On March 1st, 2016, American astronaut Scott Kelly returned to Earth after spending a total of 340 days aboard the International Space Station (ISS). As part of NASA’s goal to send astronauts on long-duration space flights to Mars and beyond, this record-setting stay in space was designed to test the limit of human endurance in a microgravity environment.
Also known as the Twin Study, this experiment consisted of Kelly spending nearly a year in space while his identical twin (Mark Kelly) remained on Earth. Since Kelly’s return, the two have been subjected to medical tests to see what long-term effects microgravity has had of Scott’s Kelly’s physique. The final results of this test, which were just released, reveal that Scott has experienced changes at the genetic level.
The study was conducted by NASA’s Human Research Program, and the preliminary findings were released at their Investigator’s Workshop on the week of January 23rd, 2017. According to these findings, Scott Kelly showed indications of inflammation, changes in his telomeres and telomerase (parts of the chromosonal system related to aging), a decrease in bone density and gastrointestinal changes – all of which were expected.
As NASA reported in their preliminary findings:
“By measuring large numbers of metabolites, cytokines, and proteins, researchers learned that spaceflight is associated with oxygen deprivation stress, increased inflammation, and dramatic nutrient shifts that affect gene expression… After returning to Earth, Scott started the process of readapting to Earth’s gravity. Most of the biological changes he experienced in space quickly returned to nearly his preflight status. Some changes returned to baseline within hours or days of landing, while a few persisted after six months.”
At the same time, the study took into account possible genomic and cognitive changes between the two brothers. These findings were recently clarified by NASA, which indicated that 93% of Scott Kelly’s genes returned to normal after he returned to Earth while the remaining 7% points were missing. These were attributed to “longer-term changes in genes related to his immune system, DNA repair, bone formation networks, hypoxia, and hypercapnia.”
In other words, in addition to the well-documented effects of microgravity – such as muscle atrophy, bone density loss and loss of eyesight – Scott Kelly also experienced health effect caused by a deficiency in the amount of oxygen that was able to make it to his tissues, an excess of CO2 in his tissues, and long-term effects in how his body is able to maintain and repair itself.
At the same time, the report indicated that Scott Kelly experienced no significant changes when it came to cognitive performance. The preliminary findings touched on this, indicating that Scott showed a slight decrease in speed and accuracy when undergoing cognitive performance testing compared to his brother. This decrease was more pronounced when he first landed, but was attributed to readjustment to Earth’s gravity.
Mathias Basner – a professor at the University of Pennsylvania, Philadelphia, who was in charge of conducting the tests – also found no real difference in cognition between 6 month and 12 month missions. This is especially important since typical stays aboard the ISS last six months, whereas long term missions to Mars would take 150-300 days – depending on the alignment of the planets and the speed of the spacecraft.
A two way trip to Mars, as well as the time spent in Mars lower-gravity environment (37.6 % that of Earth’s), could take multiple years. As such, the Twin Study was intrinsic to NASA’s efforts to prepare for its proposed “Journey to Mars“, which is expected to take place sometime in the 2030s. These and other studies being conducted aboard the ISS seek to determine what the long-term effects on astronaut health will be, and how they can be mitigated.
Typically, individual studies are released to appropriate journals more or less one at a time. But in the twins study, the data will be integrated and summarized before individual papers are published on separate themes. The idea is that taken together, their impact on our understanding of prolonged time in space will be much greater.
“The beauty of this study is when integrating rich data sets of physiological, neurobehavioral and molecular information, one can draw correlations and see patterns,” said Tejaswini Mishra, Ph.D., research fellow at Stanford University School of Medicine, who is creating the integrated database, recording results and looking for correlations. “No one has ever looked this deeply at a human subject and profiled them in this detail. Most researchers combine maybe two to three types of data but this study is one of the few that is collecting many different types of data and an unprecedented amount of information.”
Mike Snyder, Ph.D, is the head of a team of people at Stanford that will work to synthesize the data. There are roughly three steps in the overall process:
Individual researchers in areas like cognition, biochemistry, and immunology will analyze and compile their data then share their results with the Stanford team.
The Stanford team will then further integrate those results into larger data sets.
Those larger data sets will then be reviewed and analyzed to confirm and modify the initial findings.
“There are a lot of firsts with this study and that makes it exciting,” said Brinda Rana, Ph.D., associate professor of psychiatry, University of California San Diego School of Medicine. “A comparative study with one twin in space and one on Earth has never been done before. Each investigation within the study complements the other.”
NASA compares the twins study, and the new integrated method of handling all the results, to conducting a symphony. Each study is like an instrument, and instead of each one playing a solo, they will be added into a greater whole. The team at Stanford is like the conductor. If you’ve ever listened to an orchestra, you know how powerful that can be.
“The human systems in the body are all intertwined which is why we should view the data in a holistic way,” said Scott M. Smith, Ph.D., NASA manager for nutritional biochemistry at the Johnson Space Center. He conducts biochemical profiles on astronauts and his research is targeted to specific metabolites, end products of various biological pathways and processes.
“It is a more comprehensive way to conduct research.” – Chris Mason, Ph.D., associate professor, Department of Physiology and Biophysics Weill Cornell Medicine
Chris Mason Ph.D., at Weill Cornell Medicine said, “Both the universe and the human body are complicated systems and we are studying something hard to see. It’s like having a new flashlight that illuminates the previously dark gears of molecular interactions. It is a more comprehensive way to conduct research.”
Scientists involved with the twins study are very clearly excited about this new approach. Having twin astronauts is an extraordinary opportunity, and will advance our understanding of spaceflight on human physiology enormously.
“There is no doubt, the learnings from integrating our data will be priceless,” said Emmanuel Mignot, M.D., Ph.D., director of Center for Sleep Science and Medicine, Stanford University School of Medicine. He studies the immune system and is enthusiastic to study specific immune cell populations because many of the other immune studies focus only on general factors.
These dark, narrow, 100 meter-long streaks called recurring slope lineae flowing downhill on Mars are inferred to have been formed by contemporary flowing water. Recently, planetary scientists detected hydrated salts on these slopes at Hale crater, corroborating their original hypothesis that the streaks are indeed formed by liquid water. The blue color seen upslope of the dark streaks are thought not to be related to their formation, but instead are from the presence of the mineral pyroxene.
The image is produced by draping an orthorectified Infrared-Red-Blue/Green(IRB)) false color image on a Digital Terrain Model (DTM). This model was produced by researchers at the University of Arizona, much like the High Resolution Imaging Science Experiment (University of Arizona). The vertical exaggeration is 1.5.
NASA and Mars planetary scientists announced today (Sept. 28) that salty “liquid water flows intermittently” across multiple spots on the surface of today’s Mars – trumpeting a major scientific discovery with far reaching implications regarding the search for life beyond Earth and bolstering the chances for the possible existence of present day Martian microbes.
Utilizing spectroscopic measurements and imaging gathered by NASA’s Mars Reconnaissance Orbiter (MRO), researchers found the first strong evidence confirming that briny water flows on the Red Planet today along dark streaks moving downhill on crater slopes and mountain sides, during warmer seasons.
“Mars is not the dry, arid planet that we thought of in the past. Today we announce that under certain circumstances, liquid water has been found on Mars,” said Jim Green, NASA Planetary Science Director at NASA Headquarters, at a media briefing held today, Sept 28.
“When you look at Earth, water is an essential ingredient. Everywhere we go where there’s liquid water, whether its deep in the Earth or in the arid regions, we find life. This is tremendously exciting.”
“We haven’t been able to answer the question – does life exist beyond Earth? But following the water is a critical element of that. We now have great opportunities to be in the right locations on Mars to thoroughly investigate that,” Green elaborated.
“Water! Strong evidence that liquid water flows on present-day Mars,” NASA officials tweeted about the discovery.
The evidence comes in the form of the detection of mysterious dark streaks, as long as 100 meters, showing signatures of hydrated salt minerals periodically flowing in liquid water down steep slopes on the Red Planet that “appear to ebb and flow over time.”
The source of the water is likely from the shallow subsurface or possibly absorbed from the atmosphere.
Water is a key prerequisite for the formation and evolution of life as we know it. So the new finding significantly bolsters the chances that present day extant life could exist on the Red Planet.
“Our quest on Mars has been to ‘follow the water,’ in our search for life in the universe, and now we have convincing science that validates what we’ve long suspected,” said John Grunsfeld, astronaut and associate administrator of NASA’s Science Mission Directorate in Washington.
“This is a significant development, as it appears to confirm that water — albeit briny — is flowing today on the surface of Mars.”
“This increases the chance that life could exist on Mars today,” noted Grunsfeld.
The mysterious dark streaks of downhill flows are known as recurring slope lineae (RSL).
They were first detected in 2010 at dozens of sites on the sun facing slopes of deep craters by Lujendra Ojha, then a University of Arizona undergraduate student.
The new finding is highly significant because until today’s announcement, there was no strong evidence that liquid water could actually exist on the Martian surface because the atmospheric pressure was thought to be far too low – its less than one percent of Earth’s.
The flow of water is occasional and not permanent, seasonally variable and dependent on having just the right mix of atmospheric, temperature and surface conditions with salt deposits on Mars.
Portions of Mars were covered with an ocean of water billions of years ago when the planet was far warmer and more hospitable to life. But it underwent a dramatic climate change some 3 billion years ago and lost most of that water.
The RSL with flowing water appear in at least three different locations on Mars – including Hale crater, Horowitz crater and Palikir crater – when temperatures are above minus 10 degrees Fahrenheit (minus 23 Celsius). They appear during warm seasons, fade in cooler seasons and disappear during colder times.
Pure surface water ice would simply sublimate and evaporate away as the temperature rises. Mixing in surface salts lowers the melting point of ice, thereby allowing the water to potentially liquefy on Mars surface for a certain period of time rather than sublimating rapidly away.
“These are dark streaks that form in late spring, grow through the summer and then disappear in the fall,” said Michael Meyer lead scientist for the Mars Exploration Program at NASA Headquarters, at the media briefing.
Years of painstaking effort and laboratory work was required to verify and corroborate the finding of flowing liquid water.
“It took multiple spacecraft over several years to solve this mystery, and now we know there is liquid water on the surface of this cold, desert planet,” said Meyer. “It seems that the more we study Mars, the more we learn how life could be supported and where there are resources to support life in the future.”
Along with the media announcement, the researchers published their findings today in a refereed scientific paper in the Sept. 28 issue of Nature Geoscience.
“We found the hydrated salts only when the seasonal features were widest, which suggests that either the dark streaks themselves or a process that forms them is the source of the hydration. In either case, the detection of hydrated salts on these slopes means that water plays a vital role in the formation of these streaks,” said Lujendra Ojha, now at the Georgia Institute of Technology (Georgia Tech) in Atlanta, and lead author of the Sept. 28 publication in Nature Geoscience.
The scientists “interpret the spectral signatures as caused by hydrated minerals called perchlorates.”
Ojha said the chemical signatures from CRISM were most consistent with the detection of mixtures of magnesium perchlorate, magnesium chlorate and sodium perchlorate, based on lab experiments.
“Some perchlorates have been shown to keep liquids from freezing even when conditions are as cold as minus 94 degrees Fahrenheit (minus 70 Celsius).”
Perchlorates have previously been detected in Martian soil by two of NASA’s surface missions – the Phoenix lander and the Curiosity rover. There is also some evidence that NASA’s Viking missions in the 1970s measured signatures of these salts.
On Earth concentration of perchlorates are found in deserts.
This also marks the first time perchlorates have been identified from Mars orbit.
“One reason why NASA’s discovery of liquid water on #Mars is so exciting: we know anywhere there’s water on Earth, there’s some form of life,” Kelly tweeted today from on board the ISS, upon hearing today’s news.
The discovery of liquid water on Mars could also be a boon to future astronauts who could use it as a natural resource to ‘live off the land’ for sustenance and to make rocket fuel.
“If going to Mars on my Year In Space, I’d arrive soon to find water! H20 > rocket fuel, which means I could find my way back home too!,” Kelly wrote on his Facebook page.
“When most people talk about water on Mars, they’re usually talking about ancient water or frozen water,” Ojha explained.
“Now we know there’s more to the story. This is the first spectral detection that unambiguously supports our liquid water-formation hypotheses for RSL.”
The first ever ‘One-Year Mission’ to the International Space Station (ISS) started with a bang today, March 27, with the spectacular night time launch of the Russian/American crew from the Baikonur Cosmodrome in Kazakhstan at 3:42 p.m. EDT Friday (1:42 a.m., March 28 in Baikonur and culminated with a flawless docking this evening.
NASA astronaut Scott Kelly and Russian cosmonauts Mikhail Kornienko and Gennady Padalka launched aboard a Soyuz TMA-16M spacecraft to the International Space Station precisely on time today on the Expedition 43 mission.
The crew rocketed to orbit from the same pad as Russia’s Yuri Gagarin, the first human in space.
Kelly and Kornienko will spend about a year living and working aboard the space station on the marathon mission. Padalka will remain on board for six months.
The goal is to use the massive orbiting outpost to provide critical knowledge to NASA and researchers hoping to better understand how the human body reacts and adapts to long-duration spaceflight and the harsh environment of space.
The pathfinding mission is about double the normal time of most expeditions to the Earth orbiting space station, which normally last four to six months.
The one-year mission is among the first concrete steps to start fulfilling NASA’s “Journey to Mars” objective of sending “Humans to Mars” in the 2030s.
“Scott Kelly’s mission is critical to advancing the administration’s plan to send humans on a journey to Mars,” said NASA Administrator Charles Bolden, in a statement.
“We’ll gain new, detailed insights on the ways long-duration spaceflight affects the human body.”
This evening the three man international crew successfully rendezvous and docked at the ISS at the Poisk module at 9:33 p.m. EDT – just four orbits and six hours after liftoff.
‘Contact and capture confirmed, 1 year crew has arrived,’ said the NASA launch commentator Don Huot. “The one-year crew has arrived.”
“Soyuz is firmly attached to the ISS.”
Docking took place about 253 kilometers off the western coast of Colombia, South America approximately 5 hours and 51 minutes after today’s flawless launch from Baikonur.
The crews are scheduled to open the hatches between the Soyuz and ISS at about 11:15 p.m. EDT/315 GMT this evening after conducting pressure, leak and safety checks.
The arrival of Kelly, Kornienko and Padalka returns the massive orbiting outpost to its full six person crew complement.
The trio joins the current three person station crew comprising Expedition 43 commander Terry Virts of NASA, as well as flight engineers Samantha Cristoforetti of ESA (European Space Agency) and Anton Shkaplerov of Roscosmos, who have been aboard the complex since November 2014.
“Welcome aboard #Soyuz TMA-16M with Genna, Scott, and Misha- we just had a succesful docking,” tweeted Virts this evening post docking.
The 1 Year mission will provide baseline knowledge to NASA and its station partners – Roscosmos, ESA, CSA, JAXA – on how to prepare to send humans on lengthy deep space missions to Mars and other destinations in our Solar System.
A round-trip journey to Mars is likely to last three years or more! So we must determine how humans and their interactions can withstand the rigors of very long trips in space, completely independent of Earth.
Astronaut Scott Kelly will become the first American to live and work aboard the orbiting laboratory for a year-long mission and set a new American duration record.
Scott Kelly and Russian Cosmonauts Kornienko and Padalka are all veteran space fliers.
Kelly and Kornienko will stay aboard the ISS until March 3, 2016, when they return to Earth on the Soyuz TMA-18M after 342 days in space. Kelly’s combined total of 522 days in space, will enable him to surpass current U.S. record holder Mike Fincke’s mark of 382 days.
Padalka will return in September after a six month stint, making him the world’s most experienced spaceflyer with a combined five mission total of 878 days in space.
They will conduct hundreds of science experiments focusing on at least 7 broad areas of investigation including medical, psychological and biomedical challenges faced by astronauts during long-duration space flight, as well as the long term effects of weightlessness and space radiation on the human body.
Another very unique science aspect of the mission involves comparative medical studies with Kelly’s identical twin brother, former NASA astronaut and shuttle commander Mark Kelly.
“They will participate in a number of comparative genetic studies, including the collection of blood samples as well as psychological and physical tests. This research will compare data from the genetically identical Kelly brothers to identify any subtle changes caused by spaceflight,” says NASA.
Scott Kelly is a veteran NASA Space Shuttle commander who has previously flown to space three times aboard both the Shuttle and Soyuz. He also served as a space station commander during a previous six-month stay onboard.
Scott Kelly is going to spend a year in space in 2015, and he highlighted boredom as one of the things he will need to fight against during his time on the International Space Station.
“There are things I will do a little bit differently with regards to pacing myself. You wouldn’t think this is true, but you do have to kind of stay entertained over that kind of period,” said Scott Kelly in a NASA interview late last week, which you can watch above.
“No matter how exciting that kind of things is, no matter how beautiful the Earth is, when you’re doing it for a year there is still the factor of trying to keep yourself engaged and interested.”
Kelly also highlighted some of the training challenges he will face being that he will be up there twice as long as the typical six-month space station mission. While it won’t take twice as long to do emergency training, he is required to do it with twice as many astronauts/cosmonauts because he will be working with four crews in space.
He also will train with two different Soyuz spacecraft commanders (which will add “complexity”, he noted) and have twice as much science to perform. That includes several “twin” studies where scientists will compare Kelly and his identical brother Mark, a four-time shuttle flyer who retired from the program in 2011.
Another lesson learned from his last six-month flight in 2010? “I know what I want to bring this time that I didn’t have last time,” Kelly said, although he didn’t elaborate on what those items are.
Kelly and Russian cosmonaut Mikhail Kornienko will begin their mission just under one year from now.
Identical twin astronauts, one headed to space for a year and the other happily at home. Imagine just how excited health researchers are by the prospect of this situation which yes, is happening for real. Scott Kelly is preparing to blast off on a lengthy mission to the International Space Station in 2015 while his retired twin, Mark, will serve as a control.
The 50-year-old men will do a suite of experiments before, during and after the mission to see how much (if at all) Scott’s body changes from his brother in the long term. This ranges from examining their DNA, to their vision, and even changes in the gut.
“These will not be 10 individual studies,” stated Craig Kundrot of NASA’s human research program at the Johnson Space Center. “The real power comes in combining them to form an integrated picture of all levels from biomolecular to psychological. We’ll be studying the entire astronaut.”
One experiment will examine telomeres, which NASA says are “molecular caps” that sit on the ends of human DNA. As the theory goes, these telomeres are affected in space by cosmic rays (high-energy particles originating from outside the solar system) — which could speed up the aging process. If Scott’s telomeres change after the mission, this could help determine if space is linked to rapid aging.
Another experiment asks how the immune system alters. “We already know that the human immune system changes in space. It’s not as strong as it is on the ground,” said Kundrot. “In one of the experiments, Mark and Scott will be given identical flu vaccines, and we will study how their immune systems react.”
Then there are experiments looking at gut bacteria that help digestion, seeking out how human vision changes, and even a phenomenon known as “space fog” — how some astronauts find themselves losing alertness in orbit.
“You know, a lot of times people would ask, ‘So what’s it like to be a twin?’ and … the response I would usually give is, ‘Well, what’s it like not to be a twin?’ I mean, it’s just, it is,” Mark added, to which Scott responded, “It’s more like … he’s my brother but we just happen to have the same birthday, to me.”
Scott will leave Earth with Russian cosmonaut Mikhail Kornienko in 2015 for the first one-year mission in space since a handful of lengthy stays on the former Russian space station, Mir, in the 1990s. Scott will serve as Expedition 43/44 flight engineer and have the distinction of commanding two space station missions, Expedition 45 and 46. (He also commanded Expedition 26 in 2010.)
Clocks are ticking down as the countdown enters the final phase before Monday morning’s liftoff (May 16) scheduled for 8:56 a.m. EDT from Pad 39 A at NASA’s Kennedy Space Center (KSC).
Endeavour was unveiled for blastoff earlier today as a protective cocoon like structure was pulled away from the shuttle stack. The Rotating Service Structure (RSS) was retracted from around the orbiter starting at 11:45 a.m. over about 45 minutes and under a gorgeous blue sky. See my photo album
In a lucky break, expected thunderstorms that could have delayed the retraction and launch preparations actually passed through the area overnight, much earlier than expected.
Shuttle managers will gather at 11 p.m. tonight for a critical meeting and decision to give the “Go-No Go” directive to load the External Fuel Tank with supercold liquid hydrogen and liquid oxygen fuel that powers the shuttle main engines for the eight and one half minute climb to orbit. The tanking process is scheduled to begin at 11:36 p.m.
There are no technical issues at this time that would prevent a launch. The weather outlook remains at “70 Percent GO”.
The goal of Endeavour and her all veteran six man crew is to deliver the Alpha Magnetic Spectrometer (AMS) to the International Space Station. The $2 Billion AMS is a state of the art particle physics detector that will search for dark matter, dark energy and antimatter and seek to determine how the Universe was born and evolved.
The 134 mission is set to last 16 days and will feature the final 4 spacewalks of the space shuttle program.
The crew will wake up at 12 a.m. Monday. They depart for the launch pad shortly after 5 a.m.