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`Broken heart syndrome` protects grief-stricken from dyingPublished On: Thu, Jun 28th, 2012 | Cardiovascular / Cardiology | By BioNews A condition that temporarily causes heart failure in people who experience severe stress might actually protect the heart by stopping the organ being pumped with too much adrenaline, a new study has revealed. The research provides the first physiological explanation for Takotsubo cardiomyopathy, also called “broken heart syndrome” because it affects people who suffer severe emotional stress after bereavement, and suggests guidance for treatment. Around 1-2 percent of people who are initially suspected of having a heart attack are finally discovered to have this increasingly recognised syndrome. The Imperial College London study, which simulated the condition in an animal model, suggests that the body changes its response to adrenaline by switching from its usual role in stimulating the heart to reducing its pumping power. Although this results in acute heart failure, most patients make a full recovery within days or weeks. The researchers propose that the switch in the heart’s response to adrenaline might have evolved to protect the heart from being overstimulated by the particularly high doses of adrenaline that the body releases during stress. Patients with Takotsubo cardiomyopathy, most often older women, experience symptoms that resemble a heart attack, but heart tests reveal no blockage in the coronary arteries. Instead, the heart has a balloon-like appearance caused by the bottom of the heart not contracting properly. The same condition is sometimes seen in people who are injected with adrenaline to treat severe allergic reactions. In this new research, the authors simulated the condition by injecting high doses of adrenaline in anaesthetised rats. In these rats, as in Takotsubo patients, heart muscle contraction was suppressed towards the bottom of the heart. They found that these rats were protected from an otherwise fatal overstimulation of the heart, indicating that adrenaline acts through a different pathway from usual, and that this switch protects the heart from toxic levels of adrenaline. The study also examined drugs that might be useful for treating Takotsubo cardiomyopathy. Some beta blockers, used to treat high blood pressure, angina and heart failure, reproduced or enhanced the features of Takotsubo, giving new insights into the protective effects of these drugs. Levosimendan, a different type of drug given in heart failure to stimulate the heart without going through the adrenaline receptor pathways, had a beneficial effect. “Adrenaline’s stimulatory effect on the heart is important for helping us get more oxygen around the body in stressful situations, but it can be damaging if it goes on for too long,” Sian Harding, the study leader from the National Heart and Lung Institute (NHLI) at Imperial College London, said. “In patients with Takotsubo cardiomyopathy, adrenaline works in a different way and shuts down the heart instead. This seems to protect the heart from being overstimulated,” Harding added. The study has been published in the journal Circulation.
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Za ljude koji pate od intenzivne boli nakon smrti voljene osobe, često se kaže da su u opasnosti od smrti od slomljenog srca, nakon što razviju simptome slične srčanom udaru. No znanstvenici koji proučavaju sindrom slomljenog srca otkrili su da stanje zapravo ima zaštitnu ulogu sprečavajući da se u nj upucava previše adrenalina Oko jedan ili dva posto ljudi koji su u mislili da su pretrpjeli srčani udar dijagnosticiran je sindrom slomljenog srca , također poznat kao kardiomiopatija Takotsubo, piše Daily Mail. Bolesnici - uglavnom starije žene – osjećali su simptome koji nalikuju srčanom udaru, ali testovi nisu otkrili blokadu u koronarnim arterijama Umjesto toga srce je poprimilo izgled balona, a isto se stanje ponekad primjećuje kod ljudi kojima je ubrizgan adrenalin kod tretmana teških alergijskih reakcija. Studija provedena na londonskom Imperial Collegeu pokazala je da tijelo mijenja svoju reakciju na adrenalin stimulirajući srce da smanji količinu adrenalina smanjujući svoju snagu pumpanja. Ovaj se parametar vjerojatno razvio kako bi se zaštitilo srce od pretjerane stimulacije osobito visokim dozama adrenalina koje tijela otpušta kad je pod stresom. 'Adrenalin ima stimulirajući efekt na srce što je važno da bismo u organe dobili što više kisika u stresnim situacijama. No taj učinak može biti štetan ako dugo traje', kaže profesor Harding Sian. 'Kod bolesnika s kardiomiopatijom Takotsubo, adrenalin radi drukčije i zatvara srce. Čini se da štiti srce od pretjerane stimulacije.' Studija također ispituje lijekove koji bi mogli biti korisni u liječenju sindroma slomljenog srca budući da su se beta blokatori koji se koriste za liječenje visokog krvnog tlaka i angine srca pokazali uspješnima i kod sindroma Takotsubo. - Sviđa vam se članak? Preporučite ga prijateljima putem ovih servisa: Pošaljite mailom