Scrapie disease belongs to Transmissible Spongiform Encephalopathies as well as Bovine Spongiform Encephalopathy or human Creutzfeld-Jakob Disease. Scrapie is a natural disease which was first described in 1732. For years sheepbreeders fought Scrapie by eliminating sick animals and culling related animals. Evidence for a genetic resistance to Scrapie has been observed in different experiments made in the UK, the susceptibility being defined by a shorter incubation period after artificial inoculation of a scrapie isolate (Dickinson et al., 1968). The relationship between the polymorphism for the PrP gene and the incidence of natural scrapie in several breeds was gradually established since 1991 (review by Hunter et al., 1997). The PrP gene encodes for the PrP protein, the PrPsc isoform of which accumulates in the central nervous system of affected animals.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.13, 2002
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