Diabetes is a chronic metabolic problem closely related to cardiovascular disease leading to premature death.
Dyslipidemia is an important risk factor responsible for cardiovascular disease in patients with diabetes. This paper is
based on review of articles published to observe the effect of N. Sativa (black seed) on lipid levels in patients suffering
from Diabetes Mellitus. A search of indexed papers and clinical trials was done using MEDLINE and PubMed and Cochrane
search engine. All studies assessing the effect of N. Sativa ingestion on lipid levels among diabetics (animal or human)
were included. A total of 12 trials (6 human studies and 6 animal studies) fulfilling the inclusion criteria were reviewed.
Majority of human and animal trials done among humans and animals with diabetes or metabolic syndrome demonstrated
reduction in weight and improvement in serum lipid levels including decrease total lipids, triglycerides, LDL
levels. However, increase in HDL level showed questionable results. N. Sativa L and its different preparations can be used
as an adjuvant with lipid lowering drugs for control of lipids however its role as a main therapeutic agent cannot be recommended
and more metanalysis using standardized preparations with a close watch on methodological short falls is suggested
to prove its role
Keywords: Animals, black seed, dyslipidemia in diabetes, humans, Nigella Sativa.
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