For at skaffe klarhed over doseringsresponset skal lavere doser end den anbefalede dosis indgå i nogle forsøg, således at det kan vurderes, om den anbefalede dosis er den mindst mulige, der kræves for at opnå den ønskede virkning.
In order to clarify the dose response, dose rates lower than the recommended one shall be included in some trials in order to enable assessment of whether the recommended rate is the minimum necessary to achieve the desired effect.