Congestion is already building in the area and buses are being diverted after Maryhill Road was closed following last night's fire.
Drivers in north Glasgow are being warned to prepare for major delays this morning after a blaze ripped through a derelict building in Maryhill.
A police cordon remains on Maryhill Road following the fire at the Maryhill Tavern Pub and the route is inaccesible.
Traffic is being diverted up back roads in the area, through Cadder and coming back out at McDonald's on Maryhill Road.
But disruption is set to be widespread, with ongoing road works and temporary lights on Sandbank Street already causing havoc for motorists.
Bus services will be severely affected but are still running and passengers should check individual routes before leaving the house for diversions.
Emergency services raced to the pub, which has gone up in flames for the second time in seven months, around 8.50pm last night (Wednesday).
Police Scotland also confirmed they were in attendance.