In recent years, neuroscientists have made important progress in identifying the precise mechanisms by which lead exposure reduces impulse control. Here, for instance, is a recent PLOS study from the Cincinnati Lead Study, in which the blood lead level of babies born in poor areas of Cincinnati were repeatedly measured between 1979 and 1984. Twenty years later, the researchers tracked down these subjects and put them in MRI machines, allowing them to measure the brain volume of participants. The researchers found that exposure to lead as a child was linked with a significant loss of brain volume in adulthood, particularly in men. Furthermore, there was a “dose-response” effect, in which the greatest brain volume loss was seen in participants with the greatest lead exposure. What’s especially tragic is that the loss of volume was concentrated in the prefrontal cortex, a part of the brain closely associated with executive function and impulse control.