Respiratory medicine research at Midland
Respiratory diseases and disorders have a range of negative outcomes for those affected, with a reduced quality of life and an increased risk of hospitalisation. Our research aims to ensure patients are confident to manage their condition and are therefore able to have a better quality of life.
Respiratory diseases, including lung cancer, are very common in Australia. Lung cancer itself is the fourth most commonly diagnosed cancer and the most common cause of cancer-related death in both men and women. With a focus on multi-disciplinary effort across a varying range of respiratory medicine and healthcare, we aim to improve patient outcomes with knowledge and capacity development.
• A prospective cohort study looking at whether the levels of exhaled nitric oxide during an acute exacerbation of Chronic Obstructive Pulmonary Disease can predict which patients will be at higher risk of further hospital admissions over 12 months.
• Collaboration with Curtin University to evaluate the significance of physical activity and sedentary behaviour on the prognosis of patients with primary lung cancer who are not undergoing lung resection.
Manners, D., Wilcox, H., McWilliams, A., Piccolo, F., Liira, H., & Brims F. (2018) Current lung cancer screening practice amongst general practitioners in Western Australia: a cross-sectional study. Journal of Internal Medicine 48(1):78-80. doi.org/10.1111/imj.13670
Manners, D., Emery, J., Brims, J., & Pettigrew, S. (2016) Lung cancer screening - practical challenges of confining participation to those who might benefit. Australian New Zealand Journal of Public Health 40(3):205-6. doi.org/10.1111/1753-6405.12516
Popowicz, N., Bintcliffe, O., De Fonseka, D., Blyth, G., Smith, A., Piccolo, F., Martin, G., Wong, D., Edey, A., Maskell, N., & Lee, G. (2017) Dose De-escalation of Intrapleural Tissue Plasminogen Activator Therapy for Pleural Infection. The Alteplase Dose Assessment for Pleural Infection Therapy Project. Annals American Thoracic Society 14(6):929-936. doi.org/10.1513/AnnalsATS.201609-673OC
See K, Manser R, Park ER, Steinfort D, King B, Piccolo F, Manners D. (2020) The impact of perceived risk, screening eligibility and worry on preference for lung cancer screening: a cross-sectional survey. ERJ Open Res.;6(1):00158-2019. Published 2020 Mar 16. doi.org/10.1183/23120541.00158-2019
Thomas, R., Fysh, E., Smith, A., Lee, P., Kwan, H., Yap, E., Horwood, C., Piccolo, F., Lam, L., Garske, A., Shrestha, R., Kosky, C., Read, A., Murray, K., & Lee, G. (2017) Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients With Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial. Journal of American Medical Association 318(19):1903-1912. doi.org/10.1001/jama.2017.17426
Weber, M., Yap, S., Goldsbury, D., Manners, D., Tammemagi, M., Marshall, H., Brims, F., McWilliams, A., Fong, K., Kang, J., Caruana, M., Banks, E., Canfell, K. (2017) Identifying high risk individuals for targeted lung cancer screening: Independent validation of the PLCOm2012 risk prediction tool. International Journal of Cancer 15:141(2):242-253. doi: 10.1002/ijc.30673. Epub 2017 Apr 21. doi.org/10.1002/ijc.30673