On the cover: Epithelial invasion and dissemination of Shigella is facilitated by ATP released through connexin hemichannels on the epithelial membrane. Romero et al. (pp. 508–519) discover that prior to contact with the cell body, Shigella is captured by nanometer-thin micropodial extensions (NMEs) at a distance from the cell surface. The capture process involves the bacterium's type III secretion system tip complex proteins and is stimulated by ATP- and connexin-mediated signaling. Upon bacterial contact, NMEs retract, bringing bacteria in contact with the cell body where invasion occurs. The scanning electron micrograph on the cover shows wild-type Shigella interacting with a NME during the early stages of bacterial invasion. The cover image was taken using a JEOL JSM 6700F field emission scanning electron microscope operating at 5 Kv.