pyrimidine nucleotide synthesis.txt
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What is the first pyrimidine formed?
What is the first pyrimidine nucleotide formed?
What activates and inhibits CPSII?
- active = ATP, PRPP
- inhibit = UTP
What type of ribonucleosides are needed for DNA synthesis?
diphosphates (ADP, GPD, CDP, UDP)
What substrates can bind at the four substrate spots on Ribonucleotide reductase?
- ATP, dATP, dTTP, dGTP
- ATP = active
- dATP = inhibition
Why is ADA such a problem?
- Converts Adenosine into ribo/deoxyribo through salvage
- makes dATP which inhibits R.R. = lack of DNA production
What is tetrahydrofolate utilized for (2 items)?
- All purines
- only dTMP for pyrimidines
Why is folate deficiency dangerous?
There is a link to cancer b/c of a lack of dTMP and more dUTP being incorporated into DNA
What is the function of methotrexate?
What is the function of 5-fluorouracil?
inhibit ThySyn by becoming f-dUMP and competing
How does AZT Triphosphate work?
Inhibits DNA replication by competing with dTTP
What is the function of Trimethoprim?
Inhibit bacterial DHFR
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