<p>Read this paper</p>

<p><strong>Storage of Spatial Information by the Maintenance Mechanism of LTP</strong></p>

<p>Eva Pastalkova*, Peter Serrano*, Deana Pinkhasova, Emma Wallace, André Antonio Fenton†, Todd Charlton Sacktor†
<a href="http://www.sciencemag.org/content/313/5790/1141.short" rel="nofollow">http://www.sciencemag.org/content/313/5790/1141.short</a></p>

<p>It uses a conditioning task that is primarily hippocampal as it is a spatial navigation task.  They monitor the strength of CA3-CA1 connections during and after training using the fEPSP (field excitatory post-synaptic potential) slope.  </p>

<p>Also, for a review of hippocampal dependent tasks, see</p>

<p><strong>The role of hippocampal subregions in memory for stimulus associations</strong></p>

<p>Rosamund F. Langston, Cassie H. Stevenson, Claire L. Wilson, Ian Saunder, Emma R. Wood</p>

<p><a href="http://www.sciencedirect.com/science/article/pii/S0166432810004857" rel="nofollow">http://www.sciencedirect.com/science/article/pii/S0166432810004857</a></p>

CC BY-SA 3.0
2015-06-01T18:27:17.407Z
2015-06-01T18:53:41.587Z
2015-06-01T18:53:41.587Z
honi
<p>I wanted to know what a suitable classical conditioning experiment would be to analyze learning and memory capabilities in rodent models with respect to hippocampal long-term potentiation (LTP).</p>

<p>For example, I want to subject the animal to conditioning and test the behavioral readout at a certain time point after conditioning. Many , like fear conditioning experiments, are mostly attributed to amygdala processes.</p>

<p>I wish to know some classical conditioning task where I can understand primarily hippocampal processes.</p>

<p>Also is there a way to monitor hippocampal CA1-CA3 firing pattern after the training period or during the training ?</p>

<p>That is, I want to check if LTP will sustain after the training period or is there is any increased sustenance of LTP post training.</p>

<p>But if I am to do this electrophysiological experiment in hippocampal brain slices, how will I incorporate the conditioned and unconditioned aspect to this ?</p>

<neuroscience><learning><memory><measurement><methodology>
Classical conditioning paradigm for hippocampal learning
curious
# Classical conditioning paradigm for hippocampal learning

(Asked by: username_0 on 2015-05-23)

I wanted to know what a suitable classical conditioning experiment would be to analyze learning and memory capabilities in rodent models with respect to hippocampal long-term potentiation (LTP).

For example, I want to subject the animal to conditioning and test the behavioral readout at a certain time point after conditioning. Many , like fear conditioning experiments, are mostly attributed to amygdala processes.

I wish to know some classical conditioning task where I can understand primarily hippocampal processes.

Also is there a way to monitor hippocampal CA1-CA3 firing pattern after the training period or during the training ?

That is, I want to check if LTP will sustain after the training period or is there is any increased sustenance of LTP post training.

But if I am to do this electrophysiological experiment in hippocampal brain slices, how will I incorporate the conditioned and unconditioned aspect to this ?

**Tags:** neuroscience, learning, memory, measurement, methodology


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## 1 answers

### Answer by username_1 on 2015-06-01. Score: 1

Read this paper

**Storage of Spatial Information by the Maintenance Mechanism of LTP**

Eva Pastalkova\*, Peter Serrano\*, Deana Pinkhasova, Emma Wallace, André Antonio Fenton†, Todd Charlton Sacktor†
<http://www.sciencemag.org/content/313/5790/1141.short>

It uses a conditioning task that is primarily hippocampal as it is a spatial navigation task. They monitor the strength of CA3-CA1 connections during and after training using the fEPSP (field excitatory post-synaptic potential) slope.

Also, for a review of hippocampal dependent tasks, see

**The role of hippocampal subregions in memory for stimulus associations**

Rosamund F. Langston, Cassie H. Stevenson, Claire L. Wilson, Ian Saunder, Emma R. Wood

<http://www.sciencedirect.com/science/article/pii/S0166432810004857>


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