Plug the Big Holes First
Don't worry about finding and sealing all the little holes in your attic; your biggest savings will come from plugging the large ones. Once in the attic, refer to your sketch to locate the areas where leakage is likely to be greatest: where walls (inner and outer) meet the attic floor, dropped soffits (dropped-ceiling areas), and behind or under attic kneewalls.
Look for dirty insulation — this indicates that air is moving through it. Dropped soffits may be filled or covered with insulation and hard to see. Push back the insulation and scoop it out of the soffits. You will place this insulation back over the soffit once the stud cavities have been plugged and the soffits covered.
If You Have a Finished Attic, Seal Behind the Kneewalls
Finished rooms built into attics often have open cavities in the floor framing under the side-walls or kneewalls. Even though insulation may be piled against or stuffed into these spaces, they can still leak air. Again, look for signs of dirty insulation to indicate air is moving through. You need to plug these cavities in order to stop air from traveling under the floor of the finished space.
Caution: Some attics have vermiculite insulation, which may contain asbestos, a health hazard. Vermiculite is a lightweight, pea-size, flaky gray mineral. Don't disturb vermiculite insulation unless you've had it tested by an approved lab to be sure it doesn't contain asbestos. Contact your local health department for the name of an approved lab.
For additional details and images, download the Seal and Insulate DIY Guide (PDF, 12.8 MB).