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Plumbline develops different therapies customized to various animal species, by virtue of our DNA plasmid-based platform technology, which self-activates after it is introduced into the cell.
A DNA vaccine consists of a DNA containing information about a therapeutic molecule and a plasmid (vector) to deliver it. Compared to conventional DNA vaccines, our DNA vaccine products are highly effective in delivering vaccines through electroporation, and are designed to be optimal for each animal species, resulting in robust immune response, including CD4+, CD8+ T cell and antibody formation
Electroporation (EP) is a technology using an electric current to deliver a DNA plasmid into the cell. This technique uses a square-wave to create a temporary passage on the cell membrane, which allows the DNA plasmid to flow into the cytoplasm and cell nucleus. This is the most effective and safe way to deliver DNA vaccines into the cells.
Our EP, licensed from Inovio Pharmaceuticals, Inc., uses a constant current method to minimize tissue damage and maintain a constant pulse to improve DNA vaccine delivery efficiency.
The current Good Manufacturing Practice (cGMP) is a quality management standard approved by the US Food and Drug Administration (FDA). Regulatory agencies in developed countries strictly apply the GMP regulations such as cGMP. When importing products, companies are required to manufacture and manage them according to cGMP or equivalent regulations (EU-GMP, etc.).
We work with GeneOne Life Science to produce high quality products in a cGMP plasmid production facility.