http___www.telegram.hr_zivot_znanstvenici-tvrde-da-su-stvorili-gensku-terapiju-koja-bi-jednim-tretmanom-mogla-unistiti-alergije__1.xml
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The University of Queensland in Australia has come up with a research on developing a single treatment to cure asthma for a lifetime. The research team is headed by Associate Professor Ray Steptoe at the UQ Diamantina Institute and has found a method to ‘turn-off’ the response from the immune system that is responsible for allergic reactions in animals. Professor Steptoe explains, “When someone has an allergy or asthma flare-up, the symptoms they experience results from immune cells reacting to the protein in the allergen.” The complication in curing asthma is that the immune cells, also called T-cells, develop a kind of immune ‘memory’ and don’t get affected by the treatments. This new gene therapy is able to ‘wipe’ the memory of those T-cells and hence can help in desensitizing the immune system in such a way that it can tolerate the allergen. “Our work used an experimental asthma allergen, but this research could be applied to treat those who have severe allergies to peanuts, bee venom, shellfish and other substances,” says Dr. Steptoe. He also adds that the results would be subjected to further pre-clinical investigation, and then to replicate results using human cells in the laboratory. Describing the medical procedures involved in the therapy, Dr. Steptoe explains that first the stem cells are taken and then a gene is inserted which is responsible for the regulation of allergen protein. Thereafter, those cells are put into the recipient. Then they produce new blood cells that express the protein and target specific immune cells. This ‘turns off’ the allergic response of the cells. Rather than various short-term treatments with varying degrees of relief, the research team aims at developing a single injected gene therapy to treat asthma and various food allergies. “We haven’t quite got it to the point where it’s as simple as getting a flu jab, so we are working on making it simpler and safer so it could be used across a wide cross-section of affected individuals,” Dr. Steptoe says. A safe one-off treatment for asthma could make the lives of about 300 million lives suffering from Asthma worldwide.
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Ozbiljne alergije mogu se izliječiti genskom terapijom, piše u novoj studiji objavljenoj u časopisu JCI Insight. Znanstvenici tvrde da je moguće da samo jedan tretman štiti od ozbiljnih alergija, kao što je astma, tijekom cijelog života. Stručnom timu znanstvenika, koji je vodio profesor Ray Steptoe sa Sveučilišta Queensland u Australiji, uspjelo je, kod životinja, isključiti imunološku reakciju koja uzrokuje alergijsku reakciju. Profesor Steptoe kaže da kada je netko alergičan pa ima astmu ili crvenilo, simptomi su rezultat reakcije imunoloških stanica na protein u alergenu. Ove imunološke stanice, tzv. T stanice, razvijaju oblik imunološke memorije i postaju vrlo otporne na dostupne tretmane. Sada možemo izbrisati memoriju T stanica kod životinja genskom terapijom, desenzibilirajući imunološki sustav tako da tolerira protein. Stvaranje lijeka za široku upotrebu U laboratoriju su uzete matične stanice krvi, ubačen je gen koji regulira protein u alergenu i nakon toga su takve stanice vraćene davatelju. Ove genetskim inženjeringom dobijene stanice proizvode nove krvne stanice kod kojih izostaje alergijska reakcija. Steptoe kaže da će eventualni cilj postupka biti jedna injekcija genske terapije koja će zamijeniti kratkoročne tretmane koji ciljaju simptome alergije sa različitim stupnjem efikasnosti. “Nismo još došli do točke da bude jednostavno kao cijepljenje protiv gripe i sada radimo na tome da postupak učinimo jednostavnijim i sigurnijim za široku upotrebu. Ovog časa, ciljna populacija su one osobe koje imaju astmu ili potencijalno kobne alergije na hranu”, kaže profesor Steptoe. - Studije stalno iznova dokazuju da nam psi i mačke super utječu na zdravlje, izvukli smo 6 konkretnih načina kako - Izvukli smo nekoliko stvari za koje stručnjaci kažu da nije baš najpametnije raditi u sezoni alergija - Dosta je izgledno da ćemo se u budućnosti još više boriti s alergijama, zahvaljujući globalnom zatopljenju