<p>There is a clear heritable component that seems to be "highly genetically heterogeneous and may be caused by both inheritable and de novo gene variations" <a href="https://doi.org/10.3389/fncel.2019.00385" rel="nofollow noreferrer">(Rylaarsdam, Gomboa, 2019)</a>. There has been hundreds of genes implicated in autism and a complex interaction of non-heritable gene variations as well, "genetic modifiers such as copy number variation, single nucleotide polymorphisms, and epigenetic alterations likely play a key role" (Rylaarsdam, Gomboa, 2019). </p>

<p>The Rylaarsdam review article summarises the current state of play in terms of the genetic and non-heritable gene factors as well. </p>

<p><strong>Reference:</strong> </p>

<p>Rylaarsdam, L., &amp; Guemez Gamboa, A. D. (2019). Genetic Causes and Modifiers of Autism Spectrum Disorder. Frontiers in Cellular Neuroscience, 13, [385]. <a href="https://doi.org/10.3389/fncel.2019.00385" rel="nofollow noreferrer">https://doi.org/10.3389/fncel.2019.00385</a></p>

CC BY-SA 4.0
2019-11-05T07:45:35.783Z
2019-11-05T07:45:35.783Z
Poidah
<p>In <a href="https://neurology.mhmedical.com/book.aspx?bookID=1049" rel="nofollow noreferrer">Principles of Neural Science 5th edition</a>, Chapter 3, It Is said that Autism Is a genetic disorder but which genes are involved Is not clear, how do we know there Is a genetic basis and Is not a response to environmental factors (or a combination)?</p>

CC BY-SA 4.0
2019-11-05T07:35:08.390Z
Possible duplicate of [Is autism caused by genetics?](https://psychology.stackexchange.com/questions/17284/is-autism-caused-by-genetics)
Poidah
<autism><genetics>
Clues for genetic basis in Autism Spectrum Disorders
CoffeDeveloper
# Clues for genetic basis in Autism Spectrum Disorders

(Asked by: username_0 on 2019-10-28)

In [Principles of Neural Science 5th edition](https://neurology.mhmedical.com/book.aspx?bookID=1049), Chapter 3, It Is said that Autism Is a genetic disorder but which genes are involved Is not clear, how do we know there Is a genetic basis and Is not a response to environmental factors (or a combination)?

**Tags:** autism, genetics

> **Comments:**
> **username_1**: Possible duplicate of [Is autism caused by genetics?](https://psychology.stackexchange.com/questions/17284/is-autism-caused-by-genetics)  

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## 1 answers

### Answer by username_1 on 2019-11-05. Score: 1

There is a clear heritable component that seems to be "highly genetically heterogeneous and may be caused by both inheritable and de novo gene variations" [(Rylaarsdam, Gomboa, 2019)](https://doi.org/10.3389/fncel.2019.00385). There has been hundreds of genes implicated in autism and a complex interaction of non-heritable gene variations as well, "genetic modifiers such as copy number variation, single nucleotide polymorphisms, and epigenetic alterations likely play a key role" (Rylaarsdam, Gomboa, 2019).

The Rylaarsdam review article summarises the current state of play in terms of the genetic and non-heritable gene factors as well.

**Reference:**

Rylaarsdam, L., & Guemez Gamboa, A. D. (2019). Genetic Causes and Modifiers of Autism Spectrum Disorder. Frontiers in Cellular Neuroscience, 13, [385]. <https://doi.org/10.3389/fncel.2019.00385>


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