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Polysorbate 80, also known as polyoxyethylene sorbitan monooleate or Tween™ 80, is an amber-colored, viscous liquid with a slightly bitter taste. It is used primarily as an emulsifier in food products, cosmetics, vitamins, medicines, and vaccines. The product is a derivative of sorbitol and oleic acid, and is manufactured worldwide
In the 1980s, Polysorbate 80 was put forward as a potential cure for baldness, and was initially well received; however, in 1986, a lengthy hearing involving manufacturers, the United States Food and Drug Administration (FDA), the Federal Trade Commission (FTC), and the US Postal Service, a court ruling prevented manufacturers from making anti-baldness claims
There has been some controversy over the potential health risks of Polysorbate 80. The primary concern involves injection of the chemical into the body, and a study in 1993 showed that its injection into baby female rats resulted in malformed reproductive organs. Years later, reports of this study caused many to question if this compound was safe when used in flu vaccines for the H1N1 virus.
Polysorbate 80 (brand names include Alkest, Canarcel and Tween, which is a registered trademark of ICI Americas, Inc.) is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is a viscous, water-soluble yellow liquid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups which are polymers of ethylene oxide. In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case the oleic acid (see polysorbate for more detail). Polysorbate 80 is often used in food and other products as an emulsifier.
Polysorbate 80 is used as a solubilizing agent in IV formulations of the antiarrhythmic drug amiodarone. Rare case reports of liver toxicity have been published suggesting polysorbate 80 may contribute to liver toxicity with the IV formulation of amiodarone. The package labeling of amiodarone warns that polysorbate 80 is also known to leach DEHP (dioctyl phthalate) from PVC and dosing recommendations should be followed closely.
Polysorbate 80 and Histidine, a marriage of disaster by Cynthia A. Janak
"Polysorbate 80 is a very effective surfactant used to trick and open up the blood brain barrier (Lannone, Sun, Kreuter and Tianbin for starters) , and allow nano-drugs to be dragged through into the brain."--Hilary Butler
An excipient is generally a pharmacologically inactive substance formulated with the active ingredient ("API") of a medication. Excipients are commonly used to bulk up formulations that contain potent active ingredients (thus often referred to as "bulking agents," "fillers," or "diluents"), to allow convenient and accurate dispensation of a drug substance when producing a dosage form. They also can serve various therapeutic-enhancing purposes, such as facilitating drug absorption or solubility, or other pharmacokinetic considerations. Excipients can also be useful in the manufacturing process, to aid in the handling of the active substance concerned such as by facilitating powder flowability or non-stick properties, in addition to aiding in vitro stability such as prevention of denaturation over the expected shelf life. The selection of appropriate excipients also depends upon the route of administration and the dosage form, as well as the active ingredient and other factors.
Originally posted by BearTruth
reply to post by abeverage
Well, shall I start practicing "Hail, abeverage, Hail!".
What would be the appropriate toast, I don't think "To Your Good Health" would apply at that point.
Cultured microvessel brain endothelial cells of human and bovine origin were used as an in vitro model for the BBB to gain further insight into the mechanism of uptake of nanoparticles. With cells from these species we were able to show that polysorbate 80-coated nanoparticles were taken up by brain endothelial cells much more rapidly and in significantly higher amounts (20-fold) than uncoated nanoparticles. The process of uptake was followed by fluorescence and confocal laser scanning microscopy. The results demonstrate that the nanoparticles are taken up by cells and that this uptake occurs via an endocytotic mechanism.
Originally posted by BearTruth
I plan on exploring food dyes, like Yellow #5, MSG, aspartame and others.
Please feel free to post substances that are added to our foods and medicines, which concern you. Knowledge is the goal.
Originally posted by BearTruth
reply to post by texasgirl
Yes Aspartame happens to be on my list for discussion.
I also have given up a lot of the foods I used to enjoy. I quit diet sodas a very long time ago, because the aspartame gave me blinding headaches. Now I read labels, but I still miss one now and then. Aspartame is in many things, and uses different names also.
When I was growing up, my Mother loved Miracle Whip. We ate it on sandwiches, salads, deviled eggs, everything. I continued this practice as an adult also. A couple years ago, I noticed it didn't taste right to me. It was off. I checked the label and found that the ingredients were not to my liking. It smells bad to me also, now.
I have started using olive oil with vinegar and spices. I am still exploring and creating new mixes, lol. My kids will try them just to shut me up, and frequently find they like them. [/quote
Aspartame gave you blinding headaches? I should tell my client this, as she suffers from weekly migraines. She is also on so many meds that her medicine cabinet looks like a drugstore.
I was a weird, but lucky kid. I hated ketchup, mayonnaise, salad dressing and barbecue sauce so I ate many meals plain. I was a tomb boy and jumped off houses but have never broken a single bone (or had a sprain) I also ate tons of vegetables and fruits and did not really develop a taste for desserts until later in life. I still don't like mayonnaise much but I will eat it sometimes, and I still hate ketchup. I do like ranch dressing, though, but not many others. I get my taste from nuts and seeds in salads, and from cherry tomatoes.
I wonder if this has contributed to the fact I am not on any drugs and very rarely, if ever, get sick. You should try mashing avocado and lime juice with romaine lettuce, along with cherry tomatoes, yellow onions, mushrooms and sunflower nuts. I bet your kids would (grudgingly) like it!
Originally posted by rickymouse
Many of the things that people have been led to believe are bad here in America are actually necessary for proper mind function. If you do not consume them than you may need antidepressant or other medicines to make up for the deficiency. I do not know how these rumors got started in the past, probably by someone who profited by their spreading. Many chemicals that are added to foods, and the foods that they are pushing as good are not good for us if overconsumed. Proper preparation of these foods is necessary, people are doing this wrong...They then need medicines to fix the metabolic problems.
Aspartame is not good for us on a regular basis, a little occasionally won't bother us that much. Free glutamates to excess are not good for us but bound glutamates are necessary in the right moderations to keep us from getting depressed and to help us form long term memories. Adding free glutamates to foods as an attractant or using food chemistry that boosts free glutamates is not good. It creates highs and lows and moody people. Carrageenan is a bad additive, I haven't been able to find any good about it like other things that are said to be bad. I think that it is better to use agar myself. I could go on and on with hundreds of different combinations that could have problems. I personally think that the FDA is corrupt for allowing all these attractants to be added to foods and for allowing unproven chemistry to be introduced into the food supply. Let the buyer beware is the main principal of this society. I believe that most people would not believe what I know, but I have examined a lot of research and many interpretations of the research. Sometimes I wonder how the writer of an article can conclude from their research what they are concluding. Sometimes I find other evidence that substantuates their claims in other research that they do not attach, that makes their conclusions a little better but often the negative effects outweigh the positive effects ten fold.
Oh well, sorry for boring you guys with my dribble.