Bilirubin is the major product of hemoglobin catabolism. Formed in reticuloendothelial cells, bilirubin is bound to albumin and transported to the liver, where it is conjugated with glucuronide and excreted in the bile. Effective conjugation and excretion of bilirubin depends on a properly functioning hepatobiliary system and a normal red blood cell turnover rate. Measurements of serum conjugated (direct) bilirubin levels are useful in evaluating hepatobiliary and erythropoietic functions. Elevated conjugated bilirubin levels in the bloodstream are a very sensitive indicator of hepatocellular disease and biliary obstruction.
Roche Modular analyzer
Roche reagent: Jendrassik-Grof method
Ambient: 24 hours // 2-8 degrees C: 7 days // -20 degrees C: 3 months
< 0.4 mg/dL
Ambient or Cold Pak