Interaktioner med P- glycoprotein I prækliniske forsøg er det vist, at MDR1/ Mdr1a/ 1b (P- gp) er det vigtigste efflukssystem involveret i aliskirens intestinale absorption og galdeudskillelse.
P-glycoprotein interactions MDR1/ Mdr1a/ 1b (P-gp) was found to be the major efflux system involved in intestinal absorption and biliary excretion of aliskiren in preclinical studies.