Heparin is an anticoagulant. Heparin sodium has anticoagulant effect in vivo and in vitro, and can prolong the coagulation time and the international normalized ratio. Its anticoagulant action is very complex and affects many links of coagulation process.
Heparins Manufacturer: function of the heparin sodium
① Inhibit the formation and function of thrombin, so as to prevent the conversion of prothrombin into thrombin;
② When the concentration is higher, it can inhibit thrombin and other coagulation factors and prevent fibrinogen from becoming fibrin;
③ It can prevent platelet aggregation and destruction.
In addition, the anticoagulant action of heparin is related to the negatively charged sulfate radical in the molecule, while positively charged alkaline substances, such as protamine or toluidine blue, can neutralize the negative charge and thus inhibit its anticoagulant action.
Since heparin can activate and release lipoprotein esterase in the body, hydrolyze triglycerides and LDL in chylous particles, it also has lipid lowering effects.
This product is not absorbed by oral administration, so oral treatment is ineffective, must be injected, after intravenous injection evenly distributed in white blood cells and plasma, quickly developed into social tissues, not through a placenta and milk, apparent density distribution volume of 0.06L/kg, plasma protein can bind rate of 80% ~ 95%. Metabolized by liver cells, it is excreted by kidney with a half-life time of about 1 hour.
Heparin is used to prevent and treat thrombosis and embolism due to a variety of causes, such as myocardial infarction, pulmonary embolism, cerebral embolism, peripheral venous thrombosis, vascular surgery, and diffuse intravascular coagulation. Early application prevents loss of fibrinogen and coagulation factors. It can also be used as an in vitro anticoagulant during blood transfusions rather than citric acid or cardiopulmonary bypass.