<p>Google Scholar identifies several learned articles that discuss the association/overlap between bipolar disorder type 2 and autism spectrum disorder (ASD), including:</p>
<ul>
<li><p>Khanzada, N. S., Butler, M. G., &amp; Manzardo, A. M. (2017). GeneAnalytics pathway analysis and genetic overlap among autism spectrum disorder, bipolar disorder and schizophrenia. International Journal of Molecular Sciences, 18(3), 527. <a href="https://doi.org/10.3390/ijms18030527" rel="nofollow noreferrer">https://doi.org/10.3390/ijms18030527</a></p>
</li>
<li><p>Stahlberg, O., Soderstrom, H., Rastam, M., &amp; Gillberg, C. (2004). Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. Journal of neural transmission, 111(7), 891-902. <a href="https://doi.org/10.1007/s00702-004-0115-1" rel="nofollow noreferrer">https://doi.org/10.1007/s00702-004-0115-1</a></p>
</li>
<li><p>Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., ... &amp; Shieh, A. W. (2018). Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science, 362(6420). <a href="https://doi.org/10.1126/science.aat8127" rel="nofollow noreferrer">https://doi.org/10.1126/science.aat8127</a></p>
</li>
</ul>
<p>Excerpts from the above include:</p>
<blockquote>
<p>The conditions show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication.</p>
</blockquote>
<blockquote>
<p>Twenty-three genes were common to all three disorders.</p>
</blockquote>
<blockquote>
<p>Overlapping genes impacted dopamine and serotonin homeostasis and signal transduction pathways, impacting mood, behavior and physical activity level.</p>
</blockquote>
<p>My non-expert interpretation of the above is that there are genetic processes at work that drive the similarities in behaviour associated with these conditions.</p>

CC BY-SA 4.0
2020-08-31T07:16:56.473Z
2020-08-31T07:16:56.473Z
Tony Mobbs
<p>Bipolar disorder type 2 and autism spectrum disorder (ASD) is regularly seen together. What is the neurological explanation for this?</p>

<neuroscience><psychiatry><autism><personality-disorder><bipolar-disorder>
What is the neurological basis for the association between Bipolar type 2 and autism spectrum disorder (ASD)?
user270124
# What is the neurological basis for the association between Bipolar type 2 and autism spectrum disorder (ASD)?

(Asked by: username_0 on 2020-08-23)

Bipolar disorder type 2 and autism spectrum disorder (ASD) is regularly seen together. What is the neurological explanation for this?

**Tags:** neuroscience, psychiatry, autism, personality-disorder, bipolar-disorder


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## 1 answers

### Answer by username_1 on 2020-08-31. Score: 1 | Accepted answer

Google Scholar identifies several learned articles that discuss the association/overlap between bipolar disorder type 2 and autism spectrum disorder (ASD), including:

* Khanzada, N. S., Butler, M. G., & Manzardo, A. M. (2017). GeneAnalytics pathway analysis and genetic overlap among autism spectrum disorder, bipolar disorder and schizophrenia. International Journal of Molecular Sciences, 18(3), 527. <https://doi.org/10.3390/ijms18030527>
* Stahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004). Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. Journal of neural transmission, 111(7), 891-902. <https://doi.org/10.1007/s00702-004-0115-1>
* Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., ... & Shieh, A. W. (2018). Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science, 362(6420). <https://doi.org/10.1126/science.aat8127>

Excerpts from the above include:

> The conditions show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication.

> Twenty-three genes were common to all three disorders.

> Overlapping genes impacted dopamine and serotonin homeostasis and signal transduction pathways, impacting mood, behavior and physical activity level.

My non-expert interpretation of the above is that there are genetic processes at work that drive the similarities in behaviour associated with these conditions.


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