<p>see <a href="http://en.wikipedia.org/wiki/Wernicke%E2%80%93Korsakoff_syndrome#Alcohol-thiamine_interactions" rel="nofollow">http://en.wikipedia.org/wiki/Wernicke%E2%80%93Korsakoff_syndrome#Alcohol-thiamine_interactions</a></p>

<blockquote>
  <p>Strong evidence suggests that ethanol interferes directly with
  thiamine uptake in the gastrointestinal tract. Ethanol also disrupts
  thiamine storage in the liver and the transformation of thiamine into
  its active form.[20] The role of alcohol consumption in the
  development of WKS has been experimentally confirmed through studies
  in which rats were subjected to alcohol exposure and lower levels
  thiamine through a low-thiamine diet.[21] In particular, studies have
  demonstrated that clinical signs of the neurological problems that
  result from thiamine deficiency develop faster in rats that have
  received alcohol and were also deficient in thiamine than rats who did
  not receive alcohol.[21] In another study, it was found that rats that
  were chronically fed alcohol had significantly lower liver thiamine
  stores than control rats. This provides an explanation for why
  alcoholics with liver cirrhosis have a higher incidence of both
  thiamine deficiency and WKS.[20]</p>
</blockquote>

<p>[20] Todd, K. G., Hazell, A. S., &amp; Butterworth, R. F. (1999). Alcohol thiamine interactions: an update on the pathogenesis of wernicke encephalopathy. Addiction Biology, 4, 261-272.</p>

<p>[21] He, X., Sullivan, E. V., Stankovic, R. K., Harper, C. G., &amp; Pfefferbaum, A. (2007). Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus collosum ultrastructure. Neuropsychopharmacology, 32, 2207-2216.</p>

<p>but this is of course over a long period.</p>

<p>for just one instance, there's no scientifical evidence AFAIK</p>

CC BY-SA 3.0
2014-05-29T19:47:31.987Z
2014-05-29T19:47:31.987Z
Leo
<p>How exactly does alcohol consumption damage dendrites? I'm not talking about over a long period of usage, but just one instance.</p>

<neuroscience><alcohol>
How exactly does alcohol consumption damage dendrites?
Tim
# How exactly does alcohol consumption damage dendrites?

(Asked by: username_0 on 2014-05-28)

How exactly does alcohol consumption damage dendrites? I'm not talking about over a long period of usage, but just one instance.

**Tags:** neuroscience, alcohol


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## 1 answers

### Answer by username_1 on 2014-05-29. Score: 1 | Accepted answer

see <http://en.wikipedia.org/wiki/Wernicke%E2%80%93Korsakoff_syndrome#Alcohol-thiamine_interactions>

> Strong evidence suggests that ethanol interferes directly with
> thiamine uptake in the gastrointestinal tract. Ethanol also disrupts
> thiamine storage in the liver and the transformation of thiamine into
> its active form.[20] The role of alcohol consumption in the
> development of WKS has been experimentally confirmed through studies
> in which rats were subjected to alcohol exposure and lower levels
> thiamine through a low-thiamine diet.[21] In particular, studies have
> demonstrated that clinical signs of the neurological problems that
> result from thiamine deficiency develop faster in rats that have
> received alcohol and were also deficient in thiamine than rats who did
> not receive alcohol.[21] In another study, it was found that rats that
> were chronically fed alcohol had significantly lower liver thiamine
> stores than control rats. This provides an explanation for why
> alcoholics with liver cirrhosis have a higher incidence of both
> thiamine deficiency and WKS.[20]

[20] Todd, K. G., Hazell, A. S., & Butterworth, R. F. (1999). Alcohol thiamine interactions: an update on the pathogenesis of wernicke encephalopathy. Addiction Biology, 4, 261-272.

[21] He, X., Sullivan, E. V., Stankovic, R. K., Harper, C. G., & Pfefferbaum, A. (2007). Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus collosum ultrastructure. Neuropsychopharmacology, 32, 2207-2216.

but this is of course over a long period.

for just one instance, there's no scientifical evidence AFAIK


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