Recommendation Grading System
- Class I - Conditions for which there is evidence and/or general agreement that a given diagnostic evaluation, procedure or treatment is beneficial, useful, and effective.
- Class II - Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a diagnostic evaluation, procedure or treatment.
- Class II A - Weight of evidence/opinion is in favor of usefulness/efficacy.
- Class II B - Usefulness/efficacy is less well established by evidence/opinion.
- Class III - Conditions for which there is evidence and/or general agreement that a diagnostic evaluation/procedure/treatment is not useful/effective and in some cases may be harmful.
Level of Evidence
- Level A - Data derived from multiple randomized clinical trials or meta-analyses.
- Level B -Data derived from a single randomized trial, or nonrandomized studies.
- Level C - Only consensus opinion of experts, case studies, or standard-of-care.