Engagement, Retention, and Progression to Type 2 Diabetes: A Retrospective Analysis of the Cluster-Randomised "Let's Prevent Diabetes" Trial
Laura J Gray, Thomas Yates, Jacqui Troughton, Kamlesh Khunti, Melanie J Davies
PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2016
DOI: 10.1371/journal.pmed.1002078
BACKGROUND: Prevention of type 2 diabetes mellitus (T2DM) is a global priority. Let's Prevent Diabetes is a group-based diabetes prevention programme; it was evaluated in a cluster-randomised trial, in which the primary analysis showed a reduction in T2DM (hazard ratio [HR] 0.74, 95% CI 0.48-1.14, p = 0.18). We examined the association of engagement and retention with the Let's Prevent Diabetes prevention programme and T2DM incidence. METHODS AND FINDINGS: We used data from a completed cluster-randomised controlled trial including 43 general practices randomised to receive either standard care or a 6-h group structured education programme with an annual refresher course for 2 y. The primary ..
Kamlesh Khunti Author General Practice
Awarded by National Institute for Health Research (NIHR)
Awarded by National Institute for Health Research
There was no specific funding for this piece of work. The Let's Prevent Diabetes Trial was funded by National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0606-1272). This article presents independent research commissioned by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0606-1272). The funders of the trial had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The project was supported by the University of Leicester Clinical Trials Unit, the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care - East Midlands (NIHR CLAHRC - EM), and the NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester.
Life-Style Interventions
Let's Prevent Diabetes Team
Clinical Trials and Supportive Activities
Comparative Effectiveness Research
Patient Compliance
Risk Reduction Behavior
3.1 Primary Prevention Interventions To Modify Behaviours Or Promote Wellbeing
Mellitus
Impaired Glucose-Tolerance
Metaanalysis