less properly cheiro-, before vowels chir-, word-forming element meaning "hand," from Latinized form of Greek kheiro-, combining form of kheir (genitive kheiros) "the hand," from PIE root *ghes- "hand."
word-forming element of Latin origin (in mischief, miscreant, misadventure, misnomer, etc.), from Old French mes- "bad, badly, wrong, wrongly," from Vulgar Latin *minus-, from Latin minus "less" (from suffixed form of PIE root *mei- (2) "small"), which was not used as a prefix in Latin but in the Romanic languages was affixed to words as a depreciative or negative element. The form in French perhaps was influenced in Old French by *miss-, the Frankish (Germanic) form of mis- (1).
More or less confused with un- (1) through similarity in the notions of "negation" and "reversal;" an adjective such as unlocked might represent "not locked" (un- (1)) or the past tense of unlock (un- (2)).