Uncle Tom The central character, a slave belonging to Shelby.
Eliza and George Harris Mrs. Shelby's servant and her husband; they have a young son, Harry.
Arthur, Emily, and George Shelby A Kentucky farmer (Tom and Eliza's owner), his wife, and teenaged son.
Aunt Chloe Tom's wife; she is the Shelbys' cook.
Dan Haley A slave trader.
Tom Loker and Marks Slave-catchers.
Senator and Mrs. Bird An Ohio couple who help Eliza.
Simeon and Rachel Halliday A Quaker couple who help Eliza.
Augustine, Marie, and Eva St. Clare A New Orleans man who buys Tom from Haley; his wife; and their daughter.
Ophelia St. Clare St. Clare's cousin from Vermont.
Adolph, Mammy, Jane, and Rosa Some of St. Clare's slaves.
Topsy A little slave girl whom St. Clare buys for his cousin.
Simon Legree A plantation owner who buys Tom at auction.
Sambo and Quimbo Legree's slave overseers.
Cassy Legree's slave mistress and Eliza's mother.