Description : The HSPA1A protein, also known as hsp72 or hsp70, is a stress-induced chaperone [ 12677068]. Results from invertebrates have suggested that heat-shock proteins, such as HSPA1A, are involved in ageing. Overexpression of hsp70, a homologue of HSPA1A, extends lifespan in fruit flies [ 9363888]. Induction of HSPA1A after ischemia is diminished in aged rat hearts [ 7977810]. Overexpression of HSPA1A in mice with spinocerebellar ataxia type 1 offered protection against this disease, suggesting HSPA1A could protect against neurodegeneration [ 11448943]. However, in a more recent study, overexpression of hsp70 in mice was associated with growth retardation, tumor formation, and early death [ 19072255]. Whether HSPA1A is related to human ageing remains to be determined.
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.
Hum Mol Genet. 2001; 10: 1511-8.
Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death.
Rejuvenation Res. 2008; 11: 1013-20.