The complete genome sequences of many microbes were completed in the past decade. Valuable information on finding the treatment of various infections caused by pathogens can be retrieved using the comparative genomics and subtractive genomics approaches. The critical genes which are crucial for the survival of the pathogens and which are absent in the host can be screened out by using the subtractive genomics approach. The chances of cross reactivity and side effects can be decreased by selecting such non-homologous proteins which are not found in humans. The genes and their products which can be used as a potential drug targets can be identified by analyzing these genes with the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database.
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M E in Bioinformatics