Small World Protein Networks
Professor Seth Grant explains that a small world protein network is a network where all proteins are closely connected.
A small world network is a network where all of the members of that network are only a small number of steps away from each other. And we isolated all of the proteins found in these complexes at the synapse, and mapped their physical interactions with one another, and were surprised to find that each protein is only about 3 steps away from every other protein, which is exactly the property of a small world network.
protein, network, interaction, synapse, seth, grant
Professor Seth Grant explains that long-term memories are created when the synapse sends a signal to the nucleus to activate certain genes.
Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.
Cognitive information is encoded in patterns of nervous activity and decoded by molecular listening devices at the synapse. Professor Seth Grant explains how different patterns of neural firing are critical to cognition.
Professor Seth Grant provides a definition of proteomics - the study of the properties of a large numbers of proteins.
Professor Seth Grant explains that the Genes to Cognition research program is investigating the network of proteins that are important to learning.
Professor Seth Grant explains that long-term potentiation is based on the principle that synapses become stronger with experience.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
Dr. Nicole King and Dr. Seth Grant join Cold Spring Harbor Laboratory's David Micklos to discuss the evolution of complex, multicellular animals. Remarkably, the molecules that have driven brain evolution, are the same molecules found in simple unicellula
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
Dr. Nicole King and Dr. Seth Grant join Cold Spring Harbor Laboratory's David Micklos to discuss how synapses in the brain could have evolved.