Studiet bestod af to dele: en initial, ublindet 2 - armet del (del 1) hvor patienterne blev randomiseret til to forskellige behandlingsgrupper (XELOX og FOLFOX- 4) og en efterfølgende 2 x 2 4- armet del (del 2), hvor patienterne blev randomiseret til fire behandlingsgrupper (XELOX + placebo, FOLFOX - 4 + placebo, XELOX + Avastin, FOLFOX- 4 + Avastin).
The study contained two parts: an initial unblinded 2-arm part (Part I) in which patients were randomised to two different treatment groups (XELOX and FOLFOX-4) and a subsequent 2 x 2 factorial 4-arm part (Part II) in which patients were randomised to four treatment groups (XELOX + placebo, FOLFOX-4 + placebo, XELOX + Avastin, FOLFOX-4 + Avastin).