- Two oral rotavirus vaccines (Rotarix and RotaTeq) are listed on the National Immunisation Program to prevent rotavirus gastroenteritis in infants and children.
- State immunisation co-ordinators will decide which of the two vaccines to supply on the basis of tender arrangement with different manufacturers.
- Oral rotavirus vaccination protects most young children against severe dehydrating rotavirus gastroenteritis that most commonly occurs between 3 and 35 months of age. It does not provide lifetime protection.
- Rotarix is a live, monovalent, human attenuated vaccine given in 2 doses (one course) at 2 and 4 months of age. RotaTeq is a live, pentavalent, human–bovine reassortant vaccine given in 3 doses (one course) at 2, 4 and 6 months of age.
- Oral rotavirus vaccines can be given at the same time as other routine childhood vaccines.
- Both vaccines demonstrate similarly high levels of protection against severe rotavirus gastroenterits. In clinical trials vaccination reduced the rate of severe rotavirus gastroenteritis by 85% to 98%, and the rate of hospitalisation for gastroenteritis of any cause by 42% to 59%.1,2
- Safety and efficacy of either vaccine has not been established in infants under 6 weeks of age.
- Rotarix and RotaTeq are not interchangeable. Infants who receive a first dose of either vaccine should complete the entire course of vaccination using the same oral rotavirus vaccine.
- There is no evidence that one oral rotavirus vaccine is more effective than the other.
Rotarix and RotaTeq are available on the National Immunisation Program (NIP) for vaccination of all infants to prevent rotavirus gastroenteritis.
Reason for NIP listing
RotaTeq was listed on the basis of acceptable cost-effectiveness compared with standard medical management without rotavirus vaccination.3 The Pharmaceutical Benefits Advisory Committee accepted that RotaTeq and Rotarix were similar in terms of efficacy and safety, and recommended listing Rotarix on the basis that Rotarix was no less effective than RotaTeq, and at a similar cost (cost minimisation).4
The PBAC has recently become responsible for making recommendations for funding of vaccines under the NIP. Previously, the Australian Technical Advisory Group on Immunisation (ATAGI) fulfilled this role. ATAGI will continue to provide technical advice about vaccines to the PBAC and the Minister for Health and Ageing. However, the process for listing vaccines on the NIP now mirrors the process for medicines, with a company seeking listing making a submission to the PBAC, who consider the cost-effectiveness of the new vaccine and make a recommendation to the Minister.
ATAGI also produces the Australian Immunisation Handbook. The 9th edition is expected to be published in 2007.
Place in therapy
Clinical trials have shown that both Rotarix and RotaTeq are highly effective in preventing severe rotavirus gastroenteritis and reducing hospitalisations due to rotavirus gastroenteritis in children.1,2
Rotavirus causes severe dehydrating gastroenteritis
Rotavirus is the most common cause of severe gastroenteritis in infants and children under the age of 5 years.5,6 A highly contagious non-enveloped RNA virus, rotavirus is mainly transmitted from person to person, and through fomites via the faecal–oral route.7 Viral shedding in the stools of infected patients often begins before symptoms develop8 and may continue for more than 25 days in infants with severe disease.9 Severe dehydrating gastroenteritis occurs more commonly in first infection, particularly in infants 3–35 months of age.10
Rotavirus is a common cause of child hospital admissions
Rotavirus-related disease accounts for 50% of all hospital admissions for diarrhoea in children under 5 years11, with an estimated 10,000 children in this age group admitted with rotavirus gastroenteritis annually.11 Most cases requiring hospitalisation (43.7%) occur in the first year of life.13 Rotavirus is also responsible for an estimated 22,000 emergency department visits and 115,000 general practitioner visits in children under 5 years.11 The financial cost of childhood rotavirus-related illness to the Australian health care system is estimated at $30 million each year.11
Rotavirus hospitalisation rates vary across Australia. The highest rates are in the Northern Territory (149 per 100,000), where the percentage of cases for infants aged 2–11 months is twice the national average.14 Vaccination may be particularly beneficial for Indigenous children who are infected at a younger age15 and whose average annual rate of hospitalisation for rotavirus gastroenteritis is more than 4 times that of non-Indigenous children under 12 months of age.14
Preventing hospital-acquired infection
A secondary goal of vaccination is the prevention of nosocomial rotavirus infection. Rotavirus is recognised as a major aetiological factor in paediatric nosocomial diarrhoea16, with an estimated 25% of all rotavirus hospitalisations attributed to infections acquired while children are in hospital.17 A prospective study of paediatric nosocomial infection in an Adelaide hospital found that 14% of children (31 of 220) under 3 years admitted without gastroenteritis acquired rotavirus while in hospital and that hospitalisation was prolonged in this population (11 days versus 8 days, p < 0.05).18
Rotavirus vaccination reduces the severity of infections
While previous naturally acquired rotavirus infection does not confer immunity, it does reduce the severity of subsequent infections.19–21 Based on this observation it was anticipated that rotavirus vaccines would require at least 2 doses to induce sufficient cumulative immunity to prevent moderate to severe infection most commonly associated with first infection.21 ‘Catch-up’ immunisation and immunisation of older infants is not recommended for safety reasons (see Safety issues) and because natural immunity gained over time negates the benefits of vaccination in this population.
Rotavirus vaccines are effective in preventing rotavirus gastroenteritis
The efficacy of Rotarix and RotaTeq in preventing rotavirus gastroenteritis has been established in two large-scale clinical trials. The two key trials of Rotarix2 and RotaTeq1 (see Table 1) were conducted in different geographical settings and employed different clinical criteria to assess rotavirus gastroenteritis and severity. The observed differences in point estimates of efficacy may be due to non-comparable study populations and classifications of disease severity used, preventing any conclusions regarding the comparative efficacy of these products.
Summary of key findings of large-scale rotavirus vaccine trials
|Rotavirus vaccine||Study population||Protection against severe rotavirus gastroenteritis||Protection against any rotavirus gastroenteritis||Reduction in rate of rotavirus-associated hospitalisation||Reduction in rate of hospitalisation for severe gastroenteritis of any cause|
|Rotarix Rota-0232||63,225 healthy infants from Latin America and Finland||85% (95% CI 72% to 92%)* from 2 weeks after dose 2 until 1 year of age||Not included||85% (95% CI 70% to 94%)* from 2 weeks after dose 2 until 1 year of age||42% (95% CI 29% to 53%)* from 2 weeks after dose 2 until 1 year of age|
|Rotarix Rota-03623||3994 healthy infants from Europe||96% (95%CI 90% to 99%) from 2 weeks after dose 2 until 1 year of age||87% (95% CI 80% to 92%) from 2 weeks after dose 2 until 1 year of age||100% (95% CI 82% to 100%) from 2 weeks after dose 2 until 1 year of age||Not included|
Rotavirus Safety and Efficacy Trial (REST)1
|68,038 healthy infants from 11 countries, including the USA and Finland||98% (95% CI 88% to 100%)† from 2 weeks after dose 3 through first full rotavirus season||74% (95% CI 67% to 80%)† from 2 weeks after dose 3 through first full rotavirus season||96% (95% CI 91% to 98%)‡ from 2 weeks after dose 3 for up to 2 years||59% (95% CI 52% to 65%)‡ after dose 1 for up to 2 years|
* Efficacy cohort (n = 17,867)
† Clinical efficacy substudy (n = 4512)
‡ Effectiveness cohort (n = 57,134)
Rotarix and RotaTeq are effective against common circulating rotavirus strains
RotaTeq is a live, reassortant, pentavalent human–bovine rotavirus vaccine containing 5 rotavirus reassortants: G1, G2, G3, G4 and P derived from human and bovine viral species.22 Rotarix is a live, monovalent, human attenuated rotavirus vaccine derived from the most common human rotavirus strain G1P.23
RotaTeq significantly reduced the number of hospitalisations and emergency department visits for rotavirus gastroenteritis caused by individual serotypes G1, G3, G4 and G9 in the REST study.1,22 Efficacy of Rotarix was demonstrated against severe rotavirus gastroenteritis caused by serotypes G1, G3, G4 and G9.2 There are some data for the efficacy of both vaccines against G2 rotavirus; however, protection may be less than with other strains*. On re-analysis of the REST study, efficacy of RotaTeq was demonstrated against hospitalisation and emergency department visits for G2 rotavirus (92% [95% CI 35% to 99%]).24 For Rotarix, pooled analysis of four studies demonstrated efficacy of Rotarix against severe rotavirus gastroenteritis caused by G2 (71% [95% CI 20% to 91%]).23
Substantial geographical variation exists from year to year in the prevalence of rotavirus strains across Australia.13,25–29 The changing pattern of prevailing rotavirus serotypes may affect the efficacy of rotavirus vaccines over time. The efficacy of current rotavirus vaccines has not been sufficiently established against emerging rotavirus strains such as G12.13
*The uncertainty is because in these trials very few infections were caused by serotypes other than G1 and this is reflected in the wide confidence intervals.
Protection for more than 2 rotavirus seasons has not been established
Protective efficacy of RotaTeq and Rotarix has been demonstrated through two full rotavirus seasons.1,2,30 During the first and second rotavirus seasons Rotarix provided 90% efficacy (95% CI 10% to 100%) and 83% efficacy (95% CI 7% to 98%), respectively, against severe rotavirus gastroenteritis.30 RotaTeq demonstrated an efficacy of 98% (95% CI 88% to 100%) against severe rotavirus gastroenteritis during the first season and 88% (95% CI 49% to 99%) efficacy through a second rotavirus season.1
Rotavirus vaccines can be given with routine childhood vaccines
Rotarix and RotaTeq can be given with any of the following routine childhood vaccines:22,23
- diphtheria–tetanus–acellular pertussis vaccine (DTPa)
- Haemophilus influenzae type b vaccine (Hib)
- inactivated polio vaccine (IPV)
- hepatitis B vaccine
- pneumococcal vaccine.
Rotarix can also be given with meningococcal serogroup C vaccine.23 Co-administration of RotaTeq with meningococcal serogroup C vaccine is not currently included in the RotaTeq product information.22 Studies have shown that immune responses and safety profiles of co-administered vaccines were unaffected. Administration of rotavirus vaccine, or placebo, with routine childhood vaccines was associated with a comparable adverse-reaction profile.22,23
Safety and efficacy in premature infants
Rotarix was well tolerated in premature infants (29–36 weeks’ gestation) but data regarding its efficacy in this population is currently unavailable.23 RotaTeq can be given to premature infants (25–36 weeks’ gestation) according to chronological age.22 Vaccination of older infants and children is not recommended.
Both Rotarix and RotaTeq were generally well tolerated in clinical trials. No serious adverse events occurred compared with placebo in two, large phase III clinical trials involving about 130,000 infants.
Vaccine side effects
Very common adverse effects of RotaTeq (≥ 10%) reported by parents within the first week after the first dose included diarrhoea (18% of vaccine recipients versus 15% of placebo recipients), vomiting (10% versus 8%) and pyrexia (21% versus 19%).22
Adverse reactions reported with a higher incidence in Rotarix recipients than placebo recipients included irritability (46% versus 42%), loss of appetite (16% versus 12%), diarrhoea (5% versus 3%), flatulence (2% versus 0.8%) and fever (9% versus 7%).23
Risk of intussusception
A previous live rotavirus vaccine, Rotashield, was voluntarily withdrawn in the US in 1999 less than 12 months after licensing because of an association with intussusception (a rare* but potentially fatal condition) among otherwise healthy infants.31–34 There is evidence that the risk of vaccine-related intussusception was age related, with most cases (80%) in half the infants receiving their first dose of vaccine after 3 months of age.33,35
The incidence of naturally occurring intussusception increases with age and peaks around 6 months of age.36 The first dose of Rotarix should be given between 6 and 14 weeks of age, and the first dose of RotaTeq between 6 and 12 weeks of age, when the background incidence of naturally occurring intussusception is low.22,23,33,36 The final dose of Rotarix and RotaTeq should be given by 24 weeks and 32 weeks of age, respectively, to minimise the overlap with naturally occurring intussusception.22,23,36
The possibility of an excess risk of intussusception with either vaccine cannot be completely ruled out until the vaccines are used in larger numbers of infants.35 Recent postmarketing surveillance data from the US do not suggest to date an association between RotaTeq and intussusception.37
*Average annual incidence 10.1 per 100,000 infants in Australia under 1 year, 1994–2000.36
The safety and efficacy of Rotarix and RotaTeq have not been established in immunocompromised infants, including infants with HIV.
Contraindications to rotavirus vaccination
- Known or suspected hypersensitivity to any components of the vaccine.22,23,38
- History of chronic gastrointestinal disease that increases susceptibility to developing intussusception.23
- As with other vaccines, rotavirus vaccination should be postponed in acute febrile illness.22,23
Use with caution
Consider potential risks and benefits in administering rotavirus vaccines in the following contexts.22,23,38
- History of gastrointestinal disease: the efficacy and safety of rotavirus vaccination has not been established in infants with pre-existing and/or active gastrointestinal illnesses. Pre-existing chronic gastrointestinal disease, which does not increase susceptibility to intussusception, is not a contraindication to vaccination. Postpone vaccination in children with moderate to severe diarrhoea or vomiting.
- Infants with known or suspected primary or secondary immunodeficiency states, including those with HIV.
- Immunocompromised contacts: viral shedding in stools, particularly after the first vaccine could pose a risk of transmission of virus to close contacts. Advise contacts to observe good hygiene practices (washing hands regularly, especially after changing nappies).
- The interval between receipt of blood products and rotavirus vaccination should be as long as possible, but vaccination should not be delayed beyond the upper age limits for dosing.
Report suspected adverse events after immunisation to the relevant health authority in Australian Capital Territory, New South Wales, the Northern Territory, Queensland, South Australia and Western Australia. In Victoria and Tasmania suspected adverse reactions should be reported to the Adverse Drug Reactions Advisory Committee (ADRAC) online or by using the 'Blue Card' distributed with Australian Prescriber. For information about reporting adverse reactions, see the Therapeutic Goods Administration website.
For more information on reporting of adverse events following immunisation, see the Immunise Australia Program website.
Rotarix and RotaTeq are for oral use only. Never inject either vaccine. For practical aspects of administration see Table 2.
Practical aspects of rotavirus vaccination 22,23,38
|Rotavirus vaccine||Vaccine presentation||Course||First dose administered||Age for routine doses||Minimum dose intervals|
(oral administration only)
|White powder in glass vial requiring reconstitution with dilutent in glass pre-filled syringe (for oral use only)||2 doses.
Complete vaccine course by 24 weeks of age
|6–14 weeks||2 and 4 months||4 weeks|
(oral administration only)
|Ready-to-use liquid oral doses, available as single pre-filled 2 mL unit doses in plastic dosing tube with twist-off cap||3 doses.
Complete vaccine course by 32 weeks of age
|6–12 weeks||2, 4 and 6 months||4 weeks|
Administer the liquid to the inside of the cheek. Replacement of partially lost doses due to spitting or regurgitation is not advised because the safety of administering higher than the recommended dose of rotavirus vaccines has not been established. The efficacy of a partially administered dose is unknown.38 Feeding restrictions after administration are not necessary. For infants who inadvertently received the first dose of either vaccine later than the recommended cut-off age, complete vaccination as per the schedule, as long as minimum dose intervals can be maintained and the full vaccination course can be completed within the recommended upper age limit.10,38
Information for patients
Advise parents and/or carers of the following:22,23,38
- Children who receive rotavirus vaccination are less likely to develop severe rotavirus-associated gastroenteritis and are less likely to be hospitalised or require medical attention for gastroenteritis.22,23
- Vaccination against rotavirus provides most infants with protection against severe dehydrating gastroenteritis during the time at which they are most at risk. It does not provide lifetime protection.22,23
- Like most vaccines, rotavirus vaccines do not provide complete protection. Gastroenteritis due to rotavirus and other infections may still occur. Gastroenteritis may result from rotavirus infection or other infectious or non-infectious causes.22,23 Advise parents to seek medical treatment for their child if they develop gastroenteritis and or any signs of mild to moderate dehydration, including:39
- restlessness or irritability (sleepiness/listlessness in severe dehydration)
- sunken eyes
- thirst and drinking eagerly (drinking poorly or not at all in severe dehydration).
- Maintain good hygiene practices — handwashing regularly and after nappy changes, especially in households where there is an immunocompromised contact.
- Report any adverse effects of vaccination. Contact their doctor immediately if the infant shows any signs or symptoms of atypical gastrointestinal upset.
- Rotavirus vaccines are not interchangeable. Infants who receive a first dose of either vaccine should complete the entire course of vaccination using the same rotavirus vaccine. Therefore, if a family moves to a State with a different vaccine they may need to pay for the remaining dose(s) of the original vaccine. Advise parents of different number of doses per course for different vaccines.
- Vesikari T, Matson DO, Dennehy P, et al. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med 2006;354:23–33. [PubMed]
- Ruiz-Palacios GM, Perez-Schael I, Velazquez FR, et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med 2006;354:11–22. [PubMed]
- Pharmaceutical Benefits Advisory Committee. Public summary document: Rotavirus vaccine, live, oral liquid, pentavalent, 2 mL unit dose RotaTeq® November 2006. Australian Government Department of Health and Ageing. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ pbac-psd-rotavirus-nov06 (accessed 11 April 2007).
- Pharmaceutical Benefits Advisory Committee. Public summary document: Human Rotavirus Vaccine, lyophilised powder and solvent for oral administration, 1 mL dose, Rotarix® November 2006. Australian Government Department of Health and Ageing. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ pbac-psd-rotarix-nov06 (accessed 19 June 2007).
- Parashar UD, Hummelman EG, Bresee JS, et al. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis 2003;9:565–72. [PubMed]
- Parashar UD, Gibson CJ, Bresee JS, et al. Rotavirus and severe childhood diarrhea. Emerg Infect Dis 2006;12:304–6. [PubMed]
- Butz AM, Fosarelli P, Dick J, et al. Prevalence of Rotavirus on High-Risk Fomites in Day-Care Facilities. Pediatrics 1993;92:202–5. [PubMed]
- Zahn M, Marshall GS. Clinical and epidemiological aspects of rotavirus infection. Pediatr Ann 2006;35:23–8. [PubMed]
- Parashar UD, Bresee JS, Gentsch JR, et al. Rotavirus. Emerg Infect Dis 1998;4:561–70. [PubMed]
- Parashar UD, Alexander JP, Glass RI, et al. Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006; 55:1–13. [PubMed]
- Carlin J, Chondros P, Masendcyz P, et al. Rotavirus infection and rates of hospitalisation for acute gastroenteritis in young children in Australia, 1993–1996. Med J Aust 1998;168:252–6. [PubMed]
- Galati JC, Harsley S, Richmond P, Carlin JB. The burden of rotavirus-related illness among young children on the Australian health care system. Aust N Z J Public Health 2006;30:416–21. [PubMed]
- Kirkwood CD, Cannan D, Bogdanovic-Sakran N, et al. National Rotavirus Surveillance Program annual report, 2005–06. Comm Dis Intell 2006;30:434–8. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ cda-cdi3004c. htm (accessed 21 May 2007).
- Newall AT, MacIntyre R, Wang H, et al. Burden of severe rotavirus disease in Australia. J Paediatr Child Health 2006;42:521–7. http:/
/ www. blackwell-synergy. com/ doi/ abs/ 10. 1111/ j. 1440-1754. 2006. 00915. x
- 15. Schultz R. Rotavirus gastroenteritis in the Northern Territory, 1995-2004. Med J Aust 2006;185:354–6. [PubMed]
- Gleizes O, Desselberger U, Tatochenko V, et al. Nosocomial rotavirus infection in European countries. Pediatr Infect Dis J 2006;25:S12–S21. [PubMed]
- Fischer TK, Bresee JS, Glass RI. Rotavirus vaccines and the prevention of hospital-acquired diarrhea in children. Vaccine 2004;22 (Suppl 1):S49-54. [PubMed]
- Ringenbergs M, Davidson G, Spence J, Morris S. Prospective study of nosocomial rotavirus infection in a paediatric hospital. Aust Paediatr J 1989;25:156–60. [PubMed]
- Bishop RF, Barnes GL, Cipriani E, Lund JS. Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. N Engl J Med 1983;309:72–6. [PubMed]
- Cunliffe NA, Nakagomi O. A critical time for rotavirus vaccines: a review. Expert Rev Vaccines 2005;4:521–32. [PubMed]
- Velazquez FR, Matson DO, Calva JJ, et al. Rotavirus infection in children as protection against subsequent infections. N Engl J Med 1996;335:1022–8. [PubMed]
- CSL Limited/Merck and Co Inc. RotaTeq product information 3 May 2006.
- GlaxoSmithKline. Rotarix product information 22 February 2007.
- Pharmaceutical Benefits Advisory Committee. Public summary document: Rotavirus vaccine, live, oral liquid, pentavalent, 2 mL unit dose, RotaTeq® July 2006 Australian Government Department of Health and Ageing.2006. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ pbac-psd-rotavirus2ml-july06 (accessed 31 May 2007).
- Kirkwood C, Bogdanovic-Sakran N, Cannan D, et al. National Rotavirus Surveillance Program annual report, 2004–05. Comm Dis Intell 2006;30:133–6. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ cda-cdi3001h. htm (accessed 21 May 2007).
- Kirkwood C, Bogdanovic-Sakran N, Bishop R, Barnes G. Report of the Australian Rotavirus Surveillance Program, 2003–2004. Comm Dis Intell 2004;28:481–5. http:/
/ www. health. gov. au/ internet/ wcms/ Publishing. nsf/ Content/ cda-2004-cdi2804e. htm (accessed 21 May 2007).
- Kirkwood CD, Bogdanovic-Sakran N, Clark R, et al. Report of the Australian Rotavirus Surveillance Program 2002–03. Comm Dis Intell 2003;27:492–5. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ cda-pubs-cdi-2003-cdi2704-htm-cdi2704i. htm (accessed 21 May 2007).
- Bishop RF, Masendycz PJ, Bugg HC, et al. Epidemiological patterns of rotaviruses causing severe gastroenteritis in young children throughout Australia from 1993 to1996 J Clin Microbiol 2000;39:1085–91. [PubMed]
- Masendycz P, Bogdanovic-Sakran N, Kirkwood C, et al. Report of the Australian Rotavirus Surveillance Program, 2000/2001. Comm Dis Intell 2001;25:143–6. http:/
/ www. health. gov. au/ internet/ wcms/ publishing. nsf/ Content/ cda-pubs-cdi-2001-cdi2503-cdi2503o. htm (accessed 21 May 2007).
- Vesikari T, Karvonen A, Puustinen L, et al. Efficacy of RIX4414 live attenuated human rotavirus vaccine in Finnish infants. Pediatr Infect Dis J 2004;23:937–43. [PubMed]
- Murphy TV, Gargiullo PM, Massoudi MS, et al. Intussusception among Infants Given an Oral Rotavirus Vaccine. N Engl J Med 2001;344:564–72. http:/
/ content. nejm. org/ cgi/ content/ abstract/ 344/ 8/ 564
- Rothman KJ, Young-Xu Y, Arellano F. Age dependence of the relation between reassortant rotavirus vaccine (RotaShield) and intussusception. J Infect Dis 2006;193:898 [author reply –9]. [PubMed]
- Simonsen L, Viboud C, Elixhauser A, et al. More on RotaShield and intussusception: the role of age at the time of vaccination. J Infect Dis 2005;192 [Suppl 1]:S36–43. [PubMed]
- Bines J. Intussusception and rotavirus vaccines. Vaccine 2006;24:3772–6. [PubMed]
- Glass RI, Bresee JS, Parashar UD, et al. The future of rotavirus vaccines: a major setback leads to new opportunities. Lancet 2004;363:1547–50. [PubMed]
- Justice F, Carlin J, Bines J. Changing epidemiology of intussusception in Australia. J Paediatr Child Health 2005;41:475–8. [PubMed]
- Department of Health and Human Services Centres for Disease Control and Prevention. Postmarketing monitoring of intussusception after rotateq vaccination – United States, February 1, 2006 – February 15, 2007. MMWR 2007;56:218–22. http:/
/ www. cdc. gov/ mmwr/ preview/ mmwrhtml/ mm5610a3. htm (accessed 21 May 2007).
- National Health and Medical Research Council. The Australian Immunisation Handbook Draft 9th edn. Australian Government Department of Health and Ageing, 2007. http:/
/ www. immunise. health. gov. au/ (accessed 21 May 2007).
- Elliott EJ, Dalby-Payne JR. MJA practice essentials - paediatrics: 2. Acute infectious diarrhoea and dehydration in children. Medical Journal of Australia 2004;181:565–70. http:/
/ www. mja. com. au/ public/ issues/ 181_10_151104/ ell10338_fm. html