Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb
Yuki Hirota, Masato Sawada, Yasuyuki S. Kida, Shih Hui Huang, Osamu Yamada, Masanori Sakaguchi, Toshihiko Ogura, Hideyuki Okano, Kazunobu Sawamoto
Neuronal precursor cells generated by stem cells in the subventricular zone (SVZ) migrate and differentiate into mature interneurons in the olfactory bulb (OB). The mechanisms responsible for the dynamic morphological changes in cells during this process are largely unknown. Wnt/planar cell polarity (PCP) signaling regulates various developmental events, including neuronal migration and neurite formation. Here, we studied the function of two components of the PCP pathway, Dishevelled2 and Van Gogh like-2, in the newborn neurons in the postnatal mouse OB. Electroporation- or lentivirus-mediated introduction of vectors carrying a knockdown or dominant-negative construct of these genes into the SVZ altered the distribution and dendrite formation of newborn neurons in the OB, suggesting that PCP signaling is involved in regulating the maturation of new neurons in the OB.
https://doi.org/10.1002/stem.1137
Published - 2012 8月
分子医療
10.1002/stem.1137
「Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。
Cell Polarity Medicine & Life Sciences 100%
Olfactory Bulb Medicine & Life Sciences 92%
Signal Transduction Medicine & Life Sciences 63%
Lateral Ventricles Medicine & Life Sciences 44%
Neurons Medicine & Life Sciences 37%
Electroporation Medicine & Life Sciences 24%
Lentivirus Medicine & Life Sciences 23%
Neurites Medicine & Life Sciences 22%
Hirota, Y., Sawada, M., Kida, Y. S., Huang, S. H., Yamada, O., Sakaguchi, M., Ogura, T., Okano, H., & Sawamoto, K. (2012). Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. Stem Cells, 30(8), 1726-1733. https://doi.org/10.1002/stem.1137
Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. / Hirota, Yuki; Sawada, Masato; Kida, Yasuyuki S. その他.
In: Stem Cells, Vol. 30, No. 8, 08.2012, p. 1726-1733.
Hirota, Y, Sawada, M, Kida, YS, Huang, SH, Yamada, O, Sakaguchi, M, Ogura, T, Okano, H & Sawamoto, K 2012, 'Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb', Stem Cells, vol. 30, no. 8, pp. 1726-1733. https://doi.org/10.1002/stem.1137
Hirota Y, Sawada M, Kida YS, Huang SH, Yamada O, Sakaguchi M その他. Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. Stem Cells. 2012 8月;30(8):1726-1733. doi: 10.1002/stem.1137
Hirota, Yuki ; Sawada, Masato ; Kida, Yasuyuki S. その他. / Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb. In: Stem Cells. 2012 ; Vol. 30, No. 8. pp. 1726-1733.
@article{c73d5f5045204d778edffc68281a8836,
title = "Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb",
abstract = "Neuronal precursor cells generated by stem cells in the subventricular zone (SVZ) migrate and differentiate into mature interneurons in the olfactory bulb (OB). The mechanisms responsible for the dynamic morphological changes in cells during this process are largely unknown. Wnt/planar cell polarity (PCP) signaling regulates various developmental events, including neuronal migration and neurite formation. Here, we studied the function of two components of the PCP pathway, Dishevelled2 and Van Gogh like-2, in the newborn neurons in the postnatal mouse OB. Electroporation- or lentivirus-mediated introduction of vectors carrying a knockdown or dominant-negative construct of these genes into the SVZ altered the distribution and dendrite formation of newborn neurons in the OB, suggesting that PCP signaling is involved in regulating the maturation of new neurons in the OB.",
keywords = "Dishevelled2, Mouse, Neurogenesis, Olfactory bulb, Planar cell polarity pathway, Subventricular zone, Van Gogh like-2",
author = "Yuki Hirota and Masato Sawada and Kida, {Yasuyuki S.} and Huang, {Shih Hui} and Osamu Yamada and Masanori Sakaguchi and Toshihiko Ogura and Hideyuki Okano and Kazunobu Sawamoto",
doi = "10.1002/stem.1137",
journal = "International Journal of Cell Cloning",
T1 - Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb
AU - Hirota, Yuki
AU - Sawada, Masato
AU - Kida, Yasuyuki S.
AU - Huang, Shih Hui
AU - Yamada, Osamu
AU - Sakaguchi, Masanori
AU - Ogura, Toshihiko
AU - Sawamoto, Kazunobu
N2 - Neuronal precursor cells generated by stem cells in the subventricular zone (SVZ) migrate and differentiate into mature interneurons in the olfactory bulb (OB). The mechanisms responsible for the dynamic morphological changes in cells during this process are largely unknown. Wnt/planar cell polarity (PCP) signaling regulates various developmental events, including neuronal migration and neurite formation. Here, we studied the function of two components of the PCP pathway, Dishevelled2 and Van Gogh like-2, in the newborn neurons in the postnatal mouse OB. Electroporation- or lentivirus-mediated introduction of vectors carrying a knockdown or dominant-negative construct of these genes into the SVZ altered the distribution and dendrite formation of newborn neurons in the OB, suggesting that PCP signaling is involved in regulating the maturation of new neurons in the OB.
AB - Neuronal precursor cells generated by stem cells in the subventricular zone (SVZ) migrate and differentiate into mature interneurons in the olfactory bulb (OB). The mechanisms responsible for the dynamic morphological changes in cells during this process are largely unknown. Wnt/planar cell polarity (PCP) signaling regulates various developmental events, including neuronal migration and neurite formation. Here, we studied the function of two components of the PCP pathway, Dishevelled2 and Van Gogh like-2, in the newborn neurons in the postnatal mouse OB. Electroporation- or lentivirus-mediated introduction of vectors carrying a knockdown or dominant-negative construct of these genes into the SVZ altered the distribution and dendrite formation of newborn neurons in the OB, suggesting that PCP signaling is involved in regulating the maturation of new neurons in the OB.
KW - Dishevelled2
KW - Mouse
KW - Neurogenesis
KW - Olfactory bulb
KW - Planar cell polarity pathway
KW - Subventricular zone
KW - Van Gogh like-2
U2 - 10.1002/stem.1137
DO - 10.1002/stem.1137
JO - International Journal of Cell Cloning
JF - International Journal of Cell Cloning