Laboratory for the Carbohydrate, Peptide and Glycopeptide Research was established at the very beginning of Ruđer Bošković Institute. Present name to the laboratory was given in 1992. Research of its associates include synthesis of various functional compounds from the group of peptides, peptidomimetics and glycopeptides, their conformational studies and studies of their interaction with various bio molecules. Laboratory offers inspiring surrounding for working at MA and PhD theses.more » Research activities of the Laboratory of Molecular Spectroscopy cover a wide range of themes in the field of application of infrared spectroscopy in physical and analytical chemistry. Laboratory is equipped by the room for simpler organic syntheses, and infrared spectrometer. Accessories allow spectral measurements of liquid and solid samples.more » Laboratory of Synthetic Organic Chemistry is continuing the tradition of the former Laboratory of Synthetic and Physical Organic Chemistry dealing with the chemistry of cage molecules. Research in the laboratory is concerned with the synthesis of cage molecules, study of the reaction mechanisms performed on cage molecules, as well as the use of cage molecules as building blocks in constructions of supramolecular assemblies. Covering various synthetic, analytical and spectroscopic techniques on a wide range of substrates, the research activities in the laboratory are ideal for training young researchers in graduate and post-graduate education (BSc, MSc, and PhD thesis).more » The group is involved in design and synthesis of novel small molecules that non-covalently bind to DNA/RNA, determination of their affinity and mode of binding as well as DNA/RNA induced spectroscopic changes. - Recognition of specific secondary structures of various DNA/RNA - Recognition of specific nucleobase or sequence of nucleobases (basepairs) within DNA/RNA Recognition is manifested by difference in affinity and / or differences in spectroscopic response caused by binding of small molecule to targeted DNA/RNA. Small molecules designed and synthesized are characterized by heterocyclic aromatic systems (usually DNA/RNA intercalators, such as pyrene, phenanthridine, etc.) equipped by various substituents that control selectivity.more » Research activities of the LSNC are focused on two topics: Supramolecular chemistry of low molecular weight organo- and hydro-gelators and Medicinal chemistry of biologically active nucleosides and nucleobase derivatives.more » Ivana Antol Bara Baborsky Željka Ban Danijela Barić PhD Vesna Blažek PhD Lidija Brkljačić Ivo Crnolatac dr.sc. Karmen Čondić-Jurkić Ines Despotović Irena Dokli PhD Zoran Džolić Leo Frkanec Prof. Dr. Zoran Glasovac PhD Matija Gredičak PhD Zdenko Hameršak dr.sc. Trpimir Ivšić Andreja Jakas PhD Ivanka Jerić Milan Jokić dr.sc. Iva Jušinski Anamarija Knežević PhD Renata Kobetić dr.sc. Darko Kontrec Borislav Kovačević Maja Majerić Elenkov Janja Makarević Davor Margetić Josipa Matić Marija Matković PhD Mihaela Matovina PhD Milica Perc Davorka Pevec Rak Ivo Piantanida Tomislav Portada doc- dr. sc. Tihomir Pospišil Ante Pupačić Nena Peran Marijana Radić Stojković dr.sc. Petra Radošević Marin Roje Dijana Saftić PhD David Matthew Smith Josipa Suć Marina Šekutor Nataša Šijaković Vujičić Đani Škalamera MChem Tamara Šmidlehner Vjekoslav Štrukil Tatjana Šumanovac Ramljak Marin Šundov Filip Šupljika Pavle Trošelj Lidija-Marija Tumir Lidija Varga-Defterdarović Mario Vazdar Robert Vianello Vladimir Vinković Kristina Vlahoviček-Kahlina Danijela Vojta Tamara Vraneša Biserka Žinić Dr. Sc. Cage Compounds: Building Blocks for Molecular Architecture Cage compounds are characterized by three-dimensional structures which have defined rigid geometry and as such, they are very useful synthons in organic synthesis, as well as the indispensable substrates for the mechanistic studies. Moreover, the various atomic positions in a cage can serve as branching points where the additional ligating group can be introduced. These substituted derivatives can be used as building blocks in supramolecular chemistry. The first step towards employing cage compounds in the synthesis of more complex molecular systems is the understanding of their reactions.more » Characterization and identification of pollen by vibrational spectroscopy and chemometrics Vibrational (infrared and Raman) spectroscopy of pollen shows great potential for systematic collection of data on ecosystem and plant-environment interactions. The study demonstrates rapid and economical spactroscopic measurement of biochemical composition of pollen grains that provides efficient phenotyping of seed plants. Pollen content can significantly vary between closely related plant genera and species, and can even mirror the seasonal adaptation of the parent plant.more » Chiral building blocks for biological active molecules. Synthesis and reactivity Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases - CompBAND Croatian-German bilateral project 2012 – 2013: Croatian-German bilateral project with Prof. Frank Würthner, Julius-Maximilians-Universität Würzburg, Germanymore » Croatian-Slovenian bilateral project 2012 – 2013:Croatian-Slovenian bilateral project with Prof. Jurij Lah, Univerza v Ljubljani, Fakulteta za kemijo in kemijsko tehnologijo, Slovenijamore » Design and synthesis of novel aryl-gunidiniocarbonyl-pyrrol compounds and investigation of their interactions with DNA/RNA Bilateral Croatian-German Projectmore » Design, synthesis and research of interactions of small molecules with DNA, RNA and proteins The project funded by Ministry of Science, education and sports, "Design, synthesis and research of interactions of small molecules with DNA, RNA and proteins" No. 098-0982914-2918 (PI: Ivo Piantanida)more » EU CMST COST Action CM1304: Emergence and Evolution of Complex Chemical Systems Chair of the Action: Prof. Sijbren OTTO (NL); Prof. Dr. Leo FRKANEC (HR), Management Committee Member (MC)more » Fluorophore Modified Noble Metal Nanoparticles – New Materials For Bio- and Chemical Sensors Bilateral scientific project co-funded by the Croatian Ministry of science, education and sports and The National Science Fund of Bulgaria, the duration of the project: 2010 - 2012; TK 09 0015, coordinator, Bulgarian side: Prof. Dr. Ilijana Timtcheva, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.more » Gas-phase Studies on Novel Guanidines as Superbases and as Bifunctional Sensors Host-Guest Interactions in Polycyclic Systems Makrocyclic ligands, structural changes in solutions and molecular spectroscopies Mechanism of [2+2] photocycloaddition in norbornadiene Mechanochemistry for the clean and efficient metal-catalysed synthesis of pharmaceutical targets and the study of their molecular recognition Non-covalent interactions in design of novel photosensitive molecules Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and study of physico-chemical properties of systems obtained through self-association by non-covalent interactions. It is multidisciplinary, covering topics in physical-organic, supramolecular and computational chemistry, photophysics and materials science.more » Novel amphyphilic B-lactones: study of structure -reactivity relationship Optimizing bidirectional “highway” for photoactive response through guanidine-chromophore junction Suradnja s dr. Mariom Barbattiem s Max-Planck instituta u Muelheimu, Njemačkamore » Organic and Bioorganic Processes in the Ground and the Excited States Photochemistry of polycyclic molecules: From mechanistic studies to new drugs and medicinal applications HRZZ Photons are phenomenal reagents which open new opportunities in chemical synthesis that cannot be attained in the chemistry of ground state. The goal of the project was to find new photochemical transformations applicable in organic synthesis, as well as investigation of the photochemical reaction mechanisms. In addition, the aim of the project was to go beyond the state of the art, and ultimately find application of photochemistry in new medical treatments and synthesis of new compounds, potential drug molecules for treating malignant diseases.more » Preparation of hybrid soft materials combining supramolecular anthraquinone-based gel systems and gold nanoparticles (SupraNanoGels) The observation of chirality on inorganic nanoparticles (NPs) systems is an interesting and highly important phenomenon which has recently attracted considerable attention and has become a hot topic in nanoscience research.more » Programme funded by Croatian Ministry of science, education and sports, Programme No. 0982914 “Interactions of small novel molecules with macromol... Supramolecular Synthesis of Self-Assembled Functional Nanomaterials and Complex Chemical Systems Synthesis and efficacy of chlorophyllin derivatives as photosensitizers for photodynamic therapy Croatian-Chinese scientifiy and technological cooperation with Prof. Dr. Zhi-Long Chen from College of Chemistry and Biology, Donghua University, Shanghaimore » Circular Dichroism and Optical Rotational Dispersion Spectrometer (CD-ORD) Spectrometer Jasco J-815 measures spectra of circular dichroism CD and optical rotational dichroism ORD, together with simultaneous measurement of several variants of UV/vis spectra. During the measurement instrument is under flow of nitrogen. High performance liquid chromatography coupled with mass spectrometry The system consists of HPLC Agilent 1200 Series and triple quadrupole mass spectrometer Agilent 6410.more » Infrared spectrometer FTIR spectrometer ABB Bomem MB102 measure all kinds of infrared spectra of solid and liquid samples.more » Ultraviolet / visual spectrometer UV / vis spectrometer Varian Cary 100 Bio records spectra in double beam and single beam mode. Spectral range: 190 - 900 nm
1.1 2.1 3.1 4.1 4.2 5.1 6.1 7.1 8.1 9.1 10.1 11.1 11.2 12.1 12.2 13.1 13.2 14.1 14.2 15.1 16.1 16.2 16.3 17.1 18.1 18.2 19.1 19.2 19.3 20.1 20.2 20.3 21.1 22.1 23.1 24.1 25.1 26.1 27.1 28.1 29.1 30.1 31.1 32.1 33.1 34.1 35.1 36.1 37.1 38.1 39.1 40.1 41.1 42.1 43.1 44.1 45.1 46.1 47.1 48.1 49.1 50.1 51.1 52.1 53.1 54.1 55.1 56.1 57.1 58.1 59.1 60.1 61.1 62.1 63.1 64.1 65.1 66.1 67.1 68.1 69.1 70.1 71.1 72.1 73.1 74.1 75.1 76.1 77.1 78.1 79.1 80.1 81.1 82.1 83.1 84.1 85.1 86.1 87.1 88.1 89.1 90.1 91.1 92.1 93.1 94.1 95.1 96.1 97.1 98.1 99.1 100.1 101.1 102.1 103.1 104.1 105.1 106.1 107.1 108.1 109.1 110.1 111.1 112.1 113.1 114.1 115.1 116.1 117.1 118.1 119.1 120.1 121.1 122.1 123.1 124.1 125.1 126.1 127.1 128.1 129.1 130.1 131.1 132.1 133.1 134.1 136.1 137.1 138.1 139.1 140.1 141.1 142.1 143.1 144.1 145.1 146.1 147.1 148.1 149.1 150.1 151.1 152.1 152.2 152.3 153.1 154.1 155.1 155.2 156.1 157.1 158.1 159.1 160.1 160.2 160.3 161.1 162.1 163.1 163.2 164.1 165.1 165.2 166.1 167.1 167.2 168.1 169.1 170.1 170.2 170.3 171.1 172.1 172.2 172.3 172.4 173.1 174.1 174.2 175.1 176.1 177.1 178.1 179.1 180.1 181.1 182.1 183.1 184.1 184.2 185.1 186.1 187.1 188.1 189.1 190.1 191.1 192.1 193.1 193.2 194.1 195.1 196.1 197.1 198.1 199.1 200.1 201.1 202.1 203.1 204.1 205.1
Zavod za organsku kemiju i biokemiju Misija Zavoda za organsku kemiju i biokemiju je održati i unaprijediti postojeću visoku razinu znanstvenih istraživanja na izabranim suvremenim temama organske kemije i biokemije, promovirati i intenzivirati međunarodnu suradnju u navedenim područjima, te aktivno doprinijeti razvoju visokog obrazovanja iz organske kemije i biokemije na Sveučilištima u Hrvatskoj. v.d. predstojnik dr. sc. Davor Margetić Tajništvo Barica Baborsky tel. fax. e-mail: baborsky@irb.hr Istraživanja u Zavodu za organsku kemiju i biokemiju (OKB) pokrivaju široki raspon suvremenih tema u eksperimentalnoj i teorijskoj organskoj kemiji i biokemiji: razvoj novih sintetskih metoda i njihova primjena u pripravi novih organskih spojeva i materijala, eksperimentalne i računalne studije svojstava molekula i reakcijskih mehanizama te istraživanja u području medicinske kemije. U zadnjih nekoliko godina značajno smo doprinijeli visokom obrazovanju u Hrvatskoj. Znanstvenici Zavoda za OKB vode preko 30 kolegija na diplomskim i doktorskim studijima na Sveučilištima u Zagrebu, Rijeci, Osijeku, Splitu i Dubrovniku. Mnogi znanstvenici Zavoda za OKB su članovi europskih znanstvenih organizacija i tijela poput ESF, COST, EuCheMS i članovi ili predsjednici u nacionalnim povjerenstvima, odborima i radnim skupinama. Neki od njih su bili članovi Organizacijskih odbora međunarodnih simpozija (ESOC, ESOR) te COST i FP-6 radionica. Godine 2005., na temelju EU patentne prijave “Potential anticancer drugs”, iz Laboratorija za supramolekularnu i nukleozidnu kemiju, osnovana je spin-off tvrtka „BioZyne“, a 2006. iz Laboratorija za stereoselektivnu katalizu i biokatalizu, osnovana je spin-off tvrtka „CHIRALLICA“. Za rad na kiralnim stacionarnim fazama i kiralnoj separaciji te proizvodnji kiralnih HPLC-kolona tvrtka je dobila certifikat ISO 9001. Grupa za kvantnu organsku kemiju (GKOK) bavi se primjenom najsuvremenijih teorijskih pristupa pri istraživanju važnih problema u organskoj kemiji i biokemiji. U žarištu istraživanja su razumijevanje strukture i uloge proteina, te svojstva i dizajn funkcionalnih molekula kao što su (super)kiseline i baze.više » Istraživački rad u laboratoriju usmjeren je na molekularnu enzimologiju metalopeptidaza - odnos strukture i aktivnosti, mehanizam katalize i proteinske interakcije.više » Suradnici laboratorija bave se istraživanjima strukture, svojstava i aktivnosti organskih i organometaloidnih spojeva primjenjujući temeljne principe fizikalno-organske kemije. Istraživanja obuhvaćaju sintezu modelnih spojeva, studij reakcijskih mehanizama te istraživanje molekulske i elektronske strukture spektroskopskim i kvantnokemijskim metodama. U pripravi spojeva se uz klasične metode sinteze, koriste i visokotlačne i mikrovalne tehnike.više » Laboratorij za kemiju ugljikohidrata, peptida i glikopeptida Istraživanja članova laboratorija usmjerena su na pripravu funkcionalnih spojeva iz skupine peptida, peptidomimetika i glikopeptida, studij njihove konformacije te izučavanje njihove interakcije s biomolekulama. U tu svrhu koristi se interdisciplinarni pristup temeljen na kombiniranom i integriranom korištenju metoda i tehnika sintetske organske i bioorganske kemije te fizikalne, analitičke i strukturne kemije.više » Djelatnosti Laboratorija za molekulsku spektroskopiju pokrivaju širok raspon tema unutar područja primjene infracrvene spektroskopije u fizikalnoj i analitičkoj kemiji. Laboratorij je opremljen prostorom u kojemu se mogu provoditi jednostavnije sinteze te infracrvenim spektrometrom. Dodatna oprema omogućuje snimanje spektara tekućih i krutih uzoraka.više » Laboratorij za sintetsku organsku kemiju nastavlja tradiciju Laboratorija za sintetsku i fizikalnu organsku kemiju. Pod sadašnjim nazivom laboratorij djeluje od 1990. godine. Suradnici laboratorija bave se istraživanjima koja obuhvaćaju sintezu kavezastih molekula, studij mehanizama njihovog nastajanja i pregrađivanja te primjenu ovih polikarbocikličkih molekula za pripravu supramolekularnih sustava.više » Grupa se bavi dizajnom i sintezom novih malih molekula koje pokazuju aktivnost prema DNA/RNA, te određivanjem afiniteta i načina vezanja malih molekula na DNA/RNA.više » Istraživačke aktivnosti LSNK laboratorija uglavnom su usmjerena na dvije teme: supramolekularna kemija organo- i hidro- gelatora male molekulske težine i medicinsku kemiju biološki aktivnih derivata nukleozida i nukleobaza.više » Marija Abramić dr. sc. Ivana Antol dr. sc. Bara Baborsky Željka Ban dipl.inž. Goran Baranović dr .sc. Danijela Barić dr. sc. Nikola Basarić dr.sc. Vesna Blažek Bregović dr. sc. Anamarija Briš dipl. ing. Lidija Brkljačić dipl.ing. Ivo Crnolatac dr. sc. Karmen Čondić-Jurkić Ines Despotović dr. sc. Irena Dokli dr.sc. Zoran Džolić dr. sc. Leo Frkanec prof. dr. sc. Zoran Glasovac dr. sc. Matija Gredičak dr.sc. Zdenko Hameršak dr.sc. Marko Hanževački mag. chem. Trpimir Ivšić dr. sc. Andreja Jakas dr. sc. Ivanka Jerić dr. sc. Milan Jokić dr.sc. Iva Jušinski dr. sc. Anamarija Knežević dr. sc. Renata Kobetić dr. sc. Darko Kontrec doktor znanosti Borislav Kovačević dr. sc. Maja Majerić Elenkov dr. sc. Janja Makarević dr. sc. Mirjana Maksić dr. sc. Davor Margetić dr. sc. Marija Matković dr.sc. Mihaela Matovina dr. sc. Milica Perc Davorka Pevec Rak Ivo Piantanida dr. sc. Tomislav Portada doc. dr. sc. Tihomir Pospišil dipl.kem.ing Ante Pupačić Nena Radić dr. sc. Marijana Radić Stojković dr.sc. Petra Radošević Marin Roje dr. sc. Dijana Saftić dr. sc. David Matthew Smith dr. sc. Josipa Suć dipl.ing. Marina Šekutor dr. sc. Nataša Šijaković Vujičić dr. sc. Đani Škalamera mag. chem. Vjekoslav Štrukil dr.sc. Tatjana Šumanovac Ramljak dr. sc. Marin Šundov Pavle Trošelj dr. sc. Lidija-Marija Tumir dr. sc. Lidija Varga-Defterdarović dr. sc. Mario Vazdar dr. sc. Robert Vianello dr. sc. Vladimir Vinković Kristina Vlahoviček-Kahlina mag.chem. Tamara Vraneša Biserka Žinić Dr. sc. Artificial receptors for Bacillus anthracis Specific Anthrose Detection Biokatalitička primjena halogenhidrin dehalogenaza u svrhu priprave kiralnih građevnih blokova Broenstedove i Lewisove kiseline i baze u kemiji i biokemiji Computational predicition of structure and catalytic activity of new organic superacids Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases - CompBAND Dizajn i sinteza novih aril-guanidiniokarbonil-pirola te ispitivanje njihovih interakcja s DNA/RNA Hrvatsko-Njemački bilateralni Projektviše » Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima. Projekt MZOŠ-a "DIZAJN, SINTEZA I ISPITIVANJE INTERAKCIJA MALIH MOLEKULA S DNA, RNA I PROTEINIMA" broj 098-0982914-2918 (voditelj Ivo Piantanida)više » Endemic Nephropathy: proteomics approach for biomarkers discovery and etiology study EU COST: CMST Action CM1304: Emergence and Evolution of Complex Chemical Systems Chair of the Action: Prof. Sijbren OTTO (NL); Dr. Leo FRKANEC (HR), Management Committee Member (MC)više » Fluorescent Anion Sensors: Synthesis and Spectroscopic Characterization Fluorophore Modified Noble Metal Nanoparticles – New Materials For Bio- and Chemical Sensors The National Science Fund of Bulgaria, period 2010 - 2012; TK 09 0015, coordinator Prof. Ilijana Timtcheva, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.više » Fotoaktivni nano-strukturirani gelski sustavi kontroliranih optičkih svojstava Glavni istraživač: Mladen Žinićviše » Fotokemija policikličkih molekula: od istraživanja mehanizama reakcije do novih lijekova i medicinskih primjena HRZZ Fotoni su izvanredni reagensi koji otvaraju nove mogućnosti u kemijskoj sintezi spojeva koji ne mogu biti pripravljeni kemijom osnovnog stanja. Zadatak projekta bio je pronaći nove fotokemijske transformacije primjenjive u organskoj sintezi kao i ispitivanje mehanizama reakcija tih transformacija. Osim toga, zadatak projekta bio je ići i dalje od trenutnih spoznaja te naći primjenu fotokemije u novim medicinskim tretmanima i sintezi spojeva, potencijalnih lijekova za maligne bolesti.više » Host-guest međudjelovanja u policikličkim sustavima Hrvatsko-njemački bilateralni Projekt 2012 – 2013: hrvatsko-njemački bilateralni Projekt s Prof. Frank Würthner, Julius-Maximilians-Universität Würzburg, Njemačkaviše » Hrvatsko-slovenski bilateralni projekt 2012 – 2013: hrvatsko-slovenski bilateralni Projekt s Prof. Jurij Lah, Univerza v Ljubljani, Fakulteta za kemijo in kemijsko tehnologijo, Slovenijaviše » Istraživanje novih gvanidina kao potencijalnih superbaza i bifunkcionalnih senzora u plinskoj fazi Bilateralna suradnja s dr. Marijom Schlangen s Tehničkog sveučilišta u Berlinuviše » Izgradnja hrvatskoga kemijskog nazivlja Karakterizacija i identifikacija peludi metodama vibracijske spektroskopije i kemometrikom Biokemijska analiza peludi omogućuje jednostavnu i pouzdanu procjenu međudjelovanja biljaka i okoliša, uključujući i utjecaj globalne promijene klime na biljne zajednice. No, kako bi se to postiglo, potrebno je razviti metodu za brzu analizu peludi s pripadajućom bazom podataka biokemijskih fenotipa. Vibracijska (infracrvena i Raman) spektroskopija peludi omogućuje neposredno i brzo mjerenje cijelog i nedirnutog biljnog organizma, te daje precizno stanje njegovog ukupnog biokemijskog sastava.više » Kavezasti spojevi: ugradbne jedinice u molekularnim sustavima Kavezaste spojeve karakterizira trodimenzionalna struktura definirane krute geometrije i kao takovi predstavljaju vrlo korisne sintone u organskoj kemiji ali isto tako i nezamjenjive supstrate za studij reakcijskih mehanizama. Više različitih pozicija (C-atoma) u kavezastoj molekuli mogu poslužiti kao mjesta grananja na koja se mogu uvesti dodatne funkcijske skupine. Ovako supstituirani derivati mogu biti upotrijebljeni kao građevne jedinice u supramolekularnoj kemiji. Prvi stupanj prema primjeni kavezastih spojeva u sintezi kompleksnijih molekularnih sustava je razumijevanje njihovih kemijskih reakcija.više » Kemijske preobrazbe prirodnih spojeva Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost Kiralni organski materijali - sintetska, strukturna i funkcionalna istraživanja Makrociklički ligandi, strukturne promjene otopina i molekularne spektroskopije Mechanochemistry for the clean and efficient metal-catalysed synthesis of pharmaceutical targets and the study of their molecular recognition Mehanizam [2+2] fotocikloadicije u norbornadienu Molekularna enzimologija i proteinske interkacije hidrolaza Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula Novi amfifilni B-laktoni: studij odnosa struktura-reaktivnost Oksidativni stres na molekulskoj razini – ponašanje reaktivnih kratkolančanih aldehida u modelnim fosfolipidnim membranama Optimiranje dvosmjerne komunikacije uslijed kemijske ili svjetlosne aktivacije kroz gvanidin-kromofor poveznicu Suradnja s dr. Mariom Barbattiem s Max-Planck instituta u Muelheimu, Njemačkaviše » Organski i bioorganski procesi u osnovnom i elektronski pobuđenim stanjima Preparation of hybrid soft materials combining supramolecular anthraquinone-based gel systems and gold nanoparticles (SupraNanoGels) Proučavanje fenomena kiralnosti kod anorganskih nanočestica postaje jedna od vodećih tema istraživanja u nanoznanosti.više » Program MZOŠ-a 0982914 “Interakcije novih malih molekula s makromolekulama tumorskih i upalnih procesa” Računalno proučavanje strukture i funkcije proteina Reinforcement of the Centre for Computational Solutions in the Life Sciences - RECOMPSOLS Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala Sinteza i efikasnost derivata klorofilina kao fotosentizatora za fotodinamičku terapiju Hrvatsko-kineska znanstvena i tehnologijska suradnja s prof. dr. Zhi-Long Chen, College of Chemistry and Biology, Donghua University, Shanghaiviše » Sinteze novih biološki aktivnih drivata nukleobaza i nukleotida Structure-function relationship in metallopeptidase family M49 Infracrveni spektrometar FTIR spektrometar ABB Bomem MB102 služi za sve vrste mjerenja infracrvenih spektara krutih i tekućih uzoraka.više » Spektrometar cirkularnog dikroizma i optičke rotacijske disperzije Spektrometar Jasco J-815 ima mogućnost snimanja spektara CD (cirkularnog dikroizma) te ORD (optičkog rotacijskog dikroizma) te simultano snimanje nekoliko varijanti UV/vis spektara. Za vrijeme snimanja instrument je pod obaveznim protokom dušika, a koji podešava odgovorna osoba. Spektrometar ultraljubičastog i vidljivog zračenja UV / vis spektrometar Varian Cary 100 Bio ima mogućnost dvozračnog (double beam) i jednozračnog (single beam) snimanja. Spektralno područje: 190 - 900 nm Tekućinska kromatografija visoke razlučivosti sa spektrometrom masa Sustav se sastoji od sustava za HPLC Agilent 1200 Series s DAD detektorom spektrometrom mase s trostrukim kvadrupolom Agilent 6410.više »