How To Treat IgA Nephropathy
IgA nephropathy refers to primary glomerulonephritis with IgA deposition in the mesangial region of the kidney and it is the most common primary glomeruli.
What is the cause of IgA Nephropathy?
IgA Nephropathy is an immune globulin and mainly distributes in the mucosa of respiratory tract, digestive tract and urethra. With repeated infections of the respiratory tract, digestive tract, urethra, and so on, the body will produce a large number of bacteria and IgA complexes.
The inflammatory complexes travel with the blood to the kidneys. They can pass the filtering membrane of glomeruli and deposit in the glomeruli because of higher molecular weights of immune complexes. The body's immune system removes these compounds while accidentally injuring the glomerular filtration membrane.
Therefore, frequent mucosa inflammation such as respiratory tract, gastrointestinal tract and urethra can trigger IgA Nephropathy. Besides, chronic liver disease, autoimmune disease and tumor can also cause IgA Nephropathy.
How to treat IgA Nephropathy?
Treatments for IgA Nephropathy include immunosuppressor, blood pressure control, reducing proteinuria and delaying the progression of kidney disease.
Since autoimmunity is involved in the pathological process of IgA nephropathy, immunosuppressive therapy is required. Immunosuppressive therapy should be more active because of the rapid progression of IgA nephropathy. It is generally recommended that hormone therapy be used if urinary protein levels are greater than or equal to 1g/d or if there is a pathological crescent. The dose of prednisone is 1 mg/kg/d or methylprednisolone is 0.8 mg/kg/d. After one month of treatment, the dose is decreased gradually.
2. Strictly control blood pressure
Antihypertensive therapy can not only inhibit the damage of hypertension to glomeruli, but also significantly delay the progression of nephropathy. Angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) are the preferred antihypertensive drugs, the dose can be up to 2-4 times of the antihypertensive dose. In addition, most patients need to take two or more drugs to control their blood pressure. Joint medicines include long-acting calcium antagonists, diuretics, beta-blockers, and other blood pressure drugs.
3. Eliminate swelling
Thiazide diuretics, or loop diuretics can remove excess fluid from the body, which contributes to the control of blood pressure. They are combined with ACEI or ARB to increase the antihypertensive effect.
4. Prevent infection
Bacteria infection can be given antibiotics and anti-infection therapy.
5. Reduce blood lipid
Blood cholesterol levels often increase in patients with IgA nephropathy, and cholesterol-reducing medications called stains are given.
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***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***