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Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you. Signing up only take a few minutes, so why not give it a try and see what you've been missing out on. An international team of scientists has discovered that two of the world's most devastating plagues - the plague of Justinian and the Black Death, each responsible for killing as many as half the people in Europe - were caused by distinct strains of the same pathogen, one that faded out on its own, the other leading to worldwide spread and re-emergence in the late 1800s. These findings suggest a new strain of plague could emerge again in humans in the future. "The research is both fascinating and perplexing, it generates new questions which need to be explored, for example why did this pandemic, which killed somewhere between 50 and 100 million people die out?" questions Hendrik Poinar, associate professor and director of the McMaster Ancient DNA Centre and an investigator with the Michael G. DeGroote Institute for Infectious Disease Research. The findings are dramatic because little has been known about the origins or cause of the Justinian Plague - which helped bring an end to the Roman Empire - and its relationship to the Black Death, some 800 years later. Scientists hope this could lead to a better understanding of the dynamics of modern infectious disease, including a form of the plague that still kills thousands every year. The Plague of Justinian struck in the sixth century and is estimated to have killed between 30 and 50 million people - virtually half the world's population as it spread across Asia, North Africa, Arabia and Europe. The Black Death would strike some 800 years later with similar force, killing 50 million Europeans between just 1347 and 1351 alone. Using sophisticated methods, researchers from many universities including McMaster University, Northern Arizona University and the University of Sydney, isolated miniscule DNA fragments from the 1500-year-old teeth of two victims of the Justinian plague, buried in Bavaria, Germany. These are the oldest pathogen genomes obtained to date. Using these short fragments, they reconstructed the genome of the oldest Yersinia pestis, the bacterium responsible for the plague, and compared it to a database of genomes of more than a hundred contemporary strains. The results are currently published in the online edition of The Lancet Infectious Diseases. They show the strain responsible for the Justinian outbreak was an evolutionary 'dead-end' and distinct from strains involved later in the Black Death and other plague pandemics that would follow. The third pandemic, which spread from Hong Kong across the globe is likely a descendant of the Black Death strain and thus much more successful than the one responsible for the Justinian Plague. "We know the bacterium Y. pestis has jumped from rodents into humans throughout history and rodent reservoirs of plague still exist today in many parts of the world. If the Justinian plague could erupt in the human population, cause a massive pandemic, and then die out, it suggest it could happen again. Fortunately we now have antibiotics that could be used to effectively treat plague, which lessens the chances of another large scale human pandemic" says Dave Wagner, an associate professor in the Center for Microbial Genetics and Genomics at Northern Arizona University. The samples used in the latest research were taken from two victims of the Justinian plague, buried in a gravesite in a small cemetery in the German town of Aschheim. Scientists believe the victims died in the latter stages of the epidemic when it had reached southern Bavaria, likely sometime between 541 and 543. The skeletal remains yielded important clues and raised more questions. Researchers now believe the Justinian Y. pestis strain originated in Asia, not in Africa as originally thought. But they could not establish a 'molecular clock' so its evolutionary time-scale remains elusive. This suggests that earlier epidemics, such as the Plague of Athens (430 BC) and the Antonine Plague (165 -180 AD), could also be separate, independent emergences of related Y. pestis strains into humans. "The tick of the plague bacteria molecular clock is highly erratic. Determining why is an important goal for future research" says Edward Holmes, an NHMRC Australia Fellow at the University of Sydney. Our response to modern infectious diseases is a direct outcome of lessons learned from ancestral pandemics, say the researchers. "This study raises intriguing questions about why a pathogen that was both so successful and so deadly died out. One testable possibility is that human populations evolved to become less susceptible," says Holmes. "Another possibility is that changes in the climate became less suitable for the plague bacterium to survive in the wild," says Wagner. The research was funded in part by the Social Sciences and Humanities Research Council of Canada, Canada Research Chairs Program, U.S. Department of Homeland Security, U.S. National Institutes of Health and the Australian National Health and Medical Research Council. Article adapted by Medical News Today from original press release. Click 'references' tab above for source. Visit our Infectious Diseases / Bacteria / Viruses category page for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report: MLA McMaster University. "The cause of one of the most devastating pandemics in human history uncovered." Medical News Today. MediLexicon, Intl., 29 Jan. 2014. Web. APA McMaster University. "The cause of one of the most devastating pandemics in human history uncovered." Medical News Today. Retrieved from http://www.medicalnewstoday.com/releases/271781. Please note: If no author information is provided, the source is cited instead. For any corrections of factual information, or to contact our editorial team, please use our feedback form. 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Vrsta kuge koja je u prošlosti nazivana i “Crna smrt” ponovno bi se mogla pojaviti na zemlji i opasno zaprijetiti čovječanstvu, tvrde znanstvenici. Informacije su dospjele u javnost kada je jedna skupina znanstvenika istraživala povjesno poznatu Justinijanovu kugu. Znanstvenici su izolirali tragove iz zuba žrtava od prije 1500 godina i zaključili da je pristutna bakterija razvijenija od ona za koju se smatra da je kriva za “Crnu smrt”. Sve ukazuje na bubu Yersinia pesti, preko koje se ovakva bakterija može proširiti sa pacova na ljude. Dave Wagner, član međunarodnog tima znanstvenika sa Sveučilišta Northern Arizona u SAD-u , rekao je:“Znamo da je bakterija Yersinia pestis prenesena s glodavaca na ljude kroz povijest i rezervoari kuge danas postoje u mnogim dijelovima svijeta i dostupni su mnogobrojnim štakorima.” “Ako je Justinijan kuga mogla izbiti u ljudskoj populaciji , izazvati golemu pandemiju, a zatim odumrijeti, to sugerira da bi se isto moglo dogoditi opet. Srećom sada imamo antibiotike koje se mogu koristiti za učinkovito liječenje kuge, što umanjuje izglede za još jednu veliku razmjeru pandemije,” dodao je liječnik. Rezultati, objavljeni u časopisu The Lancet Infectious Diseases, otkrili su da je soj odgovoran za Justinijanovu kugu evolucijska slijepa ulica. Onse pojavio, načinio štetu i nestao sa Zemlje, što nema veze s kasnijom pojavom Crne smrti. Pandemija koja se u 19. stoljeću proširila diljem svijeta iz Hong Konga, vjerojatno je potomak uspješnijeg soja, tvrde znanstvenici. Stručnjaci misle da je soj bakterije Y. Pestis nastao u Aziji, ne u Africi, kao se u početku mislilo . Martić