- Oxcarbazepine is structurally a derivative of carbamazepine, adding an
extra oxygen atom to the benzylcarboxamide group. This difference
helps reduce the impact on the liver of metabolizing the drug, and also
prevents the serious forms of anemia occasionally associated with
carbamazepine. Aside from this reduction in side effects, it is thought to
have the same mechanism as carbamazepine -sodium channel
inhibition- and is generally used to treat partial seizures in epileptic
children and adults.
- Oxcarbazepine is the standard treatment for epilepsy.
- Oxcarbazepine works by keeping the brain’s “overexcitable” nerve cells
under control. This suppresses or reduces the frequency of such
- Oxcarbazepine is structurally a derivative of carbamazepine, adding an
- Triptol® is used to treat partial seizures with or without secondarily
generalized tonic-clonic seizures.
- Triptol® can be used alone or in combination with other antiepileptic
- Triptol® is used in Pediatrics:
- Monotherapy in the treatment of partial seizures in children 4-6 years.
- Adjunctive therapy in the treatment of partial seizures in children 2-16
Dosage & Administration
- Triptol® can be used either as a monotherapy or in combination with
other anti-epileptic drugs. In both monotherapy and combination
therapy, Triptol® should be started with a clinically effective dose given
in two doses per day. The dose may be increased according to the
patient's clinical response. In the case of co-treatment, it may be
necessary to reduce the dosage of the other anti-epileptic or increase the
dose of Triptol® more slowly.
- Triptol® can be taken with or without food. The oral suspension is
available for use in younger children who are unable to swallow tablets.
Before using a Triptol® suspension, the bottle should be carefully
cooled and the dose should be immediately withdrawn from the bottle.
The suspension can be swallowed directly from a dose-measuring
syringe or can be diluted in a small glass of water before directly
- When the oral suspension of Triptol® is prescribed, the dose should be
determined in milliliters.
- In case of monotherapy or joint treatment in adults: The treatment can
be started with a daily dose of 600mg, divided into two doses. the daily
dose can be increased at weekly intervals, in increments not exceeding
- Children: In monotherapy and joint therapy, starting dose therapy (8-10
mg / kg / day) is divided into two doses. The best results are usually with
a dose of (30mg/kg/day). The maximum dose for child is 46mg/kg/day.
- If the clinical condition is called, the daily dose may be increased at weekly
intervals in increments not exceeding 10 mg / kg / day, up to a maximum
dose of 60 mg / kg / day.
- Elderly patients: It is recommended to adjust the dose in elderly patients
with renal impairment who may be at risk of low blood sodium.
- Patients with renal impairment: In patients with renal impairment (creatine
clearance less than 30 ml / min), treatment is started at the usual half-dose
(300mg / day) and the dose is increased at intervals of not less than one
week until the desired clinical response is achieved. They should be
monitored well during dose calibration.
- Your doctor may increase the dose gradually to find the best dose for you.
- The best results are usually with doses between 600 and 2,400 mg per day.
If you forget to take Triptol:-
- If you have forgotten one dose, take it as soon as you remember. However,
if it is time for your next dose, do not take the missed dose. Go back to your
regular dosing timetable. Do not take a double dose to make up for a
- Treatment may be needed for many years to control the seizures. Do not
change the dose or stop treatment without talking to your doctor.
- Each film coated tablet of Triptol® 300 contains:
Oxcarbazepine 300 mg
Triptol® should not be administered to patients who have shown hyperse-
nsitivity to Oxcarbazepine or any of the ingredients of the Triptol® or if
you are allergic to eslicarbazepine.
Please tell your doctor or pharmacist if you are taking, have recently taken
or might take any other medicines and this applies especially to:
- Hormonal contraceptives, such as oral contraceptives.
- Other antiepileptic and enzyme inducing medicines, such as carbamaz-
epine, phenobarbital, phenytoin or lamotrigine and rifampicin.
- Medicines that reduce the level of sodium in your blood, such as diuretics
(used to help the kidneys get rid of salt and water by increasing the amount
of urine produced), desmopressin and nonsteroidal anti-inflammatory
medicines, such as indometacin and ibuprofen.
- Lithium and monoamine oxidase inhibitors (medicines used to treat mood
swings and some types of depression).
- Medicines that control the body’s immune system, such as ciclosporin
- Contact your doctor if you become pregnant, think you may be pregnant or
are planning to become pregnant while taking Triptol®. It is important that
seizures during pregnancy are controlled but Triptol® may affect the
growth of your unborn baby.
- Your doctor will discuss the benefits and possible risks of the use Triptol®
- Triptol® should not be used during breast feeding.
- Very common: tiredness; headache; dizziness; drowsiness; feeling
sick (nausea); being sick (vomiting); double vision.
- Common: weakness; memory disturbances; impaired concentration;
apathy; agitation; confusion; blurred vision; visual disturbance;
constipation; diarrhoea; stomach (abdominal) pain; acne; hair loss;
balance disturbances; weight increased.
- If you or anyone take too many Triptol® you should contact you
doctor directly or go to the nearest hospital even if there are no signs
of discomfort. Symptoms of overdose are drowsiness, dizziness,
nausea, vomiting, an abnormal degree of muscular or bodily activity,
lack of co-ordination of movements and uncontrolled eye movements.
Effects on ability to drive and use machines:-
- You should be aware that Oxcarbazepine can cause side effects like
dizziness and drowsiness, blurred vision, double visions, lack of muscle
coordination or depressed level of consciousness, which can influence
your ability to drive or operate machines. Do not drive or operate
machines if you experience such side effects.
- Tell your doctor or pharmacist before takingTriptol®: if you have ever
shown unusual sensitivity, if you have kidney disease, if you have
serious liver disease, if you are taking diuretics, if you have heart
disease, shortness of breath and/or swelling of the feet or legs due to
fluid build-up, if your blood level of sodium is low, if you are a woman
taking a hormonal contraceptive.
- Tell your doctor if you develop any of the following symptoms after
talking Triptol® : if you experience an allergic reaction, if you notice
symptoms of hepatitis such as jaundice, if you notice possible
symptoms of blood disorders such as tiredness, being short of breath
when exercising, looking pale, headache, chills, dizziness, frequent
infections leading to fever, sore throat, mouth ulcers, bleeding or
bruising more easily than normal, nose bleeds, reddish or purplish
patches, or unexplained blotches on the skin, if you have a fast or
unusually slow heart beat.
- Triptol® can lower the sodium levels in your blood further which may
lead to symptoms of sodium shortage, If you have a renal disease your
doctor may examine your blood before and at regular intervals after starting
treatment with Oxcarbazepine.
- if you have heart problems such as heart failure, (breathlessness and
- if you have a heart rhythm disorder.
- if you are planning to become pregnant
- Triptol® 300 tablet : Blister of 10 tablets pack of 3 blisters.
- Tablet : store in at temperature not exceed 25°C, a way from light.