The industry based on fossil raw materials will not be sustainable for many decades, and it is necessary to start the shift towards natural materials in a biorefinery as the main source of carbon-based materials. The production of biomass is around 1·1014 tons C/year being one of the most abundant resources of carbon in the world. The hydrothermal treatment can be used for a double fold, to produce bio-oils or to produce bio-based streams (C5’s, C6’s and lignin). The hydrothermal fractionation of biomass in subcritical water can be carried out using the following pilot plant. The obtention of different added value products depends mainly on the temperature and reaction time.