Amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid deposits. Amyloidosis may be treated with chemotherapy, but the disease often returns.
In this study, researchers are evaluating the safety and effectiveness of combining bendamustine (a drug approved for treating chronic lymphocytic leukemia and non-Hodgkin lymphoma) and dexamethasone (a steroid commonly used as part of cancer therapy) in patients with amyloidosis that has returned despite prior therapy. Other studies have suggested that this combination of drugs may be effective for these patients.
Bendamustine is given intravenously (by vein) and dexamethasone is taken orally (by mouth).