Increased amounts of circulating DNA in plasma have been found in a variety of disorders including cancer, autoimmune diseases, infections, certain fetal diseases, trauma, and stroke. Circulating DNA is known to be highly fragmented and low in concentration, which makes it difficult to purify.
NucleoSpin Plasma XS is designed to isolate fragmented DNA larger than 50 bp from human EDTA blood plasma. The kit overcomes the limitations of conventional kits (large membrane diameter associated with large default elution volumes, and a resulting DNA concentration which is too low to be directly used as PCR template). NucleoSpin Plasma XS allows elution in only 5–20 µl, resulting in highly concentrated DNA!