<s> [INST] <<SYS>> You are a responsible assistant committed to providing accurate and helpful responses. Avoid sharing harmful or biased content. Clarify any unclear or incorrect questions rather than providing false or misleading information. <</SYS>> What is Variant Creutzfeldt–Jakob disease and can you explain it in depth? [/INST] Variant Creutzfeldt–Jakob disease (vCJD), commonly referred to as "mad cow disease" or "human mad cow disease" to distinguish it from its BSE counterpart, is a fatal type of brain disease within the transmissible spongiform encephalopathy family. Initial symptoms include psychiatric problems, behavioral changes, and painful sensations. In the later stages of the illness, patients may exhibit poor coordination, dementia and involuntary movements. The length of time between exposure and the development of symptoms is unclear, but is believed to be years to decades. Average life expectancy following the onset of symptoms is 13 months.It is caused by prions, which are misfolded proteins. Spread is believed to be primarily due to eating bovine spongiform encephalopathy (BSE)-infected beef. Infection is also believed to require a specific genetic susceptibility. Spread may potentially also occur via blood products or contaminated surgical equipment. Diagnosis is by brain biopsy but can be suspected based on certain other criteria. It is different from typical Creutzfeldt–Jakob disease, though both are due to prions.Treatment for vCJD involves supportive care. As of 2020, 178 cases of vCJD have been recorded in the United Kingdom, due to a 1990s outbreak, and 50 cases in the rest of the world. The disease has become less common since 2000. The typical age of onset is less than 30 years old. It was first identified in 1996 by the National CJD Surveillance Unit in Edinburgh, Scotland.

Signs and symptoms
Initial symptoms include psychiatric problems, behavioral changes, and painful sensations. In the later stages of the illness, patients may exhibit poor coordination, dementia and involuntary movements. The length of time between exposure and the development of symptoms is unclear, but is believed to be years. Average life expectancy following the onset of symptoms is 13 months.

Cause
Tainted beef
In the UK, the primary cause of vCJD has been eating beef tainted with bovine spongiform encephalopathy. A 2012 study by the Health Protection Agency showed that around 1 in 2,000 people in the UK show signs of abnormal prion accumulation.Jonathan Quick, instructor of medicine at the Department of Global Health and Social Medicine at Harvard Medical School, stated that bovine spongiform encephalopathy or BSE is the first man-made epidemic, or "Frankenstein" disease, because a human decision to feed meat and bone meal to previously herbivorous cattle (as a source of protein) caused what was previously an animal pathogen to enter into the human food chain, and from there to begin causing humans to contract vCJD.

Blood products
As of 2018, evidence suggests that while there may be prions in the blood of individuals with vCJD this is not the case in individuals with sporadic CJD.In 2004, a report showed that vCJD can be transmitted by blood transfusions. The finding alarmed healthcare officials because a large epidemic of the disease could result in the near future. A blood test for vCJD infection is possible but is not yet available for screening blood donations. Significant restrictions exist to protect the blood supply. The UK government banned anyone who had received a blood transfusion since January 1980 from donating blood. Since 1999 there has been a ban in the UK for using UK blood to manufacture fractional products such as albumin.
Whilst these restrictions may go some way to preventing a self-sustaining epidemic of secondary infections, the number of infected blood donations is unknown and could be considerable. In June 2013 the government was warned that deaths, then at 176, could rise five-fold through blood transfusions.On 28 May 2002, the United States Food and Drug Administration instituted a policy that excludes from blood donation anyone having spent at least six months in certain European countries (or three months in the United Kingdom) from 1980 to 1996. Given the large number of U.S. military personnel and their dependents residing in Europe, it was expected that over 7% of donors would be deferred due to the policy. Later changes to this policy have relaxed the restriction to a cumulative total of five years or more of civilian travel in European countries (six months or more if military). The three-month restriction on travel to the UK, however, has not been changed.In New Zealand, the New Zealand Blood Service (NZBS) in 2000 introduced measures to preclude permanently donors having resided in the United Kingdom (including the Isle of Man and the Channel Islands) for a total of six months or more between January 1980 and December 1996. The measure resulted in ten percent of New Zealands active blood donors at the time becoming ineligible to donate blood. In 2003, the NZBS further extended restrictions to permanently preclude donors having received a blood transfusion in the United Kingdom since January 1980, and in April 2006, restrictions were further extended to include the Republic of Ireland and France.Similar regulations are in place where anyone having spent more than six months for Germany or one year for France living in the UK between January 1980 and December 1996 is permanently banned from donating blood.In Canada, individuals are not eligible to donate blood or plasma if they have spent a cumulative total of three months or more in the UK, or France from 1 January 1980 to December 31, 1996. They are also ineligible if they have spent a cumulative total of five years or more in the Republic of Ireland since January 1, 1980 through 31 December 2001 or spent a cumulative total of six months or more in Saudi Arabia from January 1, 1980, through December 31, 1996 or if they have had a blood transfusion in the UK, France or Western Europe since 1980.In Poland, anyone having spent cumulatively six months or longer between 1 January 1980 and 31 December 1996 in the UK, Ireland, or France is permanently barred from donating.In France, anyone having lived or stayed in the United Kingdom a total of over one year between 1 January 1980 and 31 December 1996 is permanently barred from donating.In the Czech Republic, anyone having spent more than six months in the UK or France between the years 1980 and 1996 or received transfusion in the UK after the year 1980 is not allowed to donate blood.In Finland, anyone having lived or stayed in the British Isles a total of over six months between 1 January 1980 and 31 December 1996 is permanently barred from donating.

Sperm donation
In the U.S., the FDA has banned import of any donor sperm, motivated by a risk of variant Creutzfeldt-Jakob disease, inhibiting the once popular import of Scandinavian sperm. Despite this, the scientific consensus is that the risk is negligible, as there is no evidence Creutzfeldt–Jakob is sexually transmitted.

Occupational contamination
In France, the last two victims of variant Creutzfeldt-Jakob disease, who died in 2019 and 2021, were research technicians at the National Research Institute for Agriculture, Food and the Environment (INRAE). Emilie Jaumain, who died in 2019, at the age of 33, had been the victim of a work accident in 2010, during which she had pricked herself with a tool contaminated with infected brain. The efficacy of this route of contamination has been unambiguously demonstrated in primates. Pierrette C., who died in 2021, had been victim of the same type of work accident. After her diagnosis, a moratorium was initiated in all French laboratories on research activities on infectious prions. In March 2022, INRAE recognized the occupational cause of these two deaths. This raises serious questions about the safety of personnel in these laboratories. Indeed, inspections have noted serious failures in the protection of agents in the face of this deadly risk, and the long incubation period of this disease leads to fears of new cases in the future, hence great concern.

Other causes
Eating other types of brains such as those from squirrels is not recommended as one person contracted vCJD from eating the brain of a squirrel.

Mechanism
Despite the consumption of contaminated beef in the UK being high, vCJD has infected a small number of people. One explanation for this can be found in the genetics of people with the disease. The human PRNP protein which is subverted in prion disease can occur with either methionine or valine at amino acid 129, without any apparent physiological difference. Of the overall Caucasian population, about 40% have two methionine-containing alleles, 10% have two valine-containing alleles, and the other 50% are heterozygous at this position. Only a single person with vCJD tested was found to be heterozygous; most of those affected had two copies of the methionine-containing form. It is not yet known whether those unaffected are actually immune or only have a longer incubation period until symptoms appear.

Diagnosis
Definitive
Examination of brain tissue is required to confirm a diagnosis of variant CJD. The following confirmatory features should be present:
Numerous widespread kuru-type amyloid plaques surrounded by vacuoles in both the cerebellum and cerebrum – florid plaques.
Spongiform change and extensive prion protein deposition shown by immunohistochemistry throughout the cerebellum and cerebrum.

Suspected
Current age or age at death less than 55 years (a brain autopsy is recommended, however, for all physician-diagnosed CJD cases).
Psychiatric symptoms at illness onset and/or persistent painful sensory symptoms (frank pain and/or dysesthesia).
Dementia, and development ≥4 months after illness onset of at least two of the following five neurologic signs: poor coordination, myoclonus, chorea, hyperreflexia, or visual signs. (If persistent painful sensory symptoms exist, ≥4 months delay in the development of the neurologic signs is not required).
A normal or an abnormal EEG, but not the diagnostic EEG changes often seen in classic CJD.
Duration of illness of over 6 months.
Routine investigations do not suggest an alternative, non-CJD diagnosis.
No history of getting human pituitary growth hormone or a dura mater graft from a cadaver.
No history of CJD in a first degree relative or prion protein gene mutation in the person.

Classification
vCJD is a separate condition from classic Creutzfeldt–Jakob disease (though both are caused by PrP prions). Both classic and variant CJD are subtypes of Creutzfeldt–Jakob disease. There are three main categories of CJD disease: sporadic CJD, hereditary CJD, and acquired CJD, with variant CJD being in the acquired group along with iatrogenic CJD. The classic form includes sporadic and hereditary forms. Sporadic CJD is the most common type.ICD-10 has no separate code for vCJD and such cases are reported under the Creutzfeldt–Jakob disease code (A81.0).

Epidemiology
The Lancet in 2006 suggested that it may take more than 50 years for vCJD to develop, from their studies of kuru, a similar disease in Papua New Guinea. The reasoning behind the claim is that kuru was possibly transmitted through cannibalism in Papua New Guinea when family members would eat the body of a dead relative as a sign of mourning. In the 1950s, cannibalism was banned in Papua New Guinea.
In the late 20th century, however, kuru reached epidemic proportions in certain Papua New Guinean communities, therefore suggesting that vCJD may also have a similar incubation period of 20 to 50 years. A critique to this theory is that while mortuary cannibalism was banned in Papua New Guinea in the 1950s, that does not necessarily mean that the practice ended. Fifteen years later Jared Diamond was informed by Papuans that the practice continued.These researchers noticed a genetic variation in some people with kuru that has been known to promote long incubation periods. They have also proposed that individuals having contracted CJD in the early 1990s represent a distinct genetic subpopulation, with unusually short incubation periods for bovine spongiform encephalopathy (BSE). This means that there may be many more people with vCJD with longer incubation periods, which may surface many years later.Prion protein is detectable in lymphoid and appendix tissue up to two years before the onset of neurological symptoms in vCJD. Large scale studies in the UK have yielded an estimated prevalence of 493 per million, higher than the actual number of reported cases. This finding indicates a large number of asymptomatic cases and the need to monitor.

Society and culture
In 1997, a number of people from Kentucky developed CJD. It was discovered that all had consumed squirrel brains. A coincidental relationship between the disease and this dietary practice may have been involved.
In 2008, UK scientists expressed concern over the possibility of a second wave of human cases due to the wide exposure and long incubation of some cases of vCJD. In 2015, a man from New York developed vCJD after eating squirrel brains. From November 2017 to April 2018, four suspected cases of the disease arose in Rochester.

United Kingdom
Researchers believe one in 2,000 people in the UK is a carrier of the disease, linked to eating contaminated beef. The survey provides the most robust prevalence measure to date—and identifies abnormal prion protein across a wider age group than found previously and in all genotypes, indicating "infection" may be relatively common. This new study examined over 32,000 anonymous appendix samples. Of these, 16 samples were positive for abnormal prion protein, indicating an overall prevalence of 493 per million population, or one in 2,000 people are likely to be carriers. No difference was seen in different birth cohorts (1941–1960 and 1961–1985), in both sexes, and there was no apparent difference in abnormal prion prevalence in three broad geographical areas. Genetic testing of the 16 positive samples revealed a higher proportion of valine homozygous (VV) genotype on the codon 129 of the gene encoding the prion protein (PRNP) compared with the general UK population. This also differs from the 176 people with vCJD, all of whom to date have been methionine homozygous (MM) genotype. The concern is that individuals with this VV genotype may be susceptible to developing the condition over longer incubation periods.

Human BSE foundation
In 2000 a voluntary support group was formed by families of people who had died from vCJD. The goal was to support other families going through a similar experience. This support was provided through a National Helpline, a Carers Guide, a website and a network of family befriending. The support groups had an internet presence at the turn of the 21st century. The driving force behind the foundation was Lester Firkins, whose young son had died from the disease.In October 2000 the report of the government inquiry into BSE chaired by Lord Phillips was published </s>


<s> [INST] <<SYS>> You are a responsible assistant committed to providing accurate and helpful responses. Avoid sharing harmful or biased content. Clarify any unclear or incorrect questions rather than providing false or misleading information. <</SYS>> What is Acute erythroid leukemia and can you explain it in depth? [/INST] Acute erythrocyte leukemia is a rare form of acute myeloid leukemia (less than 5% of AML cases) where the myeloproliferation is of erythrocytic precursors. It is defined as type "M6" under the FAB classification.

Signs and symptoms
The most common symptoms of AEL are related to pancytopenia (a shortage of all types of blood cells), including fatigue, infections, and mucocutaneous bleeding. Almost half of people with AEL exhibit weight loss, fever and night sweats at the time of diagnosis. Almost all people with AEL are anemic, and 77% have a hemoglobin level under 10.0 g/dl. Signs of thrombocytopenia are found in about half of people with AEL.

Causes
The causes of AEL are unknown. Prior to a 2008 reclassification by the World Health Organization, cases that evolved from myelodysplastic syndromes, myeloproliferative neoplasms, chemotherapy for other cancers or exposure to toxins were defined as secondary AEL. These cases are now likely to instead be classified as acute myeloid leukemia with myelodysplasia-related changes or therapy-related AML. +

Diagnosis
Acute erythroid leukemias can be classified as follows:

M6a (Erythroleukemia)
50% or more of all nucleated bone marrow cells are erythroblasts, dyserythropoiesis is prominent and 20% or more of the remaining cells (non- erythroid) are myeloblasts.

M6b (Pure erythroid leukemia)
In rare cases the erythroid lineage is the only obvious component of an acute leukemia; a myeloblast component is not apparent. The erythroid component consists predominantly or exclusively of proerythroblasts and early basophilic erythroblasts. These cells may constitute 90% or more of the marrow elements. Despite this lack of myeloblasts, these cases should be considered acute leukemias. In a WHO proposal the blastic leukemias that are limited to the erythroid series are designated pure erythroid malignancies.

M6c (Erythroleukemia and Pure erythroid leukemia)
Myeloblast- and proerythroblast-rich mixed variant.

Treatment
Treatment for erythroleukemia generally follows that for other types of AML, not otherwise specified. It consists of chemotherapy, frequently consisting of
cytarabine, daunorubicin, and idarubicin. It can also involve bone marrow transplantation.

Prognosis
Information on prognosis is limited by the rarity of the condition. Prognosis appears to be no different from AML in general, taking into account other risk factors. Acute erythroid leukemia (M6) has a relatively poor prognosis. A 2010 study of 124 patients found a median overall survival of 8 months. A 2009 study on 91 patients found a median overall survival for erythroleukemia patients of 36 weeks, with no statistically significant difference to other AML patients. AEL patients did have a significantly shorter disease-free survival period, a median of 32 weeks, but this effect was explained by other prognostic factors. That is, AEL is often associated with other risk factors, like monosomal karyotypes and a history of myelodysplastic syndrome. Prognosis is worse in elderly patients, those with a history of myelodysplastic syndrome, and in patients who had previously received chemotherapy for the treatment of a different neoplasm.

Epidemiology
Acute erythroid leukemia is rare, accounting for only 3–5% of all acute myeloid leukemia cases. One study estimated an occurrence rate of 0.077 cases per 100,000 people each year. 64–70% of people with this condition are male, and most are elderly, with a median age of 65.

History
The first known case of acute erythroid leukemia was described in 1912 by M. Copelli under the name erythromatosis </s>


<s> [INST] <<SYS>> You are a responsible assistant committed to providing accurate and helpful responses. Avoid sharing harmful or biased content. Clarify any unclear or incorrect questions rather than providing false or misleading information. <</SYS>> What is Falling and can you explain it in depth? [/INST]  </s>


<s> [INST] <<SYS>> You are a responsible assistant committed to providing accurate and helpful responses. Avoid sharing harmful or biased content. Clarify any unclear or incorrect questions rather than providing false or misleading information. <</SYS>> What is Condylar hyperplasia and can you explain it in depth? [/INST] Condylar hyperplasia  (mandibular hyperplasia) is over-enlargement of the mandible bone in the skull. It was first described by Robert Adams in 1836 who related it to the overdevelopment of mandible. In humans, mandibular bone has two condyles which are known as growth centers of the mandible. When growth at the condyle exceeds its normal time span, it is referred to as condylar hyperplasia. The most common form of condylar hyperplasia is unilateral condylar hyperplasia where one condyle overgrows the other condyle leading to facial asymmetry. Hugo Obwegeser et al. classified condylar hyperplasia into two categories: hemimandibular hyperplasia and hemimandibular elongation. It is estimated that about 30% of people with facial asymmetry express condylar hyperplasia.In 1986, Obwegeser and Makek specifically detailed two hemimandibular anomalies, hemimandibular hyperplasia and hemimandibular elongation. These anomalies can be clinically present in a pure form or in combination.

Cause
Condylar hyperplasia has an unknown cause. Several theories exist in literature which related to the cause of condylar hyperplasia. One theory states that an event of a trauma leading to increase in number of repair mechanism and hormones in that area may lead to increase in growth of mandible on that side.  Another theory states that an increase in loading of the temporomandibular joint can lead to increase in expression of bone forming molecules. Condylar hyperplasia predominantly affects women with 64% of patients being women.

Diagnosis
Diagnosis of asymmetry can be done through many different methods. PA cephalometry, panoramic radiograph, and nuclear imaging are some of the techniques that can be used for diagnosis. Primarily nuclear imaging techniques such as single-photon emission computed tomography (SPECT), positron emission tomography (PET), and bone scintigraphy are taken along with other data before a patient is diagnosed for Condylar Hyperplasia. In SPECT imaging, an increase uptake of the isotope is seen on the affected in comparison to the non-affected side. A difference of at least 10% or a minimum ratio of 55% to 45% uptake of technetium-99m is seen when comparing affected vs non-affected side respectively. An uptake of more than 55% and difference of at least 10% indicates an active condylar growth.

Classification
Hugo Obwegesr and Makek classified condylar hyperplasia into three categories, listed in the table below </s>


<s> [INST] <<SYS>> You are a responsible assistant committed to providing accurate and helpful responses. Avoid sharing harmful or biased content. Clarify any unclear or incorrect questions rather than providing false or misleading information. <</SYS>> What is Assault and can you explain it in depth? [/INST] An assault is the act of committing physical harm or unwanted physical contact upon a person or, in some specific legal definitions, a threat or attempt to commit such an action. It is both a crime and a tort and, therefore, may result in criminal prosecution, civil liability, or both. Generally, the common law definition is the same in criminal and tort law.
Traditionally, common law legal systems have separate definitions for assault and battery. When this distinction is observed, battery refers to the actual bodily contact, whereas assault refers to a credible threat or attempt to cause battery. Some jurisdictions combined the two offences into a single crime called "assault and battery", which then became widely referred to as "assault". The result is that in many of these jurisdictions, assault has taken on a definition that is more in line with the traditional definition of battery. The legal systems of civil law and Scots law have never distinguished assault from battery.
Legal systems generally acknowledge that assaults can vary greatly in severity. In the United States, an assault can be charged as either a misdemeanor or a felony. In England and Wales and Australia, it can be charged as either common assault, assault occasioning actual bodily harm (ABH) or grievous bodily harm (GBH). Canada also has a three-tier system: assault, assault causing bodily harm and aggravated assault. Separate charges typically exist for sexual assaults, affray and assaulting a police officer. Assault may overlap with an attempted crime; for example an assault may be charged as an attempted murder if it was done with intent to kill.

Related definitions
Battery
In jurisdictions that make a distinction between the two, assault usually accompanies battery if the assailant both threatens to make unwanted contact and then carries through with this threat. See common assault. The elements of battery are that it is a volitional act, done for the purpose of causing a harmful or offensive contact with another person or under circumstances that make such contact substantially certain to occur, and which causes such contact.

Aggravated assault
Aggravated assault is, in some jurisdictions, a stronger form of assault, usually using a deadly weapon. A person has committed an aggravated assault when that person attempts to:

cause serious bodily injury to another person with a deadly weapon
have sexual relations with a person who is under the age of consent
cause bodily harm by recklessly operating a motor vehicle during road rage; often referred to as either vehicular assault or aggravated assault with a motor vehicle.Aggravated assault can also be charged in cases of attempted harm against police officers or other public servants.

Defenses
Although the range and precise application of defenses varies between jurisdictions, the following represents a list of the defenses that may apply to all levels of assault:

Consent
Exceptions exist to cover unsolicited physical contact which amount to normal social behavior known as de minimis harm. Assault can also be considered in cases involving the spitting on, or unwanted exposure of bodily fluids to others.
Consent may be a complete or partial defense to assault. In some jurisdictions, most notably England, it is not a defense where the degree of injury is severe, as long as there is no legally recognized good reason for the assault. This can have important consequences when dealing with issues such as consensual sadomasochistic sexual activity, the most notable case being the Operation Spanner case. Legally recognized good reasons for consent include surgery, activities within the rules of a game (mixed martial arts, wrestling, boxing, or contact sports), bodily adornment (R v Wilson [1996] Crim LR 573), or horseplay (R v Jones [1987] Crim LR 123). However, any activity outside the rules of the game is not legally recognized as a defense of consent. In Scottish law, consent is not a defense for assault.

Arrest and other official acts
Police officers and court officials have a general power to use force for the purpose of performing an arrest or generally carrying out their official duties. Thus, a court officer taking possession of goods under a court order may use force if reasonably necessary.

Punishment
In some jurisdictions such as Singapore, judicial corporal punishment is part of the legal system. The officers who administer the punishment have immunity from prosecution for assault.
In the United States, the United Kingdom, Australia and Canada, corporal punishment administered to children by their parent or legal guardian is not legally considered to be assault unless it is deemed to be excessive or unreasonable. What constitutes "reasonable" varies in both statutory law and case law. Unreasonable physical punishment may be charged as assault or under a separate statute for child abuse.
Many countries, including some US states, also permit the use of corporal punishment for children in school. In English law, s. 58 Children Act 2004 limits the availability of the lawful correction defense to common assault under s. 39 Criminal Justice Act 1988.

Prevention of crime
This may or may not involve self-defense in that, using a reasonable degree of force to prevent another from committing a crime could involve preventing an assault, but it could be preventing a crime not involving the use of personal violence.

Defense of property
Some jurisdictions allow force to be used in defense of property, to prevent damage either in its own right, or under one or both of the preceding classes of defense in that a threat or attempt to damage property might be considered a crime (in English law, under s5 Criminal Damage Act 1971 it may be argued that the defendant has a lawful excuse to damage property during the defense and a defense under s3 Criminal Law Act 1967) subject to the need to deter vigilantes and excessive self-help. Furthermore, some jurisdictions, such as Ohio, allow residents in their homes to use force when ejecting an intruder. The resident merely needs to assert to the court that they felt threatened by the intruders presence.

Regional details
The following are the countries with the most cases of assault according to the United Nations in 2018.

Australia
The term assault, when used in legislation, commonly refers to both common assault and battery, even though the two offences remain distinct. Common assault involves intentionally or recklessly causing a person to apprehend the imminent infliction of unlawful force, whilst battery refers to the actual infliction of force.Each state has legislation relating to the act of assault, and offences against the act that constitute assault are heard in the magistrates court of that state or indictable offences are heard in a district or supreme court of that state. The legislation that defines assault of each state outline what the elements are that make up the assault, where the assault is sectioned in legislation or criminal codes, and the penalties that apply for the offence of assault.In New South Wales, the Crimes Act 1900 defines a range of assault offences deemed more serious than common assault and which attract heavier penalties. These include:

Assault with further specific intent
Acts done to the person with intent to murder
Wounding or grievous bodily harm
Use or possession of a weapon to resist arrest

Assault causing certain injuries
Actual bodily harm – the term is not defined in the Crimes Act, but case law indicates actual bodily harm may include injuries such as bruises and scratches, as well as psychological injuries if the injury inflicted is more than merely transient (the injury does not necessarily need to be permanent)
Wounding – where there is breaking of the skin;
Grievous bodily harm – which includes the destruction of a foetus, permanent or serious disfiguring, and transmission of a grievous bodily disease

Assault causing death
Death
Death when intoxicated (in regards to the offender)

Canada
Assault is an offence under s. 265 of the Canadian Criminal Code. There is a wide range of the types of assault that can occur. Generally, an assault occurs when a person directly or indirectly applies force intentionally to another person without their consent. It can also occur when a person attempts to apply such force, or threatens to do so, without the consent of the other person. An injury need not occur for an assault to be committed, but the force used in the assault must be offensive in nature with an intention to apply force. It can be an assault to "tap", "pinch", "push", or direct another such minor action toward another, but an accidental application of force is not an assault.
The potential punishment for an assault in Canada varies depending on the manner in which the charge proceeds through the court system and the type of assault that is committed. The Criminal Code defines assault as a dual offence (indictable or summary offence). Police officers can arrest someone without a warrant for an assault if it is in the publics interest to do so notwithstanding S.495(2)(d) of the Code. This public interest is usually satisfied by preventing a continuation or repetition of the offence on the same victim.
Some variations on the ordinary crime of assault include:

Assault: The offence is defined by section 265 of the Code.
Assault with a weapon: Section 267(a) of the Code.
Assault causing bodily harm: See assault causing bodily harm Section 267(b) of the Code.
Aggravated assault: Section 268 of the Code.
Assaulting a peace officer, etc.: Section 270 of the Code.
Sexual assault: Section 271 of the Code.
Sexual assault with a weapon or threats or causing bodily harm: Section 272 of the Code.
Aggravated sexual assault: See aggravated sexual assault.An individual cannot consent to an assault with a weapon, assault causing bodily harm, aggravated assault, or any sexual assault. Consent will also be vitiated if two people consent to fight but serious bodily harm is intended and caused (R v Paice; R v Jobidon). A person cannot consent to serious bodily harm.

Ancient Greece
Assault in Ancient Greece was normally termed hubris. Contrary to modern usage, the term did not have the extended connotation of overweening pride, self-confidence or arrogance, often resulting in fatal retribution. In Ancient Greece, "hubris" referred to actions which, intentionally or not, shamed and humiliated the victim, and frequently the perpetrator as well. It was most evident in the public and private actions of the powerful and rich.
Violations of the law against hubris included, what would today be termed, assault and battery; sexual crimes ranging from forcible rape of women or children to consensual but improper activities; or the theft of public or sacred property. Two well-known cases are found in the speeches of Demosthenes, a prominent statesman and orator in ancient Greece. These two examples occurred when first, in addition to other acts of violence, Meidias allegedly punched Demosthenes in the face in the theater (Against Meidias), and second (Against Konon), when the defendant allegedly severely beat him.
Hubris, though not specifically defined, was a legal term and was considered a crime in classical Athens. It was also considered the greatest sin of the ancient Greek world. That was so because it not only was proof of excessive pride, but also resulted in violent acts by or to those involved. The category of acts constituting hubris for the ancient Greeks apparently broadened from the original specific reference to mutilation of a corpse, or a humiliation of a defeated foe, or irreverent, "outrageous treatment", in general.
The meaning was eventually further generalized in its modern English usage to apply to any outrageous act or exhibition of pride or disregard for basic moral laws. Such an act may be referred to as an "act of hubris", or the person committing the act may be said to be hubristic. Atë, Greek for ruin, folly, delusion, is the action performed by the hero, usually because of their hubris, or great pride, that leads to their death or downfall.
Crucial to this definition are the ancient Greek concepts of honor (timē) and shame. The concept of timē included not only the exaltation of the one receiving honor, but also the shaming of the one overcome by the act of hubris. This concept of honor is akin to a zero-sum game. Rush Rehm simplifies this definition to the contemporary concept of "insolence, contempt, and excessive violence".

India
The Indian Penal Code covers the punishments and types of assault in Chapter 16, sections 351 through 358.

Whoever makes any gesture, or any preparation intending or knowing it to be likely that such gesture or preparation will cause any person present to apprehend that he who makes that gesture or preparation is about to use criminal force to that person, is said to commit an assault.
The Code further explains that "mere words do not amount to an assault. But the words which a person uses may give to their gestures or preparation such a meaning as may make those gestures or preparations amount to an assault". Assault is in Indian criminal law an attempt to use criminal force (with criminal force being described in s.350). The attempt itself has been made an offence in India, as in other states.

Nigeria
The Criminal Code Act (chapter 29 of Part V; sections 351 to 365) creates a number of offences of assault. Assault is defined by section 252 of that Act. Assault is a misdemeanor punishable by one year imprisonment; assault with "intent to have carnal knowledge of him or her" or who indecently assaults another, or who commits other more-serious variants of assault (as defined in the Act) are guilty of a felony, and longer prison terms are provided for.

Pacific Islands
Marshall Islands
The offence of assault is created by section 113 of the Criminal Code. A person is guilty of this offence if they unlawfully offer or attempt, with force or violence, to strike, beat, wound, or do bodily harm to, another.

Republic of Ireland
Section 2 of the Non-Fatal Offences against the Person Act 1997 creates the offence of assault, and section 3 of that Act creates the offence of assault causing harm.

South Africa
South African law does not draw the distinction between assault and battery. Assault is a common law crime defined as "unlawfully and intentionally applying force to the person of another, or inspiring a belief in that other that force is immediately to be applied to him". The law also recognises the crime of assault with intent to cause grievous bodily harm, where grievous bodily harm is defined as "harm which in itself is such as seriously to interfere with health". The common law crime of indecent assault was repealed by the Criminal Law (Sexual Offences and Related Matters) Amendment Act, 2007, and replaced by a statutory crime of sexual assault.

United Kingdom
Piracy with violence
Section 2 of the Piracy Act 1837 provides that it is an offence, amongst other things, for a person, with intent to commit or at the time of or immediately before or immediately after committing the crime of piracy in respect of any ship or vessel, to assault, with intent to murder, any person being on board of or belonging to such ship or vessel.
Assault on an officer of Revenue and Customs
This offence (relating to officers of HMRC) is created by section 32(1) of the Commissioners for Revenue and Customs Act 2005.
Assaulting an immigration officer
This offence is created by section 22(1) of the UK Borders Act 2007.
Assaulting an accredited financial investigator
This section is created by section 453A of the Proceeds of Crime Act 2002.
Assaulting a member of an international joint investigation team
This offence is created by section 57(2) Archived 26 February 2021 at the Wayback Machine of the Serious Organised Crime and Police Act 2005.
Attacks on internationally protected persons
Section 1(1)(a) of the Internationally Protected Persons Act 1978 (c.17) makes provision for assault occasioning actual bodily harm or causing injury on "protected persons" (including Heads of State).
Attacks on UN Staff workers
Section 1(2)(a) of the United Nations Personnel Act 1997 (c.13) makes provision for assault causing injury, and section 1(2)(b) makes provision for assault occasioning actual bodily harm, on UN staff.
Assault by person committing an offence under the Night Poaching Act 1828
This offence is created by section 2 of the Night Poaching Act 1828.Abolished offences:

Assault on customs and excise officers, etc.
Section 16(1)(a) of the Customs and Excise Management Act 1979 (c.2) provided that it was an offence to, amongst other things, assault any person duly engaged in the performance of any duty or the exercise of any power imposed or conferred on him by or under any enactment relating to an assigned matter, or any person acting in his aid. For the meaning of "assault" in this provision, see Logdon v. DPP [1976] Crim LR 121, DC. This offence was abolished and replaced by the Commissioners for Revenue and Customs Act 2005.
Assaulting a person designated under section 43 of the Serious Organised Crime and Police Act 2005
This offence was created by section 51(1) of the Serious Organised Crime and Police Act 2005. It related to officers of the Serious Organized Crime Agency and was repealed when that agency was abolished.

England and Wales
English law provides for two offences of assault: common assault and battery. Assault (or common assault) is committed if one intentionally or recklessly causes another person to apprehend immediate and unlawful personal violence. Violence in this context means any unlawful touching, though there is some debate over whether the touching must also be hostile. The terms "assault" and "common assault" often encompass the separate offence of battery, even in statutory settings such as s 40(3)(a) of the Criminal Justice Act 1988.
A common assault is an assault that lacks any of the aggravating features which Parliament has deemed serious enough to deserve a higher penalty. Section 39 of the Criminal Justice Act 1988 provides that common assault, like battery, is triable only in the magistrates court in England and Wales (unless it is linked to a more serious offence, which is triable in the Crown Court). Additionally, if a defendant has been charged on an indictment with assault occasioning actual bodily harm (ABH), or racially/religiously aggravated assault, then a jury in the Crown Court may acquit the defendant of the more serious offence, but still convict of common assault if it finds common assault has been committed.

Aggravated assault
An assault which is aggravated by the scale of the injuries inflicted may be charged as offences causing "actual bodily harm" (ABH) or, in the severest cases, "grievous bodily harm" (GBH).

Assault occasioning actual bodily harm
The offence of is created by section 47 of the Offences against the Person Act 1861.
Inflicting grievous bodily harm
Also referred to as "malicious wounding" or "unlawful wounding". This offence is created by section 20 of the Offences against the Person Act 1861.
Causing grievous bodily harm with intent
Also referred to as "wounding with intent". This offence is created by section 18 of the Offences against the Person Act 1861.Other aggravated assault charges refer to assaults carried out against a specific target or with a specific intent:

Assault with intent to rob
The penalty for assault with intent to rob, a common law offence, is provided by section 8(2) of the Theft Act 1968.
Racially or religiously aggravated common assault
This offence is created by section 29(1)(c) of the Crime and Disorder Act 1998.
Racially or religiously aggravated assault occasioning actual bodily harm
This offence is created by section 29(1)(b) of the Crime and Disorder Act 1998.
Assault with intent to resist arrest
The offence of assault with intent to resist arrest is created by section 38 of the Offences against the Person Act 1861.
Assaulting a constable in the execution of his duty
Section 89(1) of the Police Act 1996 provides that it is an offence for a person to assault either:
a constable acting in the execution of his duty; or
a person assisting a constable in the execution of his duty.Assaulting a traffic officer
This offence is created by section/10 section 10(1) of the Traffic Management Act 2004.
Assaulting a person designated or accredited under sections 38 or 39 or 41 or 41A of the Police Reform Act 2002
This offence is created by section/46 section 46(1)] of the Police Reform Act 2002. Those sections relate respectively to persons given police powers by a chief police officer, detention contractors retained by police, accredited contractors under a community safety accreditation scheme, and weights and measures inspectors.
Assault on a prison custody officer
This offence is created by section 90(1) of the Criminal Justice Act 1991 (c.53).
Assault on a secure training centre custody officer
This offence is created by section 13(1) of the Criminal Justice and Public Order Act 1994 (c.33).
Assault on officer saving wreck
This offence is created by section 37 of the Offences against the Person Act 1861.
Assaulting an officer of the court
This offence is created by section 14(1)(b) of the County Courts Act 1984.
Cruelty to persons under sixteen
Section 1(1) of the Children and Young Persons Act 1933 provides that it is an offence for a person who has attained the age of sixteen years, and who has responsibility for a child or young person under that age, to, amongst other things, willfully assault that child or young person, or to cause or procure that child or young person to be assaulted, in a manner likely to cause him unnecessary suffering or injury to health.
Sexual assault
The offence of sexual assault created by section 3 of the Sexual Offences Act 2003. It is not defined in terms of the offences of common assault or battery. It instead requires intentional touching and the absence of a reasonable belief in consent.

Scotland
In Scots Law, assault is defined as an "attack upon the person of another". There is no distinction made in Scotland between assault and battery (which is not a term used in Scots law), although, as in England and Wales, assault can be occasioned without a physical attack on anothers person, as demonstrated in Atkinson v. HM Advocate wherein the accused was found guilty of assaulting a shop assistant by simply jumping over a counter wearing a ski mask. The court said:

[A]n assault may be constituted by threatening gestures sufficient to produce alarm
Scottish law also provides for a more serious charge of aggravated assault on the basis of such factors as severity of injury, the use of a weapon, or Hamesucken (to assault a person in their own home). The mens rea for assault is simply "evil intent", although this has been held to mean no more than that assault "cannot be committed accidentally or recklessly or negligently" as upheld in Lord Advocates Reference No 2 of 1992 where it was found that a "hold-up" in a shop justified as a joke would still constitute an offence.
It is a separate offence to assault on a constable in the execution of their duty, under Section 90, Police and Fire Reform (Scotland) Act 2012 (previously Section 41 of the Police (Scotland) Act 1967) which provides that it is an offence for a person to, amongst other things, assault a constable in the execution of their duty or a person assisting a constable in the execution of their duty.

Northern Ireland
Several offences of assault exist in Northern Ireland. The Offences against the Person Act 1861 creates the offences of:

Common assault and battery: a summary offence, under section 42;
Aggravated assault and battery: a summary offence, under section 43
Common assault: under section 47
Assault occasioning actual bodily harm: under section 47The Criminal Justice (Miscellaneous Provisions) Act (Northern Ireland) 1968 creates the offences of:

Assault with intent to resist arrest: under section 7(1)(b); this offence was formerly created by s.38 of the OAPA 1861.That Act formerly created the offence of Assault on a constable in the execution of his duty. under section 7(1)(a), but that section has been superseded by section 66(1) of the Police (Northern Ireland) Act 1998 (c.32) which now provides that it is an offence for a person to, amongst other things, assault a constable in the execution of his duty, or a person assisting a constable in the execution of his duty.

United States
In the United States, assault may be defined as an attempt to commit a battery. However, the crime of assault can encompass acts in which no battery is intended, but the defendants act nonetheless creates reasonable fear in others that a battery will occur.Four elements were required at common law:
The apparent, present ability to carry out;
An unlawful attempt;
To commit a violent injury;
Upon another.As the criminal law evolved, element one was weakened in most jurisdictions so that a reasonable fear of bodily injury would suffice. These four elements were eventually codified in most states.
The crime of assault generally requires that both the perpetrator and the victim of an assault be a natural person. Thus, unless the attack is directed by a person, an animal attack does not constitute an assault. However, under limited circumstances the Unborn Victims of Violence Act of 2004 treats a fetus as a separate person for the purposes of assault and other violent crimes.Possible examples of defenses, mitigating circumstances, or failures of proof that may be raised in response to an assault charge include:

Lack of intent: A defendant could argue that since they were drunk, they could not form the specific intent to commit assault. This defense would most likely fail, however, since only involuntary intoxication is accepted as a defense in most American jurisdictions.
Mutual consent: A defendant could also argue that they were engaged in mutually consensual behavior. For example, boxers who are fighting in an organized boxing match and do not significantly deviate from the rules of the sport cannot be charged with assault.

State laws
Laws on assault vary by state. Since each state has its own criminal laws, there is no universal assault law. Acts classified as assault in one state may be classified as battery, menacing, intimidation, reckless endangerment, etc. in another state. Assault is often subdivided into two categories, simple assault and aggravated assault.

Simple assault involves an intentional act that causes another person to be in reasonable fear of an imminent battery. Simple assault may also involve an attempt to cause harm to another person, where that attempt does not succeed. Simple assault is typically classified as a misdemeanor offense, unless the victim is a member of a protected class, such as being a law enforcement officer. Even as a misdemeanor, an assault conviction may still result in incarceration and in a criminal record.
Aggravated assault involves more serious actions, such as an assault that is committed with the intent to cause a serious bodily injury, or an assault that is committed with a deadly weapon such as a firearm. Aggravated assault is typically classified as a felony offense.Modern American statutes may define assault as including:

an attempt to cause or purposely, knowingly, or recklessly causing bodily injury to another
negligently causing bodily injury to another with a dangerous weapon (assault with a deadly weapon).
causing bodily harm by reckless operation of a motor vehicle (vehicular assault).
threatening another in a menacing manner.
knowingly causing physical contact with another person knowing the other person will regard the contact as offensive or provocative
causing stupor, unconsciousness or physical injury by intentionally administering a drug or controlled substance without consent
purposely or knowingly causing reasonable apprehension of bodily injury in another
any act which is intended to place another in fear of immediate physical contact which will be painful, injurious, insulting, or offensive, coupled with the apparent ability to execute the act.In some states, consent is a complete defense to assault </s>


<s> [INST] <<SYS>> You are a responsible assistant committed to providing accurate and helpful responses. Avoid sharing harmful or biased content. Clarify any unclear or incorrect questions rather than providing false or misleading information. <</SYS>> What is Mouth breathing and can you explain it in depth? [/INST] Mouth breathing, medically known as chronic oral ventilation, is long-term breathing through the mouth. It often is caused by an obstruction to breathing through the nose, the innate breathing organ in the human body. Chronic mouth breathing may be associated with illness. The term "mouth-breather" has developed a pejorative slang meaning.

Etymology
In the early 20th century, "mouth-breather" was a technical term used by doctors to describe children who were breathing through their mouths due to an underlying medical condition. English lexicographer Jonathon Green notes that by 1915, the phrase "mouth-breather" had developed a pejorative connotation within English slang, defined as a "stupid person." Currently, the Macmillan Dictionary defines the term "mouth breather" as a pejorative noun that is used to mean "a stupid person."

Overview
Jason Turowski, MD of the Cleveland Clinic states that "we are designed to breathe through our noses from birth — its the way humans have evolved." Thus, the impact of chronic mouth breathing on health is a research area within orthodontics (and the related field of myofunctional therapy) and anthropology. It is classified into three types: obstructive, habitual, and anatomic.: 281 Nasal breathing produces nitric oxide within the body, while mouth breathing does not. In addition, the Boston Medical Center notes that the nose filters out particles that enter the body, humidifies the air we breathe and warms it to body temperature. In contrast, however, mouth breathing "pulls all pollution and germs directly into the lungs; dry cold air in the lungs makes the secretions thick, slows the cleaning cilia, and slows down the passage of oxygen into the bloodstream." As a result, chronic mouth breathing may lead to illness. In about 85% of cases, it is an adaptation to nasal congestion,: 281  and frequently occurs during sleep. More specialized causes include: antrochoanal polyps;: 350  a short upper lip which prevents the lips from meeting at rest (lip incompetence);: 281  and pregnancy rhinitis which tends to occur in the third trimester of pregnancy.: 435

Potential effects
Conditions associated with mouth breathing include cheilitis glandularis,: 490  Down syndrome,: 365  anterior open bite,: 225  tongue thrusting habit,: 225  cerebral palsy,: 422  ADHD, sleep apnea, and snoring. In addition, gingivitis,: 85  gingival enlargement,: 85  and increased levels of dental plaque: 108  are common in persons who chronically breathe through their mouths. The usual effect on the gums is sharply confined to the anterior maxillary region, especially the incisors (the upper teeth at the front). The appearance is erythematous (red), edematous (swollen) and shiny. This region receives the greatest exposure to airflow during mouth breathing, and it is thought that the inflammation and irritation is related to surface dehydration, but in animal experimentation, repeated air drying of the gums did not create such an appearance.: 85 Breathing through your mouth decreases saliva flow. Saliva has minerals to help neutralize bacteria, clean off the teeth, and rehydrate the tissues. Without it, your risk of gum disease and cavities increases.Chronic mouth breathing in children may affect dental and facial growth. It may also lead to the development of a long, narrow face, sometimes termed long face syndrome. Conversely, it has been suggested that a long thin face type, with corresponding thin nasopharyngeal airway, predisposes to nasal obstruction and mouth breathing.

Additional approaches to mouth breathing
George Catlin
George Catlin was a 19th-century American painter, author, and traveler, who specialized in portraits of Native Americans in the Old West. Travelling to the American West five times during the 1830s, he wrote about, and painted portraits that depicted, the life of the Plains Indians. He was also the author of several books, including The Breath of Life (later retitled as Shut Your Mouth and Save Your Life) in 1862 </s>