<p>We are taught that the amplitude of a neuron's spike is always the same (within a negligibly small range)--all or none. But it seems that anomalous physiological conditions like certain diseases or drugs might cause neurons to violate the all-or-none rule. Similarly, I wonder if in EBS, the spikes have greater amplitude. Can anyone tell me of any specific conditions that alter spike amplitude?</p>

CC BY-SA 4.0
2022-10-20T07:39:32.980Z
Welcome. What is EBS? Can you add sources that make you suspect the effect of this EBS on APs?
AliceD
CC BY-SA 4.0
2022-10-20T17:19:39.790Z
Thank you, Alice. Electric brain stimulation. I don't have a source; it just seems that if the voltage of the stimulation is greater, that would affect the amplitudes of the APs of the local neurons.
Anasker
<neuroscience><neurophysiology><electrophysiology><drugs>
Can disease, drugs, or other physiological conditions violate the all-or-none rule for action potential?
Anasker
# Can disease, drugs, or other physiological conditions violate the all-or-none rule for action potential?

(Asked by: username_0 on 2022-10-20)

We are taught that the amplitude of a neuron's spike is always the same (within a negligibly small range)--all or none. But it seems that anomalous physiological conditions like certain diseases or drugs might cause neurons to violate the all-or-none rule. Similarly, I wonder if in EBS, the spikes have greater amplitude. Can anyone tell me of any specific conditions that alter spike amplitude?

**Tags:** neuroscience, neurophysiology, electrophysiology, drugs

> **Comments:**
> **username_1**: Welcome. What is EBS? Can you add sources that make you suspect the effect of this EBS on APs?  
> **username_0**: Thank you, Alice. Electric brain stimulation. I don't have a source; it just seems that if the voltage of the stimulation is greater, that would affect the amplitudes of the APs of the local neurons.  

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## 0 answers

