<p>Because it's not as easy at it may seem.
There is no direct biological distinguishment of any kind in such a case.
It's like some prefer red, some prefer blue, some like both equally. </p>

<p>In order to link this condition to any bio-chemical causes, very long term studies would be needed and the persons with Bipolar Disorder will likely not volunteer for such studies.</p>

<p>It is not excluded that a very long term study may find a bio-chemical distinguishment unique to these individuals but that did not happened yet.</p>

<p>Related references (There are probably hundreds of references. Here's a few): </p>

<ul>
<li><p>Semeniken, K. R., &amp; Dudás, B. (2012). Bipolar Disorder: Diagnosis, Neuroanatomical and Biochemical Background. In Clinical, Research and Treatment Approaches to Affective Disorders. InTech.<br>Retrievable from: <a href="https://www.intechopen.com/download/pdf/30151" rel="nofollow noreferrer">https://www.intechopen.com/download/pdf/30151</a></p></li>
<li><p>Biochemistry and neuropathology of bipolar disorder by Professor Wayne Drevets (Video)<br>Retrievable from: <a href="https://www.dnalc.org/view/2084-Biochemistry-and-neuropathology-of-bipolar-disorder.html" rel="nofollow noreferrer">https://www.dnalc.org/view/2084-Biochemistry-and-neuropathology-of-bipolar-disorder.html</a></p></li>
<li><p>Biochemistry of Bipolar Disorder by Doctor Ellen Leibenluft (Video)<br>Retrievable from: <a href="https://www.dnalc.org/view/2356-Biochemistry-of-Bipolar-Disorder.html" rel="nofollow noreferrer">https://www.dnalc.org/view/2356-Biochemistry-of-Bipolar-Disorder.html</a></p></li>
<li><p>Manji, H. K., Quiroz, J. A., Payne, J. L., Singh, J., Lopes, B. P., Viegas, J. S., &amp; Zarate, C. A. (2003). The underlying neurobiology of bipolar disorder. <em>World Psychiatry</em>, 2(3), 136.<br>PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525098/" rel="nofollow noreferrer">PMC1525098</a> PMID: <a href="https://www.ncbi.nlm.nih.gov/pubmed/16946919" rel="nofollow noreferrer">16946919</a> </p></li>
<li><p>Biochemistry Features Of Bipolar Disorders And Advanced Nutrient Therapies by William J. Walsh, PhD, FACN (Webinar Video)<br>Retrievable from: <a href="http://ibpf.org/article/biochemistry-features-bipolar-disorders-and-advanced-nutrient-therapies" rel="nofollow noreferrer">http://ibpf.org/article/biochemistry-features-bipolar-disorders-and-advanced-nutrient-therapies</a></p></li>
</ul>

CC BY-SA 4.0
2018-05-02T13:22:16.280Z
Welcome and thanks for your answer. Could you please provide us with your sources for the claims made in the 2nd and 3rd paragraphs? This allows other users to background read on your material.
Chris Rogers
CC BY-SA 4.0
2018-05-03T13:05:12.453Z
i have added some references. It would be nice to find a study that can centralize many of the findings. That way common markers could be found way more easy.
Overmind
CC BY-SA 4.0
2018-05-04T15:04:17.747Z
Thank you so much for adding references. This is an awesome answer.
Seanny123
CC BY-SA 4.0
2018-05-02T04:50:30.123Z
2018-05-03T14:54:48.290Z
2018-05-03T14:54:48.290Z
Overmind
<p>I could be wrong, since I'm not a doctor and all, but it's my understanding based on about ten years of studying issues like bipolar disorder online that to be diagnosed with bipolar disorder, as well as other disorders, like OCD, people merely need to have a set of symptoms, which disrupt their lives sufficiently, which hopefully respond to certain kinds of treatment (and of course, they probably need to be diagnosed in order for them to officially have it). This, as opposed to a <em>specific</em> physiological and/or genetic condition that causes or might cause the symptoms. It's not like strep throat where you can test for bacteria for a <em>definitive</em> diagnosis. There could be infinite causes of bipolar disorder as I understand it.</p>

<p>Thus, any tests that could diagnose it might miss a plethora of cases, and many of the people diagnosed by those tests might manage their condition perfectly already (which means they don't have bipolar disorder).</p>

<p>It's my understanding that the aim of such tests would be to assist doctors in making a good diagnosis rather than to replace the doctor's decision.</p>

<p>Nevertheless, there could be other conditions with symptoms similar to bipolar disorder, which do have a definitive underlying cause: e.g. vitamin B12 deficiency. I guess it's probably up to the doctor to decide if the individual also has bipolar disorder.</p>

<p>Anyway, I'm not saying bipolar disorder is all in one's head. At least some of the symptoms are physiological (such as how patients tend to get more manic if they take anti-depressants). I'm sure a lot of doctors use that criteria to help them diagnose the condition already. While I don't know another condition that would match that issue, it's possible there is one. However, just because symptoms are physiological doesn't mean they always have the same cause, which means they could have different methods of diagnosis.</p>

<p>Now, all that being said, while I still think a definitive test is possible, a new way of testing would perhaps be needed. A blood test isn't going to tell you behaviors or how well a person is managing their symptoms, or if the person is using good coping mechanisms that might cause them to not need a diagnosis. A blood test may tell you things that predispose people to behaviors and symptoms, however.</p>

<p>I wrote this answer before I read Bryan Crause's (I just read it). So, sorry that I repeated some of it.</p>

CC BY-SA 3.0
2018-04-28T15:20:45.337Z
Welcome and thanks for your interesting answer. It's perfectly fine to write a second answer with a bit of overlap. Could you provide us with your sources to allow other users to background read on your material?
AliceD
CC BY-SA 3.0
2018-04-27T21:42:23.120Z
2018-04-28T02:14:23.960Z
2018-04-28T02:14:23.960Z
Brōtsyorfuzthrāx
<p>From <a href="https://neurosciencenews.com/depression-bipolar-blood-test-18197/" rel="nofollow noreferrer">https://neurosciencenews.com/depression-bipolar-blood-test-18197/</a>:</p>
<blockquote>
<p>A new blood test can distinguish the severity of a person’s depression
and their risk for developing severe depression at a later point. The
test can also determine if a person is at risk for developing bipolar
disorder. Researchers say the blood test can also assist in tailoring
individual options for therapeutic interventions.</p>
</blockquote>

CC BY-SA 4.0
2021-04-13T19:15:34.367Z
2021-04-13T20:04:24.317Z
2021-04-13T20:04:24.317Z
Rodrigo Camargos
<p><strong>Short Answer</strong></p>

<p>Science is hard, brains are complicated, and the premises of your question that there is not work being done or advancements in this area is false.</p>

<p><strong>Longer Answer</strong></p>

<p>There is no known specific cause of bipolar disorder (as for many other psychological disorders). There is no simple statement like "bipolar disorder happens when you are low on XYZ so let's test for XYZ." Bipolar disorder and many others are in fact <em>defined</em> by the DSM based on <em>symptoms</em> - diagnosing them in another way is not the gold standard.</p>

<p>That said, you seem to be implying especially in your comment "why isn't one being developed" that this isn't an active area of research. <a href="https://scholar.google.com/scholar?hl=en&amp;as_sdt=0%2C50&amp;q=%22bipolar+disorder%22+%22biomarker%22&amp;btnG=" rel="noreferrer">It is - a helpful search term for you will be 'biomarker'</a>; Google Scholar returns 4,480 results since 2017 for ("bipolar disorder" "biomarker").</p>

<p>However, all of the suggested biomarkers are some combination of A) Not specific (i.e., are positive for other conditions), B) Not sensitive (i.e., are negative for people that do have bipolar disorder), C) Expensive or invasive (i.e., not really worth doing if they have issues with A and B), or highly dependent on other individual factors.</p>

CC BY-SA 3.0
2018-04-27T16:03:43.800Z
2018-04-27T16:03:43.800Z
Bryan Krause
<p>I was involved in a discussion where somebody had asked if others had thoughts of doing risky things during their manic episodes. Two people commented, including myself. I worried that only relying on a specific set of guidelines established by the diagnostic and Statistical Manual on Mental Disorders fifth edition could lead to disastrous consequences.</p>

<p>Let's say somebody came into a psychiatrist's office. The person has previously read the DSMV and understands the criteria. That person played their cards right to convince the psychiatrist to diagnose them with Bipolar Disorder, when in truth that person might not likely have it at all. Instead, their true motive would have been to get free benzos so they could space out and get high.</p>

<p>On the other end of the spectrum, some people have been misdiagnosed, leading to unwanted and unnecessary medications.</p>

<p>For both of these situations, why can't blood tests and other physical and objective means be used to insure that neither party is in doubt? You can't lie on a blood test or magneto encephalogram, so why not this?</p>

CC BY-SA 3.0
2018-04-27T03:08:28.983Z
because there are no objective biomarkers for bipolar disorder.
honi
CC BY-SA 3.0
2018-04-27T06:15:16.127Z
I know, but why isn't one being developed? That's what this question is asking. There's got to be some hidden biomarker.
The Harmonic Rainbow
CC BY-SA 3.0
2018-04-28T01:24:54.750Z
Free benzos? More likely a prescription for valproate, which is more or less the same thing as sniffing paint thinner. I think you're confusing mania with anxiety...
got trolled too much this week
<neuroscience><psychiatry><bipolar-disorder><drugs>
Why aren't any advancements being made in physically diagnosing Bipolar and other psychiatric disorders?
The Harmonic Rainbow
# Why aren't any advancements being made in physically diagnosing Bipolar and other psychiatric disorders?

(Asked by: username_0 on 2018-04-26)

I was involved in a discussion where somebody had asked if others had thoughts of doing risky things during their manic episodes. Two people commented, including myself. I worried that only relying on a specific set of guidelines established by the diagnostic and Statistical Manual on Mental Disorders fifth edition could lead to disastrous consequences.

Let's say somebody came into a psychiatrist's office. The person has previously read the DSMV and understands the criteria. That person played their cards right to convince the psychiatrist to diagnose them with Bipolar Disorder, when in truth that person might not likely have it at all. Instead, their true motive would have been to get free benzos so they could space out and get high.

On the other end of the spectrum, some people have been misdiagnosed, leading to unwanted and unnecessary medications.

For both of these situations, why can't blood tests and other physical and objective means be used to insure that neither party is in doubt? You can't lie on a blood test or magneto encephalogram, so why not this?

**Tags:** neuroscience, psychiatry, bipolar-disorder, drugs

> **Comments:**
> **username_1**: because there are no objective biomarkers for bipolar disorder.  
> **username_0**: I know, but why isn't one being developed? That's what this question is asking. There's got to be some hidden biomarker.  
> **username_2**: Free benzos? More likely a prescription for valproate, which is more or less the same thing as sniffing paint thinner. I think you're confusing mania with anxiety...  

---

## 4 answers

### Answer by username_9 on 2018-04-27. Score: 13 | Accepted answer

**Short Answer**

Science is hard, brains are complicated, and the premises of your question that there is not work being done or advancements in this area is false.

**Longer Answer**

There is no known specific cause of bipolar disorder (as for many other psychological disorders). There is no simple statement like "bipolar disorder happens when you are low on XYZ so let's test for XYZ." Bipolar disorder and many others are in fact *defined* by the DSM based on *symptoms* - diagnosing them in another way is not the gold standard.

That said, you seem to be implying especially in your comment "why isn't one being developed" that this isn't an active area of research. [It is - a helpful search term for you will be 'biomarker'](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C50&q=%22bipolar+disorder%22+%22biomarker%22&btnG=); Google Scholar returns 4,480 results since 2017 for ("bipolar disorder" "biomarker").

However, all of the suggested biomarkers are some combination of A) Not specific (i.e., are positive for other conditions), B) Not sensitive (i.e., are negative for people that do have bipolar disorder), C) Expensive or invasive (i.e., not really worth doing if they have issues with A and B), or highly dependent on other individual factors.


---

### Answer by username_3 on 2018-05-02. Score: 3

Because it's not as easy at it may seem.
There is no direct biological distinguishment of any kind in such a case.
It's like some prefer red, some prefer blue, some like both equally.

In order to link this condition to any bio-chemical causes, very long term studies would be needed and the persons with Bipolar Disorder will likely not volunteer for such studies.

It is not excluded that a very long term study may find a bio-chemical distinguishment unique to these individuals but that did not happened yet.

Related references (There are probably hundreds of references. Here's a few):

* Semeniken, K. R., & Dudás, B. (2012). Bipolar Disorder: Diagnosis, Neuroanatomical and Biochemical Background. In Clinical, Research and Treatment Approaches to Affective Disorders. InTech.  
  Retrievable from: <https://www.intechopen.com/download/pdf/30151>
* Biochemistry and neuropathology of bipolar disorder by Professor Wayne Drevets (Video)  
  Retrievable from: <https://www.dnalc.org/view/2084-Biochemistry-and-neuropathology-of-bipolar-disorder.html>
* Biochemistry of Bipolar Disorder by Doctor Ellen Leibenluft (Video)  
  Retrievable from: <https://www.dnalc.org/view/2356-Biochemistry-of-Bipolar-Disorder.html>
* Manji, H. K., Quiroz, J. A., Payne, J. L., Singh, J., Lopes, B. P., Viegas, J. S., & Zarate, C. A. (2003). The underlying neurobiology of bipolar disorder. *World Psychiatry*, 2(3), 136.  
  PMCID: [PMC1525098](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525098/) PMID: [16946919](https://www.ncbi.nlm.nih.gov/pubmed/16946919)
* Biochemistry Features Of Bipolar Disorders And Advanced Nutrient Therapies by William J. Walsh, PhD, FACN (Webinar Video)  
  Retrievable from: <http://ibpf.org/article/biochemistry-features-bipolar-disorders-and-advanced-nutrient-therapies>

> **Comments:**
> **username_4**: Welcome and thanks for your answer. Could you please provide us with your sources for the claims made in the 2nd and 3rd paragraphs? This allows other users to background read on your material.  
> **username_3**: i have added some references. It would be nice to find a study that can centralize many of the findings. That way common markers could be found way more easy.  
> **username_5**: Thank you so much for adding references. This is an awesome answer.  

---

### Answer by username_6 on 2018-04-27. Score: 2

I could be wrong, since I'm not a doctor and all, but it's my understanding based on about ten years of studying issues like bipolar disorder online that to be diagnosed with bipolar disorder, as well as other disorders, like OCD, people merely need to have a set of symptoms, which disrupt their lives sufficiently, which hopefully respond to certain kinds of treatment (and of course, they probably need to be diagnosed in order for them to officially have it). This, as opposed to a *specific* physiological and/or genetic condition that causes or might cause the symptoms. It's not like strep throat where you can test for bacteria for a *definitive* diagnosis. There could be infinite causes of bipolar disorder as I understand it.

Thus, any tests that could diagnose it might miss a plethora of cases, and many of the people diagnosed by those tests might manage their condition perfectly already (which means they don't have bipolar disorder).

It's my understanding that the aim of such tests would be to assist doctors in making a good diagnosis rather than to replace the doctor's decision.

Nevertheless, there could be other conditions with symptoms similar to bipolar disorder, which do have a definitive underlying cause: e.g. vitamin B12 deficiency. I guess it's probably up to the doctor to decide if the individual also has bipolar disorder.

Anyway, I'm not saying bipolar disorder is all in one's head. At least some of the symptoms are physiological (such as how patients tend to get more manic if they take anti-depressants). I'm sure a lot of doctors use that criteria to help them diagnose the condition already. While I don't know another condition that would match that issue, it's possible there is one. However, just because symptoms are physiological doesn't mean they always have the same cause, which means they could have different methods of diagnosis.

Now, all that being said, while I still think a definitive test is possible, a new way of testing would perhaps be needed. A blood test isn't going to tell you behaviors or how well a person is managing their symptoms, or if the person is using good coping mechanisms that might cause them to not need a diagnosis. A blood test may tell you things that predispose people to behaviors and symptoms, however.

I wrote this answer before I read Bryan Crause's (I just read it). So, sorry that I repeated some of it.

> **Comments:**
> **username_7**: Welcome and thanks for your interesting answer. It's perfectly fine to write a second answer with a bit of overlap. Could you provide us with your sources to allow other users to background read on your material?  

---

### Answer by username_8 on 2021-04-13. Score: 1

From <https://neurosciencenews.com/depression-bipolar-blood-test-18197/>:

> A new blood test can distinguish the severity of a person’s depression
> and their risk for developing severe depression at a later point. The
> test can also determine if a person is at risk for developing bipolar
> disorder. Researchers say the blood test can also assist in tailoring
> individual options for therapeutic interventions.


---

