<p>Actually it's a bit complicated but in simple terms : </p>

<p>Neurotransmitters are stored in a synapse in synaptic vesicles, clustered beneath the membrane in the axon terminal located at the presynaptic side of the synapse. Neurotransmitters are released into and diffused across the synaptic cleft, where they bind to specific receptors in the membrane on the postsynaptic side of the synapse.</p>

<p>Most neurotransmitters are about the size of a single amino acid, however, some neurotransmitters may be the size of larger proteins or peptides. A released neurotransmitter is typically available in the synaptic cleft for a short time before it is metabolized by enzymes, pulled back into the presynaptic neuron through reuptake, or bound to a postsynaptic receptor. Nevertheless, short-term exposure of the receptor to a neurotransmitter is typically sufficient for causing a postsynaptic response by way of synaptic transmission.</p>

<p>In response to a threshold action potential or graded electrical potential, a neurotransmitter is released at the presynaptic terminal. Low level "baseline" release also occurs without electrical stimulation. The released neurotransmitter may then move across the synapse to be detected by and bind with receptors in the postsynaptic neuron. Binding of neurotransmitters may influence the postsynaptic neuron in either an inhibitory or excitatory way. This neuron may be connected to many more neurons, and if the total of excitatory influences are greater than those of inhibitory influences, the neuron will also "fire". Ultimately it will create a new action potential at its axon hillock to release neurotransmitters and pass on the information to yet another neighboring neuron.</p>

CC BY-SA 3.0
2016-01-30T05:08:12.607Z
2016-01-30T05:08:12.607Z
Shayan Kabiri
<p>I think emotions and hormones frames the overall thinking processes of the brain. However, I'm interested in how this works on a neuronal level. For example, dopamine is some kind of reward signal for the brain. How does it interact with individual neurons or synapses and affect the way they behave?</p>

<neuroscience><cognitive-neuroscience><emotion><cognitive-modeling><neuro-transmitters>
How do neuro transmitters interact with neurons in the brain?
danijar
# How do neuro transmitters interact with neurons in the brain?

(Asked by: username_0 on 2016-01-28)

I think emotions and hormones frames the overall thinking processes of the brain. However, I'm interested in how this works on a neuronal level. For example, dopamine is some kind of reward signal for the brain. How does it interact with individual neurons or synapses and affect the way they behave?

**Tags:** neuroscience, cognitive-neuroscience, emotion, cognitive-modeling, neuro-transmitters


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## 1 answers

### Answer by username_1 on 2016-01-30. Score: 1 | Accepted answer

Actually it's a bit complicated but in simple terms :

Neurotransmitters are stored in a synapse in synaptic vesicles, clustered beneath the membrane in the axon terminal located at the presynaptic side of the synapse. Neurotransmitters are released into and diffused across the synaptic cleft, where they bind to specific receptors in the membrane on the postsynaptic side of the synapse.

Most neurotransmitters are about the size of a single amino acid, however, some neurotransmitters may be the size of larger proteins or peptides. A released neurotransmitter is typically available in the synaptic cleft for a short time before it is metabolized by enzymes, pulled back into the presynaptic neuron through reuptake, or bound to a postsynaptic receptor. Nevertheless, short-term exposure of the receptor to a neurotransmitter is typically sufficient for causing a postsynaptic response by way of synaptic transmission.

In response to a threshold action potential or graded electrical potential, a neurotransmitter is released at the presynaptic terminal. Low level "baseline" release also occurs without electrical stimulation. The released neurotransmitter may then move across the synapse to be detected by and bind with receptors in the postsynaptic neuron. Binding of neurotransmitters may influence the postsynaptic neuron in either an inhibitory or excitatory way. This neuron may be connected to many more neurons, and if the total of excitatory influences are greater than those of inhibitory influences, the neuron will also "fire". Ultimately it will create a new action potential at its axon hillock to release neurotransmitters and pass on the information to yet another neighboring neuron.


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