Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock
T. J. Oglesby, D. R. Schultz, Roland Schein, C. L. Sprung, J. E. Volanakis
We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.
Complement and Inflammation
Complement C2
Complement Factor B
Acute-Phase Reaction
Oglesby, T. J., Schultz, D. R., Schein, R., Sprung, C. L., & Volanakis, J. E. (1989). Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. Complement and Inflammation, 6(1), 27-35.
Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. / Oglesby, T. J.; Schultz, D. R.; Schein, Roland; Sprung, C. L.; Volanakis, J. E.
In: Complement and Inflammation, Vol. 6, No. 1, 01.01.1989, p. 27-35.
Oglesby, TJ, Schultz, DR, Schein, R, Sprung, CL & Volanakis, JE 1989, 'Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock', Complement and Inflammation, vol. 6, no. 1, pp. 27-35.
Oglesby TJ, Schultz DR, Schein R, Sprung CL, Volanakis JE. Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. Complement and Inflammation. 1989 Jan 1;6(1):27-35.
Oglesby, T. J. ; Schultz, D. R. ; Schein, Roland ; Sprung, C. L. ; Volanakis, J. E. / Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock. In: Complement and Inflammation. 1989 ; Vol. 6, No. 1. pp. 27-35.
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title = "Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock",
abstract = "We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.",
author = "Oglesby, {T. J.} and Schultz, {D. R.} and Roland Schein and Sprung, {C. L.} and Volanakis, {J. E.}",
journal = "Complement and Inflammation",
T1 - Measurement of complement proteins C2 and B in systemic lupus erythematosus and septic shock
AU - Oglesby, T. J.
AU - Schultz, D. R.
AU - Schein, Roland
AU - Sprung, C. L.
AU - Volanakis, J. E.
N2 - We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.
AB - We developed sensitive radioassays to quantitate the homologous complement proteins C2 and B, in intact form, in sera from patients with diseases associated with hypocomplementemia. In a study of systemic lupus erythematosus (SLE) patients, we found a subset of patients (6/40) with low C2 concentrations, though overall, C2 concentration was not related to disease activity. Protein B concentration was increased in 23/40 SLE patients, apparently not due to a generalized acute phase response. Among patients with both gram-negative and gram-positive septic shock, C2 and B concentrations were low in a subset of patients with pre-existing cirrhosis, suggesting hepatic hyposynthesis of these proteins may be important in their prognosis and predisposition to severe infections.
JO - Complement and Inflammation
JF - Complement and Inflammation