Dette er målkoncentrationen fra de prækliniske data for at kunne hæmme receptorfosforylering in vitro, hvilket resulterer i tumorstase/ vækstreduktion in vivo.
By day 14, combined plasma concentrations of sunitinib and is active metabolite are 62.9 - 101 ng/ ml which are target concentrations predicted from preclinical data to inhibit receptor phosphorylation in vitro and result in tumour stasis/ growth reduction in vivo.