Males were dosed for 52 days from day 14 before mating and females were dosed from day 14 before mating to day 4 of lactation throughout the mating and pregnancy period. Hematological, blood biochemical, and histopathological examinations were performed in both sexes, and urinalysis was conducted in males.
and blood urea nitrogen in females, the NOAEL of disodium succinate hexahydrate for repeated dose toxicity was considered to be 100 mg/kg bw/day for male rats and 300 mg/kg bw/day for female rats (100 and 300 mg of disodium succinate hexahydrate are equivalent to 60 and 180 mg of disodium succinate , respectively).
There is no available information on humans.
In an oral repeated dose toxicity study in rats, higher levels of urinary protein in males and blood urea nitrogen in females were observed at 300 and 1,000 mg/kg bw/day, respectively. The NOAEL of disodium succinate hexahydrate for repeated dose toxicity was considered to be 100 mg/kg bw/day for male rats and 300 mg/kg bw/day for female rats (100 and 300 mg of disodium succinate hexahydrate are equivalent to 60 and 180 mg of disodium succinate , respectively).