Hos ikke- inficerede frivillige resulterede multiple doser på 200- 400 mg per dag i 10 dage i en lavere grad af akkumulation (22- 42% lavere) end forudset samt kortere terminal halveringstid på 40- 55 timer (halveringstid for enkeltdosis 52- 76 timer).
In uninfected volunteers, multiple doses of 200 to 400 mg per day for 10 days resulted in a lower than predicted extent of accumulation (22 to 42% lower) and a shorter terminal half-life of 40 to 55 hours (single dose half-life 52 to 76 hours).