People with unicentric Castleman disease usually do well once the affected lymph node is removed. However, having Castleman disease may increase your risk of lymphoma.
Complications of multicentric Castleman disease can be life-threatening and may include:
- Infection leading to the failure of multiple organs
- Cancer, such as lymphoma or Kaposi's sarcoma
The outlook for people with multicentric Castleman disease varies, depending on the nature of their disease. The presence of HIV/AIDS tends to worsen the outcome.
Research also indicates that people who have multicentric Castleman disease with POEMS syndrome that doesn't involve bone lesions may have worse outcomes, while people who have multicentric Castleman disease with the bone lesion variant of POEMS syndrome tend to do better.