The foundations of the Eczacıbaşı Sports Club were laid in the 1950s with the start-up of football and tennis tournaments and other sports activities within the Eczacıbaşı Group. In 1966, these activities took a professional turn with the establishment of the Eczacıbaşı Sports Club by Dr. Nejat F. Eczacıbaşı and Şakir Eczacıbaşı. In 1967, the Club became a member of the National Sports Federation, after which it began to develop and train some of the most valuable basketball, volleyball and table tennis players in the history of Turkish sports.
Since 1968, the Eczacıbaşı VitrA Women's Volleyball Team has won 28 National Championships – 17 of them in a record-breaking streak – as well as eight National Cups, and one Super Cup. Internationally, it has played in 12 championship finals. In 1999, the team won the "European Cup Winners' Cup", the first European Cup for a Turkish volleyball team. In 2015, it won the CEV DenizBank European Champions League and the FIVB Women's Club World Championship, and in 2016, a second world championship to become the first team ever to win the FIVB Women's Club World Championship trophy two years in a row. In 2018, Eczacıbaşı VitrA added the CEV Cup to its growing collection of international trophies.
In addition to its A-team, the Club has three junior teams that have contributed numerous players over the years to the A team, other first division teams and Turkey's national volleyball teams. Collectively, these teams have won more than 40 national championships.
Before focusing its resources exclusively on women's volleyball in the early 1990s, the Club won 13 National Championships in table tennis, eight National Championships in men's basketball, 12 National Championships in men's volleyball. In 2002, the Eczacıbaşı Sports Club also established a highly successful chess team, which won three national championships before the team was disbanded in 2007.
In July 2001, the Eczacıbaşı Sports Club moved its teams to a new, 1,700 square meter sports facility that has a CEV-approved competition hall with seating for up to 1,000 spectators.
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