High rates of trauma exposure and post-traumatic stress disorder (PTSD) in low-income, urban populations underscore the urgent need for research in this under-represented group. In such samples, exposure to trauma may begin early in life;studies of children and young adults from similar samples suggest that initial trauma exposure during childhood or adolescence is common. In addition, women are at higher risk for anxiety than men;although some new research indicates specific genetic and endocrine factors that play a role in this difference, the timeline of emergence of these sex differences are still unclear. Of particular concern is the perpetuation of the cycle mental health disorders, in that children of depressed or anxious mothers are at higher risk of developing anxiety and depression themselves. Risk factors include biological factors such as genetics as well as environmental factors, such as increased risk of child trauma exposure. Our recent study identified a gene polymorphism of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor as a risk genotype for PTSD in women. The proposed study will target the same candidate gene in children at risk for trauma and PTSD, using psychophysiological biomarkers of anxiety. The proposed study will investigate these biomarkers in children at high risk for trauma exposure prior to puberty and will re-test them again after puberty in order to examine the emergence of sex differences in PTSD. We have developed several physiological, startle-based phenotypes that are related to PTSD. Specifically, we have found that impaired inhibition of fear-potentiated startle is a robust biomarker of PTSD in survivors of combat and civilian trauma. Furthermore, dark-enhanced startle is associated with PTSD specifically in women, providing a physiological index for measuring sex differences in anxiety. Preliminary data from a low-income, primarily African American urban population collected from school-age children indicate that these same startle-based phenotypes are sensitive to developmental as well as pubertal changes.
Up to 23 million people will be diagnosed with post-traumatic stress disorder (PTSD) in the United States. A growing number of studies indicate that low-income families and children living in urban environments are at especially high risk for both exposure to traumatic events and PTSD. The ultimate goal of this proposal is to combine clinical research and basic neuroscience methods to inform the development of novel and effective approaches for measuring risk for psychopathology in children and adolescents, particularly in high-risk environments such as low- income, urban, minority populations.
|Maheu, Marissa E; Ressler, Kerry J (2017) Developmental pathway genes and neural plasticity underlying emotional learning and stress-related disorders. Learn Mem 24:492-501|
|Cao, Minhnguyen; Powers, Abigail; Cross, Dorthie et al. (2017) Maternal emotion dysregulation, parenting stress, and child physiological anxiety during dark-enhanced startle. Dev Psychobiol 59:1021-1030|
|Berg, Carla J; Haardörfer, Regine; McBride, Colleen M et al. (2017) Resilience and biomarkers of health risk in Black smokers and nonsmokers. Health Psychol 36:1047-1058|
|van Rooij, Sanne J H; Cross, Dorthie; Stevens, Jennifer S et al. (2017) Maternal buffering of fear-potentiated startle in children and adolescents with trauma exposure. Soc Neurosci 12:22-31|
|Cross, Dorthie; Vance, L Alexander; Kim, Ye Ji et al. (2017) Trauma Exposure, PTSD, and Parenting in a Community Sample of Low-Income, Predominantly African American Mothers and Children. Psychol Trauma :|
|Michopoulos, Vasiliki; Powers, Abigail; Gillespie, Charles F et al. (2017) Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond. Neuropsychopharmacology 42:254-270|
|Sawamura, Takehito; Klengel, Torsten; Armario, Antonio et al. (2016) Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala. Neuropsychopharmacology 41:832-46|
|Mandavia, Amar; Robinson, Gabriella G N; Bradley, Bekh et al. (2016) Exposure to Childhood Abuse and Later Substance Use: Indirect Effects of Emotion Dysregulation and Exposure to Trauma. J Trauma Stress 29:422-429|
|Stevens, Jennifer S; van Rooij, Sanne J H; Jovanovic, Tanja (2016) Developmental Contributors to Trauma Response: The Importance of Sensitive Periods, Early Environment, and Sex Differences. Curr Top Behav Neurosci :|
|Cross, Dorthie; Kim, Ye Ji; Vance, L Alexander et al. (2016) Maternal Child Sexual Abuse Is Associated With Lower Maternal Warmth Toward Daughters but Not Sons. J Child Sex Abus 25:813-826|
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