8. A comparison of time-related changes in trans-nonachlor, oxychlordane and trans-chlordane residues in rat tissues and the relationship between tissue residue levels, functional changes and gender.
Short term: To compare changes in trans-nonachlor, oxychlordane and trans-chlordane residues over time in fat and other tissues (using the rat model), and to relate fat and tissue residue levels to clinical changes in male and female rats. Long term: To provide current information on the toxicity of chlordane metabolites and constituents, including trans-nonachlor and oxychlordane.
9. Spatial and long-term trends in organic contaminants and metals in fish species important to the commercial, sports, and domestic fisheries of Great Slave Lake and the Slave River ecosystem.
i.	Determine mercury, metals and persistent organic contaminant pollutants (POPs) concentrations in lake trout harvested from two locations (West Basin near Hay River, East Arm at Lutsel K'e) and burbot harvested from one location (West Basin at Fort Resolution) in 2015 to further extend the long-term (1993-2013 (POPs) and 1993-2014 (mercury)) database. ii.	Determine POPs trends in lake trout and burbot using our 1993-2014 data base. iii.	Continue our investigations of mercury trends in predatory fish to include lakes in the Deh Cho, Great Bear Lake, and other lakes as opportunities arise. iv.	Participate in and contribute information to AMAP expert work groups for trend monitoring for POPs and mercury. v.	Integrate our mercury trend assessments with studies we are conducting in the western provinces as part of Canada's Clear Air Regularly Agenda for its Mercury Science Assessment. vi.	Work with communities in capacity building and training.
The primary scope of the project is to investigate the long-term time trend of brominated flame retardants for the contamination and possible effects in relation to the contamination of peregrine falcon eggs. The contamination by the conventional POP compounds will also be identified. Totally 36 out of 53 collected eggs will be analysed. Time trend analysis will be performed based on a multi-variant methodology for a period of 18 years. The result will contribute to the assessment of organic pollutant contaminationm in Greenland including the effect on vulnerable wild life.
Polar bears are at the top of the arctic marine food chain. Owing to the high lipid content of their diet, polar bears appear particularly prone to bioaccumulate organochlorines. Polar bears from East Greenland and Svalbard have higher contaminant levels than polar bears elsewhere in the Arctic. Levels of PCBs in these areas might negatively affect reproduction and survival. So far more than 130 polar bear samples have been collected since 1999. These samples are being analysed for organochlorines and pathological effects.