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All ProjectsShow only active projects 14C i 137Cs u sedimentima – usporedba metoda i primjena na recentne sedimente Odredit će se profili 14C i 137Cs u recentnim jezerskim sedimentima s područja Plitvičkih jezera u Hrvatskoj. Pomoći ćemo kolegama u Novom Sadu da razviju metodu mjerenja 14C aktivnosti u okolišu tehnikom apsorpcije CO2 i provesti harmonizaciju metoda pripreme uzoraka i mjernih procedura, te međulaboratorijsku interkomparaciju.more » A multidisciplinary approach to discover selective drugs targeting cancer stem cells: The role of potassium transport - MultiCaST The main goal of the proposed research is to understand cancer stem cell (CSC) biology and to develop novel CSC-directed compounds. We will strive to elucidate the molecular basis of potassium ion transport involvement in CSC-phenotype acquisition, modulation and targeting and identify key mechanisms of these processes as novel biomarkers for improved diagnostic options and innovative mechanism-based therapeutic approaches.more » Adhesion of liposomes at electrode Proposed project is based on the application of electrochemicial method and the theoretical model in study of adhesion mechanism of liposome at the charged electrode. Results would contribute to the better understanding of fundamental processes important for vesicular transport (intra and extracellualr) and reaction of cell membrane on environmental stress.more » Alzheimer's disease - the role of cholesterol on processing and localization of APP-family members This project aims to analyze whether the molecular mechanisms of the cholesterol effect on APP and amyloid-B peptide (AB) may involve APP-family members, APLP1 and APLP2. We will elucidate whether cholesterol affects processing of APLP1 and APLP2, like APP, and whether the cholesterol effect on APP is mediated by APLP1/2-regulated trafficking of APP.more »
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Svi projekti COST Action CM1201: Biomimetic Radical Chemistry CMST COST Action CM1201 Biomimetic Radical Chemistryviše » ADP-ribozilacija proteina u modelnom prokariotu Streptomyces coelicolor i čovjeku Posttranslacijska modifikacija proteina ima važnu ulogu u regulaciji funkcije proteina i interakciji proteina s drugim molekulama. ADP-ribozilacija proteina je posttranslacijska modifikacija kojom se skupina ADP-riboze iz NAD+ prenosi na ciljne proteine.više » Effective modulation of ZnO band gap and the modulation mechanism study (ZnO band gap study) With a wide band gap of 3.37eV and a large exciton banding energy of 60meV at room temperature, ZnO has been considered as a promising material for optoelectronic devices, such as short-wavelenghth light-emitting diodes and laser diodes.više » EU COST: CMST Action CM1304: Emergence and Evolution of Complex Chemical Systems Chair of the Action: Prof. Sijbren OTTO (NL); Dr. Leo FRKANEC (HR), Management Committee Member (MC)više » Gene expression mediated by satellite DNA (RegSat) Satellite DNAs are major building elements of pericentromeric and centromeric heterochromatin in many eukaryotes.više » MLCS Strojno učenje iz složenih struktura podataka U Institutu "Ruđer Bošković" razvijamo postupke strojnog učenja već dugi niz godina i uspješno ih primjenjujemo u raznim područjima uključujući kemiju, biologiju, medicinu, društvene znanosti, ekonomiju, i proizvodnju. Unutar ovog projekta razvijamo nove postupke koji mogu otkrivati znanje iz podataka u složenim strukturama.više » Nekovalentne interakcije u dizajnu novih fotoosjetljivih molekula Projekt se bavi sa dva ključna cilja istraživanja u Europskoj uniji: očuvanje energije i okoliša. Znanstveni pristup temelji se na kombinaciji teorijskog i eksperimentalnog znanja i iskustva suradnika, a uključuje kvantno-kemijske izračune i modeliranje u molekularnom dizajnu, kemijske sinteze i proučavanje fizikalno-kemijskih svojstava sustava dobivenih kroz samoudruživanje putem nekovalentnih interakcija. Projekt je multidisciplinaran, pokriva teme iz fizikalno-organske, supramolekularne i računalne kemije, fotofizike i znanosti o materijalima.više »