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ACTA STInG Writing Clinical Trial Simulators Workshop
The use of simulation is growing in the design of clinical trial designs as an augmentation of, or replacement for, sample size calculations. Usually this is in order to be able to: estimate operating characteristics of the planned trial other than simply power, to be able to estimate actual type-1 error and power taking into account factors such as the effect of dropouts, and to be able to use trial designs that are too complex for sample size calculation such as adaptive designs. This course will introduce statisticians to the concepts, software, and engineering skills required to write and use a trial simulator. It is intended for statisticians with some programming experience (e.g. R, SAS), and introduce them to design considerations of writing a simulator and testing whether the simulator is correct. The course will teach how to use simulations to engineer and guide design decisions, including the importance of simulating single example trials and summarizing key operating characteristics across many simulations. It will also focus on effective communication strategies for presenting simulation results to clinical colleagues.
Although not necessary, it would be beneficial for delegates to bring a laptop with R installed so that they can try to run a simple simulator.
By the end of this course, participants should be able to:
• Understand what clinical trial simulation is and the vital role it plays in the development of a clinical trial design
• Have the foundational tools to start writing and testing clinical trial simulators
• Appreciate the value of reviewing individual simulated trials
• Understand how to present operating characteristics summarized across many simulated trials
Morning tea provided.
Room 1.036, Level 1 HELP, Royal Children’s Hospital, Parkville, VIC, 3052
Standard $100, ACTA Member $80, Students $60
More information on this workshop can be found here.