Liver Disease News and Research
The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.
CAR T cells produced in vivo using modified mRNA treat cardiac injury
A new study by researchers from the University of Pennsylvania shows that experimental immunotherapy can temporarily reprogram the immune cells of patients.
Novel peptide vaccine alleviates conditions of dyslipidemia
Professor Yuichi Oike and his group of researchers recently produced a peptide vaccine that mitigates conditions of dyslipidemia.
Scientists discover new genetic link to non-alcoholic inflammatory liver disease
Non-alcoholic fatty liver disease (NAFLD) is the accumulation of fat in the liver unrelated to alcohol abuse or other liver diseases.
Researchers employ hepatic organoids for disease modeling
Associate Professor Tamer Önder created and analyzed the hepatic organoid culture system utilizing human induced pluripotent stem cell as an intermediate.
Brown fat protects against secondary obesity-related diseases, says study
Research demonstrated that obese individuals with active brown fat possess a healthier metabolism and utilize more energy than obese people without.
Study identifies DNA mutations that impact metabolism and insulin sensitivity in liver disease patients
For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease.
Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk
A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.
Potential biomarkers help diagnose progressive stages of liver disease
Results of national research pinpointed potential biomarkers that could ultimately be employed for the diagnosis of progressive stages of liver disease.
Study analyzes the health benefits of time-restricted eating
Time-restricted eating (TRE) is a dietary regimen in which eating is restricted to particular hours. It has received great attention in weight-loss circles.
Modification in some RNA molecules could protect against non-alcoholic fatty liver
RNA molecules while carrying genetic instructions from DNA to the protein-making machinery of cells could help guard against non-alcoholic fatty liver.
Liver fibrosis might be treatable with selective immunotoxins
Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.
Lipidomics study reveals schizophrenic patients' resistance to antipsychotic drugs
Scientists discovered 22 lipids in the blood plasma of schizophrenia patients that were linked to slower symptom improvement over time.
New method for generating metabolic profiles of individual cells
Researchers from the EMBL and the German Cancer Research Center (DKFZ) demonstrated a new technique to create metabolic profiles of individual cells.
Diet plays a crucial role in liver disease outcome, mouse model shows
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.
High-fat, high-sugar diet reduces intestinal immune cell activity in mice
A team of researchers led by Thaddeus Stappenbeck discovered that a high-fat, high-sugar diet relates to reduced intestinal immune cell activity in mice.
Disease-driving B cells play a role in non-alcoholic fatty liver disease
A study by researchers proposes that disease-driving B cells—a kind of white blood cell—have a role in the development of non-alcoholic fatty liver disease.
Using genetic engineering to grow synthetic livers
News-Medical talks to Dr. Mo Ebrahimkhani about his research using genetic engineering together with a machine-learning algorithm to mature a lab-grown 'designer liver organoid'.
Research shows lipogenesis process is dysregulated in obesity, fatty liver disease
The production of fat in the human body is essentially regulated by gut hormones.
Dietary supplement helps to partially prevent fatty liver disease in rats
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats.
Reducing food intake can reduce risk of liver cancer caused by fatty liver
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease.