Around 1840, Fort DeSoto was established in present-day Hernando County in the northeast edge of present-day Brooksville to protect settlers in the area from Native Americans. Fort DeSoto became a small community center, trading post, and way station on the route to Tampa. When settlement by the fort began around 1845, it was alternatively known as Pierceville.
Then encompassing a significantly larger area of west central Florida than it does today, Hernando County was officially established on February 27, 1843, two years prior to Florida's admission into the Union. It was created from portions of Alachua, Hillsborough and Orange Counties and included all of present day Citrus and Pasco Counties. Named for Spanish explorer Hernando de Soto, whose name has also been honored in De Soto County, Hernando County was briefly renamed Benton County in 1844 for Missouri Senator Thomas Hart Benton, a strong supporter of territorial expansion who aided in the county's creation.