The tumor microenvironment: A critical determinant of neoplastic evolution
Léon C L T van Kempen, Dirk J. Ruiter, Goos N P van Muijen, Lisa Coussens
Evolution of neoplastic cells has generally been regarded as a cumulative intrinsic process resulting in altered cell characteristics enabling enhanced growth properties, evasion of apoptotic signals, unlimited replicative potential and gain of properties enabling the ability to thrive in ectopic tissues and in some cases, ability to metastasize. Recently however, the role of the neoplastic microenvironment has become appreciated largely due to the realization that tumors are not merely masses of neoplastic cells, but instead, are complex tissues composed of both a non-cellular (matrix proteins) and a cellular 'diploid' component (tumor-associated fibroblasts, capillary-associated cells and inflammatory cells), in addition to the ever-evolving neoplastic cells. With these realizations, it has become evident that early and persistent inflammatory responses observed in or around many solid tumors, play important roles in establishing an environment suitable for neoplastic progression by providing diverse factors that alter tissue homeostasis. Using cutaneous melanoma and squamous cell carcinoma as tumor models, we review the current literature focussing on inflammatory and tumor-associated fibroblast responses as critical mediators of neoplastic progression for these malignancies.
European Journal of Cell Biology
https://doi.org/10.1078/0171-9335-00346
Choristoma
Thromboplastin
Diploidy
Cutaneous melanoma
Cutaneous squamous cell carcinoma
van Kempen, L. C. L. T., Ruiter, D. J., van Muijen, G. N. P., & Coussens, L. (2003). The tumor microenvironment: A critical determinant of neoplastic evolution. European Journal of Cell Biology, 82(11), 539-548. https://doi.org/10.1078/0171-9335-00346
The tumor microenvironment : A critical determinant of neoplastic evolution. / van Kempen, Léon C L T; Ruiter, Dirk J.; van Muijen, Goos N P; Coussens, Lisa.
In: European Journal of Cell Biology, Vol. 82, No. 11, 2003, p. 539-548.
van Kempen, LCLT, Ruiter, DJ, van Muijen, GNP & Coussens, L 2003, 'The tumor microenvironment: A critical determinant of neoplastic evolution', European Journal of Cell Biology, vol. 82, no. 11, pp. 539-548. https://doi.org/10.1078/0171-9335-00346
van Kempen LCLT, Ruiter DJ, van Muijen GNP, Coussens L. The tumor microenvironment: A critical determinant of neoplastic evolution. European Journal of Cell Biology. 2003;82(11):539-548. https://doi.org/10.1078/0171-9335-00346
van Kempen, Léon C L T ; Ruiter, Dirk J. ; van Muijen, Goos N P ; Coussens, Lisa. / The tumor microenvironment : A critical determinant of neoplastic evolution. In: European Journal of Cell Biology. 2003 ; Vol. 82, No. 11. pp. 539-548.
@article{ec349439d5a94eaca0c6636d6ab421f5,
title = "The tumor microenvironment: A critical determinant of neoplastic evolution",
abstract = "Evolution of neoplastic cells has generally been regarded as a cumulative intrinsic process resulting in altered cell characteristics enabling enhanced growth properties, evasion of apoptotic signals, unlimited replicative potential and gain of properties enabling the ability to thrive in ectopic tissues and in some cases, ability to metastasize. Recently however, the role of the neoplastic microenvironment has become appreciated largely due to the realization that tumors are not merely masses of neoplastic cells, but instead, are complex tissues composed of both a non-cellular (matrix proteins) and a cellular 'diploid' component (tumor-associated fibroblasts, capillary-associated cells and inflammatory cells), in addition to the ever-evolving neoplastic cells. With these realizations, it has become evident that early and persistent inflammatory responses observed in or around many solid tumors, play important roles in establishing an environment suitable for neoplastic progression by providing diverse factors that alter tissue homeostasis. Using cutaneous melanoma and squamous cell carcinoma as tumor models, we review the current literature focussing on inflammatory and tumor-associated fibroblast responses as critical mediators of neoplastic progression for these malignancies.",
keywords = "Cutaneous melanoma, Cutaneous squamous cell carcinoma, Fibroblast, Inflammation, Tumor microenvironment",
author = "{van Kempen}, {L{\'e}on C L T} and Ruiter, {Dirk J.} and {van Muijen}, {Goos N P} and Lisa Coussens",
doi = "10.1078/0171-9335-00346",
journal = "European Journal of Cell Biology",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
T1 - The tumor microenvironment
T2 - A critical determinant of neoplastic evolution
AU - van Kempen, Léon C L T
AU - Ruiter, Dirk J.
AU - van Muijen, Goos N P
AU - Coussens, Lisa
N2 - Evolution of neoplastic cells has generally been regarded as a cumulative intrinsic process resulting in altered cell characteristics enabling enhanced growth properties, evasion of apoptotic signals, unlimited replicative potential and gain of properties enabling the ability to thrive in ectopic tissues and in some cases, ability to metastasize. Recently however, the role of the neoplastic microenvironment has become appreciated largely due to the realization that tumors are not merely masses of neoplastic cells, but instead, are complex tissues composed of both a non-cellular (matrix proteins) and a cellular 'diploid' component (tumor-associated fibroblasts, capillary-associated cells and inflammatory cells), in addition to the ever-evolving neoplastic cells. With these realizations, it has become evident that early and persistent inflammatory responses observed in or around many solid tumors, play important roles in establishing an environment suitable for neoplastic progression by providing diverse factors that alter tissue homeostasis. Using cutaneous melanoma and squamous cell carcinoma as tumor models, we review the current literature focussing on inflammatory and tumor-associated fibroblast responses as critical mediators of neoplastic progression for these malignancies.
AB - Evolution of neoplastic cells has generally been regarded as a cumulative intrinsic process resulting in altered cell characteristics enabling enhanced growth properties, evasion of apoptotic signals, unlimited replicative potential and gain of properties enabling the ability to thrive in ectopic tissues and in some cases, ability to metastasize. Recently however, the role of the neoplastic microenvironment has become appreciated largely due to the realization that tumors are not merely masses of neoplastic cells, but instead, are complex tissues composed of both a non-cellular (matrix proteins) and a cellular 'diploid' component (tumor-associated fibroblasts, capillary-associated cells and inflammatory cells), in addition to the ever-evolving neoplastic cells. With these realizations, it has become evident that early and persistent inflammatory responses observed in or around many solid tumors, play important roles in establishing an environment suitable for neoplastic progression by providing diverse factors that alter tissue homeostasis. Using cutaneous melanoma and squamous cell carcinoma as tumor models, we review the current literature focussing on inflammatory and tumor-associated fibroblast responses as critical mediators of neoplastic progression for these malignancies.
KW - Cutaneous melanoma
KW - Cutaneous squamous cell carcinoma
KW - Fibroblast
KW - Tumor microenvironment
U2 - 10.1078/0171-9335-00346
DO - 10.1078/0171-9335-00346
JO - European Journal of Cell Biology
JF - European Journal of Cell Biology
10.1078/0171-9335-00346