Innovative Programs & Services
Mechanisms of Kidney Tubular Atrophy:
Urinary tract obstruction during kidney development may cause kidney malformation, which is a leading cause of renal failure in children. Our active research aims to understand the mechanism of tubular atrophy, which could guide our future strategies in preventing and/or slowing down the progression of chronic kidney disease.
We are a part of the Cure Glomerulonephropathy Network (CureGN), a multicenter study of four glomerular diseases including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and IgA nephropathy (IGAN). Collaborating with the adult nephrology division at Columbia University Medical Center, we follow patients longitudinally to better understand the causes of disease, response to therapy, and disease progression. The ultimate objective is to cure glomerulonephropathy.
GIGA-Kids Study (Genomics of IgA-related Disorders in Kids Study) is a multicenter collaborative study based at Columbia University and sponsored by the Midwest Pediatric Nephrology Consortium (MWPNC). Together, we are studying over 1,000 children with IgA nephropathy or Henoch-Schönlein purpura (with or without nephritis) for the purpose of genetic, genomic and biomarker investigations.