<p>Free-running circadian periods were estimated to vary from 13 to 65 hours in normal subjects according to a 1979 study by R.A. Wever. This paper was referenced in a more recent article regarding the circadian pacemaker (Czeisler et al., 1999). I could not access the Wever article directly to assess quality. However, the Czeisler article takes issue with the methods of earlier work that purported to show circadian rhythms longer than about 24 hours: </p>

<blockquote>
  <p>...the generality of these
  findings has been limited by reports that activity (16, 17), knowledge of time of day (18), and
  exposure to ordinary indoor room light (19, 20)
  can shift circadian phase or alter the observed
  free-running circadian period in humans and
  thus may have influenced those observations
  (21)." </p>
</blockquote>

<p>Czeisler et al. sought to control these confounds and estimate a rhythm with very little variance centered at 24.18 hours.</p>

<blockquote>
  <p>Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N.,
  Mitchell, J. F., Rimmer, D. W., … Kronauer, R. E. (1999). Stability,
  Precision, and Near-24-Hour Period of the Human Circadian Pacemaker.
  Science, 284(5423), 2177–2181. doi:10.1126/science.284.5423.2177 <a href="http://www.cscb.northwestern.edu/jcpdfs/czeisler99.pdf" rel="nofollow">PDF</a></p>
  
  <p>R. A. Wever, The Circadian System of Man: Results of Experiments Under
  Temporal Isolation (Springer-Verlag, New York, 1979); Experientia 40,
  1226 (1984).</p>
</blockquote>

CC BY-SA 3.0
2013-01-31T04:54:39.527Z
65 hours? how is that possible?
Jeff
CC BY-SA 3.0
2013-01-31T04:29:37.310Z
2013-02-02T19:12:36.730Z
2013-02-02T19:12:36.730Z
jflournoy
<p>I can't find the exact study you had in mind, but I think that you are referring to <a href="https://sleep.med.harvard.edu/people/faculty/210/Charles+A+Czeisler+PhD+MD" rel="nofollow">Dr. Charles Czeisler's</a> seminal (and long-term) work on circadian rhythms.</p>

<p>In a <a href="http://www.ncbi.nlm.nih.gov/pubmed/23090946" rel="nofollow">recent study</a> of his, he considered the effect of the wavelength of light on the extent to which it was able to reset the circadian "clock", which is the cycle you are referring to.  He did experiments in the 70s and 80s with maintaining subjects in "time free" environments to gauge the intrinsic phase of the rhythm.  </p>

<p>As an aside, some of the more theoretical mathematical work in this area was done by <a href="http://en.wikipedia.org/wiki/Arthur_Winfree" rel="nofollow">Art Winfree</a> and a pop-sci account of his work and Czeisler's  can be found in Steven Strogatz's book <a href="http://rads.stackoverflow.com/amzn/click/0786887214" rel="nofollow">Sync</a>.</p>

<blockquote>
  <p>Rüger, M, St. Hillaire, MA et al. (2013)Human phase response curve to a single 6.5 h pulse of short-wavelength light.  <em>Journal of Physiology, 591</em>(Pt 1),353-63. <a href="http://dx.doi.org/10.1113/jphysiol.2012.239046" rel="nofollow">[DOI]</a></p>
</blockquote>

CC BY-SA 3.0
2013-01-31T04:24:57.227Z
2013-01-31T04:24:57.227Z
Chuck Sherrington
<p>There was an article published some years ago about a sleep study (I think from Germany) that showed about 10-20% of people (European's I think) are genetically predisposed to function on a 30-hour* cycle. (As opposed to the 24 hour Circadian rhythm.)</p>

<p>*I think it was 30 hours, but don't know for sure. And I can't seem to find any reference to the study or what this "sleep disorder" is called. From Googling, I <strong>don't</strong> believe it is any of the following:</p>

<ul>
<li>Delayed sleep phase disorder</li>
<li>Segmented Sleep Disorder</li>
<li>Non-24-hour sleep-wake disorder</li>
</ul>

<p>The study was <strong>most likely</strong> related to cognitive function and may have been funded by a space agency.</p>

<p>Hope this is on topic here, I just saw this site in Area 51 but didn't read much about it.</p>

<cognitive-psychology><reference-request><sleep>
What is the sleep study that showed that a percentage of humans have a biological clock that is ~28 hours or greater?
Garrett Fogerlie
# What is the sleep study that showed that a percentage of humans have a biological clock that is ~28 hours or greater?

(Asked by: username_0 on 2013-01-29)

There was an article published some years ago about a sleep study (I think from Germany) that showed about 10-20% of people (European's I think) are genetically predisposed to function on a 30-hour\* cycle. (As opposed to the 24 hour Circadian rhythm.)

\*I think it was 30 hours, but don't know for sure. And I can't seem to find any reference to the study or what this "sleep disorder" is called. From Googling, I **don't** believe it is any of the following:

* Delayed sleep phase disorder
* Segmented Sleep Disorder
* Non-24-hour sleep-wake disorder

The study was **most likely** related to cognitive function and may have been funded by a space agency.

Hope this is on topic here, I just saw this site in Area 51 but didn't read much about it.

**Tags:** cognitive-psychology, reference-request, sleep


---

## 2 answers

### Answer by username_1 on 2013-01-31. Score: 6

Free-running circadian periods were estimated to vary from 13 to 65 hours in normal subjects according to a 1979 study by R.A. Wever. This paper was referenced in a more recent article regarding the circadian pacemaker (Czeisler et al., 1999). I could not access the Wever article directly to assess quality. However, the Czeisler article takes issue with the methods of earlier work that purported to show circadian rhythms longer than about 24 hours:

> ...the generality of these
> findings has been limited by reports that activity (16, 17), knowledge of time of day (18), and
> exposure to ordinary indoor room light (19, 20)
> can shift circadian phase or alter the observed
> free-running circadian period in humans and
> thus may have influenced those observations
> (21)."

Czeisler et al. sought to control these confounds and estimate a rhythm with very little variance centered at 24.18 hours.

> Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N.,
> Mitchell, J. F., Rimmer, D. W., … Kronauer, R. E. (1999). Stability,
> Precision, and Near-24-Hour Period of the Human Circadian Pacemaker.
> Science, 284(5423), 2177–2181. doi:10.1126/science.284.5423.2177 [PDF](http://www.cscb.northwestern.edu/jcpdfs/czeisler99.pdf)
>
> R. A. Wever, The Circadian System of Man: Results of Experiments Under
> Temporal Isolation (Springer-Verlag, New York, 1979); Experientia 40,
> 1226 (1984).

> **Comments:**
> **username_2**: 65 hours? how is that possible?  

---

### Answer by username_3 on 2013-01-31. Score: 4

I can't find the exact study you had in mind, but I think that you are referring to [Dr. Charles Czeisler's](https://sleep.med.harvard.edu/people/faculty/210/Charles+A+Czeisler+PhD+MD) seminal (and long-term) work on circadian rhythms.

In a [recent study](http://www.ncbi.nlm.nih.gov/pubmed/23090946) of his, he considered the effect of the wavelength of light on the extent to which it was able to reset the circadian "clock", which is the cycle you are referring to. He did experiments in the 70s and 80s with maintaining subjects in "time free" environments to gauge the intrinsic phase of the rhythm.

As an aside, some of the more theoretical mathematical work in this area was done by [Art Winfree](http://en.wikipedia.org/wiki/Arthur_Winfree) and a pop-sci account of his work and Czeisler's can be found in Steven Strogatz's book [Sync](http://rads.stackoverflow.com/amzn/click/0786887214).

> Rüger, M, St. Hillaire, MA et al. (2013)Human phase response curve to a single 6.5 h pulse of short-wavelength light. *Journal of Physiology, 591*(Pt 1),353-63. [[DOI]](http://dx.doi.org/10.1113/jphysiol.2012.239046)


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