The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.
Adaptive Immunitygenetics Animals Antibodies, Viral Bronchicytologyphysiology COVID-19geneticsimmunologyvirology Camelusgeneticsimmunologyvirology Ciliaphysiology Communicable Diseases, Emerginggeneticsimmunologytransmissionvirology Coronavirus Infectionsgeneticsimmunologytransmissionvirology Disease Reservoirsvirology Female Genetic Predisposition to Disease Host Microbial Interactionsgeneticsimmunology Humans Immunity, Innategenetics Male Middle East Respiratory Syndrome Coronavirusimmunologyisolation & purificationpathogenicity Respiratory Mucosacytologyphysiology SARS-CoV-2immunologypathogenicity United Arab Emirates Virus Replicationgeneticsimmunology Zoonosesgeneticsimmunologytransmissionvirology