Accurate diagnosis of Parkinson’s disease, and the related disease “dementia with Lewy bodies,” can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high. New research indicates that a biopsy of the submandibular gland can help identify the same pathology that is seen in the brain, providing some of the increased accuracy of brain biopsy, but not the increased risk.
Chronic lack of sleep and irregular sleep-wake cycles may be risk factors of Parkinson’s disease, new work suggests. In an animal model, the researchers show that disturbances in circadian rhythm that exist before Parkinson’s onset dramatically worsen motor and learning deficits brought on by the disease.
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