Wireless networks have become a key element in healtheare institutions for streamlining access to clinical information. With the advent of wireless technology, handheld devices such as PDAs, pagers and Pocket PCs are now deployed into modern hospital systems. However, integrating confidential data and wireless technology introduces significant risk and increases the potential threat to sensitive medical information. This paper investigates the fundamental concepts required to understand PDA security issues in the health sector. It examines the various risk and threat issues, the security measures needed to secure PDA use, and the appropriate security infrastructure for healthcare settings.