Eye Cells Believed to be Retinal Stem Cells are Misidentified
Cells isolated from the eye that many scientists believed were retinal stem cells are, in fact, normal adult cells, investigators at St. Jude Children’s Research Hospital have found.
Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies
For the first time, scientists have shown that amniotic fluid (the protective liquid surrounding an embryo) may be a potential new source of hematopoietic stem cells for therapeutic applications.
Distinguishing Single Cells with Nothing But Light
Researchers at the University of Rochester have developed a novel optical technique that permits rapid analysis of single human immune cells using only light.
Scientists Prove Human Heart Can Regenerate Cells
Scientists said on Thursday they had shown the human body regenerates heart cells at a rate of about one percent a year, a discovery that could one day reduce the need for transplants.
Building a Better Cell Culture System
Howard Hughes Medical Institute researchers have created a new type of “intelligent scaffold” for growing human cells that mimics conditions inside the body better than the standard, flat Petri dishes often used in laboratories.
Are the Lab Rat’s Days Numbered?
New efforts to build complex living ‘microtissues’ from cultured cells represent some of the most promising progress toward reducing the need for laboratory creatures.
Mice and Men Should Have More in Common in Clinical Trials
Just as no two humans are the same, a Purdue University scientist has shown treating mice more as individuals in laboratory testing cuts down on erroneous results and could significantly reduce the cost of drug development.
Monitoring the On Switch that Turns Stem Cells into Muscle
A team of American researchers have created a “switch” that allows mutations or light signals to be turned on in muscle stem cells to monitor muscle regeneration in a living mammal.
Alnylam Initiates Phase I Clinical Study of ALN-VSP in Patients with Liver Cancer
Alnylam Pharmaceuticals, Inc. recently announced that it has initiated a Phase I human clinical trial of ALN-VSP, an RNAi-based therapy, to evaluate its safety, tolerability, pharmacokinetics, and pharmacodynamics in patients with advanced liver cancers.
Genzyme Gene Therapy Fails to Help People with Leg Disease Walk Longer
Genzyme said recently at a medical meeting that its gene therapy for people with peripheral artery disease failed in a clinical trial to help them regain some mobility.
After Heart Attack, Bone Marrow Stem Cells Increase Blood Flow Within Heart
Patients treated with their own bone marrow stem cells after a heart attack experienced increased circulation within the heart, a study by Emory University School of Medicine physicians found.
Combination Adult Stem Cell Therapy Improves Severe Limb Ischemia
TCA Cellular Therapy researchers treated ten patients during the Phase I safety/efficacy clinical trial using a combination of the patient’s own endothelial progenitor cells and mesenchymal stem cells.
First Patient Treated in Osiris Phase II Stem Cell Trial for Heart Attacks
Osiris Therapeutics, Inc. recently announced the treatment of the first patient in a Phase II clinical trial evaluating Prochymal for the treatment of heart attacks.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Generation of Induced Pluripotent Stem Cells from Human Blood
In this study, the researchers describe the derivation of induced pluripotent stem cells from CD34+ mobilized human peripheral blood cells using retroviral transduction of OCT4/ SOX2/ KLF4/ MYC.
Histone Deacetylase Inhibition Elicits an Evolutionarily Conserved Self-Renewal Program in Embryonic Stem Cells
This study shows that a narrow concentration of the naturally occurring short-chain fatty acid, sodium butyrate, supports the extensive self-renewal of mouse and human ESCs, while promoting their convergence toward an intermediate stem cell state.
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