New York . While exercising daily may seem daunting, how about popping a pill that could help transform your workouts, with science getting closer to that goal, with researchers identifying a molecule in the blood that changes during exercise. is generated.
This can be especially helpful for older or frail people who can’t get enough exercise, and taking medication to help them slow down osteoporosis, heart disease, or other conditions.
According to researchers from Baylor College of Medicine and Stanford University, the drug molecules can effectively reduce food intake and obesity in rats.
The findings, detailed in the journal Nature, also improve understanding of the physiological processes that underlie the interplay between exercise and hunger.
Dr. Yong Ju, Professor of Pediatrics, Nutrition and Molecular and Cellular Biology at Baylor, said, “Regular exercise has been shown to promote weight loss, control appetite and improve metabolic profiles, particularly for overweight and obese people. has been proven.”
“If we can understand the mechanism by which exercise triggers these benefits, we are closer to helping many people improve their health,” Xu said.
The team conducted a comprehensive analysis of blood plasma compounds from rats after intense treadmill running. The most significantly inspired molecule was a modified amino acid called Lac-Phe. It is synthesized from lactate and phenylalanine.
In rats with diet-induced obesity, a high dose of Lac-Phe reduced food intake by about 50 percent compared to control rats over a 12-hour period without affecting their agitation or energy expenditure.
When administered to rats for 10 days, Lac-Fe reduced cumulative food intake and body weight and improved glucose tolerance.
The researchers also identified an enzyme called CNDP2, which is involved in the production of Lac-Phe, and showed that mice lacking this enzyme did not lose as much weight on one exercise regime as a control group on the same exercise plan. did.
Interestingly, the team also found a strong increase in plasma Lac-Phe levels after horse racing and physical activity in humans. Data from a human exercise group showed that sprint exercise induced the most dramatic increase in plasma Lac-Phe, followed by resistance training and then endurance training.
The team’s next goal is to find out how Lac-Phe mediates its effects in the body, including the brain.
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