By James C. Bobrow MD
Reports the anatomy, body structure, embryology and pathology of the lens. Covers the epidemiology, assessment and administration of cataracts; provides an outline of lens and cataract surgical procedure; and explores the problems and specific events of cataract surgical procedure. final significant revision 2008 2009.
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Additional info for 2011-2012 Basic and Clinical Science Course, Section 11: Lens and Cataract (Basic & Clinical Science Course)
Gestation , the lumen of the lens vesicle is obliterated. The elongated cells are called the primary lens f ibers. As the fiber cells mature, their nuclei and other membrane-bound organelles undergo degradation, a process that reduces light scattering. The primary lens fibers make up the embryonic nucleus that will ultimately occupy the central area of the lens in adu lt life. The cells of the anterior lens vesicle remai n as a monolayer of cuboidal cells, the lens epithelium. Subsequent growth of the lens is due to proliferation within the epithelium.
The Eye in Systemic Disease. Philadelphia: Lippincott; 1990:309414. 5 13-580. Goldberg ME Persistent fetal vasculatu re (PFV): an integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (P HPV) . LlV Edward Jackson Memorial Lecture. Am J Ophthalmol. 1997; 124:587-626. Hiles DA, Kilty LA. Disorders of the lens. In: Isenberg S), ed. The Eye in Infancy. 2nd ed. St Louis: Mosby; 1994:336- 373. Jaffe NS, Horwitz J. Lens alterations. In: Podos SM, Yanoff M, eds.
Chemical modification and proteolytic cleavage of crystallins (le ns proteins) result in the fo rmation of high-molecular-weight protein aggregates. These aggregates may become large enough to cause abrupt fluc tuations in the local refractive index of the lens, thereby scatte ring light and redu cing transparency_ Chemical modification oflens nuclear protein s also increases pigmentation, such that the lens increasingly takes on a yellow or brownish hue with advancing age (Fig 5-1). Other age- related changes include decreased concentratio ns of glutathione and potassium and increased concentrations of sodium and calcium in the lens cell cytoplasm.
2011-2012 Basic and Clinical Science Course, Section 11: Lens and Cataract (Basic & Clinical Science Course) by James C. Bobrow MD