In vitro- forsøg med humane levermikrosomer har vist, at paliperidon ikke væsentligt hæmmer metaboliseringen af lægemidler, som metaboliseres af cytokrom P450- isozymer, herunder CYP1A2, CYP2A6, CYP2C8/ 9/ 10, CYP2D6, CYP2E1, CYP3A4 og CYP3A5.
In vitro studies in human liver microsomes showed that paliperidone does not substantially inhibit the metabolism of medicines metabolised by cytochrome P450 isozymes, including CYP1A2, CYP2A6, CYP2C8/ 9/ 10, CYP2D6, CYP2E1, CYP3A4, and CYP3A5.