<p>how do you know where is your electrode in the brain? Whether you're in the soma, axon, its terminal, dendrites - wouldn't it change your signal (and how)?</p>

<p>What happens if you are recording from a neuropil region? There are just so many possibilities when you stick up an electrode - how do you control this and keep your sanity?</p>

CC BY-SA 4.0
2020-05-03T23:58:04.930Z
@StevenJeuris Individual dendrites are certainly possible; individual axons to my knowledge are only accessible in special circumstances, the squid giant axon would be a classical example used by Hodgkin and Huxley.
Bryan Krause
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2020-05-03T23:58:47.670Z
@baca You can record plenty of spikes in gray matter, too. Individual spikes will be much more prominent in gray matter. I haven't done much recording in white matter so I don't know much about recording spikes there or if it's possible to resolve them.
Bryan Krause
CC BY-SA 4.0
2020-05-04T00:01:44.207Z
@user25887 This is pretty broad because electrophysiology is a huge field with many different techniques - do you have a particular *type* of experiment in mind? Maybe a paper reference to start from?
Bryan Krause
<neuroscience><electrophysiology>
to electrophysiologists, where is your electrode?
user25887
# to electrophysiologists, where is your electrode?

(Asked by: username_0 on 2020-04-30)

how do you know where is your electrode in the brain? Whether you're in the soma, axon, its terminal, dendrites - wouldn't it change your signal (and how)?

What happens if you are recording from a neuropil region? There are just so many possibilities when you stick up an electrode - how do you control this and keep your sanity?

**Tags:** neuroscience, electrophysiology

> **Comments:**
> **username_1**: @StevenJeuris Individual dendrites are certainly possible; individual axons to my knowledge are only accessible in special circumstances, the squid giant axon would be a classical example used by Hodgkin and Huxley.  
> **username_1**: @baca You can record plenty of spikes in gray matter, too. Individual spikes will be much more prominent in gray matter. I haven't done much recording in white matter so I don't know much about recording spikes there or if it's possible to resolve them.  
> **username_1**: @username_0 This is pretty broad because electrophysiology is a huge field with many different techniques - do you have a particular *type* of experiment in mind? Maybe a paper reference to start from?  

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