Hepatitis C genotypes: the key to pathogenicity?
Determining the strain of hepatitis C virus (HCV) may be important in predicting the course of HCV infection and in planning treatment strategies for HCV-associated liver disease. Researchers have been able to classify HCV into specific genetic types, and studies are investigating the relationship of these strains to disease severity. One study revealed that the serious liver diseases cirrhosis and hepatocellular carcinoma were significantly associated with HCV type II (1b). In addition, patients infected with this strain showed less response to interferon therapy than those infected with other strains. A higher level of virus in the blood was associated with decreased interferon responsiveness as well. Since chronic HCV infection may have a long latent period before the development of liver disease, testing for the specific strain can be useful in evaluating and managing patients prior to severe illness.
Publication Name: Annals of Internal Medicine
Sunburn can damage the skin and increase the risk of skin cancer. Guidelines for prevention and treatment of sunburn are provided.
Publication Name: Postgraduate Medicine
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