Revista Medica Herediana
versión impresa ISSN 1018-130X
MANRIQUE, Helard et al. Type 2 diabetes, obesity and diabetic ketoacidosis in children: Case report. Rev Med Hered [online]. 2011, vol.22, n.3, pp. 139-142. ISSN 1018-130X.
A 14-year-old woman presented with recent history of type 2 diabetes and diabetic ketoacidosis. Initial treatment included hydration and IV insulin. The anti-GAD was negative, and C-peptide was normal. Clinical evolution was good. Long-term treatment included metformin, diet and exercise. Type 2 diabetes has traditionally been viewed as a disorder of adults. However, as the prevalence of obesity in youth is increasing, type 2 diabetes is now occurring in children and adolescents. Sustained hyperglycemia can impair the secretion of insulin by the beta-cells of the pancreas. Glucose toxicity explains why some patients newly diagnosed with type 2 diabetes have weight loss, diabetic ketoacidosis, and low measured insulin and C-peptide. Diabetic ketoacidosis in obese adolescents with new-onset diabetes does not imply the diagnosis of type 1 diabetes.(Rev Med Hered 2011;22:139-142).
Palabras llave : Type 2 diabetes; obesity; diabetic ketoacidosis; insulin resistance; glucose toxicity.