Doménicos Theotokópoulos (Greek: Δομήνικος Θεοτοκόπουλος) known as El Greco (The Greek in Spanish) was born in Crete in 1541, and died in 1614. He was a Mannerist painter, sculptor, and architect of the Spanish Renaissance. In 1560, he went to Venice, Italy, where Titian became his greatest mentor; he also had the influence of Tintoretto and Michelangelo. From Venice, El Greco moved to Rome, where he worked from 1570 to 1576. In Rome, El Greco admired Parmigianino who could gave him the inspiration for his stylized figures. Around 1576, he settled in Toledo Spain and was considered the first great genius of the Spanish School. Some of his paintings are regarded as the most vivid works in the world.
Curiously, the paintings of his Italian period were very different in style from his later works. Some of the first are Christ Healing the Blind Man (1560s), The Annunciation (1570-1575), and Christ Driving the Traders from the Temple (c. 1570)... Man of eccentric habits and ideas, of tremendous determination, extraordinary reticence, and extreme devoutness’ he was valued and respected by the intellectuals of Toledo.  He excelled also as a portraitist.
The Burial of the Count of Orgaz (1586 - 1588) is considered to be his best-known work. It is central to our understanding of El Greco because it encapsulates the object of his art, which is to suggest a visionary experience—something that is not an extension of our physical world but of our imaginative faculties;  the success of this painting brought him a great number of commissions from the Church.
El Greco did not have followers, and his art was forgotten for many years. At present he is regarded as one of the most important representatives of European Mannerism.