Freshman Organic Chemistry
Yale,, Fall 2008 , Prof. J. Michael McBride
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Updated On 02 Feb, 19
How Do You Know - Force Laws, Lewis Structures and Resonance - Double Minima, Earnshaws Theorem and Plum - Puddings - Coping with Smallness and Scanning Probe Microscopy - X-Ray Diffraction-Seeing Bonds by Electron Difference Density - Quantum Mechanical Kinetic Energy - One-Dimensional Wave Functions - Chladni Figures and One - Electron Atoms - Reality and the Orbital Approximation - Orbital Correction and Plum - Pudding Molecules - Overlap and Atom - Pair Bonds - Overlap and Energy - Match - Checking Hybridization Theory with XH_3-Chemical Reactivity: SOMO, HOMO, and LUMO - Recognizing Functional Groups - Reaction Analogies and Carbonyl Reactivity - Amide, Carboxylic Acid and Alkyl Lithium-Oxygen and the Chemical Revolution - Rise of the Atomic Theory - Berzelius to Liebig and W�hler - Radical and Type Theories (1832-1850)-Valence Theory and Constitutional Structure (1858) - Determining Chemical Structure by Isomer Counting (1869)
Models in 3D Space (1869-1877); Optical Isomers - Vant Hoffs Tetrahedral Carbon and ChiralityCommunicating Molecular Structure in Diagrams and Words - Stereochemical Nomenclature; Racemization and Resolution - Preparing Single Enantiomers and the Mechanism of Optical Rotation - Esomeprazole as an Example of Drug Testing and Usage - Preparing Single Enantiomers and Conformational Energy - Stereotopicity and Baeyer Strain Theory -Conformational Energy and Molecular Mechanics - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes - Understanding Molecular Structure and Energy through Standard Bonds - Bond Energies, the Boltzmann Factor and Entropy - Potential Energy Surfaces, Transition State Theory and Reaction Mechanism
4.1 ( 11 )
Freshman Organic Chemistry (CHEM 125)
Professor McBride outlines the course with its goals and requirements, including the required laboratory course. To the courses prime question "How do you know" he proposes two unacceptable answers (divine and human authority), and two acceptable answers (experiment and logic). He illustrates the fruitfulness of experiment and logic using the rise of science in the seventeenth century. Londons Royal Society and the "crucial" experiment on light by Isaac Newton provide examples. In his correspondence with Newton Samuel Pepys, diarist and naval purchasing officer, illustrates the attitudes and habits which are most vital for budding scientists - especially those who would like to succeed in this course. The lecture closes by introducing the underlying goal for the first half of the semester understanding the Force Law that describes chemical bonds.
0000 - Chapter 1. Introduction Logistics
0537 - Chapter 2. The Goals of Freshman Organic Chemistry How Do You Know?
1517 - Chapter 3. Bacons Instauration Experimentation over Philosophy
3017 - Chapter 4. How to Succeed in Chem 125 Following Samuel Pepys
4156 - Chapter 5. Atoms, Molecules, and Hookes Law
Complete course materials are available at the Open Yale Courses website httpopen.yale.educourses
This course was recorded in Fall 2008.
Sep 12, 2018
Excellent course helped me understand topic that i couldn't while attendinfg my college.
March 29, 2019
Great course. Thank you very much.