<p>Glutamate availability in the brain is strictly dependent on <em>de novo</em> synthesis of glutamine in astrocytes. This process  requires the enzymes pyruvate carboxylase and glutamine synthetase to form glutamine, which is then converted into glutamate by deamidation via phosphate-activated glutaminase in a reaction that also yields ammonia <a href="https://www.ncbi.nlm.nih.gov/pubmed/25236722" rel="nofollow noreferrer">(Schousboe <em>et al</em>., 2014)</a>. </p>

<p>In other words, whatever you ingest in terms of glutamate or glutamine via your food doesn't reach the brain and won't play a role in psychosis. </p>

<p>This is good news, as glutamate is an abundant, naturally occurring amino acid and is found in tomatoes, grapes, cheese, mushrooms and other foods. It is also widely used as a flavor enhancer with an umami taste that intensifies the meaty, savory flavor of food. It's commonly used in stock, soups, ramen, savoury snacks <em>etc</em>. (source: <a href="https://en.wikipedia.org/wiki/Monosodium_glutamate" rel="nofollow noreferrer">wikipedia</a>).  </p>

<p><sub><strong>Reference</strong><br>
<strong>-</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25236722" rel="nofollow noreferrer">Schousboe <em>et al</em>., <em>Adv Neurobiol</em> (2014); <strong>11</strong>:13-30</a></sub></p>

CC BY-SA 4.0
2019-06-29T20:54:49.277Z
2019-06-29T22:56:37.953Z
2019-06-29T22:56:37.953Z
AliceD
<p>There is the glutamate hypothesis of schizophrenia. Which tells you that excessive levels may increase the risk of obtaining schizophrenia.</p>

<p>L-glutamine turns into glutamate directly. Does this mean that L-glutamine supplementation, which is common among bodybuilders, increases the risk?</p>

<cognitive-psychology><abnormal-psychology><clinical-psychology><feeding>
Relation between L-glutamine supplementation and risk of schizophrenia
jiniyt
# Relation between L-glutamine supplementation and risk of schizophrenia

(Asked by: username_0 on 2019-06-29)

There is the glutamate hypothesis of schizophrenia. Which tells you that excessive levels may increase the risk of obtaining schizophrenia.

L-glutamine turns into glutamate directly. Does this mean that L-glutamine supplementation, which is common among bodybuilders, increases the risk?

**Tags:** cognitive-psychology, abnormal-psychology, clinical-psychology, feeding


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## 1 answers

### Answer by username_1 on 2019-06-29. Score: 1

Glutamate availability in the brain is strictly dependent on *de novo* synthesis of glutamine in astrocytes. This process requires the enzymes pyruvate carboxylase and glutamine synthetase to form glutamine, which is then converted into glutamate by deamidation via phosphate-activated glutaminase in a reaction that also yields ammonia [(Schousboe *et al*., 2014)](https://www.ncbi.nlm.nih.gov/pubmed/25236722).

In other words, whatever you ingest in terms of glutamate or glutamine via your food doesn't reach the brain and won't play a role in psychosis.

This is good news, as glutamate is an abundant, naturally occurring amino acid and is found in tomatoes, grapes, cheese, mushrooms and other foods. It is also widely used as a flavor enhancer with an umami taste that intensifies the meaty, savory flavor of food. It's commonly used in stock, soups, ramen, savoury snacks *etc*. (source: [wikipedia](https://en.wikipedia.org/wiki/Monosodium_glutamate)).

**Reference**  
**-** [Schousboe *et al*., *Adv Neurobiol* (2014); **11**:13-30](https://www.ncbi.nlm.nih.gov/pubmed/25236722)


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