Phenylalanine is one of the very bio-active important amino acid. The body naturally converts L-Phenylalanine to the amino acid L-Tyrosine, which is then transformed into L-DOPA. The decarboxylation process of L-DOPA leads to the synthesis of brain neurotransmitter dopamine.
Once converted into dopamine, the enzyme dopamine-beta-hydroxylase converts dopamine into the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). The triad of neurotransmitters is collectively known as ” catecholamines”. As an Nootropic product, one can discover a variety of types of Phenylalanine available. L-Phenylalanine is the most natural form that is found in proteins. D-Phenylalanine is an exact mirror image of L-Phenylalanine which is produced in the laboratory. It is also known as the DL-Phenylalanine can be described as a mixture of both types.
L-Phenylalanine is an efficient nootropic to boost cognition function due to its ability to boost the production of norepinephrine as well as dopamine production. This results in improved concentration, motivation as well as functioning memory. D-Phenylalanine (but not L-Phenylalanine) is utilized to treat chronic pain , but the research conducted on this topic is a bit sporadic. L-Phenylalanine can also increase T3 and 4 production. T3 (triiodothyronine) and T4 (thyroxine) which are essential to maintain general physical and cognitive health. Phenylalanine assists:
- Cognitive Stress. L-Phenylalanine is a component of the catecholamine-t consisting of the neurotransmitters dopamine, norepinephrine and epinephrine. Stressors that cause sleep deprivation or extreme such as cold and heat can reduce catecholamine levels. L-Phenylalanine replenishes them and helps maintain optimal cognition.
- Neurotransmitters. Phenylalanine is the essential precursor for dopamine, norepinephrine and epinephrine. When your levels of dopamine increase it makes you more able to concentrate and manage your thoughts, and remain productive.
- Attention Deficit Disorder (ADHD). L-Phenylalanine is a good treatment for those suffering from ADHD symptoms. L-Phenylalanine can work in conjunction with other pharmaceutical medications like Ritalin as well as Adderall by increasing the dopamine levels in the extracellular space. Making these drugs more efficient. As well as reducing side effects such as crashes after the drug is worn off.
- 1 What is Phenylalanine Used For?
- 2 L-Phenylalanine Vs. D-Phenylalanine: What’s the difference?
- 3 L-Phenylalanine Supplement Benefits for the Brain?
- 4 L-Phenylalanine benefits
- 5 L-Phenylalanine High?
- 6 L-Phenylalanine Dosage
- 7 L-Phenylalanine is a recommended Dosage
- 8 DL-Phenylalanine Side Effects
- 9 Phenylalanine Foods
- 10 Phenylalanine in Drinks
- 11 Phenylalanine in Gum
What is Phenylalanine Used For?
L-Phenylalanine is an essential amino acid you can get through food or supplements. The enzyme Phenylalanine Hydroxylaseconverts Phenylalanine within your body to an amino acid Lyrosine.
The amino acid L-Tyrosine is Phenylalanine Phenylalanine can be found in proteins-rich foods such as soybeans, cheese and nuts, seeds Lamb, beef chicken, pork eggs, fish dairy, beans as well as whole grain. Aspartame, an artificial sweetener, also is a source of Phenylalanine. The brain converts L-Tyrosine into L-DOPA, which produces dopamine, a neurotransmitter.
Dopamine that is not used up is transformed into neurons that produce the norepinephrine (noradrenaline) as well as Epinephrine (adrenaline). The triad of neurotransmitters is collectively known as ” catecholamines”.
A lot of neurohackers favor the L-Phenylalanine in comparison to others catecholamine precursors since it enhances the production of neurotransmitters without directly increasing the levels of neurotransmitters. This is the most important part since a sweeping increase in neurotransmitters all over the place can cause problems as well as the development of tolerance. This could negate the reason of using the nootropic in the first place. For instance, insufficient epinephrine could affect cognitive function. In addition, too much norepinephrine may reduce attention, processing speed as well as the executive functions.
L-Phenylalanine Vs. D-Phenylalanine: What’s the difference?
L-Phenylalanine is an amino acid that is essential, that is why you should get it through food. It can also be taken as an added supplement. The body is unable to synthesize Phenylalanine by itself. L-Phenylalanine (LPA) is transformed to the amino acid Lyrosine within your liver. When L-Tyrosine crosses through the brain-blood barrier and enters the blood-brain barrier, it transforms into L-DOPA. It is then transformed into neurotransmitters dopamine, norepinephrine (noradrenaline) and epinephrine (adrenaline).
D-Phenylalanine (DPA) is a synthetic form of, and a mirror image of, L-Phenylalanine that was created in the laboratory. DPA has a distinct mechanism of action within the body as compared to LPA. D-Phenylalanine (DPA) reduces the activity on the enzymes carboxypeptidase A or endorphinase and the enzyme enkephalinase. These enzymes degrade endorphins. The slowing of these enzymes that decrease endorphins could aid in reducing the pain. The DL-Phenylalanine combination is a 50/50 mix of D-Phenylalanine and L-Phenylalanine. Combining the two in theory , you can have the benefit of an antidepressant as well as a pain reliever.
L-Phenylalanine Supplement Benefits for the Brain?
L-Phenylalanine improves brain health and function in a variety of ways. Two of them are notable.
- L- Phenylalanine decreases depression. L-Phenylalanine converts into L-Tyrosine, which transforms into L-DOPA within the brain. L-DOPA then is used to create the feel-good dopamine, a neurotransmitter. Therefore depression could be due to not receiving enough of the amino acid (L-Phenylalanine) in the chain of events required to make dopamine.
In a study conducted in Germany 20 patients suffering from depression received between 75 and 200 mg each day of DL-Phenylalanine over 20 days. After the study, 12 depressed patients were released without further treatment. Four of them had an improvement in their depression symptoms. Four patients did not show any reaction.
- L-Phenylalanine increases neurotransmitters. L-Phenylalanine transforms into L-Tyrosine after being it is taken as an supplement. Then it transforms into dopamine, a neurotransmitter. Dopamine controls the movement of your body. It is essential to attention, memory and problem solving.
Dopamine that is not used can transform into neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Norepinephrine is essential in regulating emotions, attention sleep, dreaming, and learning. Epinephrine drives your ‘flight-or-flight’ response. This is what triggers your response to danger in emergency situations or when you’re in stressful situations or situations.
The balance of neurotransmitters in the brain is essential to an well-functioning, healthy brain. This is why many neurohackers opt for L-Phenylalanine as a way to enable the body to produce the neurotransmitters it requires. Instead of creating imbalance by stimulating one neurotransmitter over the other. A study conducted in Venezuela focused on ADHD as well as autism, as well as the effects of amino acids in these neuropsychiatric disorders. 40 autism-related subjects and 11 people with ADHD as well as the healthy 41 subjects enrolled in this study. Researchers found that people who suffer from ADHD were suffering from decreased Phenylalanine and an increase in Glycine, which affected their inhibitory neurotransmission system. Insufficient Phenylalanine and a higher level of lysine were found in people with autism.
Another study conducted at Ohio State University looked at amino acids in 28 ADHD patients. The study found that all patients who suffered from ADHD were significantly lower in levels of the amino acids phenylalanine, tyrosine, histidine, tryptophan and isoleucine. The study concluded that each patient suffered from a common deficiency in the transport of amino acids and absorption, and absorption.
As we age our body and brain change in chemistry and energy metabolism. Dopaminergic neurons are damaged or die.
- Neurotransmitter levels decline
- Thyroid hormones decline
- Stress levels increase
- The decline in mood and working memory
These changes are usually blamed on the process of aging. However, they could also be the result of lifestyle and dietary choices. If not addressed, they can cause neurodegenerative illnesses such as Parkinson’s disease, a decline in the quality of life, and depression.
L-Phenylalanine may increase levels of neurotransmitters like dopamine, norepinephrine , and epineph. It can also help a slow thyroid to produce higher levels of T4 as well as T3. L-Phenylalanine is a stimulant for cognition , particularly in stressful situations. It aids in improving decision-making flow state, the ability to think creatively, as well as cognitive flexibility and working memory.
L-Phenylalanine is converted into L-Tyrosine, which transforms into L-DOPA in order to create dopamine. L-DOPA also helps create melanin in the body. This process aids in the elimination from neurotoxic chemicals known as quinones. It also chelates heavy metals such as mercury and lead that can build up and cause damage to neurons.
The dopamine not utilized by your brain can be used to create norepinephrine (noradrenaline) which is essential for attention, emotions sleep, dreaming, and learning. L-Phenylalanine could be a powerful nootropic when combined with ADHD/ADD medications like Ritalin and Adderall. It assists in the supply of extracellular dopamine that is needed to boost the efficacy of stimulants to increase the absorption of dopamine within your brain.
Remember that L-Phenylalanine can be an intermediate to catecholamines . So if you’re not ‘low’ on dopamine , norepinephrine or epinephrine You may not feel you’re not feeling anything. Many neurohackers have reported a boost in mood, improved concentration, focus, more energy levels, and a general feeling of wellbeing.
L-Phenylalanine may help you adjust the level of motivation. It may help reduce anxiety levels, particularly social anxiety. L-Phenylalanine supplementation can lower blood pressure when it is elevated due to an environment or stressful event. Do it prior to the event that is stressful if you are able to.
L-Phenylalanine assists in buffering adverse effects from stimulants such as amphetamines or caffeine. It can enhance and prolong effect of Ritalin or Adderall and also reduces the risk of crash. If you’re an athlete or manual work You’ll discover that taking L-Phenylalanine prior to an exercise or job will leave you feeling fantastic afterward.
It can help reduce some of the negative effects of stress that is caused by stressors that are short-term in nature. L-Phenylalanine aids your body to produce L-Tyrosine, which is needed to make melanin. As a result, you might be able to achieve a tan on the beach.
A number of studies have examined the use of Phenylalanine to treat depression. One study published in the journal Arzneimittel-Forschung looked at using DL-Phenylalanine in a small group of patients who failed to respond to popular antidepressants like MAOIs. In this study researchers collaborated with 23 patients who were diagnosed with depression who were not responding to antidepressants that are commonly prescribed. They received the equivalent of 50 to 100 milligrams of Phenylalanine every day over a period of 15 days.
Researchers discovered the Phenylalanine significantly improved the mood for 17 of the patients. In just 13 days after the trial lasting 15 days. Another study published in The Journal of Neural Transmission examined DL-Phenylalanine usage with 20 patients suffering from depression.
The participants were given 75-200 mg/day of DL-phenylalanine over a period of 20 days. The study revealed that 8 patients fully were able to recover from depression. Another 4 also saw a marked improvement in their mood. Four patients also experienced mild to moderate improvement, and 4 others did not react to treatments. This study demonstrates the fact that Phenylalanine is a powerful antidepressant effects. It is also effective in the vast majority patients who suffer from depressive symptoms.
Phenylalanine for ADHD
Phenylalanine to treat ADHD appears at first glance to be an effective solution to ADHD symptoms. It’s a precursor of the neurotransmitter dopamine that is targeted by stimulants such as Ritalin as well as Adderall. However, the limited clinical data tell an entirely different story regarding its the practical application. In this study, which was a double-blind crossover 19 patients suffering from ADD were treated with the DL-phenylalanine or a placebo for two weeks.
Thirteen of these ADD patients saw a substantial improvement of ADD symptoms when compared to placebo. Patients also noticed an improvement in their mood. However, the patients who responded with DL-Phenylalanine did not experience any positive effects within three months. It’s also interesting to note that a subsequent study of ADHD patients who were treated with L-phenylalanine (not DL-Phenylalanine) did not show any clinical benefits. A different study from 1987 treated 11 hyperactive males for two weeks with D-Phenylalanine for two weeks.
There was no improvement or decline of the behavior. There is a current theory that suggests there are a variety of different kinds of ADD and ADHD. The symptoms result from malfunctions in various parts of the brain based on the type of ADHD. It is true that that some suffering from ADHD might be benefited from supplements their diet with Phenylalanine. It is true that DL-Phenylalanine could be the most effective alternative. Test it out to see whether it does the trick for you.
L-Phenylalanine is a recommended Dosage
The recommended dosage of L-Phenylalanine for cognitive benefits is 500 mg, up to 3 times per day. It is possible that your body reacts differently to lower doses. Even more so if you’re stacking it with stimulants such as ADHD medication. Pay attention to your body and observe what you feel and react to.
Because L-Phenylalanine is an amino acid to ensure optimal absorption, and therefore in no way competing with the other amino acids. you should take it at least one hour prior to eating. L-Phenylalanine is most effective when taken on an empty stomach.
Take L-Phenylalanine along together with Vitamin B6 and Vitamin C to increase absorption. Also, give your body the nutrients it requires to make the neurotransmitters norepinephrine, dopamine and epinephrine. L-Phenylalanine is required together as L-Tyrosine to produce CoQ10. CoQ10 required to power the brain’s mitochondria.
DL-Phenylalanine Side Effects
L-Phenylalanine rapidly transforms into the amino acid non-essential L-Tyrosine after taking it. It is therefore considered to be extremely safe and non-toxic. The majority of neurohackers do not have negative side effects. Important Warning People suffering from Phenylketonuria (PKU), and women who are nursing or pregnant and breastfeeding should not consume the phenylalanine supplement.
PKU is an inheritable condition in which excess phenylalanine may accumulate within the body. Aspartame, which is found in artificial sweeteners like NutraSweet is a major source of the chemical phenylalanine. People suffering from PKU shouldn’t use aspartame. If you are pregnant, consult your physician about the use of the artificial sweetener. In higher doses, there are reports of stomach problems and migraines. Experts believe that L-Phenylalanine can be harmful in doses that exceed 5000 mg. Higher doses will provide you with no additional advantage.
If you have tried the prescribed doses of L-Phenylalanine but don’t notice any benefits the nootropic might not be the right choice for you. It is possible to consider the L-Tyrosine as well as NALT instead. L-Phenylalanine may boost your thyroid hormones. If you’re hyperthyroid, it is not recommended to take L-Phenylalanine.
If are taking MAO inhibitors (MAOI’s) like selegiline Azilect, Marplan, or Nardil, you shouldn’t take L-Phenylalanine. MAOI’s affect the brain and alter neurotransmitters. Therefore, taking L-Phenylalanine with MAOI’s can upset the balance between neurotransmitters required to maintain the best brain health and cognition. When combined with MAOI’s, L-Phenylalanine can cause a significant rise in blood pressure that could result in stroke or heart attack. Other side effects that may be associated with unusually high doses of phenylalani.
Phenylalanine is an essential amino acid that is widely found in different kinds of food. However, certain foods are rich in this nutrient and are the best sources of it. Here are some foods with high phenylalanine content that you can eat on a daily basis.
- Wheat germ
Phenylalanine food list is not extensive, but it is still necessary to have the knowledge of these foods to prevent seizures.
A list of phenylalanine foods includes: beef, chicken, eggs, pork, fish, lamb and peanuts. The foods that contain phenylalanines are those that come from animal proteins. The downside to this list is that it only has a few examples of the foods that contain phenylalanines.
Phenylalanine is an amino acid that plays a role in the production of the neurotransmitters dopamine, adrenaline, and noradrenaline. It is also an essential amino acid which means that it cannot be manufactured in the body and needs to be obtained from food.
Phenylalanine sources include meats, dairy products, soybeans, lentils, wheat germ, bran cereal (oatmeal), soy flour (tempeh), wheat flour (pasta), soy protein powders.
Phenylalanine deficient foods include white breads or pasta made with enriched white flour because these are enriched with synthetic phenylalanine substitutes.
Phenylalanine in Drinks
Phenylalanine is an amino acid that is found in many drinks. This amino acid can cause health risks to some people, so it is important to know the amount of phenylalanine in your drink.
Various drinks have different levels of phenylalanine, which means that the drink’s name will not always be a good indicator of whether or not it contains this amino acid.
It might be worth looking at the ingredients list for your drink to see if it contains any sources of protein, as this may indicate that it contains phenylalanine.
Phenylalanine is an amino acid that is found in many drinks, such as tea, coffee, soft drinks and juice. It also occurs naturally in some foods such as almonds. In the human brain it is a precursor for the neurotransmitters dopamine and norepinephrine.
The article talks about the use of Phenylalanine in drinks and how it affects the production of neurotransmitters – dopamine and norepinephrine – which are responsible for feelings of pleasure and happiness. Without these two neurotransmitters one can become stressed or anxious. The article further elaborates on how a lack of these two neurotransmitters can lead to depression.
Phenylalanine in Coke
Phenylalanine is found in many kinds of drinks. It can be found in milk, soy milk, fruit juice, and sodas.
Phenylalanine is an essential amino acid that is needed for growth and development. It can also help protect against mental decline later in life, which makes it an important amino acid to consume throughout the day.
Phenylalanine in Gum
Phenylalanine is a natural amino acid that can be found in gum.
It is best to avoid chewing gums with this amino acid as it can have side effects on the human body. In some cases, an overdose can lead to seizures and mental disorders.
Phenylalanine is an amino acid that is present in many different types of food, most notably in cheese and soy beans. This article will explore the role of phenylalanine in gum.
Phenylalanine is an amino acid that can be found in foods like cheese and soybeans. As it is not an essential amino acid, the body can produce it on its own with carbohydrate intake. It can also be found in gum, where it acts as a sweetener to make the taste more appealing.