Herman T. Briscoe Professor
Analytical, biological, inorganic, organic, and physical chemistry.
(See also general University Graduate School requirements.)
This degree may be conferred upon the holder of a bachelor's degree or master's degree in another discipline.
The M.A.T. program permits a secondary school teacher with minimum training in chemistry to achieve certification for the teaching major in chemistry in the secondary school. Teachers already holding such certification may strengthen their training by taking advanced lecture and laboratory work in chemistry. Students with B.A. or B.S. degrees in chemistry, but with no education courses, may complete requirements for a secondary Indiana teaching certificate and strengthen their chemistry training.
Offered by the School of Library and Information Science. Students in this joint program receive the Master of Library Science degree or the Master of Information Science degree and are certified as information specialists in chemistry.
The program leading to the Ph.D. degree emphasizes the attainment of a high level of competency in a specialized area of chemistry, but also requires the development of broad knowledge and experience. By the time the degree is earned, the student should show promise of becoming a capable and independent investigator in chemistry. The major emphasis for the Ph.D. is on research while in residence on the Bloomington campus. Research should be the student's greatest challenge and the focus of the major portion of his or her energy. The student's attitude toward and progress in research is a most important factor in graduate committee decisions.
A doctoral student in chemistry can choose to minor within the chemistry department or can elect to minor in some other department. In the latter case, the requirements are specified by the minor department. Students electing to minor within the department must complete a minimum of 6 credit hours in areas of chemistry other than the major area. The course work comprising an inside minor must be approved by the advisory committee.
All doctoral students in chemistry are required to enroll in C500 Introduction to Research during their first year of study.
Ph.D. Minor in Chemistry
C315 Chemical Measurements Laboratory I (3 cr.)
C502 Spectroscopic Methods in Inorganic Chemistry (3 cr.) P: C361. Chemical applications of group theory and the elucidation of structure and bonding in inorganic molecules and complexes by vibrational, nuclear magnetic resonance, Mossbauer and electronic absorption spectroscopy.
C503 Spectrometric Methods of Structure Determination (3 cr.) P: graduate standing. Elucidation of molecular structure utilizing IR, UV, and NMR spectroscopy, mass spectrometry, and other methods.
C506 Biogeochemistry (3 cr.) The formation and processing of organic material in natural environments. Microbiology of sediments. The global biogeochemical cycles of carbon, nitrogen, and sulfur. Geochemistry of organic materials. Organic geochemical evidence of evolutionary events.
C509 Special Laboratory Problems (1-5 cr.) Nonmajors only. P: 8 credit hours of chemistry toward graduate degree, consent of instructor. P or C: 500-level lecture course in research field. Participation in scientific research to gain understanding of its philosophy and techniques.
C511 Advanced Analytical Methods I (4 cr.) Theory and practice of analytical separation techniques and analytical spectroscopy; chromatographic methods of separation, fundamentals of gas and liquid chromatography, overview of spectroscopic instrumentation, atomic and molecular spectroscopy for analysis.
C512 Advanced Analytical Methods II (4 cr.) Theory and practice of electrochemical (potentiometric and voltammetric) methods of analysis; introduction to analytical chemistry of the elements and statistics for analytical chemistry.
C540 Advanced Organic Chemistry (3 cr.) P: C362 and C342. Valence and molecule structure, electronic interpretation of organic reactions, stereochemistry.
C543 Organic Reactions (3 cr.) Synthesis of organic compounds, degradation reactions, selected topics in organic reactions.
C561 Atomic and Molecular Quantum Theory (3 cr.) P: graduate standing or consent of instructor. Elements of quantum theory, solution of elementary problems with chemical applications, approximate methods, atomic structure, molecular symmetry and normal vibrations, the molecular orbital description of molecules.
C562 Computational Quantum Chemistry (3 cr.) P: C561 or consent of instructor. Electronic structure theory at the Hartree-Fock and semiempirical levels, computer calculations on elementary systems, elements of group theory and linear vector spaces, electron correlation, structure of potential surfaces.
C566 Molecular Optical Spectroscopy (3 cr.) P: C561 or consent of instructor. Interaction of radiation with matter. Spectroscopic probes of the rotational, vibrational, and electronic structure of molecules. Advanced laser methods.
C568 Advanced Statistical Mechanics (3 cr.) P: C567 or consent of instructor. Selected topics such as pair correlation functions in classical liquids, laser and reaction-transport, nonequilibrium phenomena, critical phenomena, reaction rates, condensed media, NMR, precipitation and polymer kinetics, Green's function methods, and computational methods.
C571 Chemical Information Technology (3 cr.) P: consent of instructor. Chemical structure and data representation and search system; chemical information and database system: laboratory information management systems, spectral and crystallographic databases, chemical reaction databases, patent information management systems, commercial chemical information databases, electronic chemical publishing systems; bio-informatics.
C572 Computational Chemistry and Molecular Modeling (3 cr.) P: C571 or consent of instructor. Molecular modeling: computer models of molecules and their behavior in gas and condensed phases; implicit and explicit solvation models; quantum and molecular mechanics; search strategies for conformational analysis, geometry optimization methods; information content from Monte Carlo and molecular dynamics simulations. Statistics and chemometrics: multivariate statistics and experimental design, numerical methods, calibration and chemical analysis, optimization methods, artificial intelligence. Molecular design: de novo design techniques; quantitative structure activity relationships (QSAR); comparative molecular field analysis (CoMFA); docking; molecular diversity and combinatorial libraries.
C578 Seminar: Chemical Informatics (1-3 cr.) P: C571 or consent of the instructor. Topics vary yearly and include the following: chemometrics, chemical publishing and display of chemical electronic information, bibliometrics, patent searching, among others. II Sem.
C581 Macromolecular Structure and Interaction (3 cr. Principles of inter- and intro- molecular interactions; structural stability of proteins and nucleic acids; thermodynamic and kinetic analysis of complex binding; experimental methods for analysis of macromolecular structure and binding.
C582 Biomolecular Catalysis (3 cr.) PTheory and analysis of biochemical catalysis; enzyme kinetics; cofactors; regulation of enzymatic reactions.
C585 Structure and Function of Biological Membranes (3 cr.) Biochemistry and biophysics of lipids, membranes, and membrane proteins; fundamentals of membrane transport; interfacial catalysis; transmembrane signal transduction.
C611 Electroanalytical Chemistry (1.5-3 cr.).) Theory and practice of electrochemical techniques (such as cyclic voltammetry, chronocoulometry, stripping analysis, thin-layer electrochemistry, and spectroelectrochemistry) used for analysis and for the characterization of inorganic and organic systems. (May be offered in alternate years.)
C612 Spectrochemical Methods of Analysis (1.5-3 cr.) New instrumentation and techniques employed in spectrochemistry; in-depth treatment of commonly used spectrochemical methods. (May be offered in alternate years.)
C613 Mass Spectrometry and Stable Isotopes (1.5-3 cr.) Topics in mass spectroscopic instrumentation and applications and in the natural chemistry of the stable isotopes of C, H, N, O, S, and rare gases. (May be offered in alternate years.)
C614 Chromatography (1.5-3 cr.) Theoretical and practical aspects of chromatographic methods of separation; fundamentals of gas and liquid chromatography, related instrumentation, and selected applications. (May be offered in alternate years.)
C615 Bioanalytical Chemistry (1.5-3 cr.) Survey of modern analytical techniques, including spectrochemical, electrochemical, and separation methods, used in biochemical analysis and their applications. (May be offered in alternate years.)
C616 Surface Analysis and Surface Chemistry (1.5 cr.) An overview of the modern instrumental techniques of surface analysis will be presented, together with a survey of their applications to solve surface chemical problems. Topics include electron and ion spectroscopies, SIMS, LEED, thermal desorption spectroscopy, surface electron and ion microscopies, catalysis, microelectronics fabrication, and corrosion.
C619 Seminar: Analytical Chemistry (1 cr.) P: consent of instructor. Individual student seminars covering new methods or applications of chemical analysis or characterization. Required of all analytical chemistry majors.
C630 Structure and Bonding (3 cr.) P: C502 and C561. Applications of quantum mechanics to the electronic and geometric structure of inorganic molecules. Advanced ligand field and molecular orbital theories. The Jahn-Teller effects and orbital symmetry studies of stereochemistry. Inorganic photochemistry. (May be offered in alternate years.)
C632 Structure, Function, and Spectroscopy of Metal Ions in Biological Systems (3 cr.) Introduction to the field of bioinorganic chemistry and spectroscopic methods for determining structure/function relationship of metal ions in biology. Emphasis on oxygen carriers, metal ion transport and storage, as well as oxidoreductases involved in oxygen, hydrogen, and nitrogen metabolism. A discussion of electron transfer proteins, photosystems, and the role of metals in medicine will also be included.
C633 Inorganic Chemistry of Main Group Elements (3 cr.) The syntheses, structure, and industrial application of compounds and materials in which main group elements play a major role. All elements except the d-block transition metals are included as main group elements. This includes the f-block lanthanides and actinides as well.
C634 Transition Metal Chemistry (3 cr.) Survey of the properties of the transition metals with emphasis on common oxidation levels, coordination geometries, and compounds with "classical" ligands; "hard" and "soft" acids and bases; d-orbitals and their energies in different geometries; formation constants and the Chelate Effect; the Jahn-Teller theorem; low-, intermediate-, and high-spin systems; mixed valency; metal-ligand multiple bonding, metal-metal bonds; coordination clusters and their biological relevance.
C635 Mechanisms of Inorganic Reactions (3 cr.) Analysis of the experimental and theoretical basis for our understanding of the reactions associated with main group and transition metal ions and inorganic reagents in solution. Classes of reactions include ligand substitutions, redox reactions, electron transfer reactions, reactions within the coordination sphere of metal ions including catalysis by photochemical and electrochemical activation.
C636 Organometallic Chemistry and Catalysis (3 cr.) Synthesis and reactivity of organo-main group and transition metal compounds, including application to organic synthesis. Predictive principles and generic C-C and C-H bond-forming reactions, including hydrogenation, coupling, addition to olefins or alkynes, and metatheses. These reactions are also extended to reactions on surfaces and solid-state processes.
C637 Physical Methods in Structural Chemistry (3 cr.) Application of X-ray diffraction, dynamic NMR and mass spectroscopy to structural and mechanistic problems throughout the periodic table, with emphasis on what techniques are optimal for particular questions, as well as the potential weaknesses of each.
C638 Seminar: Inorganic Chemistry (1-3 cr.) P: consent of instructor. Topics not ordinarily covered by regularly scheduled courses, such as boron hydrides, X-ray diffraction, metal-metal bonds, bioinorganic chemistry, platinum metals chemistry, inorganic photochemistry, etc. (May be offered in alternate years.)
C639 Characterization of Paramagnetic Molecules (3 cr.) Definitions of diamagnetism, paramagnetism, magnetization and magnetic susceptibility; the Curie Law; orbital angular momentum; the Van Vleck equation; zero-field splitting; exchange interactions in dinuclear and polynuclear metal clusters. Basic concepts of paramagnetic NMR; spin delocalization mechanisms and isotropic shifts; contact and dipolar contributions. EPR of transition complexes; g-value anisotropy as a function of coordination geometry.
C643 Organic Natural Products (3 cr.) P: C540 and C543; or consent of instructor. Synthesis and chemical-physical analysis of the structure of alkaloids, antibiotics, bacterial metabolites, plant pigments, steroids, and terpenes. (May be offered in alternate years.)
C644 Physical Organic Chemistry (1-3 cr.) P: C342 and C362. Application of physical-chemical techniques to the study of structure and mechanism of reaction of organic compounds.
C648 Seminar: Organic Chemistry (1-3 cr.) P: consent of instructor. Recent developments in such areas as sulfur compounds, heterocycles, stereochemistry, polymers, and synthesis. (May be repeated.)
C668 Seminar: Physical Chemistry (1-3 cr.) P: consent of instructor. Topics such as chemical applications of matrix algebra and group theory, digital computing techniques, solid state chemistry, high temperature processes, electrochemistry, theory of solutions, spectroscopy, and surface chemistry. (May be repeated.)
C681 Advanced Protein Biosynthesis and Processing (1.5 cr.) Detailed analysis of protein synthesis, post-translational modification, and macromolecular assembly, including the role these modifications play in mature protein function, biosynthesis, structure, function, and analysis of complex oligosaccharides.
C683 Advanced Nucleic Acid Biochemistry (1.5 cr.) Mechanistic analysis of nucleic acid metabolism; specificity and role of DNA polymerases and repair pathways; DNA replication and recombination mechanisms; RNA structural motifs and physical properties; RNA synthesis and processing in gene expression; catalytic RNA molecules; applications of RNA molecules.
C685 Advanced Macromolecular Structure and Interaction (1.5 cr.) Supplements and extends B503; emphasis on stability and folding mechanisms of proteins and nucleic acids and detailed thermodynamic analysis of binding interactions.
C686 Structural Methods (1.5 cr.) Fundamental principles of circular dichrosim, nuclear magnetic resonance, and X-ray crystallography in the study of protein and nucleic acid structures. Theoretical and practical aspects will be presented, with particular emphasis on application strategies.
C688 Seminar in Biochemistry Attendance and participation in the weekly Biochemistry Program seminar series.
C810 Research: Analytical Chemistry (cr. arr.)*
C830 Research: Inorganic Chemistry (cr. arr.)*
C840 Research: Organic Chemistry (cr. arr.)*
C860 Research: Physical Chemistry (cr. arr.)*
C880 Research: Biological Chemistry (cr. arr.)*