1861 – August Karl Gustav Bier was born on the 24th of November in Helsen, which is near Arolsen in the Dukedom of Waldeck. German pioneer of spinal anaesthesia.
– Bier became a professor at the Charité in Berlin.
1881 – He made his "Abitur" on the "Alte Landesschule" (Old School of the State Waldeck) in Korbach, the capital of Waldeck.
1889 – He became professor and began his career in Kiel.
– There he made experiments with his assistants and on himself with a solution of cocaine he injected into the spinal channel.
1898 – Performed the first planned spinal aneasthetic on his assistant, Dr. Hildebrandt.
– Bier pioneered the use of intravenous procaine analgesia. He also introduced the "tin helmet" into the German Army in World War One.
– He invented spinal anesthesiology and he implemented lumbar anesthesiology at the University-hospital at Kiel.
1908 – Pioneered the use of intravenous procaine analgesia.
1936 – He promoted callisthenics and the "Studiengemeinschaft für tierärztliche Homöopathie" [Study Group for Veterinary Homeopathy], founded to investigate the alleged systemic effects of homeopathic drugs.
1949 – He died on the 12th of March in Sauen, Brandenburg.