A Clinical Study to Demonstrate Safety and Efficacy of E7777 (Denileukin Diftitox) in Persistent or Recurrent Cutaneous T-Cell Lymphoma
The purpose of this trial is to assess the efficacy and safety of E7777 (improved purity ONTAK [denileukin diftitox]) in patients with persistent and recurrent cutaneous T-cell lymphoma. A Lead-in dose-finding part will be used to determine the dose of E7777 that should be used to test efficacy and safety.
Participants must meet all of the following criteria to be included in the study:
Age greater than or equal to 18 years.
Histopathologic diagnosis of CTCL (mycosis fungoides [MF] or Sezary Syndrome [SS]), confirmed by skin biopsy, or lymph node, or blood assessment, of current disease.
CD25 assay-positive tumor, defined as detectable CD25 on greater than or equal to 20% of total lymphoid infiltrate in biopsied lesions by immunohistochemistry.
CTCL disease stage at study entry as follows, according to ISCL/EORTC (Olsen 2011).
Lead-In Part: Stage IA - IV, except participants with CNS involvement.
Main Study: Stage IA - IVA2 including lymph node disease N2 and N3
History of prior therapies for CTCL as follows: must have had prior therapy, any number of prior therapies allowed.
Topical treatments (except topical chemotherapy) and steroids are not considered as prior therapies.
A minimum washout period of 4 weeks after previous CTCL therapy is recommended before the first dose of E7777.
Participants must have recovered from any adverse effects from any previous CTCL therapy to Common Terminology Criteria for Adverse Events (CTCAE) Grade <2 before starting study drug. A shorter washout may be allowed if participant is experiencing progressive disease despite ongoing treatment.
Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 in the Lead-In Part and performance status of 0 or 1 in the Main Study.
Life expectancy greater than or equal to 3 months in the Lead-In Part and greater than or equal to 12 months in the Main Study.
Adequate bone marrow reserves as evidenced by:
platelets greater than or equal to 100,000/mm3 (100 x 10^9/L)
clinically stable hemoglobin greater than or equal to 9 g/dL (90 g/L) and hematocrit greater than or equal to 27% without transfusion support
Normal hepatic function as evidenced by:
bilirubin and alkaline phosphatase less than or equal to 1 x the upper limit of normal (ULN).
aspartate aminotransferase (AST) less than or equal to 75 U/L and alanine aminotransferase (ALT) less than or equal to 100 U/L.
albumin greater than or equal to 3.0 g/dL (30 g/L).
Adequate renal function as evidenced by serum creatinine less than or equal to 1.8 mg/dL (158 umol/L) OR calculated creatinine clearance greater than or equal to 50 mL/min (per the Cockcroft-Gault formula) with less than 2+ protein OR 24- hour urine creatinine clearance greater than or equal to 50 mL/minute with 24- hour urine protein less than 1g.
Provide written informed consent prior to any study-specific screening procedures.
Females may not be lactating or pregnant at Screening or Baseline
All females will be considered to be of childbearing potential unless they are postmenopausal or have been sterilized surgically
Male participants must have had a successful vasectomy (confirmed azoospermia) or they and their female partner must meet the criteria above
Participants who meet any of the following criteria will be excluded from the study:
Prior denileukin diftitox therapy
Use of topical steroids within 14 days of Day 1 of initial therapy is not allowed.Topical steroids or systemic low dose steroids of less than or equal to 10 milligram per day (mg/day) prednisone are allowed in participants with erythroderma who have been on corticosteroids for a prolonged period of time and where discontinuation may lead to rebound flare in disease. The concomitant steroid medication is allowed as long as the type of steroid, route of administration, and steroid dose remain the same as what the participant had been receiving for a prolonged period of time.
Active malignancy (except for CTCL, definitively treated basal or squamous cell carcinoma of the skin, and carcinoma in-situ of the cervix) within the past 24 months.
Serious intercurrent illness
Significant cardiac disease requiring ongoing treatment, including congestive heart failure (CHF), severe coronary artery disease (CAD), cardiomyopathy, uncontrolled cardiac arrhythmia, unstable angina pectoris, or myocardial infarction (MI)
Significant pulmonary symptoms or disease
History of uncontrolled seizure disorder or active central nervous system disease
Major surgery within 2 weeks of study enrollment
Significant or uncontrolled infections requiring systemic anti-infective therapy
Known human immunodeficiency virus (HIV) infection; known active hepatitis B or hepatitis C infection
Females who are pregnant (positive urine test) or breastfeeding
Any history of a medical condition or a concomitant medical condition that, in the opinion of the investigator, would compromise the participant's ability to safely complete the study.
Can be done from home
cutaneous, lymphoma, partial, rate, recurrent
Nam H Dang, M.D.
nam.dang@medicine.ufl.edu
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