Question: What disease was responsible for the most deadly epidemic in U.S. history?
Answer: The most deadly epidemic to ever strike the United States occurred in 1918. As America prepared for war, a soldier at an Army fort in Kansas reported to the base hospital with flu-like symptoms. There, he was diagnosed as having a strain of flu that was called Spanish Influenza (since it was erroneously believed the strain had originated in Spain). Before the year was out, 675,000 Americans would die from the flu -- more than the total of all Americans to die in all wars in the 20th century.