Interleukin 19 (IL19) is a protein that in humans is encoded by the IL19 gene.
The protein encoded by this gene is a cytokine that belongs to the IL-10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the interleukin-20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
^ a b "Entrez Gene: Interleukin 19".
^ Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A (Jan 2003). "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines". The Journal of Biological Chemistry. 278 (5): 3308–13. doi:10.1074/jbc.M208602200. PMID 12403790.
^ Kragstrup TW, Andersen T, Holm C, Schiøttz-Christensen B, Jurik AG, Hvid M, Deleuran B (May 2015). "Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity". Clinical and Experimental Immunology. 180 (2): 233–42. doi:10.1111/cei.12577. PMC 4408158. PMID 25639337.
This page was last edited on 1 September 2017, at 05:29 (UTC).