The tools to predict those most at risk of developing type 1 diabetes have only recently been developed. But German researchers say they can predict who will likely develop the chronic disease. In the largest international study of its kind, scientists of Helmholtz Zentrum München found that young people develop type 1 diabetes within a maximum of 20 years after the first appearance of so-called multiple autoantibodies in the blood. Using the biomarker CD40 as a T cell marker we show that T1D have significantly (p lt 10-7) greater percentages of CD4CD40 cells than controls or T2D subjects. “If you have two or more autoantibodies, it’s nearly inevitable that you will develop the disease. Results: After 6 months 121 people with Type 1 diabetes had enrolled and used PKB. If a casual plasma glucose equal to 200 mg/dl or above is detected, the confirming test used should be a fasting plasma glucose or an oral glucose tolerance test.
Autoantibodies to glutamic acid decarboxylase