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Text: Further information on experimental design is available in the Nature Research ' Life Sciences Reporting Summary ' linked to this article .   Compartment - specific eQTLs show greater cell - type specificity and distal regulatory element enrichment . a , Diagram describing the integration of kidney eQTLs , GWAS , singlecell expression and regulatory region . b , Heatmap of cell - type - specific expression of identified CKD target genes . The blue / yellow color corresponds to the level of expression ( z - score ) . Endo , endothelial ; Podo , podocyte ; PT , proximal tubule ; LOH , loop of Henle ; DCT , distal convoluted tubule ; CD - PC , collecting duct principal cell ; CD - IC , collecting duct intercalated cell ; Fibro , fibroblast ; Macro , macrophage ; Neutro , neutrophil ; NK , natural killer cell . c , Density plots of best eVariants in tubule ( top ) and glomerulus ( bottom ) and the relationship to transcription start site ( TSS ) . d , Distance of top eVariants from TSS ( -log 10 ) by groups . e , Odds ratios of the top eVariants on kidney promoter by groups . The groups were compared to randomly selected variants matched by MAF and distance to TSS ( n = 5,000 randomly selected times ) . Center lines show the medians ; box limits indicate the 25 th and 75 th percentiles ; whiskers extend to the 5 th and 95 th percentiles , outliers are represented by dots ( d , e ) . f , Odds ratios ( y - axis ) of eGenes from each group enriched by kidney - specific cell type expression . P was calculated by two - sided Fisher 's exact test . RTEC : PT , LOH and     Colocalization of CKD GWAS leading SNPs with kidney compartment eQTLs . a , GWAS variant and eQTL variant are not the same one , but in the same LD ( r 2 > 0.8 ) ; b , The regulatory direction of risk allele of each SNP on its target gene . ↑ , higher gene expression with risk allele ; ↓ , lower gene expression with risk allele ; N / A , this gene or SNP was excluded by data pre - processing .<|eot_id|><|start_header_id|>assistant<|end_header_id|>

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