A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (amls) encompasses four major categories: 1) aml with recurrent genetic abnormalities 2) aml with multilineage dysplasia 3) therapy-related aml 4) aml not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of aml has been recently reduced from 30% (french-american-british [fab] classification) to 20% (who classification). (who, 2001)
A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia.
A progressive, proliferative disease of blood cells, originating from immature granulocytes.
Acute leukemia arising from myeloid tissue in which the granular, polymorphonuclear leukocytes and their precursors predominate.
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce neutrophils; basophils; eosinophils; and monocytes.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (myeloid progenitor cells) in the bone marrow and other sites.
Leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.
Leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow; patients usually have chromosomal abnormalities in marrow cells.
leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute myeloid leukemia (aml), there are too many of a specific type of white blood cell called a myeloblast.aml is the most common type of acute leukemia in adults. This type of cancer usually gets worse quickly if it is not treated. Possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. Symptoms of aml include:
shortness of breath
easy bruising or bleeding
bleeding under the skin
weakness or feeling tired
weight loss or loss of appetite
tests that examine the blood and bone marrow diagnose aml. Treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted immune therapy. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute
This term refers to acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. It includes entities classified according to the french-american-british classification scheme.