<p>A paper just came out last week in Neuron demonstrating dendrite-specific gating:<br>
<a href="http://www.cell.com/neuron/fulltext/S0896-6273(16)00054-4?elsca1=etoc&amp;elsca2=email&amp;elsca3=0896-6273_20160302_89_5_&amp;elsca4=Cell%20Press" rel="nofollow">http://www.cell.com/neuron/fulltext/S0896-6273(16)00054-4?elsca1=etoc&amp;elsca2=email&amp;elsca3=0896-6273_20160302_89_5_&amp;elsca4=Cell%20Press</a><br>
Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells
Erik B. Bloss, Mark S. Cembrowski, Bill Karsh, Jennifer Colonell, Richard D. Fetter, Nelson Spruston<br>
DOI: <a href="http://dx.doi.org/10.1016/j.neuron.2016.01.029" rel="nofollow">http://dx.doi.org/10.1016/j.neuron.2016.01.029</a></p>

CC BY-SA 3.0
2017-06-10T00:46:22.220Z
After looking into the paper again, it seems like the paper only demonstrates dendrite-type-specific targeting. On other words, based on an activation pattern, most neurons that share a specific dendrite branch type get activated. But there is no targeting of individual neurons. Am I misinterpreting the paper? I'd be happy if you could comment on this.
danijar
CC BY-SA 3.0
2017-06-11T06:38:05.153Z
presumably there are separate, cell-specific targeting mechanisms.  E.g. STDP
honi
CC BY-SA 3.0
2017-06-12T19:22:35.447Z
Thanks. Are you aware of any such work related on the thalamus?
danijar
CC BY-SA 3.0
2017-06-13T03:12:24.717Z
no, i'd doubt it exists honestly.
honi
CC BY-SA 3.0
2016-03-07T03:47:14.897Z
2016-03-07T03:47:14.897Z
honi
<p>For example, the upward connection between layers in the neocortex flows through the thalamus which is assumed to have a gating function.</p>

<p>I wonder whether there is a single value per gate, determining the degree to which patterns can pass. Or can the gate be different for different synapses or signals at the same time? In this case, there would be more like a vector of degrees for all individual synapses of the gated nerve cord.</p>

<p>Is there anything known about this?</p>

<neuroscience><cognitive-neuroscience><computational-modeling>
Do gating mechanisms in the neocortex have individual degrees for all gated connections?
danijar
# Do gating mechanisms in the neocortex have individual degrees for all gated connections?

(Asked by: username_0 on 2016-02-04)

For example, the upward connection between layers in the neocortex flows through the thalamus which is assumed to have a gating function.

I wonder whether there is a single value per gate, determining the degree to which patterns can pass. Or can the gate be different for different synapses or signals at the same time? In this case, there would be more like a vector of degrees for all individual synapses of the gated nerve cord.

Is there anything known about this?

**Tags:** neuroscience, cognitive-neuroscience, computational-modeling


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## 1 answers

### Answer by username_1 on 2016-03-07. Score: 2 | Accepted answer

A paper just came out last week in Neuron demonstrating dendrite-specific gating:  
<http://www.cell.com/neuron/fulltext/S0896-6273(16)00054-4?elsca1=etoc&elsca2=email&elsca3=0896-6273_20160302_89_5_&elsca4=Cell%20Press>  
Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells
Erik B. Bloss, Mark S. Cembrowski, Bill Karsh, Jennifer Colonell, Richard D. Fetter, Nelson Spruston  
DOI: <http://dx.doi.org/10.1016/j.neuron.2016.01.029>

> **Comments:**
> **username_0**: After looking into the paper again, it seems like the paper only demonstrates dendrite-type-specific targeting. On other words, based on an activation pattern, most neurons that share a specific dendrite branch type get activated. But there is no targeting of individual neurons. Am I misinterpreting the paper? I'd be happy if you could comment on this.  
> **username_1**: presumably there are separate, cell-specific targeting mechanisms.  E.g. STDP  
> **username_0**: Thanks. Are you aware of any such work related on the thalamus?  
> **username_1**: no, i'd doubt it exists honestly.  

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