<p>I wouldn't know why multi-site cortical extracellular recordings would not be feasible? What would the practical experimental or technical limitation be in your opinion? </p>

<p>As long as you have a <a href="http://alascience.com/product/extracellular-multichannel/" rel="nofollow noreferrer">multichannel amplifier suitable for extracellular recording</a> and you consider the choice between using a common reference, <em>i.e.</em>, monopolar recordings <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666412/" rel="nofollow noreferrer">(Ludwig <em>et al</em>., 2009)</a>, or using paired recording-reference electrodes for bipolar measurements <a href="http://journal.frontiersin.org/article/10.3389/fncom.2010.00004/full" rel="nofollow noreferrer">(Boatman-Reich <em>et al</em>., 2010)</a> you should be fine. </p>

<p><sub><strong>References</strong><br>
<strong>-</strong> <a href="http://journal.frontiersin.org/article/10.3389/fncom.2010.00004/full" rel="nofollow noreferrer">Boatman-Reich <em>et al</em>., <em>Front Comput Neurosci</em> (2010)</a><br>
<strong>-</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666412/" rel="nofollow noreferrer">Ludwig <em>et al</em>., <em>J Neurophysiol</em> (2009); <strong>101</strong>(3): 1679–89</a></sub></p>

CC BY-SA 3.0
2017-09-17T19:34:30.157Z
2017-09-17T19:34:30.157Z
AliceD
<p>I wonder whether it is technically possible today to have simultaneous extracellular recording in awake rodents (e.g., mice) from different non-proximate sites (e.g., V1 and frontal cortex). I mean to have two or more different electrode penetrations at the same time. Using multi-array / grid / tetrode  it is possible record from many locations, but they are spatially proximate. Any references are appreciated.</p>

CC BY-SA 3.0
2017-09-18T17:23:08.150Z
This is very widely done!!
Memming
<neuroscience><electrophysiology><experimental-neuroscience>
Simultaneous extracellular recording from different distant sites (in rodents)
student
# Simultaneous extracellular recording from different distant sites (in rodents)

(Asked by: username_0 on 2017-09-16)

I wonder whether it is technically possible today to have simultaneous extracellular recording in awake rodents (e.g., mice) from different non-proximate sites (e.g., V1 and frontal cortex). I mean to have two or more different electrode penetrations at the same time. Using multi-array / grid / tetrode it is possible record from many locations, but they are spatially proximate. Any references are appreciated.

**Tags:** neuroscience, electrophysiology, experimental-neuroscience

> **Comments:**
> **username_1**: This is very widely done!!  

---

## 1 answers

### Answer by username_2 on 2017-09-17. Score: 3

I wouldn't know why multi-site cortical extracellular recordings would not be feasible? What would the practical experimental or technical limitation be in your opinion?

As long as you have a [multichannel amplifier suitable for extracellular recording](http://alascience.com/product/extracellular-multichannel/) and you consider the choice between using a common reference, *i.e.*, monopolar recordings [(Ludwig *et al*., 2009)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666412/), or using paired recording-reference electrodes for bipolar measurements [(Boatman-Reich *et al*., 2010)](http://journal.frontiersin.org/article/10.3389/fncom.2010.00004/full) you should be fine.

**References**  
**-** [Boatman-Reich *et al*., *Front Comput Neurosci* (2010)](http://journal.frontiersin.org/article/10.3389/fncom.2010.00004/full)  
**-** [Ludwig *et al*., *J Neurophysiol* (2009); **101**(3): 1679–89](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666412/)


---

