Der er rapporter om, at samtidig administration af pioglitazon og rifampicin (en inducer af cytokrom P450 2C8) har resulteret i en 54% nedsættelse af AUC for pioglitazon.
Co-administration of pioglitazone with rifampicin (an inducer of cytochrome P450 2C8) is reported to result in a 54% decrease in AUC of pioglitazone.