ARRS projects
RI-SI – CERIC
David 800 MHz
Aska 600 MHz
Lara 600 MHz
Magic 600 MHz
Oro 600 MHz
Nika 400 MHz
Ajax 300 MHz (retired)
Odie 300 MHz (retired)
NMR Centre
Marko Trajkovski
marko.trajkovski@ki.si
(01) 47-60-505
Marko Trajkovski was born on 6th April, 1984, in Brežice, Slovenia. He received his B.Sc. degree in biochemistry at University of Ljubljana, Faculty of Chemistry and Chemical Technology in 2008 with thesis entitled 'Studies of cation interactions with DNA aptamer of thrombin', that also won him a prize on 38th Krka's awards. From 2008 to 2013 he was involved in research activities as a PhD student working under mentorship of Professor Dr. Janez Plavec at the Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia. In 2011 he received award for best poster presentation by a young researcher at the "XVth Symposium on Chemistry of Nucleic Acid Components", Český Krumlov, Czech Republic. In 2013 he received title D.Sc. at University of Ljubljana, Faculty of Chemistry and Chemical Technology by elaborating Ph.D. thesis entitled 'Folding and structures of DNA G-quadruplexes', for which he received Krka's prize and Pregl's prize of National Institute of Chemistry. From 2013 his research activities comprise investigation of non-canonical structures and their interaction with small organic molecules and ions. In this regard, his work contributed to better understanding of principles governing G-quadruplex self-assembly and provided insights into specific structural motifs addressing the role of G-rich DNA in biological process, nanotechnology and medical applications.
• Folding and structural details of non-canonical nucleic acid structures
• Structures of nucleic acid - organic molecule complexes, particularly the features at the interfaces
• Interactions between nucleic acid and cations
C. Platella, M. Trajkovski, F. Doria, M. Freccero, J. Plavec and D. Montesarchio
On the interaction of an anticancer trisubstituted naphthalene diimide with G-quadruplexes of different topologies: a structural insight
Nucleic Acids Res. 2020, 48 (21), 12380-12393.
Web access at Oxford Journals
Q. Li, J. Chen, M. Trajkovski, Y. Zhou, C. Fan, K. Lu, P. Tang, X. Su, J. Plavec, Z. Xi and C. Zhou
4′-Fluorinated RNA: Synthesis, Structure, and Applications as a Sensitive 19F NMR Probe of RNA Structure and Function
J. Am. Chem. Soc. 2020, 142 (10), 4739-4748.
Web access at ACS Publications
M. Trajkovski and J. Plavec
Chasing particularities of guanine- and cytosine-rich DNA strands
Molecules 2020, 25(3), 434.
Web access at MDPI
M. M. Naeem, R. Maheshan, S. R. Costford, A. Wahedi, M. Trajkovski, J. Plavec, L. A. Yatsunyk, G. L. Ciesielski, B. A. Kaufman and N. Sondheimer
G-Quadruplex Mediated Reduction of a Pathogenic Mitochondrial Heteroplasmy
Hum. Mol. Genet. 2019, 28(19), 3163-3174.
F. Guo, Z. Yue, M. Trajkovski, X. Zhou, D. Cao, Q. Li, B. Wang, X. Wen, J. Plavec, Q. Peng, Z. Xi and C. Zhou
Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification
J. Am. Chem. Soc. 2018, 140 (38), 11893-11897.
M. Trajkovski, T. Endoh, H. Tateishi-Karimata, T. Ohyama, S. Tanaka, J. Plavec and N. Sugimoto
Pursuing origins of (poly)ethylene glycol-induced G-quadruplex structural modulations
Nucleic Acids Res. 2018, 46 (8), 4301-4315.
M. Trajkovski, E. Morel, F. Hamon, S. Bombard, M.-P. Teulade-Fichou and J. Plavec
Interactions of Pt-ttpy with G-quadruplexes originating from promoter region of the c-myc gene deciphered by NMR and gel electrophoresis analysis
Chem. Eur. J. 2015, 21 (21), 7798–7807.
Web access at Wiley Online Library
Assessing Roles Of Cations In G-quadruplex Based Nanowires By NMR
J. Phys. Chem. C 2012, 116 (44), 23821-23825.
M. Trajkovski, M. Webba da Silva and J. Plavec
Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene
J. Am. Chem. Soc. 2012, 134 (9), 4132–4141.
M. Webba da Silva, M. Trajkovski, Y. Sannohe, N. M. Hessari, H. Sugiyama and J. Plavec
Design of a G-Quadruplex Topology through Glycosidic Bond Angles
Angew. Chem. Int. Edit. 2009, 48 (48), 9167-9170.
M. Trajkovski, P. Sket and J. Plavec
Cation Localization and Movement within DNA Thrombin Binding Aptamer in Solution
Org. Biomol. Chem. 2009, 7 (22), 4677-4684.