Localized 1H-NMR spectroscopy in patients with fibromyalgia: A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
Nicolas Fayed, Javier Garcia-Campayo*, Rosa Magallón, Helena Andrés-Bergareche, Juan V. Luciano, Eva Andres, Julián Beltrán
Department of Clinical and Health Psychology
Hospital Quirónsalud Barcelona
Universidad de Zaragoza
Primary Care Prevention and Health Promotion Research Network, RedIAPP
Aragon Institute of Health Sciences (IACS)
Teaching, Research & Innovation Unit
Complutense University of Madrid
Introduction: The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables.Methods: Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing.Results: Compared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed.Conclusions: Glx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data.
Arthritis Research and Therapy
https://doi.org/10.1186/ar3072
10.1186/ar3072
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Fibromyalgia Medicine and Dentistry 100%
Nuclear Magnetic Resonance Spectroscopy Neuroscience 75%
Glutamic Acid Neuroscience 50%
Diffusion Tensor Imaging Neuroscience 50%
Glutamate Psychology 50%
Proton Nuclear Magnetic Resonance Medicine and Dentistry 37%
Inositol Medicine and Dentistry 37%
Fayed, N., Garcia-Campayo, J., Magallón, R., Andrés-Bergareche, H., Luciano, J. V., Andres, E., & Beltrán, J. (2010). Localized 1H-NMR spectroscopy in patients with fibromyalgia: A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. Arthritis Research and Therapy, 12(4), [R134]. https://doi.org/10.1186/ar3072
Fayed, Nicolas ; Garcia-Campayo, Javier ; Magallón, Rosa et al. / Localized 1H-NMR spectroscopy in patients with fibromyalgia : A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. In: Arthritis Research and Therapy. 2010 ; Vol. 12, No. 4.
@article{04539a98b5424727ab9fae13068a9958,
title = "Localized 1H-NMR spectroscopy in patients with fibromyalgia: A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate",
abstract = "Introduction: The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables.Methods: Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing.Results: Compared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed.Conclusions: Glx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data.",
author = "Nicolas Fayed and Javier Garcia-Campayo and Rosa Magall{\'o}n and Helena Andr{\'e}s-Bergareche and Luciano, {Juan V.} and Eva Andres and Juli{\'a}n Beltr{\'a}n",
note = "Funding Information: We thank Prof. M. Sarasa of the University of Zaragoza for the LCModel software package acquired through grant SAF2006-13332 from the Spanish Ministry of Science. This study was possible thanks to grant PI07/90959, 'Eficacia del tratamiento farmacol{\'o}gico y psicol{\'o}gico de la catastrofizaci{\'o}n en pacientes con fibromialgia: un estudio controlado,' from the Instituto de Salud Carlos III of the Spanish Health Ministry.",
doi = "10.1186/ar3072",
journal = "Arthritis Research and Therapy",
Fayed, N, Garcia-Campayo, J, Magallón, R, Andrés-Bergareche, H, Luciano, JV, Andres, E & Beltrán, J 2010, 'Localized 1H-NMR spectroscopy in patients with fibromyalgia: A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate', Arthritis Research and Therapy, vol. 12, no. 4, R134. https://doi.org/10.1186/ar3072
Localized 1H-NMR spectroscopy in patients with fibromyalgia : A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. / Fayed, Nicolas; Garcia-Campayo, Javier; Magallón, Rosa et al.
In: Arthritis Research and Therapy, Vol. 12, No. 4, R134, 07.07.2010.
T1 - Localized 1H-NMR spectroscopy in patients with fibromyalgia
T2 - A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
AU - Fayed, Nicolas
AU - Garcia-Campayo, Javier
AU - Magallón, Rosa
AU - Andrés-Bergareche, Helena
AU - Luciano, Juan V.
AU - Andres, Eva
AU - Beltrán, Julián
N1 - Funding Information: We thank Prof. M. Sarasa of the University of Zaragoza for the LCModel software package acquired through grant SAF2006-13332 from the Spanish Ministry of Science. This study was possible thanks to grant PI07/90959, 'Eficacia del tratamiento farmacológico y psicológico de la catastrofización en pacientes con fibromialgia: un estudio controlado,' from the Instituto de Salud Carlos III of the Spanish Health Ministry.
N2 - Introduction: The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables.Methods: Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing.Results: Compared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed.Conclusions: Glx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data.
AB - Introduction: The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables.Methods: Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing.Results: Compared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed.Conclusions: Glx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data.
U2 - 10.1186/ar3072
DO - 10.1186/ar3072
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
M1 - R134
Fayed N, Garcia-Campayo J, Magallón R, Andrés-Bergareche H, Luciano JV, Andres E et al. Localized 1H-NMR spectroscopy in patients with fibromyalgia: A controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. Arthritis Research and Therapy. 2010 Jul 7;12(4):R134. doi: 10.1186/ar3072