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Project acronym 321
Project from Cubic To Linear complexity in computational electromagnetics
Researcher (PI) Francesco Paolo ANDRIULLI
Host Institution (HI) POLITECNICO DI TORINO
Summary Computational Electromagnetics (CEM) is the scientific field at the origin of all new modeling and simulation tools required by the constantly arising design challenges of emerging and future technologies in applied electromagnetics. As in many other technological fields, however, the trend in all emerging technologies in electromagnetic engineering is going towards miniaturized, higher density and multi-scale scenarios. Computationally speaking this translates in the steep increase of the number of degrees of freedom. Given that the design cost (the cost of a multi-right-hand side problem dominated by matrix inversion) can scale as badly as cubically with these degrees of freedom, this fact, as pointed out by many, will sensibly compromise the practical impact of CEM on future and emerging technologies. For this reason, the CEM scientific community has been looking for years for a FFT-like paradigm shift: a dynamic fast direct solver providing a design cost that would scale only linearly with the degrees of freedom. Such a fast solver is considered today a Holy Grail of the discipline. The Grand Challenge of 321 will be to tackle this Holy Grail in Computational Electromagnetics by investigating a dynamic Fast Direct Solver for Maxwell Problems that would run in a linear-instead-of-cubic complexity for an arbitrary number and configuration of degrees of freedom. The failure of all previous attempts will be overcome by a game-changing transformation of the CEM classical problem that will leverage on a recent breakthrough of the PI. Starting from this, the project will investigate an entire new paradigm for impacting algorithms to achieve this grand challenge. The impact of the FFT's quadratic-to-linear paradigm shift shows how computational complexity reductions can be groundbreaking on applications. The cubic-to-linear paradigm shift, which the 321 project will aim for, will have such a rupturing impact on electromagnetic science and technology.
Computational Electromagnetics (CEM) is the scientific field at the origin of all new modeling and simulation tools required by the constantly arising design challenges of emerging and future technologies in applied electromagnetics. As in many other technological fields, however, the trend in all emerging technologies in electromagnetic engineering is going towards miniaturized, higher density and multi-scale scenarios. Computationally speaking this translates in the steep increase of the number of degrees of freedom. Given that the design cost (the cost of a multi-right-hand side problem dominated by matrix inversion) can scale as badly as cubically with these degrees of freedom, this fact, as pointed out by many, will sensibly compromise the practical impact of CEM on future and emerging technologies. For this reason, the CEM scientific community has been looking for years for a FFT-like paradigm shift: a dynamic fast direct solver providing a design cost that would scale only linearly with the degrees of freedom. Such a fast solver is considered today a Holy Grail of the discipline. The Grand Challenge of 321 will be to tackle this Holy Grail in Computational Electromagnetics by investigating a dynamic Fast Direct Solver for Maxwell Problems that would run in a linear-instead-of-cubic complexity for an arbitrary number and configuration of degrees of freedom. The failure of all previous attempts will be overcome by a game-changing transformation of the CEM classical problem that will leverage on a recent breakthrough of the PI. Starting from this, the project will investigate an entire new paradigm for impacting algorithms to achieve this grand challenge. The impact of the FFT's quadratic-to-linear paradigm shift shows how computational complexity reductions can be groundbreaking on applications. The cubic-to-linear paradigm shift, which the 321 project will aim for, will have such a rupturing impact on electromagnetic science and technology.
Project acronym 3DSPIN
Project 3-Dimensional Maps of the Spinning Nucleon
Researcher (PI) Alessandro Bacchetta
Host Institution (HI) UNIVERSITA DEGLI STUDI DI PAVIA
Summary How does the inside of the proton look like? What generates its spin?
3DSPIN will deliver essential information to answer these questions at the frontier of subnuclear physics. At present, we have detailed maps of the distribution of quarks and gluons in the nucleon in 1D (as a function of their momentum in a single direction). We also know that quark spins account for only about 1/3 of the spin of the nucleon. 3DSPIN will lead the way into a new stage of nucleon mapping, explore the distribution of quarks in full 3D momentum space and obtain unprecedented information on orbital angular momentum. Goals 1. extract from experimental data the 3D distribution of quarks (in momentum space), as described by Transverse-Momentum Distributions (TMDs); 2. obtain from TMDs information on quark Orbital Angular Momentum (OAM). Methodology 3DSPIN will implement state-of-the-art fitting procedures to analyze relevant experimental data and extract quark TMDs, similarly to global fits of standard parton distribution functions. Information about quark angular momentum will be obtained through assumptions based on theoretical considerations. The next five years represent an ideal time window to accomplish our goals, thanks to the wealth of expected data from deep-inelastic scattering experiments (COMPASS, Jefferson Lab), hadronic colliders (Fermilab, BNL, LHC), and electron-positron colliders (BELLE, BABAR). The PI has a strong reputation in this field. The group will operate in partnership with the Italian National Institute of Nuclear Physics and in close interaction with leading experts and experimental collaborations worldwide. Impact Mapping the 3D structure of chemical compounds has revolutionized chemistry. Similarly, mapping the 3D structure of the nucleon will have a deep impact on our understanding of the fundamental constituents of matter. We will open new perspectives on the dynamics of quarks and gluons and sharpen our view of high-energy processes involving nucleons.
How does the inside of the proton look like? What generates its spin?
3DSPIN will deliver essential information to answer these questions at the frontier of subnuclear physics. At present, we have detailed maps of the distribution of quarks and gluons in the nucleon in 1D (as a function of their momentum in a single direction). We also know that quark spins account for only about 1/3 of the spin of the nucleon. 3DSPIN will lead the way into a new stage of nucleon mapping, explore the distribution of quarks in full 3D momentum space and obtain unprecedented information on orbital angular momentum. Goals 1. extract from experimental data the 3D distribution of quarks (in momentum space), as described by Transverse-Momentum Distributions (TMDs); 2. obtain from TMDs information on quark Orbital Angular Momentum (OAM). Methodology 3DSPIN will implement state-of-the-art fitting procedures to analyze relevant experimental data and extract quark TMDs, similarly to global fits of standard parton distribution functions. Information about quark angular momentum will be obtained through assumptions based on theoretical considerations. The next five years represent an ideal time window to accomplish our goals, thanks to the wealth of expected data from deep-inelastic scattering experiments (COMPASS, Jefferson Lab), hadronic colliders (Fermilab, BNL, LHC), and electron-positron colliders (BELLE, BABAR). The PI has a strong reputation in this field. The group will operate in partnership with the Italian National Institute of Nuclear Physics and in close interaction with leading experts and experimental collaborations worldwide. Impact Mapping the 3D structure of chemical compounds has revolutionized chemistry. Similarly, mapping the 3D structure of the nucleon will have a deep impact on our understanding of the fundamental constituents of matter. We will open new perspectives on the dynamics of quarks and gluons and sharpen our view of high-energy processes involving nucleons.
Project acronym BOOST
Project Biomimetic trick to re-balance Osteblast-Osteoclast loop in osteoporoSis treatment: a Topological and materials driven approach
Researcher (PI) Chiara Silvia Vitale Brovarone
Summary One out of 5 people in their fifties will experience a bone fracture due to osteoporosis (OP)-induced fragility in their lifetime. The OP socio-economic burden is dramatic and involves tens of millions of people in the EU, with a steadily increasing number due to population ageing. Current treatments entail drug-therapy coupled with a healthy lifestyle but OP fractures need mechanical fixation to rapidly achieve union: the contribution of biomaterial scientists in this field is still far from taking its expected leading role in cutting-edge research. Bone remodelling is a well-coordinated process of bone resorption by osteoclasts followed by the production of new bone by osteoblasts. This process occurs continuously throughout life in a coupling with a positive balance during growth and negative with ageing, which can result in OP. We believe that an architecture driven stimulation of the osteoclast/osteoblast coupling, with an avant-garde focus on osteoclasts activity, is the key to success in treating unbalanced bone remodelling. We aim to manufacture a scaffold that mimics healthy bone features which will establish a new microenvironment favoring a properly stimulated and active population of osteoclasts and osteoblasts, i.e. a well-balanced bone cooperation. After 5 years we will be able to prove the efficacy of this approach. A benchmark will be set up for OP fracture treatment and for the realization of smart bone substitutes that will be able to locally "trick" aged bone cells stimulating them to act as healthy ones. BOOST results will have an unprecedented impact on the scientific research community, opening a new approach to set up smart, biomimetic strategies to treat aged, unbalanced bone tissues and to reduce OP-associated disabilities and financial burdens.
One out of 5 people in their fifties will experience a bone fracture due to osteoporosis (OP)-induced fragility in their lifetime. The OP socio-economic burden is dramatic and involves tens of millions of people in the EU, with a steadily increasing number due to population ageing. Current treatments entail drug-therapy coupled with a healthy lifestyle but OP fractures need mechanical fixation to rapidly achieve union: the contribution of biomaterial scientists in this field is still far from taking its expected leading role in cutting-edge research. Bone remodelling is a well-coordinated process of bone resorption by osteoclasts followed by the production of new bone by osteoblasts. This process occurs continuously throughout life in a coupling with a positive balance during growth and negative with ageing, which can result in OP. We believe that an architecture driven stimulation of the osteoclast/osteoblast coupling, with an avant-garde focus on osteoclasts activity, is the key to success in treating unbalanced bone remodelling. We aim to manufacture a scaffold that mimics healthy bone features which will establish a new microenvironment favoring a properly stimulated and active population of osteoclasts and osteoblasts, i.e. a well-balanced bone cooperation. After 5 years we will be able to prove the efficacy of this approach. A benchmark will be set up for OP fracture treatment and for the realization of smart bone substitutes that will be able to locally "trick" aged bone cells stimulating them to act as healthy ones. BOOST results will have an unprecedented impact on the scientific research community, opening a new approach to set up smart, biomimetic strategies to treat aged, unbalanced bone tissues and to reduce OP-associated disabilities and financial burdens.
Project acronym CWASI
Project Coping with water scarcity in a globalized world
Researcher (PI) Francesco Laio
Summary We intend to set up a new globalized perspective to tackle water and food security in the 21st century. This issue is intrinsically global as the international trade of massive amounts of food makes societies less reliant on locally available water, and entails large-scale transfers of virtual water (defined as the water needed to produce a given amount of a food commodity). The network of virtual water trade connects a large portion of the global population, with 2800 km3 of virtual water moved around the globe in a year. We provide here definitive indications on the effects of the globalization of (virtual) water on the vulnerability to a water crisis of the global water system. More specifically, we formulate the following research hypotheses: 1) The globalization of (virtual) water resources is a short-term solution to malnourishment, famine, and conflicts, but it also has relevant negative implications for human societies. 2) The virtual water dynamics provide the suitable framework in order to quantitatively relate water-crises occurrence to environmental and socio-economic factors. 3) The risk of catastrophic, global-scale, water crises will increase in the next decades. To test these hypotheses, we will capitalize on the tremendous amount of information embedded in nearly 50 years of available food and virtual water trade data. We will adopt an innovative research approach based on the use of: advanced statistical tools for data verification and uncertainty modeling; methods borrowed from the complex network theory, aimed at analyzing the propagation of failures through the network; multivariate nonlinear analyses, to reproduce the dependence of virtual water on time and on external drivers; multi-state stochastic modeling, to study the effect on the global water system of random fluctuations of the external drivers; and scenario analysis, to predict the future probability of occurrence of water crises.
We intend to set up a new globalized perspective to tackle water and food security in the 21st century. This issue is intrinsically global as the international trade of massive amounts of food makes societies less reliant on locally available water, and entails large-scale transfers of virtual water (defined as the water needed to produce a given amount of a food commodity). The network of virtual water trade connects a large portion of the global population, with 2800 km3 of virtual water moved around the globe in a year. We provide here definitive indications on the effects of the globalization of (virtual) water on the vulnerability to a water crisis of the global water system. More specifically, we formulate the following research hypotheses: 1) The globalization of (virtual) water resources is a short-term solution to malnourishment, famine, and conflicts, but it also has relevant negative implications for human societies. 2) The virtual water dynamics provide the suitable framework in order to quantitatively relate water-crises occurrence to environmental and socio-economic factors. 3) The risk of catastrophic, global-scale, water crises will increase in the next decades. To test these hypotheses, we will capitalize on the tremendous amount of information embedded in nearly 50 years of available food and virtual water trade data. We will adopt an innovative research approach based on the use of: advanced statistical tools for data verification and uncertainty modeling; methods borrowed from the complex network theory, aimed at analyzing the propagation of failures through the network; multivariate nonlinear analyses, to reproduce the dependence of virtual water on time and on external drivers; multi-state stochastic modeling, to study the effect on the global water system of random fluctuations of the external drivers; and scenario analysis, to predict the future probability of occurrence of water crises.
Project acronym EXPLORINGMATTER
Project Exploring Matter with Precision Charm and Beauty Production Measurements in Heavy Nuclei Collisions at LHCb
Researcher (PI) Giulia Manca
Host Institution (HI) UNIVERSITA DEGLI STUDI DI CAGLIARI
Summary Collisions of ultra relativistic nuclei are a tool to reach huge energy densities and to form a new state of matter called Quark-Gluon Plasma (QGP), where quarks and gluons can move freely. A number of experiments have studied the possible formation of QGP, but the behaviour of heavy particles such as charm (c) and beauty (b) quarks when they traverse this medium is largely unknown and is the most powerful tool to prove the creation of the QGP and to characterise it. I will perform novel measurements using the LHCb detector at CERN, which covers an unique kinematic region, essential for a full understanding of QGP and nuclear matter in general. LHCb has been optimised to perform c and b quark physics measurements in proton-proton collisions. In EXPLORINGMATTER I propose to extend the LHCb programme to collect for the first time data in heavy ion collisions. Three experimental scenarios are foreseen: (1) Collisions of protons, benchmark to understand the behaviour of the c and b particles in other more complicated environments, as well as providing the final answers to the mechanism of heavy quarkonium production; (2) Collisions of protons with heavy nuclei, where cold nuclear matter effects in high-energy collisions can be studied in detail to understand lead nuclei collisions, where QGP is expected to be formed. (3) Collisions of heavy nuclei, pursued (a) by analysing heavy nuclei interactions through a dedicated setup in which gas will be injected in the LHCb interaction region, reaching energy densities typical of dedicated fixed target experiments; (b) by collecting heavy ion collision data at the LHC. This second setup, which has not been envisaged by LHCb up to now will revolutionise the measurements in this area thanks to the LHCb coverage and precision not achievable by any other experiment. My measurements will furthermore indicate the route to new experiments that could be designed on the basis of these findings.
Collisions of ultra relativistic nuclei are a tool to reach huge energy densities and to form a new state of matter called Quark-Gluon Plasma (QGP), where quarks and gluons can move freely. A number of experiments have studied the possible formation of QGP, but the behaviour of heavy particles such as charm (c) and beauty (b) quarks when they traverse this medium is largely unknown and is the most powerful tool to prove the creation of the QGP and to characterise it. I will perform novel measurements using the LHCb detector at CERN, which covers an unique kinematic region, essential for a full understanding of QGP and nuclear matter in general. LHCb has been optimised to perform c and b quark physics measurements in proton-proton collisions. In EXPLORINGMATTER I propose to extend the LHCb programme to collect for the first time data in heavy ion collisions. Three experimental scenarios are foreseen: (1) Collisions of protons, benchmark to understand the behaviour of the c and b particles in other more complicated environments, as well as providing the final answers to the mechanism of heavy quarkonium production; (2) Collisions of protons with heavy nuclei, where cold nuclear matter effects in high-energy collisions can be studied in detail to understand lead nuclei collisions, where QGP is expected to be formed. (3) Collisions of heavy nuclei, pursued (a) by analysing heavy nuclei interactions through a dedicated setup in which gas will be injected in the LHCb interaction region, reaching energy densities typical of dedicated fixed target experiments; (b) by collecting heavy ion collision data at the LHC. This second setup, which has not been envisaged by LHCb up to now will revolutionise the measurements in this area thanks to the LHCb coverage and precision not achievable by any other experiment. My measurements will furthermore indicate the route to new experiments that could be designed on the basis of these findings.
Project acronym GRANN
Project Graphene Coated Nanoparticles and Nanograins
Researcher (PI) Liv Haahr Hornekaer
Host Institution (HI) AARHUS UNIVERSITET
Summary In a truly cross-disciplinary research project encompassing surface science, optics, nano-science, astrophysics and chemistry we will synthesize a novel family of high quality mono-layer graphene coated nanoparticles and graphene nanograins with new chemical and optical properties and investigate their catalytic activity, chemical stability and optical characteristics to gauge their relevance for and applicability in industrial catalysis, solar cells, and interstellar chemistry. This will be accomplished by extending existing expertise, knowledge and methods developed by us and by international colleagues for graphene synthesis, graphene reactivity and chemical functionalization, graphene coatings on industrially relevant samples and interstellar surface astrochemistry on carbonaceous materials, into the nanoparticle regime. Combined with state-of-the-art surface science characterization methods with emphasis on scanning tunnelling microscopy and spectroscopy, high resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and thermal desorption mass spectrometry, complemented by Raman and transmission spectroscopy, this will enable us to design, characterize, and understand the properties of this new family of particles at the atomic level. The vision is to harness and combine the remarkable properties of graphene and nanoparticles to create systems with entirely new and unexplored characteristics, to tune these characteristics to be useful for real-world applications, and to exploit the new systems as the first realistic laboratory models of catalytic nanoparticles for interstellar surface chemistry. This ambitious and cross-disciplinary research program will predominantly take place at the Surface Dynamics Laboratory at Aarhus University which is headed by the applicant, but will also involve local, national and international collaborators.
In a truly cross-disciplinary research project encompassing surface science, optics, nano-science, astrophysics and chemistry we will synthesize a novel family of high quality mono-layer graphene coated nanoparticles and graphene nanograins with new chemical and optical properties and investigate their catalytic activity, chemical stability and optical characteristics to gauge their relevance for and applicability in industrial catalysis, solar cells, and interstellar chemistry. This will be accomplished by extending existing expertise, knowledge and methods developed by us and by international colleagues for graphene synthesis, graphene reactivity and chemical functionalization, graphene coatings on industrially relevant samples and interstellar surface astrochemistry on carbonaceous materials, into the nanoparticle regime. Combined with state-of-the-art surface science characterization methods with emphasis on scanning tunnelling microscopy and spectroscopy, high resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and thermal desorption mass spectrometry, complemented by Raman and transmission spectroscopy, this will enable us to design, characterize, and understand the properties of this new family of particles at the atomic level. The vision is to harness and combine the remarkable properties of graphene and nanoparticles to create systems with entirely new and unexplored characteristics, to tune these characteristics to be useful for real-world applications, and to exploit the new systems as the first realistic laboratory models of catalytic nanoparticles for interstellar surface chemistry. This ambitious and cross-disciplinary research program will predominantly take place at the Surface Dynamics Laboratory at Aarhus University which is headed by the applicant, but will also involve local, national and international collaborators.
Project acronym INTERACTION
Project Cloud-cloud interaction in convective precipitation
Researcher (PI) Jan Olaf Mirko Härter
Host Institution (HI) KOBENHAVNS UNIVERSITET
Call Details Consolidator Grant (CoG), PE10, ERC-2017-COG
Summary State-of-the-art simulations and observations highlight the self-organization of convective clouds. Our recent work shows two aspects: these clouds are capable of unexpected increase in extreme precipitation when temperature rises; interactions between clouds produce the extremes. As clouds interact, they organize in space and carry a memory of past interaction and precipitation events. This evidence reveals a severe shortcoming of the conventional separation into "forcing" and "feedback" in climate model parameterizations, namely that the "feedback" develops a dynamics of its own, thus driving the extremes. The major scientific challenge tackled in INTERACTION is to make a ground-breaking departure from the established paradigm of "quasi-equilibrium" and instantaneous convective adjustment, traditionally used for parameterization of "sub-grid-scale processes" in general circulation models. To capture convective self-organization and extremes, the out-of-equilibrium cloud field must be described. In INTERACTION, I will produce a conceptual model for the out-of-equilibrium system of interacting clouds. Once triggered, clouds precipitate on a short timescale, but then relax in a "recovery" state where further precipitation is suppressed. Interaction with the surroundings occurs through cold pool outflow,facilitating the onset of new events in the wake. I will perform tailored numerical experiments using cutting-edge large-eddy simulations and very-high-resolution observational analysis to determine the effective interactions in the cloud system. Going beyond traditional forcing-and-feedback descriptions, I emphasize gradual self-organization with explicit temperature dependence. The list of key variables of atmospheric water vapor, temperature and precipitation must therefore be amended by variables describing organization. Capturing the self-organization of convection is essential for understanding of the risk of precipitation extremes today and in a future climate.
State-of-the-art simulations and observations highlight the self-organization of convective clouds. Our recent work shows two aspects: these clouds are capable of unexpected increase in extreme precipitation when temperature rises; interactions between clouds produce the extremes. As clouds interact, they organize in space and carry a memory of past interaction and precipitation events. This evidence reveals a severe shortcoming of the conventional separation into "forcing" and "feedback" in climate model parameterizations, namely that the "feedback" develops a dynamics of its own, thus driving the extremes. The major scientific challenge tackled in INTERACTION is to make a ground-breaking departure from the established paradigm of "quasi-equilibrium" and instantaneous convective adjustment, traditionally used for parameterization of "sub-grid-scale processes" in general circulation models. To capture convective self-organization and extremes, the out-of-equilibrium cloud field must be described. In INTERACTION, I will produce a conceptual model for the out-of-equilibrium system of interacting clouds. Once triggered, clouds precipitate on a short timescale, but then relax in a "recovery" state where further precipitation is suppressed. Interaction with the surroundings occurs through cold pool outflow,facilitating the onset of new events in the wake. I will perform tailored numerical experiments using cutting-edge large-eddy simulations and very-high-resolution observational analysis to determine the effective interactions in the cloud system. Going beyond traditional forcing-and-feedback descriptions, I emphasize gradual self-organization with explicit temperature dependence. The list of key variables of atmospheric water vapor, temperature and precipitation must therefore be amended by variables describing organization. Capturing the self-organization of convection is essential for understanding of the risk of precipitation extremes today and in a future climate.
Project acronym InvGroGra
Project Asymptotic invariants of discrete groups, sparse graphs and locally symmetric spaces
Researcher (PI) Miklos Abert
Host Institution (HI) MAGYAR TUDOMANYOS AKADEMIA RENYI ALFRED MATEMATIKAI KUTATOINTEZET
Summary The PI proposes to study the asymptotic behavior of various invariants of discrete groups and their actions, of sparse graphs and of locally symmetric spaces. The game is to connect the asymptotic behavior of an invariant on a sequence of finite models to an analytic invariant on a suitable limit object of the sequence and then use the connection to get new results in both the finite and infinite worlds. The recently emerging notion of invariant random subgroups, initiated by the PI, serves as a unifying language for convergence. These invariants include the minimal number of generators, deficiency, Betti numbers over arbitrary fields, various spectral and representation theoretic invariants, graph polynomials and entropy. The limit objects arising are invariant processes on groups, profinite actions, graphings, invariant random subgroups and measured complexes. The analytic invariants include L2 Betti numbers, spectral and Plancherel measures, cost and its higher order versions, matching and chromatic measures and entropy per site. Energy typically flows both ways between the finite and infinite world and also between the different invariants. We list five recent applications from the PI that emerged from such connections. 1) Any large volume locally symmetric semisimple space has large injectivity radius at most of its points; 2) The rank gradient of a chain equals the cost-1 of the profinite action of the chain; 3) Countable-to-one cellular automata over a sofic group preserve the Lebesque measure; 4) Ramanujan graphs have essentially large girth; 5) The matching measure is continuous for graph convergence, giving new estimates on monomer-dimer free energies. Besides asymptotic group theory and graph theory, the tools of the proposed research come from probability theory, ergodic theory and statistical mechanics. The proposed research will lead to further applications in 3-manifold theory, geometry and ergodic theory.
The PI proposes to study the asymptotic behavior of various invariants of discrete groups and their actions, of sparse graphs and of locally symmetric spaces. The game is to connect the asymptotic behavior of an invariant on a sequence of finite models to an analytic invariant on a suitable limit object of the sequence and then use the connection to get new results in both the finite and infinite worlds. The recently emerging notion of invariant random subgroups, initiated by the PI, serves as a unifying language for convergence. These invariants include the minimal number of generators, deficiency, Betti numbers over arbitrary fields, various spectral and representation theoretic invariants, graph polynomials and entropy. The limit objects arising are invariant processes on groups, profinite actions, graphings, invariant random subgroups and measured complexes. The analytic invariants include L2 Betti numbers, spectral and Plancherel measures, cost and its higher order versions, matching and chromatic measures and entropy per site. Energy typically flows both ways between the finite and infinite world and also between the different invariants. We list five recent applications from the PI that emerged from such connections. 1) Any large volume locally symmetric semisimple space has large injectivity radius at most of its points; 2) The rank gradient of a chain equals the cost-1 of the profinite action of the chain; 3) Countable-to-one cellular automata over a sofic group preserve the Lebesque measure; 4) Ramanujan graphs have essentially large girth; 5) The matching measure is continuous for graph convergence, giving new estimates on monomer-dimer free energies. Besides asymptotic group theory and graph theory, the tools of the proposed research come from probability theory, ergodic theory and statistical mechanics. The proposed research will lead to further applications in 3-manifold theory, geometry and ergodic theory.
Project acronym L.I.F.E.
Project LIVING IN A FRINGE ENVIRONMENT - Investigating occupation and exploitation of desert frontier areas in the Late Roman Empire
Researcher (PI) Corinna Rossi
Host Institution (HI) POLITECNICO DI MILANO
Summary The scope of LIFE is to offer a complete set of archaeological and environmental data to be used to investigate Late Roman settlements along frontier desert areas and to reconstruct the underlying strategy to control the empire's desert edges. The case study is the chain of Late Roman fortified settlements that punctuate the Kharga Oasis (Egypt's Western Desert), that in the Fourth Century represented a portion of the southern boundary of the empire. All these sites, located in a remote and harsh environment, share the same architectural features and are endowed with similar agricultural installations, thus suggesting the existence of a highly motivated large-scale strategy of occupation of the region. A detailed study of Umm al-Dabadib, the best-preserved site, will produce a consistent set of criteria to be applied to the analysis of its less-preserved companions. In turn, a comprehensive study of these self-contained and self-sufficient settlements with a strong military flavour will allow a reconstruction of the Late Roman strategy of control over the desert routes that met in this oasis, and will offer an important contribution to the debate on the defence of the empire's borders in the historical period from Diocletian to Constantine and beyond to the end of the Fourth Century. The sites will be studied using a combination of classic and innovative investigation techniques: 3D survey of the architectural remains, archaeological excavation of specific portions of both the built-up areas and the agricultural systems, archaeobotanical analyses, ceramic studies, analyses of satellite images, all carried out within the wider frame of an environmental study of the area and a historical analysis of the textual sources. The dissemination will take place both through the usual channels (publications on paper) and through an innovative information system accessible to scholars all over the world, which will fully exploit the potential of the latest survey technique.
The scope of LIFE is to offer a complete set of archaeological and environmental data to be used to investigate Late Roman settlements along frontier desert areas and to reconstruct the underlying strategy to control the empire's desert edges. The case study is the chain of Late Roman fortified settlements that punctuate the Kharga Oasis (Egypt's Western Desert), that in the Fourth Century represented a portion of the southern boundary of the empire. All these sites, located in a remote and harsh environment, share the same architectural features and are endowed with similar agricultural installations, thus suggesting the existence of a highly motivated large-scale strategy of occupation of the region. A detailed study of Umm al-Dabadib, the best-preserved site, will produce a consistent set of criteria to be applied to the analysis of its less-preserved companions. In turn, a comprehensive study of these self-contained and self-sufficient settlements with a strong military flavour will allow a reconstruction of the Late Roman strategy of control over the desert routes that met in this oasis, and will offer an important contribution to the debate on the defence of the empire's borders in the historical period from Diocletian to Constantine and beyond to the end of the Fourth Century. The sites will be studied using a combination of classic and innovative investigation techniques: 3D survey of the architectural remains, archaeological excavation of specific portions of both the built-up areas and the agricultural systems, archaeobotanical analyses, ceramic studies, analyses of satellite images, all carried out within the wider frame of an environmental study of the area and a historical analysis of the textual sources. The dissemination will take place both through the usual channels (publications on paper) and through an innovative information system accessible to scholars all over the world, which will fully exploit the potential of the latest survey technique.
Project acronym NICHOID
Project Mechanobiology of nuclear import of transcription factors modeled within a bioengineered stem cell niche.
Researcher (PI) Manuela Teresa Raimondi
Summary Many therapeutic applications of stem cells require accurate control of their differentiation. To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as "synthetic niches" for the cells, mimicking the native ones. The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of the nuclear pore complexes. If verified, this idea could lead to a breakthrough in biomimetic approaches to engineering stem cell differentiation. I investigate this question specifically in mesenchymal stem cells (MSC), because they are adherent and highly mechano-sensitive to architectural cues of the microenvironment. To verify my hypothesis I will use a combined experimental-computational model of mechanotransduction. I will a) scale-up an existing three-dimensional synthetic niche culture substrate, fabricated by two-photon laser polymerization, b) characterize the effect of tridimensionality on the differentiation fate of MSC cultured in the niches, c) develop a multiphysics/multiscale computational model of nuclear import of transcription factors within differentially-spread cultured cells, and d) integrate the numerical predictions with experimentally-measured import of fluorescently-labelled transcription factors. This project requires the synergic combination of several advanced bioengineering technologies, including micro/nano fabrication and biomimetics. The use of two-photon laser polymerization for controlling the geometry of the synthetic cell niches is very innovative and will highly impact the fields of bioengineering and biomaterial technology. A successful outcome will lead to a deeper understanding of bioengineering methods to direct stem cell fate and have therefore a significant impact in tissue repair technologies and regenerative medicine.
Many therapeutic applications of stem cells require accurate control of their differentiation. To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as "synthetic niches" for the cells, mimicking the native ones. The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of the nuclear pore complexes. If verified, this idea could lead to a breakthrough in biomimetic approaches to engineering stem cell differentiation. I investigate this question specifically in mesenchymal stem cells (MSC), because they are adherent and highly mechano-sensitive to architectural cues of the microenvironment. To verify my hypothesis I will use a combined experimental-computational model of mechanotransduction. I will a) scale-up an existing three-dimensional synthetic niche culture substrate, fabricated by two-photon laser polymerization, b) characterize the effect of tridimensionality on the differentiation fate of MSC cultured in the niches, c) develop a multiphysics/multiscale computational model of nuclear import of transcription factors within differentially-spread cultured cells, and d) integrate the numerical predictions with experimentally-measured import of fluorescently-labelled transcription factors. This project requires the synergic combination of several advanced bioengineering technologies, including micro/nano fabrication and biomimetics. The use of two-photon laser polymerization for controlling the geometry of the synthetic cell niches is very innovative and will highly impact the fields of bioengineering and biomaterial technology. A successful outcome will lead to a deeper understanding of bioengineering methods to direct stem cell fate and have therefore a significant impact in tissue repair technologies and regenerative medicine.
Project acronym SEMICOMPLEX
Project Divide and conquer ab initio semiclassical molecular dynamics for spectroscopic calculations of complex systems
Researcher (PI) Michele Ceotto
Host Institution (HI) UNIVERSITA DEGLI STUDI DI MILANO
Summary Given the continuing revolution in "nano" and "bio" technologies, it is urgent for chemists to be able to carry out reliable quantum dynamics simulations of complex molecular systems. The goal of this project is to fill the gap between theory and experiment and provide the community with a user-friendly computational tool for nuclear spectra (IR, vibro-electronic, etc.) calculations of very complex systems. Present theoretical methodologies are hampered either by artificial nuclear potential interactions or by local potential perturbation assumptions. The semiclassical molecular dynamics method that I have been pioneering is not affected by these limitations because it is based on ab initio classical trajectories. The nuclear forces can be calculated by any electronic structure software and trajectories can explore the entire potential surface. The remaining challenge is to overcome the exponential scaling of computational power. I will adopt a divide-and-conquer strategy to beat the curse of dimensionality. Firstly, the ab initio classical molecular dynamics is performed for the entire complex system. Then, partial spectra are calculated by using the semiclassical information derived by the projection of the trajectories onto lower dimensional spaces. Vibrational modes are not artificially decoupled. Finally, the entire spectrum is reconstructed piece by piece. This method allows chemists to have a more reliable spectral interpretation in a wider context up to the nanoscale. With the help of my own previous experience and my collaborations, I will simulate pollutant photodegradation for environmental remediation and the vibro-electronic spectra of carcinogenic molecules adsorbed on TiO2. I will also reproduce the spectroscopic properties of molecular nano-texturing of titania films for outdoor cultural heritage preservation. A new generation of semiclassical fellows will be educated to put Europe on the leading edge of quantum simulations for spectroscopy.
Given the continuing revolution in "nano" and "bio" technologies, it is urgent for chemists to be able to carry out reliable quantum dynamics simulations of complex molecular systems. The goal of this project is to fill the gap between theory and experiment and provide the community with a user-friendly computational tool for nuclear spectra (IR, vibro-electronic, etc.) calculations of very complex systems. Present theoretical methodologies are hampered either by artificial nuclear potential interactions or by local potential perturbation assumptions. The semiclassical molecular dynamics method that I have been pioneering is not affected by these limitations because it is based on ab initio classical trajectories. The nuclear forces can be calculated by any electronic structure software and trajectories can explore the entire potential surface. The remaining challenge is to overcome the exponential scaling of computational power. I will adopt a divide-and-conquer strategy to beat the curse of dimensionality. Firstly, the ab initio classical molecular dynamics is performed for the entire complex system. Then, partial spectra are calculated by using the semiclassical information derived by the projection of the trajectories onto lower dimensional spaces. Vibrational modes are not artificially decoupled. Finally, the entire spectrum is reconstructed piece by piece. This method allows chemists to have a more reliable spectral interpretation in a wider context up to the nanoscale. With the help of my own previous experience and my collaborations, I will simulate pollutant photodegradation for environmental remediation and the vibro-electronic spectra of carcinogenic molecules adsorbed on TiO2. I will also reproduce the spectroscopic properties of molecular nano-texturing of titania films for outdoor cultural heritage preservation. A new generation of semiclassical fellows will be educated to put Europe on the leading edge of quantum simulations for spectroscopy.
Project acronym TACITROOTS
Project The Accademia del Cimento in Florence: tracing the roots of the European scientific enterprise
Researcher (PI) Giulia Giannini
Summary The Accademia del Cimento (Florence) is the first European society to put experimentation at the core of scientific activity and to be supported by a public power. It lasted only ten years (1657-1667), the same years that saw the establishment of societies of greater fame and longevity such as the Royal Society and the Académie Royale des Sciences. The copious amount of records – most still unpublished – left by its members casts new light onto the process of establishment of scientific societies in Europe, on the emergence of a shared scientific discourse, and its normalisation. It also clarifies the "viral" aspect of some experiments as well as the dynamics of competition, imitation and (self-) censorship from which these institutional and scientific endeavours originated. This project analyses for the first time in its entirety the extensive corpus of unpublished documents (ca. 15,000 papers), descriptions of experiments and thousands of epistolary exchanges between members of the Cimento and scholars throughout Europe. By looking at the sources in their entirety, it aims at systematically connecting the strictly experimental, theoretical and philosophical aspects of the Accademia with its intellectual history. The research will thus analyse the hundreds of experiments designed and conducted by the members, without losing sight of the specific context in which they were produced and disseminated. It will reassess the Cimento's contribution to the development of a scientific lexicon and the materiality of its work, which was heavily reliant on the design and use of scientific instruments. The substantive body of correspondence – neglected by historians so far – will uncover members' aims and philosophical concerns, (self-) censorship mechanisms as well as the Cimento's ties with scholars in the founding process of other famous academies. This research will thus provide new insights into the origin of scientific institutions in the Early Modern period.
The Accademia del Cimento (Florence) is the first European society to put experimentation at the core of scientific activity and to be supported by a public power. It lasted only ten years (1657-1667), the same years that saw the establishment of societies of greater fame and longevity such as the Royal Society and the Académie Royale des Sciences. The copious amount of records – most still unpublished – left by its members casts new light onto the process of establishment of scientific societies in Europe, on the emergence of a shared scientific discourse, and its normalisation. It also clarifies the "viral" aspect of some experiments as well as the dynamics of competition, imitation and (self-) censorship from which these institutional and scientific endeavours originated. This project analyses for the first time in its entirety the extensive corpus of unpublished documents (ca. 15,000 papers), descriptions of experiments and thousands of epistolary exchanges between members of the Cimento and scholars throughout Europe. By looking at the sources in their entirety, it aims at systematically connecting the strictly experimental, theoretical and philosophical aspects of the Accademia with its intellectual history. The research will thus analyse the hundreds of experiments designed and conducted by the members, without losing sight of the specific context in which they were produced and disseminated. It will reassess the Cimento's contribution to the development of a scientific lexicon and the materiality of its work, which was heavily reliant on the design and use of scientific instruments. The substantive body of correspondence – neglected by historians so far – will uncover members' aims and philosophical concerns, (self-) censorship mechanisms as well as the Cimento's ties with scholars in the founding process of other famous academies. This research will thus provide new insights into the origin of scientific institutions in the Early Modern period.
Project acronym VIBRA
Project Very fast Imaging by Broadband coherent RAman
Researcher (PI) Dario Polli
Summary The VIBRA project aims at developing an innovative microscope for real-time non-invasive imaging of cells and tissues, which promises to have a revolutionary impact on several fields of biology and medicine. Chemically specific vibrational signatures of molecules enable their direct structural characterization. Reliable and quantitative endogenous bio-markers can be established, e.g., to follow cell differentiation and to identify crucial properties of tissues (malignant vs benign phenotype of a tumour). In this way neoplasms can be located and their borders with normal tissue traced for surgery. Spontaneous Raman spectroscopy demonstrated this capability, but it is intrinsically too slow for imaging. Coherent Raman microscopy, on the other hand, can reach extremely high speed (up to the video rate) but at the expense of poor chemical selectivity, being limited to a single vibrational frequency. The ground-breaking goal of VIBRA is to combine the most detailed molecular information over the entire vibrational spectrum with the highest acquisition speed. The PI will develop a complete coherent Raman microscope for near-video-rate broadband vibrational imaging. This high risk/high gain goal will be achieved by the combination of four key developments: improved pulsed laser source; optimized non-linear interaction, enhancing the signal; increase in acquisition speed, thanks to innovative spectrometers; parallel on-board data processing. In the final application phase, the VIBRA project will validate the performances of the novel vibrational imaging system studying two important bio-medical problems: cancerous cell differentiation and detection of neuronal tumours. This will pave the way towards future "virtual histopathology": intraoperative non-invasive evaluation of cancerous tissue. My vision is to allow researchers and doctors without a specific knowledge in lasers and optics to routinely visualize functional properties of cells and tissues in vivo.
The VIBRA project aims at developing an innovative microscope for real-time non-invasive imaging of cells and tissues, which promises to have a revolutionary impact on several fields of biology and medicine. Chemically specific vibrational signatures of molecules enable their direct structural characterization. Reliable and quantitative endogenous bio-markers can be established, e.g., to follow cell differentiation and to identify crucial properties of tissues (malignant vs benign phenotype of a tumour). In this way neoplasms can be located and their borders with normal tissue traced for surgery. Spontaneous Raman spectroscopy demonstrated this capability, but it is intrinsically too slow for imaging. Coherent Raman microscopy, on the other hand, can reach extremely high speed (up to the video rate) but at the expense of poor chemical selectivity, being limited to a single vibrational frequency. The ground-breaking goal of VIBRA is to combine the most detailed molecular information over the entire vibrational spectrum with the highest acquisition speed. The PI will develop a complete coherent Raman microscope for near-video-rate broadband vibrational imaging. This high risk/high gain goal will be achieved by the combination of four key developments: improved pulsed laser source; optimized non-linear interaction, enhancing the signal; increase in acquisition speed, thanks to innovative spectrometers; parallel on-board data processing. In the final application phase, the VIBRA project will validate the performances of the novel vibrational imaging system studying two important bio-medical problems: cancerous cell differentiation and detection of neuronal tumours. This will pave the way towards future "virtual histopathology": intraoperative non-invasive evaluation of cancerous tissue. My vision is to allow researchers and doctors without a specific knowledge in lasers and optics to routinely visualize functional properties of cells and tissues in vivo.
Project acronym WILLOW
Project WIreLess LOWband communications: massive and ultra-reliable access
Researcher (PI) Petar Popovski
Host Institution (HI) AALBORG UNIVERSITET
Summary The overall objective of WILLOW is to make wireless communication a true commodity by enabling lowband communications: low-rate links for massive number of devices and ultra-reliable connectivity. This research effort is a major endeavour in the area of wireless communications, taking a different path from the mainstream research that aims at "4G, but faster". Lowband communication is the key to enabling new applications, such as massive sensing, ultra-reliable vehicular links and wireless cloud connectivity with guaranteed minimal rate. The research in WILLOW is centred on two fundamental issues. First, it is the efficient communication with short packets, in which the data size is comparable to the size of the metadata, i.e. control information, which is not the case in broadband communication. Communication of short packets that come from a massive number of devices and/or need to meet a latency constraint requires fundamental rethinking of the packet structure and the associated communication protocols. Second is the system architecture in which graceful rate degradation, low latency and massive access can exist simultaneously with the broadband services. The principles from WILLOW will be applied to: (a) clean-slate wireless systems; (b) reengineer existing wireless systems. Option (b) is unique to lowband communication that does not require high physical-layer speed, but can reuse the physical layer of an existing system and redefine the metadata/data relationship to achieve massive/ultra-reliable communication. WILLOW carries high risk by conjecturing that it is possible to support an unprecedented number of connected devices and wireless reliability levels. Considering the timeliness and the relevance, the strong track record of the PI and the rich wireless research environment at Aalborg University, WILLOW is poised to make a breakthrough towards lowband communications and create the technology that will enable a plethora of new wireless usage modes.
The overall objective of WILLOW is to make wireless communication a true commodity by enabling lowband communications: low-rate links for massive number of devices and ultra-reliable connectivity. This research effort is a major endeavour in the area of wireless communications, taking a different path from the mainstream research that aims at "4G, but faster". Lowband communication is the key to enabling new applications, such as massive sensing, ultra-reliable vehicular links and wireless cloud connectivity with guaranteed minimal rate. The research in WILLOW is centred on two fundamental issues. First, it is the efficient communication with short packets, in which the data size is comparable to the size of the metadata, i.e. control information, which is not the case in broadband communication. Communication of short packets that come from a massive number of devices and/or need to meet a latency constraint requires fundamental rethinking of the packet structure and the associated communication protocols. Second is the system architecture in which graceful rate degradation, low latency and massive access can exist simultaneously with the broadband services. The principles from WILLOW will be applied to: (a) clean-slate wireless systems; (b) reengineer existing wireless systems. Option (b) is unique to lowband communication that does not require high physical-layer speed, but can reuse the physical layer of an existing system and redefine the metadata/data relationship to achieve massive/ultra-reliable communication. WILLOW carries high risk by conjecturing that it is possible to support an unprecedented number of connected devices and wireless reliability levels. Considering the timeliness and the relevance, the strong track record of the PI and the rich wireless research environment at Aalborg University, WILLOW is poised to make a breakthrough towards lowband communications and create the technology that will enable a plethora of new wireless usage modes.