The Human Recombinant Carbonic Anhydrase (CA) 2 preserves acid-base balance in blood and other tissues.
The enzyme Carbonic anhydrase 2 (CA2) belongs to the enzyme group that catalyzes rapid inter-conversion of carbon dioxide and water to carbonic acid, bicarbonate, and protons (CO2 + H2O to HCO3 + H), a reaction that takes place rather gradually in the absence of a catalyst. The majority of carbonic anhydrases enclose a zinc ion in their active site and thus is categorized as metalloenzymes. The most critical function of Carbonic anhydrase is said to preserve acid-base balance in blood and other tissues, and to help convey carbon dioxide of tissues.
Carbonic anhydrases exist in areas of life. Mammalian carbonic anhydrase is monomeric and is a part of the alpha class. Mutations in the CA2 gene cause the CA2 deficiency syndrome, an autosomal recessive disorder that results in renal tubular acidosis, osteoporosis, and cerebral calcification.
|Cat # +Size
||CA-II, CAC, Carbonic anhydrase 2, Carbonate dehydratase 2, can, cynT2, yadF, b0126, JW0122, Carbonic Anhydrase II
|Physical Form Description
||1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 50 mM NaCl, 1 mM DTT and 10% glycerol.
||29.2 kDa (260 aa, 1-260 aa)
|Purity by SDS-PAGE
||Specific activity is 50-70 nmoles/min/µg and was obtained by measuring the increase in the amount of p-nitrophenol by its esterase activity
|Amino Acid Sequence
||MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NG
||Centrifuge the vial prior to opening
||For research use only! Not to be used in humans