Nasal Therapy May Halt Memory Loss in Alzheimer’s Patients
In line with earlier research, inflammation is associated with Alzheimer’s, and current treatments to reduce inflammation in people who have this disease are not successful or lead to adverse reactions. Nevertheless, a new study on mice discovered that intranasal medicine delivery might stop memory loss in people living with Alzheimer’s. Researchers believe this treatment to be effective in people too.
Although the number of Alzheimer’s patients constantly grows, there is no cure for it by far. However, researchers speculate that neuroinflammation might be involved. This study aims to examine the impact of inflammation on Alzheimer’s disease.
The research team managed to effectively stop memory decay in mice with Alzheimer’s by noninvasive intranasal application of specific medication that facilitates the resolution of neuroinflammation. They believe this approach may have a strong therapeutic effect on the brain, unlike intravenous therapy, which is more complex. Also, intranasal medicine administration is painless.
Scientists discovered that Alzheimer’s stops the brain’s neurons from communicating for a while and blocks their connection. As per the study’s results, this method may positively impact the brain rather than negatively. In addition, they indicate that neuroinflammation may also trigger the disease. In view of the fact that neuroinflammation acts as a defense mechanism, it was not considered that anti-inflammatory treatment might aid Alzheimer’s patients.
Many previous studies did not demonstrate a direct effect of anti-inflammatory medication used to reduce Alzheimer’s progression. Moreover, the findings were limited due to methodological problems. However, it seems that noninvasive intranasal application steers clear of these methodological problems.