The stark contrast between the sexes is revealed in latest survival figures from 2010.
In that year, 202 men per 100,000 died from cancer compared with 147 women per 100,000 - a 35% difference.
When gender-specific diseases, such as prostate and breast cancer, were excluded, men were 67% more likely to die.
Liver cancer death rates were twice as high in men, who also faced triple the risk of being killed by oesophageal cancer.
The difference may partly be explained by men developing hard-to-treat cancers such as those affecting the bladder, oesophagus and liver, according to the charity Cancer Research UK, which produced the figures.
Each year around 82,500 men in the UK lose their lives to cancer, making it the leading cause of death in the male population.
The findings were presented at the Men's Health Forum conference in London.
Professor Alan White, from Leeds Metropolitan University, chairman of the Forum and co-author of the report, said: "The impact cancer has on younger men is often overlooked, but these are men whose life is cut too short by the disease.
"Our report highlights just how big a problem cancer is and highlights the need to understand the reasons why men are more likely to die of cancer. It's crucial that the NHS leads the way in taking a more proactive approach to prevent men both getting and dying from cancer prematurely."