I also think the controls are easier to use & the guilt operations are straight forward - it is fairly easy to S -rank on most operations as well.
Well, I find the first one easier (Minus the X Missions and the Final Sinner. Dang you dying children and *SPOILERSAdamSPOILERS*) than the second one, as I've been flying through on hard, but have had to drop to normal plenty of times (Nous In Emilio, GUILT Returns, The Throat one earlier on, and I'm stuck on the back to back gallbladder and appendix removal, and that's only 4-5 I think haha) But I'm also not on a conventional controller (DS) so... IDK. Of course, I've only met Nous once, and no other Neo-GUILT yet so I guess my opinion is moot so far.