Methamphetamine Use Associated With Pulmonary Arterial Hypertension In Patients With Previously Unknown Risk Factors
"We are seeing more and more PAH patients come into the clinic that are current or former methamphetamine users," said Richard Channick, M.D., professor of clinical medicine, Pulmonary and Critical Care Division at UCSD. "There is an urgency to get this message out to drug rehabilitation centers and physicians seeing patients with a history of substance abuse, and make sure they are aware of this association and of the symptoms of PAH. PAH is often misdiagnosed because the symptoms are similar to those seen with asthma and other respiratory conditions."
"Over the past few years, our physicians have made significant progress toward improving the lives of patients with PAH through earlier diagnosis, increased disease recognition, and continued development of effective therapies," said Rino Aldrighetti, president of the PHA. "However, we need to increase awareness among physicians, drug rehabilitation centers, and the general public about this association between methamphetamine usage and the development of PAH so that patients can receive proper treatment as early as possible."
In a retrospective study entitled, "Is Methamphetamine Use Associated With Idiopathic Pulmonary Arterial Hypertension," published in the December 2006 issue of CHEST, Dr. Kelly Chin and colleagues at UCSD studied rates of stimulant use -- any reported use of amphetamine, methamphetamine, or cocaine -- in 340 patients with either IPAH, PAH resulting from a known risk factor, or chronic thromboembolic pulmonary hypertension. A history of stimulant use was found in 29 percent of patients with a diagnosis of idiopathic PAH, compared with 4 percent of patients with PAH and a known risk factor, and 4 percent of patients with chronic thromboembolic pulmonary hypertension. After adjustment for differences in age and gender, patients with idiopathic PAH were eight to ten times more likely to have used stimulants than patients with these other forms of pulmonary hypertension.