Background: Vibrio cholerae is a facultative pathogen that lives in the
aquatic environment and the human host. The ability of V. cholerae to monitor
environmental changes as it transitions between these diverse environments is vital
to its pathogenic lifestyle. One way V. cholerae senses changing external stimuli is
through the three-com... read moreponent signal transduction system, VieSAB, which is encoded by
the vieSAB operon. The VieSAB system plays a role in the inverse regulation of
biofilm and virulence genes by controlling the concentration of the secondary
messenger, cyclic-di-GMP. While the sensor kinase, VieS, and the response regulator,
VieA, behave similar to typical two-component phosphorelay systems, the role of the
auxiliary protein, VieB, is unclear.
Keywords: Two-component system, Phosphorelay, Bacterial signal
transduction, Protein phosphorylation, Phosphodiesterases, Tetratricopeptide repeat
domain, Vibrio cholerae.
Mitchell, Stephanie, Ayman M. Ismail, Sophia A. Kenrick, and
Andrew Camilli. "The VieB auxiliary protein negatively regulates the VieSA signal
transduction system in Vibrio cholerae." BMC Microbiology 15, no. 1 (12, 2015):