<p>As far as I know, this effect cannot be eliminated by any practical means, other than <a href="https://en.wikipedia.org/wiki/Stratified_sampling" rel="nofollow noreferrer">stratifying</a> the subjects into groups according to type of drug, dosage, duration of use <em>etc</em>. and use statistical testing to look for any differences between the groups with, <em>e.g.</em>, <a href="https://stats.idre.ucla.edu/other/mult-pkg/introduction-to-linear-mixed-models/" rel="nofollow noreferrer">linear mixed modeling</a>.</p>

<p>However, a cursory search on Google Scholar yields multiple studies where unmedicated folks were successfully recruited into the study, <em>e.g.</em> <a href="https://academic.oup.com/schizophreniabulletin/article/42/4/1046/2413960" rel="nofollow noreferrer">Kraguljac <em>et al.</em> (2016)</a>.</p>

<p><sub><strong>Reference</strong><br>
<strong>-</strong> <a href="https://academic.oup.com/schizophreniabulletin/article/42/4/1046/2413960" rel="nofollow noreferrer">Kraguljac <em>et al</em>., <em>Schizophrenia Bull</em> (2016); <strong>42</strong>(4): 1046–55</a></sub></p>

CC BY-SA 4.0
2020-05-13T15:28:34.267Z
Another alternative is to...not worry about it. It all depends on what your research goals are, and a lot of them that concern clinical outcomes are best done in the circumstances the patients are in, which for many will include medication.
Bryan Krause
CC BY-SA 4.0
2020-05-13T18:39:54.080Z
@BryanKrause of course, but it's a real problem for the basic scientists among us who wish to elucidate the etiology and other underlying pathologic mechanisms
AliceD
CC BY-SA 4.0
2020-05-13T08:55:57.900Z
2020-05-13T15:21:06.140Z
2020-05-13T15:21:06.140Z
AliceD
<p>It is delicate to conduct studies with <strong>schizophrenic patients</strong>, considering that the results may be altered by the medication factor. What strategies should be used to counteract this effect?</p>

CC BY-SA 4.0
2020-05-09T13:33:09.233Z
The only way I can envisage you could counteract the effect of medications they may be on would be to stop their medications for a set period before the study, but I would think it would be unethical to conduct studies on unmedicated schizophrenic patients in this manner
Chris Rogers
CC BY-SA 4.0
2020-05-09T18:36:41.360Z
Chris, in this type of study and with this type of participant, stopping the medication (even temporarily) is not an option. Even for the reason you already said: there would be an ethical problem. But as serious as that, it's a clinical problem. However, strategies exist and I think the issue is relevant to the topic. I will await some response to the debate.
mxeliezer
CC BY-SA 4.0
2020-05-15T19:29:23.223Z
The question is confusing to me, maybe if you explain what you are researching it would become clear.

What do you mean by the medication factor?

Are you looking to study how the disorder unfolds, or how medication affect it without side-effects?
agiopnl
<methodology><psychopharmacology><schizophrenia><reproducible-research><neuropsychology>
How can we eliminate the effect of psychiatric medication on neuropsychological research with schizophrenic patients?
mxeliezer
# How can we eliminate the effect of psychiatric medication on neuropsychological research with schizophrenic patients?

(Asked by: username_0 on 2019-12-13)

It is delicate to conduct studies with **schizophrenic patients**, considering that the results may be altered by the medication factor. What strategies should be used to counteract this effect?

**Tags:** methodology, psychopharmacology, schizophrenia, reproducible-research, neuropsychology

> **Comments:**
> **username_1**: The only way I can envisage you could counteract the effect of medications they may be on would be to stop their medications for a set period before the study, but I would think it would be unethical to conduct studies on unmedicated schizophrenic patients in this manner  
> **username_0**: Chris, in this type of study and with this type of participant, stopping the medication (even temporarily) is not an option. Even for the reason you already said: there would be an ethical problem. But as serious as that, it's a clinical problem. However, strategies exist and I think the issue is relevant to the topic. I will await some response to the debate.  
> **username_2**: The question is confusing to me, maybe if you explain what you are researching it would become clear.  What do you mean by the medication factor?  Are you looking to study how the disorder unfolds, or how medication affect it without side-effects?  

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## 1 answers

### Answer by username_3 on 2020-05-13. Score: 3

As far as I know, this effect cannot be eliminated by any practical means, other than [stratifying](https://en.wikipedia.org/wiki/Stratified_sampling) the subjects into groups according to type of drug, dosage, duration of use *etc*. and use statistical testing to look for any differences between the groups with, *e.g.*, [linear mixed modeling](https://stats.idre.ucla.edu/other/mult-pkg/introduction-to-linear-mixed-models/).

However, a cursory search on Google Scholar yields multiple studies where unmedicated folks were successfully recruited into the study, *e.g.* [Kraguljac *et al.* (2016)](https://academic.oup.com/schizophreniabulletin/article/42/4/1046/2413960).

**Reference**  
**-** [Kraguljac *et al*., *Schizophrenia Bull* (2016); **42**(4): 1046–55](https://academic.oup.com/schizophreniabulletin/article/42/4/1046/2413960)

> **Comments:**
> **username_4**: Another alternative is to...not worry about it. It all depends on what your research goals are, and a lot of them that concern clinical outcomes are best done in the circumstances the patients are in, which for many will include medication.  
> **username_3**: @BryanKrause of course, but it's a real problem for the basic scientists among us who wish to elucidate the etiology and other underlying pathologic mechanisms  

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