can anyone shed some light on this please!!
Look forward to another interesting discussion on the same!!
There are at least 3 software packages on oral absorption topic.
The are all based on PBPK (compartment or tube assumption).
And some of them could be used for controlled release.
predicting oral drug absorption[J]. Pharm Res, 1995. 12: p. S8.
absorption[J]. Adv Drug Deliv Rev, 1996. 19(3): p. 359-76.
Pharm Biopharm, 1998. 45(2): p. 199-203.
fraction dose absorbed in humans[J]. J Med Chem, 2004. 47(16): p.
Target, 1994. 2(1): p. 23-33.
in vitro data[J]. Adv Drug Deliv Rev, 1997.
Release, 2000. 65(1-2): p. 55-62.
If you know the site of release and release kinetics: why not?
standard IVIVC for F and Fa vs in vitro release.
and PK phenomena as well as coupling with PD modeling.