According to the traditional concept of agonist activity, agonist occupation of the receptor is a fundamental condition of receptor activation . The ternary complex model furthermore postulates that in order to produce a cellular response, the agonist-receptor complex should interact with a third, guanine nucleotide-sensitive binding partner (guanine nucleotide binding, or G protein) . According to this classical concept, two classes of physiologically active ligands can be anticipated: agonists, and competitive antagonists. Synthetic agonists are thought to interact with the receptors the same way as endogenous hormones, and produce identical physiological response (the '‘pharmacophore’' concept, reviewed in . Competitive antagonists share the receptor binding site with agonists, but are not able to promote the formation of the ternary complex. Therefore, competitive antagonists pro-duce physiological response by competing with the endogenous agonist for the common receptor binding site.
|Original language||English (US)|
|Title of host publication||The Delta Receptor|
|Number of pages||20|
|State||Published - Jan 1 2003|
ASJC Scopus subject areas
- Health Professions(all)