Lymphoma accounts for one-third of all malignancies in cats and occurs in various primary anatomic sites, such as the gastrointestinal tract, kidneys, mediastinum (chest cavity) and spleen. Unlike in dogs with lymphoma, cats generally do not present with generalized peripheral lymph node enlargement.The occurrence of feline lymphoma has been strongly associated with infection by the feline leukemia virus (FeLV) and certain strains of the feline immunodeficiency virus (FIV) although over the last 10 years, the use of testing and vaccination has dramatically reduced the incidence of FeLV infection in the United States. A combination of 5 chemotherapy drugs is reported to be the most effective method to treat most types of lymphoma in cats. Radiation therapy and surgery, along with chemotherapy, are used to treat the more localized forms of lymphoma (such as intra-nasal or ocular.)Treatment goals are to improve quality of life by achieving remission with minimal toxicity and side effects from the drugs.