Hos nyretransplanterede patienter med svær, kronisk nyreinsufficiens (glomerulær filtration < 25 ml min- 1 1, 73 m- 2), bortset fra den umiddelbare post- transplantionsperiode, bør doser på mere end 1 g administreret to gange dagligt undgås.
In renal transplant patients with severe chronic renal impairment (glomerular filtration rate < 25 ml min-1 1.73 m-2), outside the immediate post-transplant period, doses greater than 1 g administered twice a day should be avoided.