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BRONCHODILATORS, THEOPHYLLINE (Systemic)
Some commonly used brand names are:
In the U.S.—
Aminophylline, oxtriphylline, and theophylline are used to treat and/or prevent the symptoms of bronchial asthma, chronic bronchitis , and emphysema. These medicines relieve cough, wheezing, shortness of breath, and troubled breathing. They work by opening up the bronchial tubes (air passages of the lungs) and increasing the flow of air through them.
Aminophylline and theophylline may also be used for other conditions as determined by your doctor.
The oral liquid, tablet, and capsule dosage forms of these medicines may be used for treatment of the acute attack or for chronic long-term treatment. The enteric-coated and extended-release dosage forms are usually used only for chronic treatment. Sometimes, aminophylline suppositories may be used but they are generally not recommended because of possible poor absorption .
These medicines are available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aminophylline, oxtriphylline, or theophylline, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to aminophylline, ethylenediamine (contained in aminophylline), oxtriphylline, or theophylline.
Diet—Make certain your health care professional knows if you are on any special diet, such as a high-protein, low-carbohydrate or a low-protein, high-carbohydrate diet.
Pregnancy—Aminophylline, oxtriphylline, and theophylline are frequently used to treat asthma in pregnant women. Although there are no studies on birth defects in humans, problems have not been reported. Some studies in animals have shown that aminophylline, oxtriphylline, and theophylline can cause birth defects when given in doses many times the human dose.
Because your ability to clear theophylline from your body may decrease later in pregnancy, your doctor may want to take blood samples during your pregnancy to measure the amount of medicine in the blood. This will help your doctor decide whether the dose of this medicine should be changed.
Theophylline crosses the placenta. Use of aminophylline, oxtriphylline, or theophylline during pregnancy may cause unwanted effects such as fast heartbeat, irritability, jitteriness, or vomiting in the newborn infant if the amount of medicine in your blood is too high.
Breast-feeding—Theophylline passes into the breast milk and may cause irritability in nursing babies of mothers taking aminophylline, oxtriphylline, or theophylline.
Children—Very young children and newborn infants require a lower dose than older children. If the amount of theophylline in the blood is too high, side effects are more likely to occur. Your doctor may want to take blood samples to determine whether a dose change is needed.
Older adults—Patients older than 60 years of age are likely to require a lower dose than younger adults. If the amount of theophylline is too high, side effects are more likely to occur. Your doctor may want to take blood samples to determine whether a dose change is needed.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aminophylline, oxtriphylline, or theophylline, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of aminophylline, oxtriphylline, or theophylline. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
For patients taking this medicine by mouth :
Use this medicine only as directed by your doctor . Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of serious side effects.
In order for this medicine to help your medical problem, it must be taken every day in regularly spaced doses as ordered by your doctor . This is necessary to keep a constant amount of this medicine in the blood. To help keep the amount constant, do not miss any doses.
Dosing—When you are taking aminophylline, oxtriphylline, or theophylline, it is very important that you get the exact amount of medicine that you need. The dose of these medicines will be different for different patients. Your doctor will determine the proper dose of these medicines for you. Follow your doctor"s orders or the directions on the label .
After you begin taking aminophylline, oxtriphylline, or theophylline, it is very important that your doctor check the level of medicine in your blood at regular intervals to find out if your dose needs to be changed. Do not change your dose of aminophylline, oxtriphylline, or theophylline unless your doctor tells you to do so .
The number of capsules or tablets or teaspoonfuls of solution or syrup that you take depends on the strength of the medicine. Also, the number of doses you take each day and the time between doses depend on whether you are taking a short-acting or long-acting form of aminophylline, oxtriphylline, or theophylline .
Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
Your doctor should check your progress at regular visits , especially for the first few weeks after you begin using this medicine. A blood test may be taken to help your doctor decide whether the dose of this medicine should be changed.
Do not change brands or dosage forms of this medicine without first checking with your doctor . Different products may not work the same way. If you refill your medicine and it looks different, check with your pharmacist.
A change in your usual behavior or physical well-being may affect the way this medicine works in your body. Check with your doctor if you :
This medicine may add to the central nervous system (CNS) stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while using this medicine. If you have questions about this, check with your doctor.
Before you have myocardial perfusion studies (a medical test that shows how well blood is flowing to your heart), tell the medical doctor in charge that you are taking this medicine. The results of the test may be affected by this medicine.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Heartburn and/or vomiting
Hives, skin rash, or sloughing of skin (with aminophylline only)
Symptoms of toxicity
Abdominal pain, continuing or severe; confusion or change in behavior; convulsions (seizures); dark or bloody vomit; diarrhea; dizziness or lightheadedness; fast and/or irregular heartbeat; nervousness or restlessness, continuing; trembling, continuing
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Headache; fast heartbeat; increased urination; nausea; nervousness; trembling; trouble in sleeping
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, aminophylline and theophylline are used in certain patients with the following medical condition:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.
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