Despite advances in modern medicine, science and technology, information sciences, difficulties many challenges especially in health and medicine remain unresolved. Several years of research involving botany, chemistry, pharmacology no significant outcome has been achieved neither in basic understanding of health and disease nor in medicine, drugs or therapies. In the process neither Science nor Shastra appear to have been much benefitted. Knowledge from Shastra can help to address present challenges in Science. The foundational logic and basic concepts can give new leads. This talk gives few examples including genetics and prakriti, bhasma and nano particles, rasayana and regenerative biology, personalized and integrative medicine to discuss how Shastra (OM) can give newer insights to basic sciences (Genome).