Genomes and Genes
Summary: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications214 found, 100 shown here
- The function of immunoglobulin A in immunityJenny M Woof
Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, UK
J Pathol 208:270-82. 2006..IgA function may also be perturbed in certain disease states, some of which are characterized by deposition of IgA in specific tissues. This review details current understanding of the roles played by IgA in both health and disease...
- IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiencyDanilo Villalta
Allergy and Immunology Unit, Azienda Ospedaliera San Maria degli Angeli, Pordenone, Italy
Clin Chem 56:464-8. 2010..IgA-anti-tTG are absent in IgA deficiency, a condition often associated with CD...
- Selective IgA deficiency in autoimmune diseasesNing Wang
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
Mol Med 17:1383-96. 2011..This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders...
- High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiencyRicardo C Ferreira
Genentech, South San Francisco, California, USA
PLoS Genet 8:e1002476. 2012Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry...
- Selective IgA deficiencyLeman Yel
University of California, Irvine, Irvine, CA, USA
J Clin Immunol 30:10-6. 2010..Most individuals with IgA deficiency are asymptomatic and identified coincidentally...
- Selective IgA deficiency in early life: association to infections and allergic diseases during childhoodMagdalena Janzi
Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden
Clin Immunol 133:78-85. 2009Selective IgA deficiency in early life is quite common in Caucasian populations, but it is unclear whether it increases the risk of infections and allergic diseases during childhood...
- Mucosal immunity to influenza without IgA: an IgA knockout mouse modelI N Mbawuike
Departments of Microbiology, Influenza Research Center, Respiratory Pathogens Research Unit, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 162:2530-7. 1999....
- Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiencyRicardo C Ferreira
Genentech, Inc, South San Francisco, California, USA
Nat Genet 42:777-80. 2010..0 x 10(-4)) or random SNPs across the genome (P < 0.0001). These findings support the hypothesis that autoimmune mechanisms may contribute to the pathogenesis of IgAD...
- Selective IgA deficiency: clinical and laboratory features of 118 children in TurkeyCaner Aytekin
Department of Pediatric Immunology, Dr Sami Ulus Maternity and Children s Health and Diseases Training and Research Hospital, 06080, Ankara, Turkey
J Clin Immunol 32:961-6. 2012Selective IgA deficiency (IgAD) is considered as the most common primary immunodeficiency...
- The prevalence of selective IgA deficiency in type 1 diabetes mellitusR S Liblau
Department of Clinical Immunology, INSERM U 25, Necker Hospital, Paris, France
APMIS 100:709-12. 1992A significant increase in the prevalence of selective IgA deficiency has been observed in patients with autoimmune disorders such as systemic lupus erythematosus and rheumatoid arthritis...
- IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency. Working Groups on Celiac Disease of SIGEP and Club del TenueF Cataldo
Clinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy
Gut 47:366-9. 2000In selective IgA deficiency (IgAD), there is no reliable screening test for coeliac disease (CD).
- Immunoglobulin levels in saliva in individuals with selective IgA deficiency: compensatory IgM secretion and its correlation with HLA and susceptibility to infectionsG Norhagen
Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
J Clin Immunol 9:279-86. 1989..of IgA, IgM, and IgG were measured in unstimulated whole saliva and serum from 63 individuals with selective IgA deficiency. Values were compared with the incidence of upper respiratory tract infections, antibiotic treatments (..
- Diagnostic accuracy of IgA anti-tissue transglutaminase antibody assays in celiac disease patients with selective IgA deficiencyD Villalta
Immunologia Clinica e Virologia, A O S Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
Ann N Y Acad Sci 1109:212-20. 2007..studies have estimated a 10- to 20-fold increased risk for celiac disease (CD) in patients with selective IgA deficiency (SIgAD)...
- Colocalization of lichen planus and vitiligo associated with selective IgA deficiencyUlker Gul
Second Dermatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
Skinmed 6:202-3. 2007..Melanocytes were decreased in number, and in some areas they were absent at the basal layer of epidermis. Clinical and histopathologic diagnosis were consistent with lichen planus and vitiligo (Figure 2)...
- Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deaminated gliadin peptide antibody assaysDanilo Villalta
Immunologia Clinica e Virologia, AO S Maria degli Angeli, Via Montereale 24, Pordenone, Italy
Clin Chim Acta 382:95-9. 2007To evaluate the diagnostic characteristics of commercially available IgG anti-tTG assays in selective IgA deficiency (SIgAD), we tested different IgG anti-tTG methods and compared the results with those obtained from two other tests: one ..
- Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16qAlejandro A Schäffer
Department of Health and Human Services, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38A Rm 6S608 8600 Rockville Pike, Bethesda, MD 20894, USA
Hum Genet 118:725-9. 2006..immunodeficiency (CVID) is an antibody deficiency syndrome that often co-occurs in families with selective IgA deficiency (IgAD). Vorechovský et al...
- Unusual absence of neurologic symptoms in a six-year old girl with ataxia-telangiectasiaG G Trimis
Pediatric Department of University of Athens, Greece
J Postgrad Med 50:270-1. 2004..It is concluded that a normal neurological assessment must not exclude the diagnosis of A-T and delay the proper interventional measures...
- Different clinical and laboratory evolutions in ataxia-telangiectasia syndrome: report of four casesW C Neves Forte
Immunology Section, Santa Casa Medical School and Hospital, Sao Paulo, Brazil
Allergol Immunopathol (Madr) 33:199-203. 2005..sequence of the most commonly observed immunocompromised conditions were in our patients, in ascending order, IgA deficiency, IgG2 deficiency and the neutrophil phagocytosis stage and common variable immunodeficiency...
- Esophagus cancer and IgA deficiency in a patient with Dubowitz syndrome: a case reportIbrahim Halil Turkbeyler
Gaziantep University Faculty of Medicine, Department of Internal Medicine, Gaziantep, Turkey
Tokai J Exp Clin Med 36:29-30. 2011..Esophageal mass biopsy revealed squamous cell carcinoma type. Both malignancy and IgA deficiency have been reported literature in patients with Dubowitz syndrome...
- The impact of an early truncating founder ATM mutation on immunoglobulins, specific antibodies and lymphocyte populations in ataxia-telangiectasia patients and their parentsA Stray-Pedersen
Department of Paediatrics, Rikshospitalet University Hospital, Oslo, Norway
Clin Exp Immunol 137:179-86. 2004..58-1.26) g/l in the other patients (P = 0.002). Among the 11 A-T patients, six had IgG2 deficiency, six had IgA deficiency (three in combination with IgG2 deficiency) and seven had low/undetectable IgE values...
- High density of intraepithelial gammadelta lymphocytes and deposits of immunoglobulin (Ig)M anti-tissue transglutaminase antibodies in the jejunum of coeliac patients with IgA deficiencyM Borrelli
Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
Clin Exp Immunol 160:199-206. 2010..Intestinal IgM anti-TG2 and immunohistochemical markers do not discriminate between IgAD and potential CD with IgAD. Therefore, the serum IgG CD-associated autoantibodies remains very important for the diagnosis of CD in IgAD...
- Profile of autoantibodies against phosphorylcholine and cross-reactivity to oxidation-specific neoantigens in selective IgA deficiency with or without autoimmune diseasesAna Elisa Fusaro
Laboratório de Investigação em Dermatologia e Imunodeficiências, LIM 56, Faculdade de Medicina da USP, Instituto de Medicina Tropical de Sao Paulo, Sao Paulo, Brazil
J Clin Immunol 30:872-80. 2010..In conclusion, the IgG NatAbs against PC may represent a compensatory defense mechanism against infections and control excess of inflammation, explaining the asymptomatic status in the IgA deficiency.
- Recurrent extended HLA haplotypes in children with selective IgA deficiencyM Cuccia-Belvedere
Dipartimento di Genetica e Microbiologia Università di Pavia, Italy
Tissue Antigens 34:127-32. 1989..supratypes as well as serum IgG, IgA and IgM levels were determined in 44 children and adolescents with severe IgA deficiency (serum IgA less than 5 mg/dl) and in first degree relatives...
- Plasma cytokine profiles in patients with celiac disease and selective IgA deficiencyFrancesco Cataldo
Clinica Pediatrica R, University of Palermo, Palermo, Italy
Pediatr Allergy Immunol 14:320-4. 2003Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD...
- Selective immunoglobulin A deficiency in Iranian blood donors: prevalence, laboratory and clinical findingsShiva Saghafi
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Iran J Allergy Asthma Immunol 7:157-62. 2008..In this study we determined the incidence of selective IgA deficiency (SIgAD) in normal adult Iranian population. 13022 normal Iranian blood donors were included in this study...
- Membranous glomerulopathy in a patient with selective IgA deficiency: is there a link?A Vanacker
Department of Nephrology, Heilig Hartziekenhuis Roeselare Menen, Roeselare, Belgium
Acta Clin Belg 66:228-30. 2011..Biochemistry showed a selective IgA deficiency (SIgAD)...
- Concomitant autoimmunity in myasthenia gravis--lack of association with IgA deficiencyRyan Ramanujam
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
J Neuroimmunol 236:118-22. 2011..b>IgA deficiency (IgAD), which is strongly associated with the same HLA haplotype as early onset MG, has recently been ..
- Myelodysplastic syndrome with trisomy 8 in an adolescent with Fanconi anaemia and selective IgA deficiencyG R Standen
Department of Haematology, University of Wales College of Medicine, Cardiff, UK
Am J Hematol 31:280-3. 1989..Immune function studies also identified a selective IgA deficiency. The relative importance of interacting constitutional and exogenous factors involved in the development of ..
- Relative IgA deficiency and small intestinal bacterial overgrowth in German shepherd dogsR M Batt
Department of Veterinary Pathology, University of Liverpool
Res Vet Sci 50:106-11. 1991..However, it is not clear whether such a defect is directly responsible for the overgrowth, or whether there is an indirect relationship between defective local immunity and bacterial overgrowth in German shepherd dogs...
- Human leukocyte antigens (HLA) associated with selective IgA deficiency in Iran and SwedenJavad Mohammadi
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
Iran J Allergy Asthma Immunol 7:209-14. 2008Selective IgA deficiency (IgAD) (serum IgA concentration of <0.07 g/l) is the most common primary immunodeficiency in Caucasians, with an estimated prevalence of 1/600...
- MSH5 is not a genetic predisposing factor for immunoglobulin A deficiency but marks the HLA-DRB1*0102 subgroup carrying susceptibilityNadia Del Pozo
Clinical Immunology Department, Hospital Clinico, San Carlos, Madrid, Spain
Hum Immunol 71:861-4. 2010The etiology of selective IgA deficiency (IgAD) is clearly influenced by human leukocyte antigen (HLA) genetic composition, although the susceptibility observed has not been ascribed to any specific gene/s...
- HLA-A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 frequencies in German immunoglobulin A-deficient individualsH K Machulla
Interbranch HLA Laboratory, Institute of Medical Immunology, Medical School, Martin Luther University of Halle Wittenberg, Germany
Scand J Immunol 52:207-11. 2000..Furthermore, for the first time this study reports a positive association of IgA deficiency with DPB1 alleles. Homozygosity rate for the gene loci DRB1 and DQB1 was increased in IgA deficiency...
- MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypesEmilio G De la Concha
Department of Immunology, Hospital Clinico San Carlos, La Paz Hospital, 28040 Madrid, Spain
J Immunol 169:4637-43. 2002Familial predisposition to IgA deficiency (IgAD) suggests that genetic factors influence susceptibility...
- Prevalence of IgA deficiency in adult systemic lupus erythematosus and the study of the association with its clinical and autoantibody profilesAna Paula França Mantovani
Rheumatology Department, Hospital Universitario Evangelico de Curitiba, Faculdade Evangélica de Medicina do PR FEPAR, Curitiba, Brazil
Rev Bras Reumatol 50:273-82. 2010b>IgA deficiency (IgAD) is the most common primary immunodeficiency, which can cause frequent infections...
- Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypesH W Schroeder
Department of Medicine, Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
Mol Med 4:72-86. 1998A common genetic basis for IgA deficiency (IgAD) and common variable immunodeficiency (CVID) is suggested by their occurrence in members of the same family and the similarity of the underlying B cell differentiation defects...
- Role for Msh5 in the regulation of Ig class switch recombinationHideharu Sekine
Medical University of South Carolina, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 104:7193-8. 2007..We also present evidence that genetic variation in MSH5 is associated with IgA deficiency and common variable immune deficiency (CVID) in humans...
- Central MHC genes affect IgA levels in the human: reciprocal effects in IgA deficiency and IgA nephropathyVance B Matthews
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Australia
Hum Immunol 63:424-33. 2002..alleles of one or more genes in the central major histocompatibility complex (MHC) predispose carriers to IgA deficiency (IgAD) or IgA Nephropathy (IgAN)...
- TACI mutation in common variable immunodeficiency and IgA deficiencyRima Rachid
Division of Immunology, Children s Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Curr Allergy Asthma Rep 6:357-62. 2006....
- Development of ulcerative colitis during the course of rheumatoid arthritis: Association with selective IgA deficiencyYuki Asada
Department of Internal Medicine, National Nagasaki Medical Center, 1001 1 Kubara, Omura, Japan
World J Gastroenterol 12:5240-3. 2006..Laboratory tests revealed low serum and saliva IgA levels, which might play a role in the development of UC. To our knowledge, this is the first case of UC occurring during the course of RA, accompanied by selective IgA deficiency.
- [IgA, an essential part of the immune system: selected issues]Agnieszka Czyzewska-Buczyńska
Katedra Propedeutyki Pediatrii, Klinika Immunologii i Reumatologii Wieku Rozwojowego Akademii Medycznej we Wrocławiu, Wrocław, Poland
Postepy Hig Med Dosw (Online) 61:38-47. 2006....
- IgA deficiency: correlation between clinical and immunological phenotypesAsghar Aghamohammadi
Department of Pediatrics, Division of Immunology and Allergy, Children Medical Center Hospital, Tehran University of Medical Sciences, 62 Gharib St, Keshavarz Blvd, 14194, Tehran, Iran
J Clin Immunol 29:130-6. 2009b>IgA deficiency (IGAD) is the most common primary antibody deficiency. Although many affected individuals have no apparent symptom, selected patients suffer from recurrent mucosal infections, allergies, and autoimmune diseases...
- Individuals with IgA deficiency and common variable immunodeficiency share polymorphisms of major histocompatibility complex class III genesF M Schaffer
Department of Pediatrics, University of Alabama at Birmingham 35294
Proc Natl Acad Sci U S A 86:8015-9. 1989b>IgA deficiency and common variable immunodeficiency are heritable disorders that can occur within the same family...
- Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family studyJavier Ortiz
Clinical Immunology Department, Hospital Clinico San Carlos, Madrid
BMC Med Genet 7:56. 2006b>IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Genetic and environmental factors are suspected to be involved in the development of the disease...
- Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentrationVincenzo Giambra
Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada
J Immunol 183:8280-5. 2009Selective IgA deficiency (IGAD) is the most common primary immunodeficiency, yet its pathogenesis is elusive. The IG (heavy) H chain human 3' Regulatory Region harbors three enhancers and has an important role in Ig synthesis. HS1...
- Resolution of Henoch-Schönlein purpura nephritis after acquired IgA deficiencyMototsugu Tanaka
Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
Pediatr Nephrol 25:2355-8. 2010We report a case of Henoch-Schönlein purpura nephritis (HSPN) with acquired IgA deficiency due to parvovirus B19 infection...
- Role of IgA in the defense against respiratory infections IgA deficient mice exhibited increased susceptibility to intranasal infection with Mycobacterium bovis BCGAriane Rodriguez
Department of Immunology, Stockholm University, Stockholm, Sweden
Vaccine 23:2565-72. 2005..Altogether, our results suggest that IgA may play a role in protection against mycobacterial infections in the respiratory tract by blocking the pathogen entrance and/or by modulating the pro-inflammatory responses...
- Physiology of IgA and IgA deficiencyC Cunningham-Rundles
Department of Medicine and Pediatrics, Mount Sinai Medical Center, New York, New York 10029, USA
J Clin Immunol 21:303-9. 2001Although secretory immunoglobulin A (IgA) is important in mucosal immunity. selective IgA deficiency is the most common primary immunodeficiency of humans. In most cases this defect is not associated with any illness...
- IgA deficiency: clinical correlates and responses to pneumococcal vaccineEki Edwards
Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
Clin Immunol 111:93-7. 2004..024). There was no relationship between a history of recurring infections and pneumococcal vaccine responses; HLA status was not related to a history of autoimmunity...
- The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiencyK Haimila
Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland
Genes Immun 10:151-61. 2009b>IgA deficiency (IgAD) and common variable immunodeficiency (CVID) often co-occur in families, associating with chronic inflammatory diseases such as celiac disease (CD)...
- IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndromeYukihiko Kawasaki
Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, 960 1295, Fukushima City, Fukushima, Japan
Pediatr Nephrol 20:662-4. 2005Selective IgA deficiency associated with glomerulonephritis is rare and no previous reports in childhood have been made of the association of IgA deficiency and membranous glomerulonephritis (MGN)...
- TACI is mutant in common variable immunodeficiency and IgA deficiencyEmanuela Castigli
Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Genet 37:829-34. 2005..that 4 of 19 unrelated individuals with common variable immunodeficiency (CVID) and 1 of 16 individuals with IgA deficiency (IgAD) had a missense mutation in one allele of TNFRSF13B (encoding TACI)...
- Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predispositionI Vorechovsky
Karolinska Institute, Department of Biosciences at Novum, Huddinge, Sweden
Am J Hum Genet 64:1096-109. 1999..Such pathogenic mechanisms may be shared by other MHC-linked complex traits associated with the production of specific autoantibodies, parental effects, and a particular MHC haplotype...
- Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiencyEmanuela Castigli
Nat Genet 39:430-1. 2007
- Progression of selective IgA deficiency to common variable immunodeficiencyAsghar Aghamohammadi
Department of Allergy and Clinical Immunology, Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Int Arch Allergy Immunol 147:87-92. 2008Selective IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Although it is often asymptomatic, selected patients show an increased frequency of infections, allergies and autoimmune manifestations...
- Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinicKelly E McGowan
Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada
Clin Chem 54:1203-9. 2008b>IgA deficiency causes false-negative IgA-based celiac serology results in patients with celiac disease...
- Role of polymorphisms in the TNFRSF13B (TACI) gene in Spanish patients with immunoglobulin A deficiencyR López-Mejías
Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
Tissue Antigens 74:42-5. 2009..Therefore, our work seems to discard a role of TNFRSF13B mutations in IgAD, concordantly with the most recent published studies...
- Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiencyStephan Borte
Department of Clinical Immunology and Transfusion Medicine, University of Leipzig, D 04103 Leipzig, Germany
Blood 114:4089-98. 2009..immunoglobulin production in B cells from patients with common variable immunodeficiency (CVID) or selective IgA deficiency (IgAD)...
- Familial aggregation of IgAD and autoimmunityGudmundur H Jorgensen
Department of Medicine, University of Iceland, Reykjavik, Iceland
Clin Immunol 131:233-9. 2009..The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families...
- Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiencyQiang Pan-Hammarstrom
Nat Genet 39:429-30. 2007
- [Epidemiological study of selective IgA deficiency among 6 nationalities in China]L Feng
Beijing Children s Hospital
Zhonghua Yi Xue Za Zhi 72:88-90, 128. 1992The frequency of selective IgA deficiency (SIgAD) was determined in 33,171 Chinese distributed in six nationalities by Ouchterlony's double diffusion with 5 mg/dl as the limit of detection...
- Fine mapping of IGAD1 in IgA deficiency and common variable immunodeficiency: identification and characterization of haplotypes shared by affected members of 101 multiple-case familiesI Vorechovsky
Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
J Immunol 164:4408-16. 2000To limit the region containing a mutation predisposing to selective IgA deficiency (IgAD) and common variable immunodeficiency (CVID), 554 informative members of 101 multiple-case families were haplotyped at the IGAD1 candidate locus in ..
- Primary immunodeficiency disorders: antibody deficiencyMark Ballow
Division of Allergy Clinical Immunology and Pediatric Rheumatology, Department of Pediatrics, Children s Hospital of Buffalo, SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo 14222, USA
J Allergy Clin Immunol 109:581-91. 2002..As discussed in this review, this has led to a better elucidation of the B-cell development and differentiation pathways and a more complete understanding of the pathogenesis of many of these antibody deficiencies...
- Fine-scale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiencyJana Kralovicova
Division of Human Genetics, School of Medicine, Southampton University Hospital, University of Southampton, Southampton, United Kingdom
J Immunol 170:2765-75. 2003Selective IgA deficiency (IgAD) and common variable immunodeficiency (CVID) are the most common primary immunodeficiencies in humans...
- Immunohistochemical findings in the intestine of IgA-deficient persons: number of intraepithelial T lymphocytes is increasedT Klemola
Children s Hospital, University of Helsinki, Finland
J Pediatr Gastroenterol Nutr 7:537-43. 1988..05 compared with pre-challenge specimens). The increase in IEL number in the jejunal mucosa of IgAdp probably indicates ineffective antigen exclusion...
- Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypesG R Harriman
Departments ofMedicine, Pediatrics, Pathology, and Molecular and Human Genetics, Howard Hughes Medical Institute, Houston, TX 77030, USA
J Immunol 162:2521-9. 1999A murine model of IgA deficiency has been established by targeted deletion of the IgA switch and constant regions in embryonic stem cells. B cells from IgA-deficient mice were incapable of producing IgA in vitro in response to TGF-beta...
- Selective IgA deficiency and coeliac diseaseP Collin
Dept of Clinical Sciences, University of Tampere, Finland
Scand J Gastroenterol 27:367-71. 1992Twenty-five children and adults with concomitant coeliac disease and selective IgA deficiency are described. IgG-class reticulin antibodies were positive in 94%...
- Selective IgA deficiency (SIgAD) in Eastern NigeriaA C Ezeoke
Department of Chemical Pathology, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Anambra State
Afr J Med Med Sci 17:17-21. 1988Fifteen cases of selective IgA deficiency were found among 3772 children. Six had IgA levels of 0.01 g/l both in their serum and saliva, and had associated allergic disorders...
- Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeperCristina M A Jacob
Instituto da Criança, Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Rua Oscar Freire 1961 apto 24 Cerqueira César CEP 05409 011 São Paulo, Brasil
J Clin Immunol 28:S56-61. 2008Both systemic and organ-specific autoimmune diseases are major manifestations of IgA deficiency (IgAD), the most common primary immunodeficiency...
- Bronchial hyper-responsiveness in selective IgA deficiencyAthina Papadopoulou
Department of Allergology Pulmonology, Penteli Children s Hospital, P Penteli, Greece
Pediatr Allergy Immunol 16:495-500. 2005..The insufficient protection provided by the respiratory mucosa in children with selective IgA deficiency (sIgAD) might facilitate the development of bronchial hyper-responsiveness (BHR) and consequently asthma ..
- Juvenile idiopathic polyarticular arthritis and IgA deficiency in the 22q11 deletion syndromeK Davies
Department of Rheumatology, Great Ormond Street Hospital for Sick Children, London, UK
J Rheumatol 28:2326-34. 2001..Of particular interest is the occurrence of IgA deficiency in 4 patients, including 2 from our own series...
- Dermatitis herpetiformis and partial IgA deficiencyNancy J Samolitis
Department of Dermatology, University of Utah Health Sciences Center, USA
J Am Acad Dermatol 54:S206-9. 2006..To date, no cases of IgA deficiency have been reported in DH...
- Autosomal recessive chronic granulomatous disease, IgA deficiency and refractory autoimmune thrombocytopenia responding to Anti-CD20 monoclonal antibodyBibi Shahin Shamsian
Department of Pediatric Hematology Oncology, Immunology, Pathology, Mofid Children s Hospital, Tehran, Iran
Iran J Allergy Asthma Immunol 7:181-4. 2008..granulomatous disease -the autosomal recessive type with mutation of NCF1 gene P47- associated with selective IgA deficiency, refractory immune thrombocytopenia that showed an excellent response to Rituximab (Anti-CD20 monoclonal ..
- Clinical assessment and management of abnormal IgA levelsFrederick M Schaffer
Section of Pulmonary, Allergy, and Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
Ann Allergy Asthma Immunol 100:280-2. 2008
- Various expression patterns of alpha1 and alpha2 genes in IgA deficiencyHiroko Suzuki
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
Allergol Int 58:111-7. 2009b>IgA deficiency (IgAD) is the most common immunodeficiency, however the pathogenesis in most cases of IgAD is unknown...
- Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40LZaheed Husain
The CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA
J Clin Immunol 26:113-25. 2006b>IgA deficiency is the most common primary immunodeficiency in humans...
- IgG2, IgG4 and IgA deficiency possibly associated with carbamazepine treatmentZenichiro Kato
Eur J Pediatr 162:209-11. 2003
- IgA deficiency and the MHC: assessment of relative risk and microheterogeneity within the HLA A1 B8, DR3 (8.1) haplotypeJavad Mohammadi
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
J Clin Immunol 30:138-43. 2010Selective IgA deficiency (IgAD; serum IgA concentration of <0.07 g/l) is the most common primary immunodeficiency in Caucasians with an estimated prevalence of 1/600...
- Intracellular cytokine production by Th1/Th2 lymphocytes and monocytes of children with symptomatic transient hypogammaglobulinaemia of infancy (THI) and selective IgA deficiency (SIgAD)D Kowalczyk
Department of Clinical Immunology, Polish American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland
Clin Exp Immunol 127:507-12. 2002..in lymphocytes and monocytes of children with transient hypogammaglobulinaemia of infancy (THI) and selective IgA deficiency (SIgAD)...
- Low prevalence of IgA deficiency in north Indian populationShelly Chandran
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Indian J Med Res 123:653-6. 2006..No data are available from India. We did a blood donor survey to look for prevalence of IgA deficiency in north India.
- Major histocompatibility complex haplotypes in Spanish immunoglobulin A deficiency patients: a comparative fine mapping microsatellite studyL Gual
Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
Tissue Antigens 64:671-7. 2004..The results obtained also indicated that the most likely susceptibility gene in the DR7 haplotypes is either DQA1 or DRB1...
- HLA antigens in IgA deficient paediatric patientsT Klemola
Children s Hospital, University of Helsinki, Finland
Tissue Antigens 32:218-23. 1988..The IgA deficiency in the patients showed significant associations with HLA A1, B8, B13, Cw6, DR3 and DR7 (P less than 0...
- A putative susceptibility locus on chromosome 18 is not a major contributor to human selective IgA deficiency: evidence from meiotic mapping of 83 multiple-case familiesI Vorechovsky
Karolinska Institute at NOVUM, Center for Biotechnology, Huddinge, Sweden
J Immunol 163:2236-42. 1999..and low levels of IgA suggested that this chromosome contains a susceptibility locus for selective IgA deficiency (IgAD), the most frequent Ig deficiency in humans...
- Cytokine genotyping (TNF and IL-10) in patients with celiac disease and selective IgA deficiencyF Cataldo
Clinica Pediatrica R, Sezione di Patologia Generale, University of Palermo, Palermo, Italy
Am J Gastroenterol 98:850-6. 2003Selective IgA deficiency (IgAD) and celiac disease (CD) are frequently associated and share the ancestral haplotype human leukocyte antigen (HLA)-8.1, which is characterized by a peculiar cytokine profile...
- Epistatic effects occurring among susceptibility and protective MHC genes in IgA deficiencyA Martinez
Department of Immunology, Hospital Clinico San Carlos, Madrid, Spain
Genes Immun 4:316-20. 2003....
- Bacterial lipopolysaccharide induces long-lasting IgA deficiency concurrently with features of polyclonal B cell activation in normal and in lupus-prone miceT Cavallo
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912
Clin Exp Immunol 84:134-8. 1991..Because immune defects are common in autoimmune diseases and IgA deficiency is prevalent in patients with systemic lupus erythematosus, we investigated: (i) whether LPS might induce IgA ..
- Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiencyRong Jin
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
Int J Mol Med 21:233-8. 2008..Elevated BAFF and APRIL expression levels might partially reflect the common immunological feature of primary antibody deficiency...
- Kabuki syndrome with trichrome vitiligo, ectodermal defect and hypogammaglobulinemia A and GRaffaella Zannolli
Department of Pediatrics, Section of Neurology, Policlinico Le Scotte, University of Siena, Siena, Italy
Brain Dev 29:373-6. 2007..Our report may provide important clues for understanding the pathogenesis of the KS...
- Enterobacterial 38-kDa outer membrane protein is an age-dependent molecular marker of innate immunity and immunoglobulin deficiency as results from its reactivity with IgG and IgA antibodyDanuta Witkowska
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
FEMS Immunol Med Microbiol 48:205-14. 2006..These data correlated with total IgA and IgG levels in immunoglobulin-deficient children. The results indicate that this protein may serve as an immunodiagnostic marker, but also as an antigen carrier in vaccines...
- Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibilitySatu Simell
The JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, and Tampere University Hospital, Finland
Scand J Gastroenterol 40:1182-91. 2005..The aim of this study was to investigate the sequence of events leading to overt CD by retrospective analysis of TGA values in serum samples collected frequently from genetically susceptible children since birth or early childhood...
- No evidence for prolonged excretion of polioviruses in persons with residual paralytic poliomyelitis in Ethiopia, Pakistan and GuatemalaAamir J Khan
Department of International Health, Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Room W5041, Baltimore, MD 21205, USA
Biologicals 34:113-6. 2006..Nevertheless, persistent poliovirus excretion among persons 2 years of age and older with residual paralytic poliomyelitis is uncommon in developing countries...
- Clinical inquiries: What blood tests help diagnose celiac disease?Bonzo K Reddick
Department of Family Medicine, University of North Carolina, Chapel Hill, NC, USA
J Fam Pract 55:1088, 1090, 1093. 2006..IgA tTG and IgA EMA offer the best diagnostic accuracy. Patients with selective IgA deficiency may have falsely negative IgA assays (strength of recommendation [SOR]: B, based on a systematic review, ..
- Anti-tissue transglutaminase antibodies and their role in the investigation of coeliac diseaseP G Hill
Department of Chemical Pathology, Haematology and Immunology, Derbyshire Royal Infirmary, Derby Hospitals NHS Foundation Trust, Derby DE1 2QY
Ann Clin Biochem 43:105-17. 2006....
- Total and relative deficiency of gut mucosal IgA in German shepherd dogs demonstrated by faecal analysisR M Littler
Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield
Vet Rec 158:334-41. 2006..The faecal concentrations of immunoglobulin G and albumin were significantly higher in the German shepherd dogs than in the controls, but their immunoglobulin M concentrations were similar...
- Immunoglobulin A and CD8 T-cell mucosal immune defenses protect against intranasal infection with Chlamydia pneumoniaeA Rodriguez
Department of Immunology, Stockholm University, Stockholm, Sweden
Scand J Immunol 63:177-83. 2006..pneumoniae infections...
- Do we need to measure total serum IgA to exclude IgA deficiency in coeliac disease?D Sinclair
Department of Clinical Biochemistry, Queen Alexandra Hospital, Portsmouth, UK
J Clin Pathol 59:736-9. 2006Screening for IgA deficiency in patients with coeliac disease is essential because of the increased incidence of IgA deficiency associated with the disease, which usually relies on the estimation of IgA levels in each case.
- Increases in serum immunoglobulins to age-related normal levels in children with IgA and/or IgG subclass deficiencyNecil Kutukculer
Ege University, The Medical School, Department of Pediatrics, Izmir, Turkey
Pediatr Allergy Immunol 18:167-73. 2007..Among 87 patients studied, the most frequent defect was partial IgA deficiency combined with IgG3 subclass deficiency (41%)...
- The clinical significance of immunoglobulin A deficiencyAmir H Abdul Latiff
Division of Clinical Immunology and Allergy, Department of Paediatrics, Faculty of Medicine and Health Sciences, Universiti Putra, Serdang, Malaysia
Ann Clin Biochem 44:131-9. 2007b>IgA deficiency is the most common primary immunoglobulin deficiency. The prevalence in Caucasians is around one in 500, whereas in some Asian populations it is very uncommon...
- Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract in patient with selective immunoglobulin A deficiency and sarcoid-like syndrome--case reportM Piascik
Department of Gastroenterology, Central Clinical Hospital of Ministry of Home Affairs, Warsaw, Poland
Adv Med Sci 52:296-300. 2007..In this case report we focus on clinical presentation and differential diagnosis of diffuse nodular lymphoid hyperplasia of the gastrointestinal tract coexisting with selective immunoglobulin A deficiency and sarcoid-like syndrome...
- Celiac disease in North Italian patients with autoimmune thyroid diseasesAglaura Cinzia Spadaccino
Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova Medical School, Padova, Italy
Autoimmunity 41:116-21. 2008..An IgA deficiency is the most frequent immunodeficiency in humans and, in general, high frequency of this disorder was ..
- Primary immune deficiency among patients with recurrent infectionsRajiva de Silva
Department of Immunology, Medical Research Institute, Colombo
Ceylon Med J 52:83-6. 2007..We investigated patients who presented during the years 2005-7 with recurrent or persistent infections or infections with opportunistic organisms, for underlying immune deficiency...
- Practical aspects of ambulatory diagnoses and management of immunodeficiency disordersChitra Dinakar
Ann Allergy Asthma Immunol 99:201-2. 2007
- IgA inducing peptideD Estes; Fiscal Year: 2005..We also hypothesize that altered IGIP regulation in dendritic cells and/or B cells is a factor in selective IgA deficiency. The specific aims that will test this hypothesis are: 1) Use an established in vitro model to determine the ..
- 2003 CIS Summer SchoolCharlotte Cunningham Rundles; Fiscal Year: 2003..The participants will be drawn from training programs, hospitals and institutions that are in North, Central or South America. Only fellows from the United States will receive funding made possible through the NIH grant. ..
- Cellular &Molecular Defects in Human B Cell DevelopmentCharlotte Cunningham-Rundles; Fiscal Year: 2013..conditions, the more prevalent immune defects which impair B cell function, common variable immune deficiency, IgA deficiency, IgG subclass and specific antibody deficiency, are still largely uncharted territory...
- Molecular Genetics of HLA and DiseaseStephen Hauser; Fiscal Year: 2009..The focus is on Multiple Sclerosis, Rheumatoid Arthritis, IgA Deficiency, Common Variable Immunodeficiency, Myasthenia Gravis, Systemic Lupus Erythematosus and Ulcerative Colitis...
- IgG glycosylation abnormalities in pediatric immunodeficiencyPeter A Nigrovic; Fiscal Year: 2013..association with clinical disease, such as mild hypogammaglobulinemia, IgG subclass deficiency, or IgA deficiency. Frequently, such patients receive empiric antibiotics or occasionally IVIG, without any mechanistic ..
- The influence of IgA on B Cell HomeostasisDennis W Metzger; Fiscal Year: 2010..RELEVANCE: IgA deficiency is the most frequent form of primary immunodeficiency in humans...
- DNA Repair Defects in IgA DeficiencyREUBEN HARRIS; Fiscal Year: 2009DNA Repair Defects in IgA Deficiency Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in humans, and it is characterized by the absence of serum IgA and an increased frequency of bacterial infections in the ..
- Altered somatic mutation in IgAD/CVID; association with deficiency of Msh4/5Hideharu Sekine; Fiscal Year: 2009Selective IgA deficiency (IgAD, 1/600) and common variable immune deficiency (CVID, 1/25,000) are the most common forms of human primary immunodeficiency in Caucasians...
- MOUSE MODEL OF IGA DEFICIENCY USING GENE TARGETINGGregory Harriman; Fiscal Year: 1993b>IgA deficiency is the most common humoral immunodeficiency in humans, affecting approximately 1 in 600 people...
- Novel Gene Control of Lymphoid Tissue DevelopmentRosemarie Seymour; Fiscal Year: 2009..b>IgA deficiency is a common form of immune deficiency in humans, and has also been implicated in autoimmunity...
- IMPROVED BLOOD SERVICE CARE FOR CYTOPENIC PATIENTSCHESTER ALPER; Fiscal Year: 2005..Project 9 will localize the chromosomal regions of the MHC for susceptibility genes for IgA deficiency and related immunoglobulin deficiency states...
- UTAH AUTISM PROGRAMWilliam McMahon; Fiscal Year: 2001..This variation will in turn be related to IgA deficiency and serotonin levels...
- CD4 T CELL DEFICIENCY AND INTESTINAL IMMUNE RESPONSESJOHN COWDERY; Fiscal Year: 1993..This project will study the effect of chronic depletion of CD4 T cells on the development of gut IgA deficiency. The preliminary data document that chronic depletion of CD4 T cells can inhibit the appearance of IgA ..
- T CELL REGULATION OF IGA SECRETIONJudy Splawski; Fiscal Year: 1990..then be utilized to examine tissue differences in IgA secretion and the specific defects in individuals with IgA deficiency. A better understanding of the regulation of the differentiation of IgA secreting cells is of major importance ..
- APRIL-TACI: Role in mucosal IgA and human IgA deficiencyEmanuela Castigli; Fiscal Year: 2006..Selective IgA deficiency is the most common immunodeficiency affecting 1/300 to 1/700 individuals, approximately half of whom suffer ..
- Primary Immune Deficiency Consortium ConferenceCharlotte Cunningham Rundles; Fiscal Year: 2008..Principle topics will focus on: Diagnosis of Immunodeficiency; Genetics, Immune Reconstruction, and the Use of Standard and Novel Therapies. ..
- Primary Immunne Deficiency Consortium ConferenceCharlotte Cunningham Rundles; Fiscal Year: 2005..Principle topics will focus on: Antibody Deficiency; Combined Immune Defects; Neutrophil Disorders; Laboratory Evaluation of Primary Immunodeficiency; Immune Reconstiution, and the Use of Standard and Novel Therapies. ..
- MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANSCharlotte Cunningham Rundles; Fiscal Year: 2001..Thus, this application will focus on the cellular and molecular mechanisms by which IL-2 reconstitutes T cell immunity in this model system. ..
- SECRETORY IMMUNOGLOBULINMICHAEL LAMM; Fiscal Year: 2002....
- TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLYInnocent Mbawuike; Fiscal Year: 2001....
- 2002 Summer School in Primary Immunodeficiency DisordersCharlotte Cunningham Rundles; Fiscal Year: 2002..Fellows participating in the course will be reimbursed for their travel expenses. No registration fee will be charged for the fellows participating in the program. ..
- Vulnerability to Smallpox Due to Declining CTL ImmunityInnocent Mbawuike; Fiscal Year: 2003..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..