- The first is an enzyme composed of the C4b-C2b complex, which forms during the Classical pathway of the complement system. It is formed when C1s cleaves off C2a from a membrane-bound C4b-C2 complex.
- The second consists of the C3bBb complex, which forms during the alternative complement pathway. It is formed when membrane bound C3b binds to factor B which is in turn cleaved by factor D in Ba and Bb. Bb remains bound to C3b while Ba is released into the surrounding medium.
A convertase (of either type) with an additional 3b (C4b2b3b or C3bBb3b) is known as "C5-convertase".
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