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Text: identified singing - regulated genes : The pattern of group differences in kIN.X ( D ) more closely mirrored GS differences ( A - B ) than did percent change ( C ) . Magnitude of expression changes during singing were not correlated to GS.motifs . X for genes from Wada et al . ( 2006 ) ( E ) , grouped as shown . Intramodular connectivity ( kIN.X ) was much more correlated to GS.motifs . X ( F ) , emphasizing the advantage of using network connectivity over expression levels to predict behavioral significance .   ( Table S2 ) . Figure S6 : Parkinson 's disease associated genes in the black singing - related module interact with other song module genes ( related to " Biological significance of singingrelated modules " section in main text ) . Figure S6 . VisANT   visualization of PD associated genes that were the most interconnected in the black module ( large spheres / nodes : CACNA1D , GRIN2B , GSK3B , TRPM7 ) , and genes with at least 1 probe in other singing - related modules that they are module assignment in area X. Edges between CACNA1D , GRIN2B , GSK3B , and TRPM7 represent co - expression relationships . Edges between these 4 genes and the smaller nodes represent interactions extracted from the literature by VisANT . The black module was enriched for PD associated genes , a list of which was obtained from the Ingenuity Knowledge Base ( p=3e-4 , Fisher 's exact test ; Table S2 ) . Node color represents module assignment ( e.g. black : GSK3B , blue : SNCAIP , dark green : NIN , orange : TSC2 , salmon : CAMK2A ) , with the 3 light grey nodes denoting genes known to interact with GSK3B that had representative probes with significant GS.motifs . X scores but were not in a singing - related module .   Table S1 . Tissue processing and trait data .<|eot_id|><|start_header_id|>assistant<|end_header_id|>

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