why is it necessary to fit a constrained spline what is the purpose of natural splining why you need to fit a constrained natural spline how to fit constrained natural spline what is constrained in r why do i need a constrained natural spline why do we need a natural spline fit can natural spline pass through intervals? ibi definition fit why is the natural spline constrained why would you want a natural spline for an interbeat interval ifi definition r can you put a constrained spline into an interval why do you need a constrained natural spline why you need to imputation for ibi r os what spline is constrained r - why do i need to fit a constrained spline? how to fit a natural spline which r algorithm is used when imputation for an ibi? why do you need natural spline fit