Role of Cell Surface Carbohydrates in Development and Disease
Michiko N. Fukuda, Tomoya O. Akama, Kazuhiro Sugihara
研究成果: Chapter
This chapter discusses the roles of cell surface carbohydrates in development, while focusing on embryo implantation, spermatogenesis, and tissue maturation. The outer surface of mammalian cells is covered by glycoproteins and glycolipids. Substantial biochemical and immunochemical evidence suggests that cell surface carbohydrates play significant roles in development and health. Functional studies of cell surface carbohydrates still leave many questions unanswered. In the last decade, genetic approaches and sophisticated chemical analyses have enabled us to reveal the function of specific carbohydrate structures in vivo, and as a result the role of carbohydrates in development and disease is understood. In the field of reproductive biology and embryology, it has been assumed that cell surface carbohydrates play important roles. These hypotheses are difficult to test because embryonic development is dynamic and the material of interest is often too limited to allow chemical analysis. Analyzing early stage embryos requires well-trained hands and skills that many biochemists and molecular biologists have only recently developed. Nonetheless, many attractive hypotheses await testing by new technologies.
Carbohydrate Chemistry, Biology and Medical Applications
Elsevier Ltd
ISBN(印刷版)
化学工学(全般)
10.1016/B978-0-08-054816-6.00013-6
!!Link to publication in Scopus
!!Link to the citations in Scopus
「Role of Cell Surface Carbohydrates in Development and Disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。
Carbohydrates Engineering & Materials Science 100%
Carbohydrate Chemical Compounds 59%
Glycolipids Engineering & Materials Science 23%
Embryology Engineering & Materials Science 22%
Glycoproteins Engineering & Materials Science 20%
Glycolipid Chemical Compounds 13%
Mammalian Cell Chemical Compounds 12%
Fukuda, M. N., Akama, T. O., & Sugihara, K. (2008). Role of Cell Surface Carbohydrates in Development and Disease. In Carbohydrate Chemistry, Biology and Medical Applications (pp. 293-310). Elsevier Ltd. https://doi.org/10.1016/B978-0-08-054816-6.00013-6
Fukuda, Michiko N. ; Akama, Tomoya O. ; Sugihara, Kazuhiro. / Role of Cell Surface Carbohydrates in Development and Disease. Carbohydrate Chemistry, Biology and Medical Applications. Elsevier Ltd, 2008. pp. 293-310
@inbook{0ec29e97dc324945814475a6458f3756,
title = "Role of Cell Surface Carbohydrates in Development and Disease",
abstract = "This chapter discusses the roles of cell surface carbohydrates in development, while focusing on embryo implantation, spermatogenesis, and tissue maturation. The outer surface of mammalian cells is covered by glycoproteins and glycolipids. Substantial biochemical and immunochemical evidence suggests that cell surface carbohydrates play significant roles in development and health. Functional studies of cell surface carbohydrates still leave many questions unanswered. In the last decade, genetic approaches and sophisticated chemical analyses have enabled us to reveal the function of specific carbohydrate structures in vivo, and as a result the role of carbohydrates in development and disease is understood. In the field of reproductive biology and embryology, it has been assumed that cell surface carbohydrates play important roles. These hypotheses are difficult to test because embryonic development is dynamic and the material of interest is often too limited to allow chemical analysis. Analyzing early stage embryos requires well-trained hands and skills that many biochemists and molecular biologists have only recently developed. Nonetheless, many attractive hypotheses await testing by new technologies.",
author = "Fukuda, {Michiko N.} and Akama, {Tomoya O.} and Kazuhiro Sugihara",
doi = "10.1016/B978-0-08-054816-6.00013-6",
booktitle = "Carbohydrate Chemistry, Biology and Medical Applications",
Fukuda, MN, Akama, TO & Sugihara, K 2008, Role of Cell Surface Carbohydrates in Development and Disease. in Carbohydrate Chemistry, Biology and Medical Applications. Elsevier Ltd, pp. 293-310. https://doi.org/10.1016/B978-0-08-054816-6.00013-6
Role of Cell Surface Carbohydrates in Development and Disease. / Fukuda, Michiko N.; Akama, Tomoya O.; Sugihara, Kazuhiro.
Carbohydrate Chemistry, Biology and Medical Applications. Elsevier Ltd, 2008. p. 293-310.
T1 - Role of Cell Surface Carbohydrates in Development and Disease
AU - Fukuda, Michiko N.
AU - Akama, Tomoya O.
AU - Sugihara, Kazuhiro
N2 - This chapter discusses the roles of cell surface carbohydrates in development, while focusing on embryo implantation, spermatogenesis, and tissue maturation. The outer surface of mammalian cells is covered by glycoproteins and glycolipids. Substantial biochemical and immunochemical evidence suggests that cell surface carbohydrates play significant roles in development and health. Functional studies of cell surface carbohydrates still leave many questions unanswered. In the last decade, genetic approaches and sophisticated chemical analyses have enabled us to reveal the function of specific carbohydrate structures in vivo, and as a result the role of carbohydrates in development and disease is understood. In the field of reproductive biology and embryology, it has been assumed that cell surface carbohydrates play important roles. These hypotheses are difficult to test because embryonic development is dynamic and the material of interest is often too limited to allow chemical analysis. Analyzing early stage embryos requires well-trained hands and skills that many biochemists and molecular biologists have only recently developed. Nonetheless, many attractive hypotheses await testing by new technologies.
AB - This chapter discusses the roles of cell surface carbohydrates in development, while focusing on embryo implantation, spermatogenesis, and tissue maturation. The outer surface of mammalian cells is covered by glycoproteins and glycolipids. Substantial biochemical and immunochemical evidence suggests that cell surface carbohydrates play significant roles in development and health. Functional studies of cell surface carbohydrates still leave many questions unanswered. In the last decade, genetic approaches and sophisticated chemical analyses have enabled us to reveal the function of specific carbohydrate structures in vivo, and as a result the role of carbohydrates in development and disease is understood. In the field of reproductive biology and embryology, it has been assumed that cell surface carbohydrates play important roles. These hypotheses are difficult to test because embryonic development is dynamic and the material of interest is often too limited to allow chemical analysis. Analyzing early stage embryos requires well-trained hands and skills that many biochemists and molecular biologists have only recently developed. Nonetheless, many attractive hypotheses await testing by new technologies.
U2 - 10.1016/B978-0-08-054816-6.00013-6
DO - 10.1016/B978-0-08-054816-6.00013-6
BT - Carbohydrate Chemistry, Biology and Medical Applications
PB - Elsevier Ltd
Fukuda MN, Akama TO, Sugihara K. Role of Cell Surface Carbohydrates in Development and Disease. In Carbohydrate Chemistry, Biology and Medical Applications. Elsevier Ltd. 2008. p. 293-310 https://doi.org/10.1016/B978-0-08-054816-6.00013-6