Following points highlights dire need to study molecular basis of microbial role in Alzheimer pathogenesis.
- Enough evidence in role of microbes in dementia and building up of amyloid plaques.
- Microbial density in brain of Alzheimer patients far more than control these deposits may produce inflammation during old age when immune system is compromised or haemochromatosis.
- Blood sample of people with Alzheimer was found to contain dormant microbes, bacterial cell wall component like lipopolysaccride such things are known to cause neuro inflammation.
- So clinical trials of antimicrobial against microbes may shed further light in novel concept.