Photoshop and Illustrator. Inkscape is good stuff for minor things though.
Paint.NET handles most of my imaging needs for now.
(Like mentioned in another thread) Transparency with PNG files, adjustable quality when saving to alter the filesize, nice 'lasso' feature which helps me change the background on certain pictures like simple avatar creation. I like it. It's my 'go-to' imaging app.
What is this Zoner13 that you speak of kind sir?
ACDSee Ultimate is my favourite.