Background Hepatitis B pathogen (HBV) is the major causative agent of chronic hepatitis causing liver cirrhosis and liver malignancy. hepatitis B among children of HBsAg-positive mothers was found in the low socio-economic class in the rural areas. Conclusions The study concluded that the prevalence of HBsAg Ophiopogonin D’ among children given birth to to HBsAg-positive mothers was high among the families living in Ophiopogonin D’ villages with low to moderate income. has shown that 61.6% of HBsAg-positive women had no family history with unknown route of transmission; although, 23.1% of HBsAg-positive women (19 from villages and 11 from the city) suspected in dental clinics. They were infected with hepatitis B after repeated visits to private dental clinics. Table 1 Socio-demographic characteristics of HBsAg-positive women from urban and rural areas of Hebron Slc2a4 district (22) showed that the risk of transmission of HBV is usually highest in the case of maternal acquisition of HBV contamination, in the third trimester of pregnancy. The association between positive HBsAg mothers with higher HBV DNA viral loads is well-documented with increased chances of mother to child transmission (23). There is need to sustain the current energetic vaccination for getting rid of hepatitis B vertical transmitting, combined with the hepatitis B immunoglobulins for everyone newborns of hepatitis B Ophiopogonin D’ carrier moms. Results present that 35% of the kids delivered to HBsAg-positive moms just received hepatitis B energetic vaccine without immunoglobulin because of unawareness from the infections or because of economic difficulties. The analysis recommends that newborns delivered to HBsAg positive moms should receive well-timed and sufficient post-exposure prophylaxis with full dental coverage plans through the Ministry of Wellness. The study email address details are limited due to a small sample size and focusing only a small endemic area. Moreover, the study has only verified a single route of transmission of HBV contamination. The present study has considered women in Hebron district and assessed the prevalence of hepatitis B among children given birth to to HBsAg positive women. The study findings have shown that majority of the infected children were infected by vertical transmission route and belonged to mothers living in villages with low to moderate income. These findings suggest the need of presenting integrated information and educational programs to prevent and control HBV transmission among this target group. Future studies need to verify the unknown routes of transmission and to reduce the possible risk factors. Moreover, other similar studies from numerous subsamples of general Palestinian populace are required to get clearer understanding of HBV epidemiology in general. Acknowledgments The author is very thankful to all the associated staff in any reference that contributed in/for the purpose of this research. Notes The author is usually accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study has been approved by the international review table (IRB) of Ethics Committee Herbon University or college, Palestine under the code SR/122/2016. Footnotes The author has no conflicts of interest to declare..