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Doubts Raised About Highly-Praised Malaria Vaccine Headed For Africa (GIN) – With much fanfare, the world’s first injectable vaccine against malaria will be introduced in three countries – Ghana, Kenya and Malawi – starting in 2018. The vaccine – known as RTS,S or Mosquirix, trains the immune system to attack the malaria parasite, which is spread by mosquito bites. It was developed by the British pharmaceutical company, GlaxoSmithKline. The World Health Organization (WHO) said the vaccine could potentially save tens of thousands of lives. But its demanding regime – once a month for three months and then a fourth dose 18 months later – is raising concerns that it may be a logistical nightmare in the poorest parts of the world. In fact, the drug failed to get a green light from the world health body in 2015 when the manufacturer had planned to roll out the drug in a major campaign. Further testing in pilot projects has been ordered by the WHO which can take up to 5 years to complete. An earlier clinical trial of the vaccine in 2012 produced disappointing results. Only about a third of the vaccinated infants had fewer infections than a control group. Moncef Slaoui, chairman of research and development at Glaxo, called the trial’s outcome at that time “less than we’d hoped for”. “But if a million babies were vaccinated, we would prevent 260,000 cases of malaria a year. This is a disease that kills 655,000 babies a year — 31 percent of that is a very large number,” he was quoted to say. Other preventative malaria treatments include the drug camoquin, used by the group Doctors Without Borders (MSF) in 2014 in Sierra Leone. Sierra Leone has the fifth highest prevalence of malaria globally, and the disease is the biggest killer of children under five in the country. MSF at the time “cautiously welcomes the WHO recommendation for the limited use of RTS,S malaria vaccine. (However) MSF will not be using the RTS,S vaccine in its programs. “Issues with the vaccine, including low protection and high required amount of doses, does not make the vaccine suitable for wide rollout in the areas that need it most (high disease burden, low resource settings) MSF calls for more research and development into a malaria vaccine that can give good protection and is easy to use in low resource contexts as a priority.” World Malaria Day is marked on April 25. About The Author Related posts Leave a Comment You must be logged in to post a comment.
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Cijepljenje novim cjepivom protiv malarije počinje sljedeće godine u tri afričke države - Gani, Keniji i Malaviju, piše BBC. Riječ je o cjepivu RTS,S koje osposobljava imunološki sustav organizma da napada parazit Plasmodium koji se širi ugrizom komarca. Da je riječ o ekstremno raširenom parazitu, pokazuje brojke prema kojima je u 2015. godini malarijom zaraženo frapantnih 296 milijuna osoba, od kojih je čak 731.000 preminulo od bolesti. Devedeset posto svih smrtnih slučajeva zabilježeno je u Africi. Prošle je godine zamijećen veliki napredak u liječenju bolesti, ali je od nje opet umrlo 429.000 osoba, od čega većina male djece u Subsaharskoj Africi. Svjetska zdravstvena organizacija (WHO) polaže velike nade u ovo cjepivo za koje kažu da ima potencijal spasiti stotine tisuća ljudskih života, no još uvijek nije razvijen plan kako će koristiti u najsiromašnijim zemljama svijeta čije stanovništvo najviše stradava od malarije. Cjepivo je dosad testirano u kontroliranim kliničkim uvjetima - prva tri puta se da je svaka tri mjeseca, a četvrti put 18 mjeseci nakon treće doze. Također, radi se o prvom cjepivu protiv te bolesti koje je dobilo pozitivno mišljenje Europske agencije za lijekove, objavio je WHO. Vlasti Kenije, Malavija i Gane odredit će u kojim će se područjima iskušati cjepivo u sklopu pilot programa borbe protiv bolesti. - Mogućnost da imamo cjepivo protiv malarije je odlična vijest. Informacije koje prikupimo u pilot projektu pomoći će nam u odlukama o njegovoj široj upotrebi - kazala je regionalna direktorica WHO-a za Afriku Matshidiso Moeti.