Located between the Departments of Beni (province of Moxos) and Cochabamba (Chapare province ). The municipalities involved are San Ignacio de Moxos and Loreto in Beni, and Villa Tunari and Morochata in Cochabamba. The park has an approximate surface of 12,000 km2.
Since 1990, it has the double status of Protected Area and Community territory of Origin (TCO). Borders with other TCOs: Yuracare and Yuqui to the east, Chiman Native Territory and Multiethnic Native Territory to the North and is a neighbor to the TCO Moseten to the West. The park harbors a great biological diversity, with more than 600 species of birds. There are archaeological sites of great historic interest. The climate varies according to the latitude from temperate to cold in the high parts to hot in the low lands.
The Area presents a varied physiography due to its transitional location between the subandinic mountain ranges and the Plains of Moxos. The south part and west of the Area is essentially mountainous with abrupt slopes and includes the mountain ranges of Mosetenes and Sejeruma. The Central regions and South are defined by the alluvial plain of Moxos.
402 species of flora were registered and the existence of 3,000 species of large plants is estimated. The extraordinary floral diversity includes species like the aliso, mountain pine, walnut, cedar, mara, palo maria and the tajibo. 714 species of fauna were registered. The most important are: the jucumari, pejichi, marimono, manechi, londra, jaguar, swamp deer, harpy, black duck, river peta, the black cayman and endemic birds. The park is characterized by an important population of the ethnic groups Moxeno, Yuracare and Chiman.