Yarui Diao
Assistant Professor of Cell Biology
I lead a functional genomics lab at Duke Cell Biology and we are particularly interested in developing and applying cutting-edge functional genomics tools to understand the transcriptional regulatory mechanism that control tissue regeneration, aging, and cancer development.
Current Appointments & Affiliations
Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2018
Assistant Professor in Orthopaedic Surgery, Orthopaedics, Orthopaedics 2018
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
349 Nanaline Duke Building, Durham, NC 27705
yarui.diao@duke.edu (919) 684-7090
Cell Biology Faculty Page
The Diao lab website
Education, Training, & Certifications
Ph.D., University of Hong Kong (China) 2011
Muscles--Regeneration
Selected Grants
Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
Publications & Artistic Works
Chowdhry, Sudhir, Ciro Zanca, Utkrisht Rajkumar, Tomoyuki Koga, Yarui Diao, Ramya Raviram, Feng Liu, et al. "NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.." Nature 569, no. 7757 (May 2019): 570–75. https://doi.org/10.1038/s41586-019-1150-2.
Full Text Link to Item
Meng, Zhipeng, Yunjiang Qiu, Kimberly C. Lin, Aditya Kumar, Jesse K. Placone, Cao Fang, Kuei-Chun Wang, et al. "RAP2 mediates mechanoresponses of the Hippo pathway.." Nature 560, no. 7720 (August 2018): 655–60. https://doi.org/10.1038/s41586-018-0444-0.
Chen, Xiaofan, Jun Wan, Bo Yu, Yarui Diao, and Wei Zhang. "PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.." Stem Cell Research & Therapy 9, no. 1 (February 9, 2018). https://doi.org/10.1186/s13287-018-0770-z.
Diao, Yarui, Rongxin Fang, Bin Li, Zhipeng Meng, Juntao Yu, Yunjiang Qiu, Kimberly C. Lin, et al. "A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells.." Nat Methods 14, no. 6 (June 2017): 629–35. https://doi.org/10.1038/nmeth.4264.
An, Yitai, Gang Wang, Yarui Diao, Yanyang Long, Xinrong Fu, Mingxi Weng, Liang Zhou, et al. "A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.." Dev Cell 41, no. 4 (May 22, 2017): 382-391.e5. https://doi.org/10.1016/j.devcel.2017.04.012.
Zhu, Han, Fang Xiao, Gang Wang, Xiuqing Wei, Lei Jiang, Yan Chen, Lin Zhu, et al. "STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration.." Cell Rep 16, no. 8 (August 23, 2016): 2102–15. https://doi.org/10.1016/j.celrep.2016.07.041.
Diao, Yarui, Bin Li, Zhipeng Meng, Inkyung Jung, Ah Young Lee, Jesse Dixon, Lenka Maliskova, Kun-Liang Guan, Yin Shen, and Bing Ren. "A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.." Genome Res 26, no. 3 (March 2016): 397–405. https://doi.org/10.1101/gr.197152.115.
Fan, Chunying, Qi Wu, Xiaoyang Ye, Hongxue Luo, Dongdong Yan, Yi Xiong, Haili Zhu, Yarui Diao, Wei Zhang, and Jun Wan. "Role of miR-211 in Neuronal Differentiation and Viability: Implications to Pathogenesis of Alzheimer's Disease.." Front Aging Neurosci 8 (2016). https://doi.org/10.3389/fnagi.2016.00166.
Wang, Yinuo, Xiaosu Zhao, Xiaoyang Ye, Hongxue Luo, Tongfeng Zhao, Yarui Diao, Hongyu Zhang, et al. "Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease.." Ann Hematol 94, no. 9 (September 2015): 1505–14. https://doi.org/10.1007/s00277-015-2414-z.
Dixon, Jesse R., Inkyung Jung, Siddarth Selvaraj, Yin Shen, Jessica E. Antosiewicz-Bourget, Ah Young Lee, Zhen Ye, et al. "Chromatin architecture reorganization during stem cell differentiation.." Nature 518, no. 7539 (February 19, 2015): 331–36. https://doi.org/10.1038/nature14222.
Ye, Xiaoyang, Hongxue Luo, Yan Chen, Qi Wu, Yi Xiong, Jinyong Zhu, Yarui Diao, Zhenguo Wu, Jianting Miao, and Jun Wan. "MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies.." Front Aging Neurosci 7 (2015). https://doi.org/10.3389/fnagi.2015.00210.
Diao, Yarui, Xing Guo, Lei Jiang, Gang Wang, Chao Zhang, Jun Wan, Yan Jin, and Zhenguo Wu. "miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma.." J Biol Chem 289, no. 1 (January 3, 2014): 529–39. https://doi.org/10.1074/jbc.M113.494716.
Luo, Hongxue, Qi Wu, Xiaoyang Ye, Yi Xiong, Jinyong Zhu, Junyu Xu, Yarui Diao, et al. "Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.." Plos One 9, no. 8 (2014). https://doi.org/10.1371/journal.pone.0101725.
Diao, Yarui, Xing Guo, Yanfeng Li, Kun Sun, Leina Lu, Lei Jiang, Xinrong Fu, et al. "Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism.." Cell Stem Cell 11, no. 2 (August 3, 2012): 231–41. https://doi.org/10.1016/j.stem.2012.05.022.
Diao, Yarui, Wei Liu, Catherine C. L. Wong, Xi Wang, Kaman Lee, Po-yan Cheung, Lifeng Pan, et al. "Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding.." Proc Natl Acad Sci U S A 107, no. 49 (December 7, 2010): 20974–79. https://doi.org/10.1073/pnas.1007225107.
Diao, Yarui, Xi Wang, and Zhenguo Wu. "SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.." Mol Cell Biol 29, no. 18 (September 2009): 5084–93. https://doi.org/10.1128/MCB.00267-09.
Teaching & Mentoring
CELLBIO 493: Research Independent Study 2019
CMB 710C: Cell & Molecular Biology Module III 2019
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