Sphingomyelin: Key Roles in Health and Disease
Sphingomyelin Involvement in Cancer and Parasites Immune Evasion
Edited by Rashika El Ridi and Junfei Jin
Lipids in Health and Disease invites you to contribute a manuscript to our new thematic series, "Sphingomyelin: Key Roles in Health and Disease".
Sphingolipids were named after the mythological sphinx because of their enigmatic nature. Sphingolipids, like the sphinx, are composed of diverse subunits: an amino diol, sphingosine, bound to a fatty acid by an amide linkage, and a polar head group. Perhaps the best known sphinx is the Great Sphinx of Giza. Similarly famous and enigmatic is sphingomyelin (SM), which contains predominantly a phosphocholine as head group. Sphingomyelin is abundant in the outer leaflet of cell plasma membranes where it with cholesterol forms lipid rafts, which serve as platforms for proteins and protein assemblies involved in signal transduction. Additionally, SM is the most abundant sphingolipid in plasma lipoproteins. Removal of the head group phosphocholine by sphingomyelinases generates a product with hydrogen as head group, ceramide, an apoptosis-inducing, and messenger death molecule.
Accumulation of SM and decrease in ceramide levels are implicated in tumor initiation, immune evasion, growth, and metastasis. Additionally, reports document SM roles in atherosclerosis, Alzheimer, and diseases mediated by human immunodeficiency virus and prion invasion. Interactions of sphingolipid metabolism of numerous parasites, such as Plamodium, Trypanosoma, Toxoplasma, Schistosoma with that of the host contribute to parasite survival and/or host defense.
We wish to welcome articles, including original research, narrative reviews, systematic reviews and meta-analysis, and mini-reviews which establish the relation between SM metabolism and cancer immune evasion, thus allowing the discovery of unprecedented approaches and new molecules for cancer prevention and therapy. Of great interest would be articles clarifying the intricacies of SM involvement in atherosclerosis, diabetes, Alzheimer, and diseases caused by viruses and prion. Such articles are expected to open avenues for prevention and therapy of these severe afflictions. The topics that will be particularly welcomed for submission in the issue are those addressing the identification and characterization of SM-related virulence factors and pathways of human parasites, and aiming towards development of novel therapeutic options and molecules.
All submissions should be made by June 30th, 2022.
This collection of articles has not been sponsored and articles have undergone the journal's standard peer-review process.
Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).
Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS
Stroke is the leading cause of death in humans worldwide, and its incidence increases every year. It is well documented that lipids are closely related to stroke. Analyzing the changes in lipid content in the ...
Authors: Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie and Yingfeng Zhang
Citation: Lipids in Health and Disease 2023 22:13
The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis
Retinol-binding protein 4 (RBP4) has been considered to be related to metabolic related diseases, such as hyperuricemia, obesity, and diabetes mellitus. However, whether nonalcoholic fatty liver disease (NAFLD...
Authors: Rui Hu, Xiaoyue Yang, Xiaoyu He and Guangyao Song
Citation: Lipids in Health and Disease 2023 22:8
Content type: Review Published on: 21 January 2023
Relationship between early-onset stroke and triglyceride-glucose index among young Chinese adults
The triglyceride–glucose index (TyG index), an alternative indicator of peripheral insulin resistance (IR), is associated with cardiovascular disease (CVD) in the general population. The aim of this research w...
Authors: Wenqi Xu, Haiyan Zhao, Xu Han, Jianrong Liu, Haixia Li, Junyan Sun, Aijun Xing, Shuohua Chen, Shouling Wu and Yuntao Wu
Effects of camelina oil supplementation on lipid profile and glycemic control: a systematic review and dose‒response meta-analysis of randomized clinical trials
This systematic review and dose–response meta-analysis of published randomized controlled trials (RCTs) was conducted to determine the effectiveness of camelina oil supplementation (COS) on lipid profiles and ...
Authors: Cyrus Jalili, Sepide Talebi, Sanaz Mehrabani, Reza Bagheri, Alexei Wong, Parsa Amirian, Mahsa Zarpoosh, Seyed Mojtaba Ghoreishy, Mohammad Ali Hojjati Kermani and Sajjad Moradi
Citation: Lipids in Health and Disease 2022 21:132
Content type: Review Published on: 7 December 2022
CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease
Non-alcoholic fatty liver (NAFLD) is a complex metabolic disease characterized by fatty degeneration of hepatocytes. Circular RNAs (circRNAs) have been reported to be essential for (NAFLD progression. The pote...
Authors: Xinlu Yuan, Yanyan Li, Song Wen, Chenglin Xu, Congcong Wang, Yanju He and Ligang Zhou
Effects of sphingolipid metabolism disorders on endothelial cells
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related t...
Authors: Yali Lai, Yue Tian, Xintong You, Jiangnan Du and Jianmei Huang
Differences in lipid metabolism in acquired versus preexisting glucose intolerance during gestation: role of free fatty acids and sphingosine-1-phosphate
The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. There is increasing evidence that GDM is a heterogeneous disease with different subtypes. An important question in this context is...
Authors: Moritz Liebmann, Katharina Grupe, Melissa Asuaje Pfeifer, Ingo Rustenbeck and Stephan Scherneck
Content type: Research Published on: 8 October 2022
Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis
Although obesity is caused by different factors, individual susceptibility to obesity differs among people under the same circumstances. The microbiota in the caecum or fresh faeces and metabolites in blood or...
Authors: Yueshan Pang, Yali Zheng, Ni Yang, Meng Zan, Lu Zhang and WeiJun Ding
Drug triggered pruritus, rash, papules, and blisters – is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?
Rash, photosensitivity, erythema multiforme, and the acute generalized exanthematous pustulosis (AGEP) are relatively uncommon adverse reactions of drugs. To date, the etiology is not well understood and indiv...
Authors: Markus Blaess, Lars Kaiser, Oliver Sommerfeld, René Csuk and Hans-Peter Deigner
Content type: Hypothesis Published on: 8 November 2021
Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion
Cell surface biochemical changes, notably excessive increase in outer leaflet sphingomyelin (SM) content, are important in cancer initiation, growth, and immune evasion. Innumerable reports describe methods to...
Authors: Hatem Tallima, Hassan M. E. Azzazy and Rashika El Ridi
Comparison of obesity-related indices for identifying nonalcoholic fatty liver disease: a population-based cross-sectional study in China
The relationship between nonalcoholic fatty liver disease (NAFLD) and obesity-related indices has been analyzed separately thus far, and evidence comparing these indices together is still lacking, especially i...
Authors: Fangfei Xie, Yuyu Pei, Quan Zhou, Deli Cao and Yun Wang
Content type: Research Published on: 10 October 2021