Clinical chemistry; application of automation, robotics, and process improvement to clinical laboratory testing.
Pathogenesis of essential hypertension and salt sensitivity – We employ a multidimensional approach to the study of high blood pressure including the molecular genetics, biochemical techniques, in-vitro, and in-vivo studies in humans. Through the use of in vivo pharmacologic experiments we have demonstrated that a defect in an intracellular enzyme results in the inability to normally excrete sodium, thus leading to elevated blood pressure. Our studies extend to the use of human subjects in the Clinical Research Center to determine the effect of pharmacologic intervention in normal and pathologic states.
Medical automation, robotics and process improvement to assist in efficient management of the clinical laboratory. For a complete list of automation articles visit http://marc.med.virginia.edu. Dr. Felder has developed a number of medical process improvement technologies and commercialized them through the UVA Patent Foundation process at UVA.
Armando I, Konkalmatt P, Felder RA, Jose PA: The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease. Transl Res 2015, 165:505-511.http://www.ncbi.nlm.nih.gov/pubmed/25134060. DOI: 10.1016/j.trsl.2014.07.006.
Han F, Konkalmatt P, Chen J, Gildea J, Felder RA, Jose PA, Armando I: MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells. Hypertension 2015, 65:1118-1125. http://www.ncbi.nlm.nih.gov/pubmed/25801876. DOI: 10.1161/HYPERTENSIONAHA.114.05096.
Li F, Yang J, Jones JE, Villar VA, Yu P, Armando I, Felder RA, Jose PA: Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology 2015, 156:2211-2221. http://www.ncbi.nlm.nih.gov/pubmed/25825816. DOI: 10.1210/en.2014-1638.
Sanada H, Yoneda M, Yatabe J, Williams SM, Bartlett J, White MJ, Gordon LN, Felder RA, Eisner GM, Armando I, Jose PA: Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade. Pharmacogenomics J 2015 http://www.ncbi.nlm.nih.gov/pubmed/25732908. DOI: 10.1038/tpj.2015.6.
Armando I, Villar VA, Jones JE, Lee H, Wang X, Asico LD, Yu P, Yang J, Escano CS, Pascua-Crusan A, Felder RA, Jose PA: Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation. FASEB J 2014, 28:1422-1434. http://www.ncbi.nlm.nih.gov/pubmed/24308971. DOI: 10.1096/fj.13-243840.
Felder RA: Automated specimen inspection, quality analysis, and its impact on patient safety: beyond the bar code. Clin Chem 2014, 60:433-434. http://www.ncbi.nlm.nih.gov/pubmed/24407911. DOI: 10.1373/clinchem.2013.219352.
Felder RA, Jackson KD, Walter AM: Process evaluation of an open architecture real-time molecular laboratory platform. J Lab Autom 2014, 19:468-473. http://www.ncbi.nlm.nih.gov/pubmed/24811476. DOI: 10.1177/2211068214533195.
Gildea JJ, Seaton JE, Victor KG, Reyes CM, Bigler Wang D, Pettigrew AC, Courtner CE, Shah N, Tran HT, Van Sciver RE, Carlson JM, Felder RA: Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. Clin Biochem 2014, 47:89-94. http://www.ncbi.nlm.nih.gov/pubmed/24976626. DOI: 10.1016/j.clinbiochem.2014.06.018.
Gildea JJ, Shah IT, Van Sciver RE, Israel JA, Enzensperger C, McGrath HE, Jose PA, Felder RA: The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney Int 2014, 86:118-126. http://www.ncbi.nlm.nih.gov/pubmed/24552847. DOI: 10.1038/ki.2014.5.
Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder RA, Mori H, Masaki T, Kobori H, Nishiyama A: Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complications 2014, 28:604-611.http://www.ncbi.nlm.nih.gov/pubmed/24996978. DOI: 10.1016/j.jdiacomp.2014.05.010.
Sanada H, Yokokawa H, Yatabe J, Williams SM, Felder RA, Jose PA, Takenosita S: Association between lifestyle-related disorders and visceral fat mass in Japanese males: a hospital based cross-sectional study. Environ Health Prev Med 2014, 19:429-435. http://www.ncbi.nlm.nih.gov/pubmed/25248615. DOI: 10.1007/s12199-014-0411-9.
Yokokawa H, Goto A, Sanada H, Watanabe T, Felder RA, Jose PA, Yasumura S: Association between control to target blood pressures and healthy lifestyle factors among Japanese hypertensive patients: longitudinal data analysis from Fukushima Research of Hypertension (FRESH). Obes Res Clin Pract 2014, 8:e364-e373.http://www.ncbi.nlm.nih.gov/pubmed/25091358. DOI: 10.1016/j.orcp.2013.08.004.
Yu P, Sun M, Villar VA, Zhang Y, Weinman EJ, Felder RA, Jose PA: Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells. Cell Signal 2014, 26:2521-2529. http://www.ncbi.nlm.nih.gov/pubmed/25049074. DOI: 10.1016/j.cellsig.2014.07.003.
Automated Storage/Retrieval Apparatus for Freezers #6,688,123, Issued 05-05-2003.
A more complete list of Dr. Felder's publications can be obtained from Pubmed.