ORGANIC SYNTHESIS forms the most important integral part of Organic Chemistry. This requires a knowledge of all carbon-carbon bonding reactions, functional group modifications, mechanisms of reactions, the stereochemistry of the reactions, protection and de-protection during organic synthesis etc. Synthesis of an organic compound often a natural product, biologically active had been considered as best supporting evidence for their structure and stereochemistry. It is possible to synthesise compounds resembling natural products and to study their biological activity. With the help of the above, structure-activity relationship can be deduced. Along with Bioinformatics the mechanism and the site of reaction of a drug can be evaluated. This can further help the synthetic organic chemist to synthesise more potent drugs for many diseases.