Bone metastasis is a destructive and costly complication of cancer cases that can cause unbearable pain and pathological fractures by weakening the architectural structure of the bone, and serious clinical problems such as hypercalcemia at life threatening levels and spinal cord compression. Prophylactic surgical procedures, palliative radiotherapy and chemotherapy are used in the management of bone metastases within certain algorithms in order to prevent the clinical problems it may cause. Nevertheless, when a cancer metastasizes to bone, the patient is often considered to be at an incurable stage. In order to change this fate, it is necessary to understand how bone metastasis develops, which interactions at cellular level occur, and which cascades of key molecular structures cause bone metastasis. Only in this way can targeted treatment strategies that can prevent bone metastasis be developed, and bone cancer metastasis concerns of cancer patients may be reduced. In this review, the mechanisms of bone metastasis, theories of metastasis, and cellular molecular interactions that may shed light on possible treatments are summarized.