Insufficient Intracellular Calcium Ion Causes Mitochondrial Dysfunction and Inactivation
of Mesenchymal Stem Cells: Sigma Anti-Bonding Molecule Calcium Carbonate (SAC), the
New Technology to Treat Aging-Related Chronic Degenerative Diseases
It is prevalently known that tumour cells prefer inefficient cellular glycolysis, but no one has proved yet the exact reason of using ineffective cellular respiration mechanism of tumour cells. However, through our research, we have investigated that it is highly related to the lack of intracellular calcium ion because as the insufficient calcium ion causes dysfunction of mitochondria which releases reactive oxygen species (ROS), it causes mitochondrial protein mutation such as TDP-43, FUS and SOD1. Therefore, endoplasmic reticulum (ER) gets stressed and it ultimately causes alteration of RNA synthesis.