Migraine is a disabling and very common health problem. This review article reported the plants used to treat migraine in traditional culture and ethnobotany of different regions of Iran. The key words such as ethnopharmacology, ethnobotany, ethnomedicine, phytopharmacology, traditional medicine, phytomedicine, and Iran, combined with migraine and headache, were used to search for relevant materials in Web of Science, PubMed, Scopus, Islamic World Science Citation Center, and Magiran. Twenty two medicinal plants from 16 families are used, according to Iranian traditional medicine, to treat migraine specifically. Most plants reported in this study were analgesic and anti-inflammatory, affecting the inflammation and cortical vascular contractile dysfunction. Because of common use of traditional medicinal plants and wide acceptance of herbal medicine and traditional medicine, more comprehensive studies should be done in pharmacy and pharmacology areas to inform pharmaceutical industries.
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