Coenzyme A which is usually abbreviated to CoA, CoASH or HSCoA is one of the fundamental molecules in cell and general energy metabolism.
This coenzyme arises from the synthesis of ATP. It is integral in the use of pantothenic acid (Vitamin B5) in general metabolism. Whilst it is involved in various metabolic pathways, the key ones are the oxidation of fatty acids (beta-oxidation) and the Krebs cycle. About 4% of all enzymatic reactions in the cell use this molecule as coenzyme.
Its role is in the transfer of acyl groups in the form of high-energy thioesters. In most cases, coenzyme A transfers the acetyl group and is then called acetyl coenzyme A (Acetyl-CoA). Free Coenzyme A, which does not carry any acyl group, is designated as CoASH, to indicate that the -SH group is free for further reactions.
Coenzyme A was first isolated in 1951 by the German biochemist Feodor Lynen of yeast cells, who later received the Nobel Prize. A detailed molecular structure was explained two years later by British scientist James Baddiley of the Institute of Lister for Preventive Medicine and the American scientist of German origin, Fritz Albert Lipmann of the University of Harvard.
Products Containing Coenzyme A
Please read our affiliate disclosure as thus page contains links to our affiliate marketing partner.
Legal Disclaimer Concerning Products On This Web-Site
The products and the information provided about specific products on or through this site have not been evaluated by the United States Food and Drug Administration or by any other national regulatory body and are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician/doctor or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problems or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication or if you suspect you might have a health problem.