TLR9 Antibody (5G5) FITC is a mouse monoclonal IgG2a
- TLR9 Antibody (5G5) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against a fusion protein consisting of the extracellular portion of human TLR9 (residues 1-815)
- recommended for detection of TLR9 of mouse and human origin by WB, IP, IF and FCM
- fluorescein conjugate for FCM, sc-47723 FITC, 100 tests
- See 5 citations for TLR9 Antibody (5G5)
The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NF˚B signaling pathway, suggesting that they play a role in the immune response.
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