Combined Factor V and Factor VIII Deficiency
Combined factor V (FV) and factor VIII (FVIII) deficiency is a very rare inherited bleeding disorder. It is completely separate from factor V deficiency and FVIII deficiency. Factor V and factor VIII are proteins in the blood which help blood clot. In this disorder, levels of both factors are much lower than normal. It is more common in communities where there are often marriages between close relatives and most cases are found around the Mediterranean Sea, especially in Israel, Iran, and Italy.