New information about the events that underlie the 'spread' of Alzheimer's disease throughout the brain has been identified by scientists.
The study, by researchers at the Gladstone Institute of Neurological Disease (GIND), follows disease progression from a vulnerable brain region that is affected early in the disease to interconnected brain regions that are affected in later stages.
AdvertisementThe findings may contribute to design of therapeutic interventions, as targeting the brain region where Alzheimer's disease originates might be simpler than targeting multiple brain areas.
An alteration in brain levels of amyloid _ proteins (A_) plays a major role in Alzheimer's disease, a devastating neurodegenerative disorder that causes progressive cognitive impairment and memory loss. Alzheimer's disease is characterized by abnormal accumulation of A_ in the brain, which leads to the formation of protein aggregates that are toxic to neurons. A_ peptides are generated when a large protein called amyloid precursor protein (APP) is cut up into smaller pieces.
One of the first brain regions affected in Alzheimer's disease is the entorhinal cortex (EC). Connections between the EC and another brain region called hippocampus are critical for memory, and disruption of this circuit may play a role in memory impairment in the beginning stages of Alzheimer's disease.
"It is not clear how EC dysfunction contributes to cognitive decline in Alzheimer's disease or whether early vulnerability of the EC initiates the spread of dysfunction through interconnected neural networks," explained senior study author and GIND director Lennart Mucke, MD. "To address these questions, we studied transgenic mice with mutant APP expressed primarily in neurons of the EC."
The majority of current mouse models of Alzheimer's disease express mutant proteins throughout the brain, making it difficult to identify the role of any specific brain region in Alzheimer's disease-related dysfunction.
Dr. Mucke and colleagues found that expressing mutant APP and A_ selectively in the EC led to age-dependent deficits in learning and memory, and other behavioral deficits including hyperactivity and disinhibition. Importantly, these abnormalities are similar to those observed in mouse models of Alzheimer's disease with mutant APP expression throughout the brain. The researchers also observed abnormalities in parts of the hippocampus that receive input from the EC, including dysfunction of synapses and A_ deposits.
"Our findings directly support the hypothesis that Alzheimer's disease-related dysfunction is propagated through networks of neurons, with the EC as an important hub region of early vulnerability," concluded Dr. Julie Harris, the lead author of the study.
"Although additional studies are needed to better understand how events in the EC are related to Alzheimer's disease, it is conceivable that early interference in the EC might be of therapeutic benefit, perhaps halting disease progression," Harris added.
The study has been published in the November 4th issue of the journal Neuron.
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