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>Proceedings of the British Society of Animal Science
>Volume 2001
>Ah receptor expression and signal transduction in bovine...
Proceedings of the British Society of Animal Science
Ah receptor expression and signal transduction in bovine and rabbit reproductive tissues and embryos
Published online by Cambridge University Press: 20 November 2017
B Fischer ,
A Hasan ,
S Kietz and
P Pocar
B Fischer
Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, D- 06097 Halle (Saale), Germany
A Hasan
S Kietz
Polychlorinated biphenyls (PCB) are persistent environmental contaminants that have been reported to adversely affect reproduction in mammals. The exact mechanism of action of these chemicals on oocyte and embryo development are not known. Previous studies in our laboratory demonstrated that PCB adversely affect in vitro oocyte maturation and embryo development in two different in vitro systems (cattle, rabbit). The objective of present study was to investigate the possible role of the arylhydrocarbon receptor (AhR) in PCB toxicity. The AhR is a transcription factor activated by ligands such as dioxins or PCB. Its transcriptional activity depends on dimerisation with its nuclear partner ARNT. The presence of AhR and ARNT was investigated in bovine and rabbit genital tract (uterus, ovary) and embryonic tissues, employing RT-PCR and immunohistochemistry.
Proceedings of the British Society of Animal Science , Volume 2001 , 2001 , pp. 65
DOI: https://doi.org/10.1017/S1752756200004476[Opens in a new window]
Copyright © The British Society of Animal Science 2001
This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
Gandolfi, F Pocar, P Brevini, T.A.L and Fischer, B 2002. Impact of endocrine disrupters on ovarian function and embryonic development. Domestic Animal Endocrinology, Vol. 23, Issue. 1-2, p. 189.
Brevini, TAL Cillo, F Antonini, S and Gandolfi, F 2005. Effects of Endocrine Disrupters on the Oocytes and Embryos of Farm Animals. Reproduction in Domestic Animals, Vol. 40, Issue. 4, p. 291.
B Fischer (a1), A Hasan (a1), S Kietz (a1) and P Pocar (a1)
DOI: https://doi.org/10.1017/S1752756200004476