Selvom den nøjagtige mekanisme ved sådan en virkning er ukendt, og dens forbindelse med mitotan eller med den underliggende lidelse er usikker, bør det tages i betragtning, når der overvejes operation.
Prolonged bleeding time appears a frequent finding (90%): although the exact mechanism of such an effect is unknown and its relation with mitotane or with the underlying disease is uncertain, it should be taken into account when surgery is considered.