<p>It depends on what you mean by psychosis. </p>

<p>Anti-psychotic medications effectively reduce the positive symptoms of schizophrenia (hallucinations, paranoia) at the expense of worsening the negative symptoms (rigidity, bradykinesia, cognitive slowing). Long-term use of antipsychotics, especially the older ones, can induce a Parkinson's-like syndrome. </p>

<p>These effects are not withdrawal so much as side effect of the medication. </p>

<p>Second generation antipsychotics are used as mood stabilizers in bipolar II and major depression. Post-marketing surveys of aripiperazole and the like have not bred rebound psychosis. </p>

<p>Use of dopamine agonists <em>is</em> associated with psychosis. </p>

CC BY-SA 3.0
2015-06-25T23:31:46.927Z
Not to be chatty, but glad to see you are back around.  :)
Chuck Sherrington
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2015-06-25T23:43:07.037Z
Thanks. Let's see if I can keep it up this time. Who would have thought a physician-scientist would be so busy?
mac389
CC BY-SA 3.0
2015-06-25T19:58:21.597Z
2015-06-25T19:58:21.597Z
mac389
<p>Can psychosis result from anti-psychotic medication withdrawal for a non-psychotic patient? That is, a patient that takes anti-psychotic medication for off label reasons, such as treatment-resistant depression, or insomnia.</p>

CC BY-SA 3.0
2015-06-25T23:44:36.850Z
When you say non-psychotic do you mean not diagnosed with a psychotic disorder? With no psych issues, psychotic or otherwise ever? No schizotypal personality disorder? Nothing that suggests unmasking rather than creation...
mac389
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2015-06-26T07:55:30.523Z
Correct, no psychotic symptoms ever. Also, the question is about dopamine antagonists.
jiniyt
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2015-06-26T16:13:32.490Z
Can you specify which class of DA antagonists? Or even a specific drug. Typical antipsychotics also bind to histamine and acetylcholine receptors. This binding influences perception.
mac389
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2015-06-27T05:44:33.097Z
atypical antipsychotics such as paliperidone, qutiapine, clozapine, olanzapine, ziprasidone.
jiniyt
<abnormal-psychology><clinical-psychology>
Anti-psychotic medication withdrawal-induced psychosis
jiniyt
# Anti-psychotic medication withdrawal-induced psychosis

(Asked by: username_0 on 2015-06-25)

Can psychosis result from anti-psychotic medication withdrawal for a non-psychotic patient? That is, a patient that takes anti-psychotic medication for off label reasons, such as treatment-resistant depression, or insomnia.

**Tags:** abnormal-psychology, clinical-psychology

> **Comments:**
> **username_1**: When you say non-psychotic do you mean not diagnosed with a psychotic disorder? With no psych issues, psychotic or otherwise ever? No schizotypal personality disorder? Nothing that suggests unmasking rather than creation...  
> **username_0**: Correct, no psychotic symptoms ever. Also, the question is about dopamine antagonists.  
> **username_1**: Can you specify which class of DA antagonists? Or even a specific drug. Typical antipsychotics also bind to histamine and acetylcholine receptors. This binding influences perception.  
> **username_0**: atypical antipsychotics such as paliperidone, qutiapine, clozapine, olanzapine, ziprasidone.  

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## 1 answers

### Answer by username_1 on 2015-06-25. Score: 3

It depends on what you mean by psychosis.

Anti-psychotic medications effectively reduce the positive symptoms of schizophrenia (hallucinations, paranoia) at the expense of worsening the negative symptoms (rigidity, bradykinesia, cognitive slowing). Long-term use of antipsychotics, especially the older ones, can induce a Parkinson's-like syndrome.

These effects are not withdrawal so much as side effect of the medication.

Second generation antipsychotics are used as mood stabilizers in bipolar II and major depression. Post-marketing surveys of aripiperazole and the like have not bred rebound psychosis.

Use of dopamine agonists *is* associated with psychosis.

> **Comments:**
> **username_2**: Not to be chatty, but glad to see you are back around.  :)  
> **username_1**: Thanks. Let's see if I can keep it up this time. Who would have thought a physician-scientist would be so busy?  

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