http___www.klokanica.hr_beba_zdravlje-i-njega_cijepljenje-protiv-hepatitisa-a-1978_1.xml
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Hepatitis A - File Under hav Jerry's Deli worker infected by hepatitis A Posted on December 2, 2010 by Drew Falkenstein Customers of Jerry's Famous Deli, an LA institution near the UCLA campus, may be at risk for developing hepatitis A infection if they ate there during the month of November. An employee of the Westwood deli, located at 10925 Weyburn Ave., was diagnosed with acute hepatitis A, a virus that is spread by close physical contact and through fecal contamination of food or drink. The Los Angeles Public Health Department has yet to receive any further reports of hepatitis A related to the deli. The Department issued a press release today: Patrons who ate sandwiches at the restaurant or who ate catered sandwiches from this location on November 18, 21, 23, or 24, 2010, should receive an immune globulin (IG) shot or a hepatitis A vaccination no later than 14 days after their exposure to prevent or reduce illness. Public Health will make the IG shot and hepatitis A vaccine available through certain public health clinics Immune globulin (IG) for hepatitis A This drug is given by injection into a muscle (intramuscular injection). How It Works Immune globulin (IG) contains antibodies that destroy the hepatitis A virus (HAV), preventing infection. Why It Is Used IG should be given to unvaccinated people at risk of infection with HAV, including: Household and sexual contacts of people diagnosed with hepatitis A. Travelers visiting foreign countries where hepatitis A is a known problem or where sanitary conditions are questionable. Revaccination with IG is needed every 3 to 5 months. If a person frequently travels to or plans to stay for longer than 3 months in a country where hepatitis A is a problem, it is recommended that he or she receive the hepatitis A vaccine. For more information, see the Prevention section of the topic Hepatitis A. All staff and residents of child care centers, hospitals, residences for the developmentally disabled, prisons, or food service settings where an outbreak of hepatitis A occurs. People who need protection against HAV infection but are allergic to the vaccine. Children younger than age 1 who need to be protected against HAV infection. How Well It Works If given within 2 weeks of exposure to the virus, immune globulin (IG) is more than 85% effective in preventing hepatitis A virus (HAV) infection.1 Immune globulin has been effective in controlling some outbreaks of HAV. Side Effects Common side effects include: Soreness and swelling around the injection site. Low-grade fever. In rare cases, a life-threatening allergic reaction may occur. This is more likely if IG is accidentally injected into an artery or vein. See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.) What To Think About Immune globulin (IG) is a safe, inexpensive, and effective means of preventing the spread of hepatitis A virus (HAV) infection. The sooner you get a shot of IG after being exposed to HAV, the greater the likelihood that infection will be prevented. IG is safe for women who are pregnant or breast-feeding. IG protection is only temporary, lasting about 3 months. If you are planning to stay longer than 3 months in an area where hepatitis A is a problem, you should receive a higher initial dose of IG, or you should get the hepatitis A vaccine (unless you are allergic to the vaccine). You should receive the same higher dose of IG every 3 to 5 months while you are still at risk. IG is prepared from blood products obtained from paid donors. In the United States, no cases of transmission of the human immunodeficiency virus (HIV) or hepatitis B virus (HBV) through IG have been reported. The safety of IG prepared in countries other than the U.S. cannot be guaranteed. Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication. From the Immunization Action CoalitionVaccine Informationfor the public and health professionals , When did the first hepatitis A vaccine become available? There are currently two hepatitis A vaccine products approved by the FDA in the United States. The first hepatitis A vaccine became available in 1995 (HAVRIX, GlaxoSmithKline), followed by the second hepatitis A vaccine in 1996 (VAQTA, Merck). They are equally safe and effective. What kind of vaccine is hepatitis A vaccine? Hepatitis A vaccine is an inactivated virus vaccine. No part of the vaccine is “live.” How is hepatitis A vaccine given? The vaccine is given by an injection into the muscle of the upper arm for adults and older children and in the thigh muscle of toddlers. Who should get this vaccine? Many people are recommended to receive hepatitis A vaccine, including people at increased risk for exposure to HAV infection and people who are more likely to get seriously ill if infected with HAV. According to CDC recommendations, people who should be vaccinated include: All children at age 1 year (12-23 months) People age 12 months or older who are traveling to or working in an area of the world except the United States, Canada, Western Europe, Japan, New Zealand, and Australia Men who have sex with men Users of illicit drugs, injectable or noninjectable People who anticipate having close personal contact with an international adoptee from a country of high or intermediate endemicity during the first 60 days following the adoptee’s arrival in the United States People who have blood clotting disorders People who work with HAV-infected primates or with HAV in a research laboratory setting (no other groups have been shown to be at increased risk for HAV infection because of occupational exposure) People with chronic liver disease Any person who wishes to be immune to HAV infection Hepatitis A vaccine is not routinely recommended for healthcare workers, sewage workers, or daycare providers. Children who are not vaccinated by age two years should be vaccinated as soon as feasible. How many doses of hepatitis A vaccine are recommended for full protection? Two doses are recommended. The second dose is given no sooner than six months after the first dose. I’m not in a group for which hepatitis A vaccine is recommended. Can I still get vaccinated to protect myself against HAV infection? Yes. Hepatitis A vaccine is safe and effective and is licensed for use in any person age 12 months and older. Any person who wishes to be immune to hepatitis A is recommended to receive the vaccine. How long does hepatitis A vaccine protect you? Estimates for long-term protection for fully vaccinated people (i.e., full two-dose series) suggest that protection from HAV infection could last for at least 25 years in adults and at least 14-20 years in children. Experts continue to study the long-term effectiveness of this vaccine to determine whether a booster dose will be needed. What organizations recommend hepatitis A vaccine? The Centers for Disease Control and Prevention, the American Academy of Pediatrics, the American Academy of Family Physicians, the American College of Obstetricians and Gynecologists, and the American College of Physicians recommend the vaccine. Is hepatitis A vaccine safe? Yes, hepatitis A vaccine is very safe. No serious adverse events have been attributed definitively to hepatitis A vaccine. Since the licensure of the first hepatitis A vaccine in 1995, millions of doses of hepatitis A vaccine have been distributed and administered worldwide as well as in the United States. What side effects have been reported with this vaccine? The most common side effect is a sore arm, which happens to one out of two adults and one out of five children. Less common side effects include headache, loss of appetite, low-grade fever, or tiredness. When these problems happen, they usually start 3–5 days after vaccination and usually last for one or two days. A very rare but serious side effect is a generalized allergic reaction. If this happens, it typically occurs within a few minutes to a few hours following the injection. How effective is hepatitis A vaccine? Hepatitis A vaccine is very effective. It appears that all adults, adolescents, and children become immune to HAV infection after getting two doses. After one dose, at least 94 out of 100 people become immune for the short term. Who should not receive hepatitis A vaccine? People who have had a serious allergic reaction to hepatitis A vaccine in the past, or who are known to be allergic to any part of the hepatitis A vaccine, should not receive it. People with moderate or severe acute illness should wait to receive hepatitis A vaccine until their condition has improved. Can I receive hepatitis A vaccine when I am pregnant? The answer to this question is not well studied, but because hepatitis A vaccine is produced from inactivated HAV, the theoretical risk to the developing fetus is expected to be low. The risk associated with vaccination, however, should be weighed against the risk for hepatitis A in women who may be at high risk for exposure to HAV. Can the vaccine cause HAV infection? Is there a vaccine that protects against both HAV and HBV infections? Yes. Twinrix, the hepatitis A and hepatitis B combination vaccine manufactured by GlaxoSmithKline, was licensed for use in the United States in 2001 for people 18 years of age and older. Three doses of Twinrix are necessary for full protection against hepatitis A and hepatitis B virus infections. In April 2007, approval was received for an alternate 4-dose schedule for Twinrix. Using this schedule, 3 doses of Twinrix can be administered at 0, 7, and 21-30 days, followed by the 4th dose at 12 months. This schedule might benefit people needing rapid protection from both hepatitis A and hepatitis B virus infections. This includes people traveling to areas with high rates of hepatitis A and hepatitis B and emergency responders, especially those being deployed to disaster areas overseas. Again, this is available only for people 18 years of age and older. What is immune globulin (IG)? IG is a preparation of antibodies that can be given before exposure to HAV for short-term protection against HAV infection and to people who have already been exposed to HAV. IG must be given within 2 weeks after exposure to HAV for maximum protection. Are there new recommendations for the use of IG and/or hepatitis A vaccine prior to travel? Yes. All susceptible people traveling to or working in countries except the United States, Canada, Western Europe, Japan, New Zealand and Australia should receive hepatitis A vaccine or IG before departure. (If traveling to the Caribbean, people should consider getting hepatitis A vaccine or IG if travel is to areas of questionable sanitation.) For unvaccinated people ages 1 through 40 years, the first dose of hepatitis A vaccine should be administered as soon as travel is considered, actually anytime prior to travel. The second dose should be given at least 6 months after the first dose. For the best protection, individuals who are over age 40, immunocompromised people (e.g., people with AIDS), and people with chronic liver disease or other chronic medical conditions planning to travel in 2 weeks or less should receive the initial dose of hepatitis A vaccine and IG at the same time. The second dose of the 2-dose hepatitis A vaccine series should be given no sooner than six months after the first dose. This second dose is needed to ensure long lasting protection. Travelers who choose not to get the hepatitis A vaccine, who are less than 12 months old, or who are allergic to the vaccine should be given IG only. The dosage of IG depends on how long you plan to be traveling and how much you weigh. What should be done for travelers who are younger than age 12 months to protect them from HAV infection? Recommendations have not changed for this age group as noted in the previous question. IG is recommended for travelers younger than age 12 months because hepatitis A vaccine is not licensed for use in this age group. Can hepatitis A vaccine be given after exposure to HAV? Yes. The recommendations for the use of hepatitis A vaccine after exposure to HAV have changed. People who recently have been exposed to HAV and who previously have not had hepatitis A vaccine should be given a single dose of hepatitis A vaccine or IG as soon as possible. Hepatitis A vaccine is preferred for healthy people age 12 months through 40 years of age. For people over 40 years of age, IG is preferred, but hepatitis A vaccine can be used if IG is unavailable. IG should be given to children younger than 12 months of age, immunocompromised people, people who have diagnosed chronic liver disease, and people for whom vaccine is contraindicated. Questions and answers about hepatitis A disease
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Što je hepatitis A? Hepatitis A je upalna bolest jetre uzrokovana virusom hepatitisa A. Bolest počinje općim simptomima kao što su groznica, slabost, povraćanje, proljev, a tek je svaki četvrti oboljeli žut! U oko 25 posto oboljelih koža i bjeloočnice postaju žute, mokraća tamnija, a stolica svjetljija. Nakon 1 do 2 tjedna simptomi bolesti nestaju, ali potpun oporavak traje duže; kod nekih pacijenata čak 6-12 mjeseci. Inkubacija nakon infekcije virusom hepatitisa A traje 15-60 dana. Virus hepatitisa A prenosi se prljavim rukama, zaraženom hranom i vodom. Infekcija se najčešće javlja unutar zajednice (vrtić, škola, obitelj). Cijepljenje se preporučuje kao siguran oblik zaštite od obolijevanja od hepatitisa A. Tko podliježe potrebi cijepljenja? Djeca s visokim rizikom ili pri putovanju u rizična područja, gdje se hepatitis A nalazi endemski (područja gdje je stalno nazočan). Kako cijepiti dijete protiv hepatitisa A? Za postizanje potpune zaštite potrebno je primiti 2 doze cjepiva u bilo kojoj dobi, počevši od navršene godine dana života. Druga se doza daje u razdoblju od 6-12 mjeseci nakon prve doze. Neka djeca ne smiju se cijepiti ili moraju pričekati - Ne smiju se cijepiti djeca koja su pri prethodnom cijepljenju protiv hepatitisa A razvila alergijsku reakciju na cjepivo i djeca koja su alergična na bilo koji sastojak cjepiva. - Djeca koja boluju od neke lakše bolesti, npr. prehlade, mogu se cijepiti, međutim u teže bolesne djece s visokom temperaturom cijepljenje protiv hepatitisa A treba odgoditi dok potpuno ne ozdrave. Koje su moguće neželjene reakcije na cijepljenje? Cjepivo protiv hepatitisa A je vrlo sigurno cjepivo. Ukoliko postoje, neželjene reakcije su u većini slučajeva vrlo blage: - bol i crvenilo na mjestu uboda - prolazno povišenje temperature, glavobolja, umor, zimica, mučnina i gubitak teka. Teži oblici neželjenih reakcija, npr. alergijske reakcije, rijetki su. Što ako se javi teška neželjena reakcija? Iako izuzetno rijetka, alergijska reakcija može se nastaviti nekoliko minuta do nekoliko sati nakon primjene cjepiva. Simptomi uključuju teško disanje, promiklost, osip, bljedilo, opću slabost, ubrzan rad srca i vrtoglavicu. Ukoliko primijetite bilo koji od ovih simptoma, odmah se javite liječniku! Autori teksta: Prof. dr. sc. Milivoj Jovančević, primarijus, spec. pedijatar; prim. dr. med. Denis Mladinić Vulić, spec. pedijatar; prof. dr. sc. Goran Tešović, spec. infektolog