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Genes May Play Role in More Severe Form of PMS TUESDAY, Jan. 3, 2017 (HealthDay News) — A new study links the activity of certain genes to a premenstrual mood disorder that affects 2 to 5 percent of women of reproductive age. The disorder, known as premenstrual dysphoric disorder (PMDD), causes more severe symptoms than premenstrual syndrome, better known as PMS. PMDD symptoms include disabling irritability, sadness and anxiety before a menstrual period. The link “adds to evidence that PMDD is a disorder of cellular response to estrogen and progesterone,” said study researcher Dr. Peter Schmidt. He’s with the National Institute of Mental Health, part of the U.S. National Institutes of Health. “For the first time, we now have cellular evidence of abnormal signaling in cells derived from women with PMDD, and a plausible biological cause for their abnormal behavioral sensitivity to estrogen and progesterone,” he said in an NIH news release. Scientists had already known that women with the disorder are especially sensitive to changes in sex hormones, even though their hormone levels are normal. For the new study, the researchers looked at how gene expression was controlled in white blood cells. They found a complex of genes that acts differently in women with the disorder compared to women without it. Dr. David Goldman, of the U.S. National Institute on Alcohol Abuse and Alcoholism, worked with Schmidt on the study. “This is a big moment for women’s health, because it establishes that women with PMDD have an intrinsic difference in their molecular apparatus for response to sex hormones — not just emotional behaviors they should be able to voluntarily control,” Goldman said. The study appears Jan. 3 in the journal Molecular Psychiatry. More information For more about PMDD and PMS, visit the Cleveland Clinic.
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Predmenstrualni sindrom, koji ženama zadaje tegobe i često ih sprječava u izvršavanju svakodnevnih obaveza, može trajati dulje nego se do sada mislilo i povezan je s manje poznatim predmenstrualnim disforičnim poremećajem Prema novim istraživanjima PMS može trajati i do tri dana nakon što ciklus počne te bi liječnici tom stanju trebali pripisati te tegobe i za vrijeme menstruacije. One su povezane s predmenstrualnim disforičnim poremećajem (PMDD) koji ima slične simptome kao PMS, ali su jače izraženi te uzrokuju otežano funkcioniranje u poslovnom, socijalnom ili društvenom životu. National Institutet of Health , piše Msnbc.com , smatra da uvjete za PMDD ima oko tri do osam posto žena, a znanstvenici misle da je to puno češći slučaj. U istraživanju je sudjelovalo 139 žena koje imaju dijagnosticiran PMDD i PMS, a nihovo stanje kroz dva ciklusa uspoređivano je sa 864 žene koje nemaju službenu dijagnozu. Ispitanice su bilježile svoje osjećaje i tegobe kroz cikluse te koliko su im tegobe ometale svakodnevne obaveze. Rezultati pokazuju da žene bez posebnih smetnji obično osjećaju PMS tri dana prije početka mjesečnice i šest dana za vrijeme ciklusa. Žene koje imaju tegobe odnosno PMDD osjećaj PMS-a imaju četiri dana prije početka mjesečnice i još šest dana nakon početka. Promjene raspoloženja i fizička stanja poput nadutosti su među najčešćim navedenim simptomima. Znanstvenici su zaključili da je za dijagnosticiranje PMDD-a potrebno barem četiri simptoma, ali su za detaljnije rezultate treba još istraživati. Novo izdanje časopisa Archives of General Psychiatry ističe da se do daljnjeg zato ženama neće dijagnosticirati PMDD sindrom, iako imaju uvjete za to. - Sviđa vam se članak? Preporučite ga prijateljima putem ovih servisa: Pošaljite mailom