Septic Arthritis Due to Staphylococcus Warneri: A Diagnostic Challenge
Barbara Legius, Kristel Van Landuyt, Patrick Verschueren, Rene Westhovens*
A septic arthritis due to an indolent infection is a challenge for timely diagnosis. In recent years septic arthritides due to Staphylococcus Warneri are increasingly reported, mostly as a complication in patients with prosthetic devices. We report on a case of a 38 year old immunocompetent male with an indolent infection with this commensal of the skin after a stay at an intensive care unit and review the available literature. Tissue cultures obtained by arthroscopy might be helpful in obtaining a correct diagnosis.
Septic arthritis is usually seen as an acute monoarthritis leading to rapid joint destruction without proper and timely treatment. More indolent infections however often escape timely diagnosis. We report on a case of a 38 year old immunocompetent male patient with an indolent septic arthritis due to Staphylococcus Warneri. The current sparse literature on infections with this commensal of the skin is reviewed with a special focus on prosthetic device infections. There is always a risk of false diagnoses of infections with commensals because of sample contamination, but tissue cultures can be very helpful in obtaining a correct diagnosis.
The patient was referred with a 6 month history of a warm, swollen and painful right knee. Initially there was redness, which resolved spontaneously. First symptoms occurred 10 weeks after a car accident which resulted in a craniocerebral trauma, with coma and intracranial hypertension, requiring temporary ventricular drainage. During ICU stay, he developed a sepsis with Klebsiella Pneumoniae and Pseudomonas Aeruginosa and there was a period of multi-organ failure. Swelling of the right knee was only noticed at the start of rehabilitation and no evidence of infection was found in the synovial fluid. There was no knee trauma reported at the time of the car accident nor during hospital stay. He was referred for further diagnosis. Patient consented orally for anonymous publication of this case report.
Staphylococcus Warneri is a coagulase-negative staphylococcus. It is a commensal of the skin, found in 50% of the population. This species usually represents less than 1% of the total staphylococcal population . Coagulase-negative staphylococci have become common nosocomial pathogens . They are an etiologic agent of infections of prosthetic devices . A few cases of S. Warneri infections have been reported in the literature. Septicaemia, endocarditis, discitis, osteomyelitis, subdural empyema and urinary tract infections have been described [4,5]. So far, 7 cases of S. Warneri endocarditis have been reported , as have been 4 cases of S. Warneridiscitis . In a series of orthopedic implant infections, Arciola et al. found S. Warneri in 2.6% of the cases [6, 7]. Campoccia et al. described articular infections with S. Warneri in the absence of prosthetic material S. Warneri related infections have also been reported in neonates . Cimiotti et al. found that S. Warneri can be pathogenic in neonates. Out of 647 bacterial isolates associated with clinical infection in neonates in a neonatal intensive care unit, 17 infections were caused by S. Warneri, including 15 bloodstream infections, 1 skin infection and 1 eye infection .
However, coagulase negative staphylococci, such as S. Warneri, as commensals of the skin, areconsidered frequent contaminants of blood cultures as well . Eng et al. reported a series of 142 patients with coagulase negative staphylococci positive blood cultures. In 96 patients only one single blood culture bottle revealed staphylococci and in these patients the presence of coagulase negative staphylococci was therefor considered as a contamination . In clinical practice therefore the diagnosis of a S. Warneri infection will depend on the weight of the evidence that this commensal could indeed be responsible for the symptoms and signs under consideration.
In this case report, we report an articular infection with S. Warneri without orthopedic implant. It is possible that S. Warneri entered the blood stream through a catheter during an admission at an ICU, 10 weeks before onset of symptoms. S. Warneri is known to be of low virulence and grow slowly . This might explain the delay between exposure of S. Warneri and onset of symptoms. Because of negative cultures of articular fluid there was a considerable delay to diagnosis. Cultures of synovial tissue, obtained by arthroscopy, revealed the causative agent as being a Staphylococcal Warneri. This case is instructive because it emphasizes the importance of tissue sampling in arthritis of unknown origin. In the absence of positive articular fluid cultures, an arthroscopic intervention with collection of synovial biopsies can lead to a diagnosis.
Culture of tissue obtained by surgical intervention might be important in other infections of unknown etiology as well. Abgrall et al. reports a prosthetic valve endocarditis due to S. Warneri, with a lack of positive blood cultures. Culture of vegetation tags of the surgically removed prosthetic valve revealed a Staphylococcus Warneri .
Staphylococcus Warneri is a coagulase negative staphylococcus that infrequently causes infections of prosthetic devices . Diagnosis can be challenging due to low virulence and slow growth . We present a case of arthritis of the knee due to S. Warneri, in the absence of a prosthetic device. Diagnosis was established by culture of arthroscopically obtained synovial tissue. This case is instructive because it emphasizes the importance of tissue sampling in arthritis of unknown origin. In the absence of positive articular fluid cultures, arthroscopic intervention can lead to a diagnosis.