Dr. Lim's research focuses on understanding the relationship and signaling crosstalk between inflammation and cancer. Chronic inflammation is a major predisposing factor for many human cancers. Conversely, cancers are often referred to as "wounds that never heal" due to the pro-inflammatory nature of tumor cells that, over time, creates a fibrostromal milieu that supports tumor cell survival, promotes invasion, subverts host immunity and protects tumor cells against chemotherapeutics or radiation. It is hoped that understanding the inflammatory circuitry in human cancer will facilitate development of therapeutics to improve treatment outcome.