Expert Answer. This reaction was developed by Alexander Williamson in 1850. Answer (i). It is an antipyretic, acting on the brain to decrease the temperature set point. Depicted in scheme 1 is ethoxide reacting with methyl iodide to yield the compound ethyl methyl ether.  During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley developed a synthesis in Britain.. Performance & security by Cloudflare, Please complete the security check to access. MEDIUM. The synthesis of an ether via the Williamson‐ether reaction. Reagents : typically use Na metal as the base to generate the alkoxide then add the alkyl halide. Phenacetin (acetophenetidin, N-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. frequently used t... A: Given,Mass of lead weight, mPt = 19.07 gMass of water, mwater = 79.75 gInitial temperature of steel,... Q: You're tasked with verifying whether or not a platinum ring bought from an online store is indeed ma... A: Given:Specific heat of water = 4.18 J/g. Find answers to questions asked by student like you. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, and by the U.S. Food and Drug Administration in 1983). But if secondary or tertiary alkyl halides are taken in place of primary alkyl halides, then elimination would compete over substitution. Scheme 1. 0 0. It involves the reaction of an . 16.6 The Williamson Ether synthesis. If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. Expert Answer 100% (7 ratings) Previous question Next question Transcribed Image Text from this Question. Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis. Phenacetin can be prepared by using Williamson Ether Synthesis with the help of acetaminophen and ethyl iodide (CH 3 CH 2 I) in the presence of a base like NaOH. Show transcribed image text. While it is considered a prescription drug, no marketed drugs contain phenacetin.. Organic Chemistry Laboratory I (CHEM 233) Uploaded by. An early formulation (1919) was Vincent's APC in Australia. A: The de Broglie wavelength of an electron can be calculated by the equation. Q: Complete the mechanism for the reaction of 2-butanol in sulfuric acid at 140 °C by adding any missin... A: The given mechanism for the reaction of 2-butanol in sulfuric acid at 140 °C is to be completed by ... Q: What is the de Broglie wavelength of an object with a mass of m = 6.76 kg moving at a speed of v = 1... A: The de-Broglie wavelength of the moving object is calculated as. Another way to prevent getting this page in the future is to use Privacy Pass. : A Report on Twenty-three Users of the Drug", https://en.wikipedia.org/w/index.php?title=Phenacetin&oldid=978751927, Creative Commons Attribution-ShareAlike License, This page was last edited on 16 September 2020, at 19:06. The first synthesis of phenacetin was reported in 1878 by . Since the reaction is S N 2, the halide should be methyl or primary. Completing the CAPTCHA proves you are a human and gives you temporary access to the web property. This reaction was developed by Alexander Williamson in 1850. 124 Qs. The first synthesis was reported in 1878 by Harmon Northrop Morse. In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an A.P.C., or "aspirin-phenacetin-caffeine" compound analgesic, as a remedy for fever and pain. a Williamson ether synthesis .