Nicknamed La Chiesoletta, it was the first church built in Garbatella, in 1818. It was on the pilgrim route between San Sebastiano and San Paolo fuori le Mura, the Via delle Sette Chiese (named after the seven patriarchal basilicas, not any local churches). It used to be the parish church for the locality, but its development as a suburb made it too small for the purpose and it was replaced by San Filippo Neri. This is next door, at number 103. Isidore was a bishop of Seville, and Eurosia a girl martyred by Muslims in Spain in the 8th century.
It is a plain little box of a building, with an attached pedimented gateway porch attributed to Valadier.
The roadside wall features a pair of round relief medallions of St Philip Neri and St Charles Borromeo, after a legend that the two saints met here in 1575. The church’s connection with the former saint accounts for the presence of the Oratorians in Garbatella.
The porch contains three plaster reliefs attributed to Canova, of the Virgin and Child with St John the Baptist; the Baptism of Christ, and Christ Welcoming the Children.
The high altar is in polychrome marble.