<p><strong>Q: How is Pain Subjective and Different from Nociception?</strong></p>
<p><strong>A:</strong> Pain is not nociception because their definitions are different. The usual definitions are like this:</p>
<blockquote>
<p><em><strong>Nociception refers to the peripheral and central nervous system (CNS) processing of information about the internal or external environment, as generated by the activation of nociceptors</strong></em>. Typically, noxious stimuli, including tissue injury, activate nociceptors that are present in peripheral structures and that transmit information to the spinal cord dorsal horn or its trigeminal homologue, the nucleus caudalis. From there, the information continues to the brainstem and ultimately the cerebral cortex, where the perception of pain is generated.  <em><strong>Pain is a product of higher brain center processing</strong></em> … (1)</p>
</blockquote>
<p><a href="https://i.sstatic.net/WYUvD.jpg" rel="nofollow noreferrer"><img src="https://i.sstatic.net/WYUvD.jpg" alt="Nociception and pain" /></a></p>
<p>Or</p>
<p>“<em><strong>Nociception (also nocioception, from Latin nocere 'to harm or hurt') is the sensory nervous system's process of encoding noxious stimuli</strong></em>. In nociception, intense chemical (e.g., cayenne powder), mechanical (e.g., cutting, crushing), or thermal (heat and cold) stimulation of sensory nerve cells called nociceptors produces a signal that travels along a chain of nerve fibers via the spinal cord to the brain.<a href="https://i.sstatic.net/WYUvD.jpg" rel="nofollow noreferrer">1</a> Nociception triggers a variety of physiological and behavioral responses and <em><strong>usually results in a subjective experience (or perception) of pain in sentient beings.</strong></em>”(2)</p>
<p>That is, nociception is defined to be the processing of noxious stimuli, which involves several levels of processing, but pain is defined to be the perception of the result of nociception processing. As there are many factors that can affect nociception at each level of processing, such as the pain control mechanism (e.g. the pain gate control) in the spinal cord and brainstem, analgesics, and even the mood of the subject, the pain perception can be altered/modified, and the final pain perception can be different even if it occurs in the same individual and from the same noxious stimuli. Also, because these factors are different among different subjects, the final pain perception in each individual is subjective – depending on various factors in each subject and different among different subjects even if it occurs from the same noxious stimuli.</p>
<p>For example:</p>
<ul>
<li><p>When your shin hits something hard and you feel pain there, if you stroke or massage the injured shin lightly, you’ll feel better with less pain – this is because the pain is modified by the pain gate control or other pain control mechanisms by the touch sensation. (3,4)</p>
</li>
<li><p>In a person who has a spinal cord transection with a loss of all sensations and voluntary movements of the legs, if you prick his foot, his foot will involuntarily jerk away from the prick, which means nociception is still being processed, but you won’t feel any pain because the pain perception in the brain does not occur (due to the spinal cord transection).</p>
</li>
<li><p>Alice has been given a flu shot in her arm, but she is a strong person and is in a good mood, so she feels little pain in her arm. On the contrary, Bob has been given a flu shot with the same needle size and ease of injection, but Bob is an irritable person and already in a bad mood, so he feels that the pain from the shot is very severe. So, the pain perceived from the same noxious stimuli is different among different subjects, depending on various factors in each subject.</p>
</li>
</ul>
<p>Therefore, the pain is different from nociception and is subjective.</p>
<p><strong>References:</strong></p>
<ol>
<li><p>National Research Council. 2009. <a href="https://www.ncbi.nlm.nih.gov/books/NBK32659/" rel="nofollow noreferrer">Mechanisms of Pain</a> In: Recognition and Alleviation of Pain in Laboratory Animals.  Washington, DC: The National Academies Press. <a href="https://doi.org/10.17226/12526" rel="nofollow noreferrer">https://doi.org/10.17226/12526</a>.</p>
</li>
<li><p>Wikipedia. <a href="https://en.wikipedia.org/wiki/Nociception" rel="nofollow noreferrer">Nociception</a></p>
</li>
<li><p>Nachum Dafny.<a href="https://nba.uth.tmc.edu/neuroscience/m/s2/chapter08.html" rel="nofollow noreferrer">Chapter 8: Pain Modulation and Mechanisms.</a> Neuroscience Online. The University of Texas Health Science Center at Houston (UTHealth).</p>
</li>
<li><p>Wikipedia. <a href="https://en.wikipedia.org/wiki/Gate_control_theory" rel="nofollow noreferrer">Gate Control Theory</a></p>
</li>
</ol>

CC BY-SA 4.0
2020-10-14T11:39:38.353Z
do you have source for `In a person who has a spinal cord transection with a loss of all sensations and voluntary movements of the legs, if you prick his foot, his foot will involuntarily jerk away from the prick, which means nociception is still being processed, but you won’t feel any pain because the pain perception in the brain does not occur (due to the spinal cord transection).`
gfdsal
CC BY-SA 4.0
2020-10-14T11:42:28.250Z
Also that  you are trying to convey that pain is a composite thing its encompasses mood, and other mental state of the person so changing the mood and mental state while giving same nocieption will result in different perception of pain. Right?
gfdsal
CC BY-SA 4.0
2020-10-14T15:46:39.293Z
@gfdsal The phenomenon of "In a person who has a spinal cord transection ... if you prick his foot, his foot will involuntary jerk away from the prick..." is called hyperreflexia after spinal shock, which occurs after spinal cord transection. Some references are https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218357/, https://www.spinalcord.com/blog/spinal-shock-what-it-is-and-how-you-treat-it , and
https://en.wikipedia.org/wiki/Spinal_shock. Or you can google search the term like “spinal shock pain hyperreflexia”.
user287279
CC BY-SA 4.0
2020-10-14T15:58:36.593Z
For the second comment, right! You can find more details about how psychological factors affect pain perception in section "MODULATORY INFLUENCES ON PAIN: ANXIETY, FEAR, AND STRESS" in reference #1 above: National Research Council. 2009. [Mechanisms of Pain.](https://www.ncbi.nlm.nih.gov/books/NBK32659/)
user287279
CC BY-SA 4.0
2020-10-14T18:39:48.657Z
Noted. It makes lot of sense now. Thanks.
gfdsal
CC BY-SA 4.0
2020-10-14T06:49:47.513Z
2020-10-14T06:49:47.513Z
user287279
<p>So pain is the sensory feeling that tells indiviual that something bad at some part of the body has happened. What I fail to understand is how is pain subjective? If we have touch receptors in the body we can technically all feel hyptactic simulation, why this cannot be said about pain.</p>
<p>In this <a href="https://esc-sec.ca/2019/09/02/do-insects-feel-pain/" rel="nofollow noreferrer">article</a> it is mentioned:</p>
<blockquote>
<p>pain is different from nociception, which is the ability to respond to damaging stimuli.  All organisms have nociception.  Even bacteria can move away from harmful environments such as high pH.  But not all animals feel pain.</p>
</blockquote>
<p>Question: How is pain subjective? Why nociception isnt considered pain?</p>

CC BY-SA 4.0
2020-10-13T21:06:25.123Z
This is the definition of pain and nociception. They are that way by definition.
Bryan Krause
CC BY-SA 4.0
2020-10-13T21:36:17.820Z
I fail to understand the distinction. What exactly is the subjectivity has to do with pain. Pain can be concretely defined by the actuation of nocieption.
gfdsal
CC BY-SA 4.0
2020-10-13T22:03:13.037Z
It *could* be defined that way, but it isn't.
Bryan Krause
<neuroscience><cognitive-neuroscience><pain>
How is Pain Subjective and Different from Nociception
gfdsal
# How is Pain Subjective and Different from Nociception

(Asked by: username_0 on 2020-10-13)

So pain is the sensory feeling that tells indiviual that something bad at some part of the body has happened. What I fail to understand is how is pain subjective? If we have touch receptors in the body we can technically all feel hyptactic simulation, why this cannot be said about pain.

In this [article](https://esc-sec.ca/2019/09/02/do-insects-feel-pain/) it is mentioned:

> pain is different from nociception, which is the ability to respond to damaging stimuli. All organisms have nociception. Even bacteria can move away from harmful environments such as high pH. But not all animals feel pain.

Question: How is pain subjective? Why nociception isnt considered pain?

**Tags:** neuroscience, cognitive-neuroscience, pain

> **Comments:**
> **username_1**: This is the definition of pain and nociception. They are that way by definition.  
> **username_0**: I fail to understand the distinction. What exactly is the subjectivity has to do with pain. Pain can be concretely defined by the actuation of nocieption.  
> **username_1**: It *could* be defined that way, but it isn't.  

---

## 1 answers

### Answer by username_2 on 2020-10-14. Score: 3 | Accepted answer

**Q: How is Pain Subjective and Different from Nociception?**

**A:** Pain is not nociception because their definitions are different. The usual definitions are like this:

> ***Nociception refers to the peripheral and central nervous system (CNS) processing of information about the internal or external environment, as generated by the activation of nociceptors***. Typically, noxious stimuli, including tissue injury, activate nociceptors that are present in peripheral structures and that transmit information to the spinal cord dorsal horn or its trigeminal homologue, the nucleus caudalis. From there, the information continues to the brainstem and ultimately the cerebral cortex, where the perception of pain is generated. ***Pain is a product of higher brain center processing*** … (1)

[![Nociception and pain](https://i.sstatic.net/WYUvD.jpg)](https://i.sstatic.net/WYUvD.jpg)

Or

“***Nociception (also nocioception, from Latin nocere 'to harm or hurt') is the sensory nervous system's process of encoding noxious stimuli***. In nociception, intense chemical (e.g., cayenne powder), mechanical (e.g., cutting, crushing), or thermal (heat and cold) stimulation of sensory nerve cells called nociceptors produces a signal that travels along a chain of nerve fibers via the spinal cord to the brain.[1](https://i.sstatic.net/WYUvD.jpg) Nociception triggers a variety of physiological and behavioral responses and ***usually results in a subjective experience (or perception) of pain in sentient beings.***”(2)

That is, nociception is defined to be the processing of noxious stimuli, which involves several levels of processing, but pain is defined to be the perception of the result of nociception processing. As there are many factors that can affect nociception at each level of processing, such as the pain control mechanism (e.g. the pain gate control) in the spinal cord and brainstem, analgesics, and even the mood of the subject, the pain perception can be altered/modified, and the final pain perception can be different even if it occurs in the same individual and from the same noxious stimuli. Also, because these factors are different among different subjects, the final pain perception in each individual is subjective – depending on various factors in each subject and different among different subjects even if it occurs from the same noxious stimuli.

For example:

* When your shin hits something hard and you feel pain there, if you stroke or massage the injured shin lightly, you’ll feel better with less pain – this is because the pain is modified by the pain gate control or other pain control mechanisms by the touch sensation. (3,4)
* In a person who has a spinal cord transection with a loss of all sensations and voluntary movements of the legs, if you prick his foot, his foot will involuntarily jerk away from the prick, which means nociception is still being processed, but you won’t feel any pain because the pain perception in the brain does not occur (due to the spinal cord transection).
* Alice has been given a flu shot in her arm, but she is a strong person and is in a good mood, so she feels little pain in her arm. On the contrary, Bob has been given a flu shot with the same needle size and ease of injection, but Bob is an irritable person and already in a bad mood, so he feels that the pain from the shot is very severe. So, the pain perceived from the same noxious stimuli is different among different subjects, depending on various factors in each subject.

Therefore, the pain is different from nociception and is subjective.

**References:**

1. National Research Council. 2009. [Mechanisms of Pain](https://www.ncbi.nlm.nih.gov/books/NBK32659/) In: Recognition and Alleviation of Pain in Laboratory Animals. Washington, DC: The National Academies Press. <https://doi.org/10.17226/12526>.
2. Wikipedia. [Nociception](https://en.wikipedia.org/wiki/Nociception)
3. Nachum Dafny.[Chapter 8: Pain Modulation and Mechanisms.](https://nba.uth.tmc.edu/neuroscience/m/s2/chapter08.html) Neuroscience Online. The University of Texas Health Science Center at Houston (UTHealth).
4. Wikipedia. [Gate Control Theory](https://en.wikipedia.org/wiki/Gate_control_theory)

> **Comments:**
> **username_0**: do you have source for `In a person who has a spinal cord transection with a loss of all sensations and voluntary movements of the legs, if you prick his foot, his foot will involuntarily jerk away from the prick, which means nociception is still being processed, but you won’t feel any pain because the pain perception in the brain does not occur (due to the spinal cord transection).`  
> **username_0**: Also that  you are trying to convey that pain is a composite thing its encompasses mood, and other mental state of the person so changing the mood and mental state while giving same nocieption will result in different perception of pain. Right?  
> **username_2**: @username_0 The phenomenon of "In a person who has a spinal cord transection ... if you prick his foot, his foot will involuntary jerk away from the prick..." is called hyperreflexia after spinal shock, which occurs after spinal cord transection. Some references are https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218357/, https://www.spinalcord.com/blog/spinal-shock-what-it-is-and-how-you-treat-it , and https://en.wikipedia.org/wiki/Spinal_shock. Or you can google search the term like “spinal shock pain hyperreflexia”.  
> **username_2**: For the second comment, right! You can find more details about how psychological factors affect pain perception in section "MODULATORY INFLUENCES ON PAIN: ANXIETY, FEAR, AND STRESS" in reference #1 above: National Research Council. 2009. [Mechanisms of Pain.](https://www.ncbi.nlm.nih.gov/books/NBK32659/)  
> **username_0**: Noted. It makes lot of sense now. Thanks.  

---

