Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic
D. M. Rothenberg*, R. J. Mccarthy, C. C. Peng, D. A. Normoyle
Background: The purpose of this randomized, double-blinded study was to compare the incidence and severity of postoperative nausea and vomiting (PONV) after dexamethasone versus droperidol following gynecologic laparoscopy, a group at high risk for developing PONV. Methods: Ninety-five patients who underwent a propofol-based general anesthetic received either dexamethasone 0.17 mg/kg IV, or droperidol 0.02 mg/kg IV, just prior to abdominal incision. Nausea, retching, vomiting, degree of sedation, and discharge times were assessed in the Post Anesthesia Care Unit (PACU), and the Ambulatory Care Unit (ACU). Following hospital discharge (24 h), the patients were contacted by telephone to assess any further complications. Results: PONV in the PACU (14.6% vs. 14.9%) and ACU (8.3% vs. 14.9%) was as common after dexamethasone as after droperidol. PONV following hospital discharge was, however, less common after dexamethasone than after droperidol (4.2% vs. 17.0%, P=0.041). Postoperatively, no complications of therapy were detected. Conclusions: We conclude that PONV is similar with dexamethasone and droperidol, but dexamethasone may have a longer duration of action in patients undergoing gynecologic laparoscopy.
Droperidol
Postoperative nausea and vomiting
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Dexamethasone Nursing and Health Professions 100%
nausea INIS 100%
vomiting INIS 100%
dexamethasone INIS 100%
Droperidol Pharmacology, Toxicology and Pharmaceutical Science 85%
Postoperative Nausea and Vomiting Nursing and Health Professions 71%
units INIS 57%
Laparoscopy Nursing and Health Professions 42%
Rothenberg, D. M., Mccarthy, R. J., Peng, C. C., & Normoyle, D. A. (1998). Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic. Acta Anaesthesiologica Scandinavica, 42(6), 637-642. https://doi.org/10.1111/j.1399-6576.1998.tb05294.x
Rothenberg, D. M. ; Mccarthy, R. J. ; Peng, C. C. et al. / Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic. In: Acta Anaesthesiologica Scandinavica. 1998 ; Vol. 42, No. 6. pp. 637-642.
@article{37dd26da3beb46e9aa459e88a5c374cf,
title = "Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic",
abstract = "Background: The purpose of this randomized, double-blinded study was to compare the incidence and severity of postoperative nausea and vomiting (PONV) after dexamethasone versus droperidol following gynecologic laparoscopy, a group at high risk for developing PONV. Methods: Ninety-five patients who underwent a propofol-based general anesthetic received either dexamethasone 0.17 mg/kg IV, or droperidol 0.02 mg/kg IV, just prior to abdominal incision. Nausea, retching, vomiting, degree of sedation, and discharge times were assessed in the Post Anesthesia Care Unit (PACU), and the Ambulatory Care Unit (ACU). Following hospital discharge (24 h), the patients were contacted by telephone to assess any further complications. Results: PONV in the PACU (14.6% vs. 14.9%) and ACU (8.3% vs. 14.9%) was as common after dexamethasone as after droperidol. PONV following hospital discharge was, however, less common after dexamethasone than after droperidol (4.2% vs. 17.0%, P=0.041). Postoperatively, no complications of therapy were detected. Conclusions: We conclude that PONV is similar with dexamethasone and droperidol, but dexamethasone may have a longer duration of action in patients undergoing gynecologic laparoscopy.",
keywords = "Ambulatory surgery, Dexamethasone, Droperidol, Postoperative nausea and vomiting",
author = "Rothenberg, {D. M.} and Mccarthy, {R. J.} and Peng, {C. C.} and Normoyle, {D. A.}",
journal = "Acta Anaesthesiologica Scandinavica",
publisher = "Blackwell Munksgaard",
Rothenberg, DM, Mccarthy, RJ, Peng, CC & Normoyle, DA 1998, 'Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic', Acta Anaesthesiologica Scandinavica, vol. 42, no. 6, pp. 637-642. https://doi.org/10.1111/j.1399-6576.1998.tb05294.x
Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic. / Rothenberg, D. M.; Mccarthy, R. J.; Peng, C. C. et al.
In: Acta Anaesthesiologica Scandinavica, Vol. 42, No. 6, 01.01.1998, p. 637-642.
T1 - Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic
AU - Rothenberg, D. M.
AU - Mccarthy, R. J.
AU - Peng, C. C.
AU - Normoyle, D. A.
N2 - Background: The purpose of this randomized, double-blinded study was to compare the incidence and severity of postoperative nausea and vomiting (PONV) after dexamethasone versus droperidol following gynecologic laparoscopy, a group at high risk for developing PONV. Methods: Ninety-five patients who underwent a propofol-based general anesthetic received either dexamethasone 0.17 mg/kg IV, or droperidol 0.02 mg/kg IV, just prior to abdominal incision. Nausea, retching, vomiting, degree of sedation, and discharge times were assessed in the Post Anesthesia Care Unit (PACU), and the Ambulatory Care Unit (ACU). Following hospital discharge (24 h), the patients were contacted by telephone to assess any further complications. Results: PONV in the PACU (14.6% vs. 14.9%) and ACU (8.3% vs. 14.9%) was as common after dexamethasone as after droperidol. PONV following hospital discharge was, however, less common after dexamethasone than after droperidol (4.2% vs. 17.0%, P=0.041). Postoperatively, no complications of therapy were detected. Conclusions: We conclude that PONV is similar with dexamethasone and droperidol, but dexamethasone may have a longer duration of action in patients undergoing gynecologic laparoscopy.
AB - Background: The purpose of this randomized, double-blinded study was to compare the incidence and severity of postoperative nausea and vomiting (PONV) after dexamethasone versus droperidol following gynecologic laparoscopy, a group at high risk for developing PONV. Methods: Ninety-five patients who underwent a propofol-based general anesthetic received either dexamethasone 0.17 mg/kg IV, or droperidol 0.02 mg/kg IV, just prior to abdominal incision. Nausea, retching, vomiting, degree of sedation, and discharge times were assessed in the Post Anesthesia Care Unit (PACU), and the Ambulatory Care Unit (ACU). Following hospital discharge (24 h), the patients were contacted by telephone to assess any further complications. Results: PONV in the PACU (14.6% vs. 14.9%) and ACU (8.3% vs. 14.9%) was as common after dexamethasone as after droperidol. PONV following hospital discharge was, however, less common after dexamethasone than after droperidol (4.2% vs. 17.0%, P=0.041). Postoperatively, no complications of therapy were detected. Conclusions: We conclude that PONV is similar with dexamethasone and droperidol, but dexamethasone may have a longer duration of action in patients undergoing gynecologic laparoscopy.
KW - Ambulatory surgery
KW - Dexamethasone
KW - Droperidol
KW - Postoperative nausea and vomiting
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
Rothenberg DM, Mccarthy RJ, Peng CC, Normoyle DA. Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic. Acta Anaesthesiologica Scandinavica. 1998 Jan 1;42(6):637-642. doi: 10.1111/j.1399-6576.1998.tb05294.x