Design of drugs and/or bioactive molecules selective vs specific enzymes
Docking-based virtual screening of chemical libraries (freely accessible, commercially available and in-house developed)
3D comparative modeling of small enzymes and protein complexes
3D modeling of protein-protein interactions
3D modeling of protein-nucleic acid interactions
3D modeling of protein-ligand interactions
Antibody design and 3D modeling of Antibody/Antigen/Receptor interactions
Set-up of ab initio approaches for the study of the protein folding
Investigation of mechanisms of action
ROS levels determination
Bioinformatics data analysis is needed to process these raw information, in order to provide clinicians with a narrow set of relevant data to better understand the starting biological question, and possibly answer it efficiently.
The most recent sequencing techniques are called Next Generation Sequencing (NGS), and provide a wide and deep genome analysis, which can be of different types depending on the biological problem to investigate.
The classic Sanger sequencing, instead, is not as massive as NGS, but is used to analyse specific genomic regions and to validate NGS data analysis results.
An accurate knowledge of the starting biological question and of specific techniques to face it is fundamental. Our experts are available to help you plan and perform successfully many kinds of scientific projects.